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Article ; Online: A study on the impact and mechanism of action of public health education on the health of the migrant population: evidence from the 2018 China migrants dynamic survey.

Dong, Bo

2024 Volume 12, Page(s) 1308751

Abstract: Background: China has the world's largest mobile population. As mobility increases, ensuring the health protection of this population is receiving more attention. Strengthening public health education is a crucial measure to improve their health and ... ...

Abstract	Background: China has the world's largest mobile population. As mobility increases, ensuring the health protection of this population is receiving more attention. Strengthening public health education is a crucial measure to improve their health and achieve equal access to basic public health services in China. Previous research has demonstrated that public health education has an impact on the health of mobile populations. However, there has been limited investigation into the mediating pathways through which health education influences the health of mobile populations, and few studies have examined the heterogeneity of this effect. Objectives: The aim of this study was to analyze the impact of public health education on the health of the mobile population and its mechanism of action. Additionally, we aimed to explore the differences in this impact among different subdivided groups. Methods: This paper analyses the impact of public health education on the health of the mobile population using the 2018 China Migrant Dynamic Survey (CMDS) Data,. The data was cleaned and 4,034 people were included in the analysis. The study employed ordered logistic regression modeling to analyze the mediating pathways through which health education affects health. Additionally, binary logistic regression model, probit model, propensity score matching method and instrumental variables were used to verify the robustness of the results. Results: The self-assessed health status of the mobile population was good, and 82.10% of them accepted public health education. However, 17.89% of the mobile population did not receive any health education. Acceptance of health education can help improve the health status of the mobile population (OR = 1.178, 95% CI = 0.979-1.418). The study found that public health education can positively impact the health of mobile populations by influencing their health and hospitalization behaviors, as well as their social support. The analysis of heterogeneity revealed that the impact of public health education is more significant among rural, middle-aged, low-education, and low-income groups of the mobile population. Conclusion: Public health education can have a positive impact on the health of the migrant populations. To further improve health education for this group, it is necessary to actively promote the establishment of health records for the migrant population, to facilitate the contracting of family doctors by the migrant population, to improve the accessibility to hospitalization services, reduce the burden of hospitalization costs, and enhance social support. Simultaneously, it is essential to offer precise and varied health education to the migrant population based on their characteristics, to promote equity among diverse groups of individuals. These findings not only help to enrich theoretical research on health education for migrant populations and the health of migrant populations but also help to improve the level of public health education for migrant populations and improve the health protection of migrant populations.
MeSH term(s)	Middle Aged ; Humans ; Transients and Migrants ; Surveys and Questionnaires ; Health Status ; Health Education ; China/epidemiology
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1308751
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Article ; Online: The impact of basic health insurance participation characteristics on the health of mobile populations: the mediating role of health service utilization behavior.

Dong, Bo

Frontiers in public health

2024 Volume 12, Page(s) 1243703

Abstract: Objectives: It is a pivotal element of China's health system reform to improve the health security of health insurance for the mobile population. Achieving this objective is integral to the success of the reform. The aim of this study was to analyze the ...

