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Article ; Online: Exogenous methionine contributes to reversing the resistance of

Dong, Chun-Liu / Wu, Tong / Dong, Yue / Qu, Qian-Wei / Chen, Xue-Ying / Li, Yan-Hua

2024 Volume 12, Issue 2, Page(s) e0280323

Abstract: Streptococcus ... ...

Abstract	Streptococcus suis
MeSH term(s)	Humans ; Animals ; Swine ; Streptococcus suis/genetics ; Macrolides/therapeutic use ; Methionine/metabolism ; Methionine/therapeutic use ; Doxycycline/therapeutic use ; Streptococcal Infections/microbiology ; Anti-Bacterial Agents/therapeutic use ; Ciprofloxacin ; Homocysteine/metabolism ; Homocysteine/therapeutic use
Chemical Substances	Macrolides ; Methionine (AE28F7PNPL) ; Doxycycline (N12000U13O) ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02803-23
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Article ; Online: GrpE and ComD contribute