Abstract	Objectives: It is a pivotal element of China's health system reform to improve the health security of health insurance for the mobile population. Achieving this objective is integral to the success of the reform. The aim of this study was to analyze the impact of different enrollment characteristics of basic health insurance on the health of the mobile population and to investigate the mediating role of health service utilization behavior. Methods: This cross-sectional study included 135,372 migrants who participated in the 2018 China Migrants Dynamic Survey (CMDS). Two indicators were employed in this study to assess the characteristics of the mobile population's involvement in basic health insurance-namely, whether or not they participated in local health insurance and the type of health insurance in which they participated. The health status of the mobile population was measured using self-assessed health. Health service utilization behavior was divided into public health service utilization and medical service utilization. Multivariate ordered logistic regression was employed to examine the effect of health insurance on the health of the mobile population. Subsequently, the Bootstrap method was applied to analyze the mediating effect of health service utilization behavior in the relationship between health insurance and the health of the mobile population. Results: Health insurance had a positive impact on health, public health services, and health service utilization among the mobile population. However, enrollment in local health insurance (OR = 1.088, 95% CI = 1.043-1.134) and enrollment in Basic Medical Insurance for Urban Employees (OR = 1.178, 95% CI = 1.090-1.273) were more likely to be associated with higher levels of health and a greater likelihood of receiving health service utilization. The results of the mediating mechanism analysis indicated that health education, health records, family doctor contracting, receiving inpatient services, and being hospitalized locally all played a partially mediating role in the impact of the place of enrollment on health. Regarding the effect of the type of enrollment on health, three types of services-namely, health education, health records, and contracting with a family doctor-played a partially mediating role, while receiving inpatient services and being hospitalized locally did not exhibit a mediating effect. The effect of the type of participation on health is partially mediated. Conclusion: Based on the impact of the different enrolment characteristics of basic health insurance on the health of the mobile population and the mediating role of health service utilization in this impact, furthermore, improvement of health insurance coverage for the mobile population should focus on improving the accessibility of health services, increasing the level of health insurance coverage, mitigating differences in treatment between the different insurance systems, and simplifying the process of transferring the health insurance relationships.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Insurance, Health ; Patient Acceptance of Health Care ; Health Services ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1243703
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Article ; Online: The promotion of pooling level of basic medical insurance and participants' health: impact effects and mediating mechanisms.

Dong, Bo

International journal for equity in health

2023 Volume 22, Issue 1, Page(s) 113

Abstract: Background: Enhancing the pooling of basic medical insurance plays a vital role in strengthening the resilience to risk and co-payment capacity of medical insurance funds. In China, there is a concerted effort to shift from municipal to provincial ... ...

Abstract	Background: Enhancing the pooling of basic medical insurance plays a vital role in strengthening the resilience to risk and co-payment capacity of medical insurance funds. In China, there is a concerted effort to shift from municipal to provincial pooling of medical insurance. While existing research suggests that provincial pooling of basic health insurance affects the health of participants, the findings are not yet consistent, and there is limited research on the specific pathways of impact between the two. Therefore, this study aims to explore the influence of provincial pooling of basic medical insurance on participants' health and analyze the mediating role of medical cost burden and medical service utilization. Methods: Using data from the 2012-2018 China Labor Dynamics Survey (CLDS), this study focuses on a sample of urban workers enrolled in basic medical insurance. After excluding samples with missing information, a total of 5,684 participants were included in the analysis. The effects of the provincial pooling policy of basic medical insurance on participants' medical cost burden, medical service utilization, and health were analyzed using double difference modeling. Furthermore, structural equation modeling was employed to explore the mediating paths between provincial pooling and health. Results: The findings reveal that provincial pooling of basic medical insurance significantly impacts participants' medical cost burden, medical service utilization, and health. Specifically, provincial pooling helps reduce the participants' medical cost burden (β = -0.1205; P < 0.001), improves the level of medical institutions visited (β = 1.7962; P < 0.001), and promotes health improvement (β = 1.8370; P < 0.001). The mediating effect analysis demonstrates that the direct effect of provincial pooling on health is 1.073 (P < 0.001), with a mediating effect of medical cost burden between provincial pooling and health measuring 0.129 (P < 0.001). Heterogeneity analysis indicates that provincial pooling is more effective in reducing the burden of medical costs for low-income (β = -0.2273; P < 0.001) and high-age participants (β = -0.2710; P < 0.001), and it also helps increase the burden of medical costs for low-income (β = 4.0875; P < 0.001) and high-age participants (β = 1.9010; P < 0.001) based on provider ranking. Moreover, it is found that provincial pooling is more beneficial in improving the health of high-income (β = 1.7984; P < 0.001) and middle- and high-age enrollees (β = 1.9220; P < 0.001; β = 0.5900; P < 0.001). Further analysis reveals that the provincial unified income and expenditure mode has a more positive effect than the provincial risk adjustment fund mode in reducing the medical expense burden of the insured (-0.2053 < -0.0775), improving the grade of medical institutions (1.8552 > 0.8878), and enhancing the health level (2.8406 > 0.6812). Conclusion: The study concludes that provincial pooling of basic medical insurance has a direct positive impact on participants' health and indirectly promotes health improvement by reducing the burden of medical costs. The effects of provincial pooling on participants' medical cost burden, medical service utilization, and health vary based on income and age. Additionally, the provincial-level unified collection and payment model proves to be more advantageous in optimizing the functioning of health insurance funds through the "law of large numbers" principle.
MeSH term(s)	Humans ; Insurance, Health ; Health Expenditures ; Poverty ; Surveys and Questionnaires ; China
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2092056-8
ISSN	1475-9276 ; 1475-9276
ISSN (online)	1475-9276
ISSN	1475-9276
DOI	10.1186/s12939-023-01927-1
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Article: Mechanism Study of Polydatin in Treating Spinal Cord Injury by Modulating Mitochondrial Membrane Potential Based on Network Pharmacology and Molecular Docking.

Dong, Bo / He, Xijing

Critical reviews in immunology

2023 Volume 44, Issue 1, Page(s) 79–90

Abstract: Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural glycosylated precursor of resveratrol, showing mitochondrial ... ...

Abstract	Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural glycosylated precursor of resveratrol, showing mitochondrial preservation effects in the central nervous system. This study aimed to identify the hub target genes of PD on mitochondrial membrane potential (MMP) in SCI. A comprehensive analysis was performed on SCI-related genes, MMP-related genes, and PD targets screening from public databases. Differential expression analysis was conducted to identify differentially expressed genes (DEGs) in SCI. Gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were employed to assess pathway enrichment. Protein-protein interaction (PPI) network analysis and molecular docking were conducted to identify key genes and evaluate the binding affinity between PD and hub genes. A total of 16,958 SCI-related genes, 2,786 MMP-related genes, 318 PD-related target genes, and 7229 DEGs were identified. Intersection analysis revealed 46 genes common to all four categories. GSEA and GSVA analysis identified significant enrichment of pathways associated with suppressed and activated SCI biological processes. The PPI network analysis identified seven core hub genes: EGFR, SRC, VEGFA, STAT3, ERBB2, TP53, and RHOA. Molecular docking revealed strong binding affinities between PD and ERBB2, EGFR, and RHOA. The findings based on computational investigation from public databases suggest that PD may have therapeutic potential for SCI by modulating MMP. These results contribute to the understanding of SCI pathogenesis and the development of novel therapeutic strategies.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Gene Regulatory Networks ; Gene Expression Profiling/methods ; Network Pharmacology ; Membrane Potential, Mitochondrial ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism
Chemical Substances	polydatin (XM261C37CQ) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1353116-5
ISSN	1040-8401
ISSN	1040-8401
DOI	10.1615/CritRevImmunol.2023049892
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Article ; Online: Development and validation of risk prediction nomograms for acute respiratory failure in elderly patients with hip fracture.

Li, Yue / Dong, Bo

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 899

Abstract: Background: Hip fractures in the elderly often lead to acute respiratory failure, but there is currently no tool to assess the prognosis of such patients. This study aims to develop a risk prediction model for respiratory failure in these patients.: ... ...

Abstract	Background: Hip fractures in the elderly often lead to acute respiratory failure, but there is currently no tool to assess the prognosis of such patients. This study aims to develop a risk prediction model for respiratory failure in these patients. Methods: A retrospective cross-sectional study was conducted using the Medical Information Mart for Intensive Care (MIMIC)-IV database, incorporating data from 3,266 patients with hip fractures aged over 55 years from 2008 to 2019. Data included demographic information, laboratory indicators, comorbidities, and treatment methods. Patients were divided into a training group (70%) and a validation group (30%). Least Absolute Shrinkage and Selection Operator (LASSO) regression was applied to select prognostic predictors, and a visualized nomogram model was constructed using multivariate logistic regression analysis. Model performance and clinical applicability were assessed. Statistical analyses were done using R4.2.2, with P < 0.05 deemed significant. Results: Seven key factors, including age, height, albumin, chloride, pneumonia, acute kidney injury (AKI), and heparin use, were associated with respiratory failure risk. The model demonstrated good performance with area under the curve (AUC) values of 0.77 and 0.73 in the training and validation sets, respectively. The calibration curve showed good agreement, and decision curve analysis (DCA) indicated the model's clinical benefit. Conclusions: This risk prediction model can effectively predict respiratory failure in hip fracture patients, assisting clinicians in identifying high-risk individuals and providing evidence-based references for treatment strategies.
MeSH term(s)	Aged ; Humans ; Nomograms ; Cross-Sectional Studies ; Retrospective Studies ; Hip Fractures/epidemiology ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-04395-z
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Article ; Online: Special topic on EvoDevo: emerging models and perspectives.

Long, Hongan / Dong, Bo

Marine life science & technology

2023 Volume 5, Issue 4, Page(s) 431–434

Language	English
Publishing date	2023-11-22
Publishing country	Singapore
Document type	Editorial
ZDB-ID	3006215-9
ISSN	2662-1746 ; 2096-6490
ISSN (online)	2662-1746
ISSN	2096-6490
DOI	10.1007/s42995-023-00208-8
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Article: Effect of parental rearing styles on adolescent ego identity: the mediating role of involutionary attitudes.

Ding, Yan / Sun, Changan / Dong, Bo

Frontiers in psychology

2024 Volume 14, Page(s) 1292718

Abstract: Previous studies have found that negative parental rearing styles can negatively predict the acquisition of ego identity, while it has not been discussed whether the overcompetitive attitudes, a stable personality, will further hinder their ego identity ... ...

Abstract	Previous studies have found that negative parental rearing styles can negatively predict the acquisition of ego identity, while it has not been discussed whether the overcompetitive attitudes, a stable personality, will further hinder their ego identity development under the model of educational involutionary. The study used the Overcompetitive Attitude Scale, the Brief Parental Rearing Styles Questionnaire, and the Ego Identity Status Scale to investigate 550 young students in a school in Suzhou in order to explore the influence of parental rearing styles on adolescents' ego identity development and the role of involutional attitudes. The results showed that: (1) Adolescents' overcompetitive attitude was positively predicted by parental rejection and overprotection, while it was negatively predicted by parental emotional warmth. (2) Parental emotional warmth significantly predicted adolescents' ego identity status more favorably than parental rejection, overprotection, and overcompetitive attitude. (3) Overcompetitive attitude plays a partial intermediary role between parental rearing style and ego identity.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1292718
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Article ; Online: Biased Complementary-Label Learning Without True Labels.

Ruan, Jianfei / Zheng, Qinghua / Zhao, Rui / Dong, Bo

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 2, Page(s) 2616–2627

Abstract: In complementary-label learning (CLL), the complementary transition matrix, denoting the probabilities that true labels flip into complementary labels (CLs) which specify classes observations do not belong to, is crucial to building statistically ... ...

Abstract	In complementary-label learning (CLL), the complementary transition matrix, denoting the probabilities that true labels flip into complementary labels (CLs) which specify classes observations do not belong to, is crucial to building statistically consistent classifiers. Most existing works implicitly assume that the transition probabilities are identical, which is not true in practice and may lead to undesirable bias in solutions. Few recent works have extended the problem to a biased setting but limit their explorations to modeling the transition matrix by exploiting the complementary class posteriors of anchor points (i.e., instances that almost certainly belong to a specific class). However, due to the severe corruption and unevenness of biased CLs, both anchor points and complementary class posteriors are difficult to predict accurately in the absence of true labels. In this article, rather than directly predicting these two error-prone items, we instead propose a divided-T estimator as an alternative to effectively learn transition matrices from only biased CLs. Specifically, we exploit semantic clustering to mitigate the adverse effects arising from CLs. By introducing the learned semantic clusters as an intermediate class, we factorize the original transition matrix into the product of two easy-to-estimate matrices that are not reliant on the two error-prone items. Both theoretical analyses and empirical results justify the effectiveness of the divided- T estimator for estimating transition matrices under a mild assumption. Experimental results on benchmark datasets further demonstrate that the divided- T estimator outperforms state-of-the-art (SOTA) methods by a substantial margin.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3190528
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Article: Short-term outcomes of robotic vs. laparoscopic surgery for rectal cancer after neoadjuvant therapy: a meta-analysis.

Zhang, Yuqiang / Dong, Bo / Li, Guanglin / Ye, Wei

Frontiers in surgery

2024 Volume 10, Page(s) 1292031

Abstract: Background: The effect of robotic surgery (RS) for rectal cancer after neoadjuvant therapy is still controversial, and a comprehensive search and analysis of the current relevant evidence is necessary. Our study aimed to evaluate the efficacy of RS for ... ...

Abstract	Background: The effect of robotic surgery (RS) for rectal cancer after neoadjuvant therapy is still controversial, and a comprehensive search and analysis of the current relevant evidence is necessary. Our study aimed to evaluate the efficacy of RS for rectal cancer after neoadjuvant therapy compared with conventional laparoscopic surgery (LS). Methods: Up to August 23, 2023, Embase, PubMed, Web of Science, and Cochrane databases were searched for studies of RS for rectal cancer after neoadjuvant therapy. Odds ratio (OR) or mean difference (MD) was used to calculate the effect sizes using RevMan 5.3. Results: A total of 12 studies reporting on 11,686 participants were included. Compared with LS, RS increased the operative time (MD 35.16 min; 95% CI: 16.24, 54.07), but it did significantly reduce the risk of the conversion to open surgery (OR 0.46, 95% CI 0.40, 0.53) and improved the TME incomplete rate (OR 0.40, 95% CI 0.17, 0.93). Moreover, there were no difference in total postoperative complications (OR 1.13, 95% CI 0.84, 1.52), circumferential resection margin positivity (OR 0.90, 95% CI 0.63, 1.27), distal margin positive (OR 0.60, 95% CI 0.29, 1.22), blood loss (MD -11.57 ml; 95% CI: -39.09, 15.94), length of hospital stay (MD -0.08 days; 95% CI: -1.26, 1.10), mortality (OR 0.59, 95% CI 0.29, 1.21), lymph node harvested (MD 0.69.; 95% CI: -0.43, 1.82), and the time of first flatus (MD -0.47 days; 95% CI: -1.19, 0.25) between the two groups. Conclusions: RS was associated with superiority over LS in reducing the risk of the conversion to open surgery and improving TME incomplete rate, which suggested that RS could be an effective method for treating rectal cancer after neoadjuvant therapy. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=460084, PROSPERO (CRD42023460084).
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1292031
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Article ; Online: MiR-375 Inhibitor Alleviates Inflammation and Oxidative Stress by Upregulating the GPR39 Expression in Atherosclerosis.

Luo, Hui / Zhao, Lin / Dong, Bo / Liu, Yanghong

International heart journal

2024 Volume 65, Issue 1, Page(s) 135–145

Abstract: Atherosclerosis may be caused or developed by an immune response and antioxidation imbalance. MicroRNA-375 (miR-375) or G-protein-coupled receptor 39 (GPR39) is involved in vascular endothelial cell injury, but their role in atherosclerosis is unknown. ... ...

Abstract	Atherosclerosis may be caused or developed by an immune response and antioxidation imbalance. MicroRNA-375 (miR-375) or G-protein-coupled receptor 39 (GPR39) is involved in vascular endothelial cell injury, but their role in atherosclerosis is unknown. This experiment aimed to determine the action of the miR-375/GPR39 axis in atherosclerosis.Human aortic endothelial cells (HAECs) were treated with 10 ng/mL of oxidised low-density lipoprotein (ox-LDL) for 24 hours to induce HAEC injury, which was treated by the miR-375 inhibitor, GPR39 inhibitor, or agonist. High-fat diet (HFD) -induced ApoE
MeSH term(s)	Humans ; Animals ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-KappaB Inhibitor alpha/metabolism ; Endothelial Cells/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Atherosclerosis/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Lipoproteins, LDL/pharmacology ; Lipoproteins, LDL/metabolism ; Oxidative Stress ; Inflammation/metabolism ; Apolipoproteins E ; Apoptosis
Chemical Substances	MicroRNAs ; NF-KappaB Inhibitor alpha (139874-52-5) ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Receptors, G-Protein-Coupled ; Lipoproteins, LDL ; Apolipoproteins E ; GPR39 protein, human ; MIRN375 microRNA, human ; GPR39 protein, mouse
Language	English
Publishing date	2024-02-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.23-155
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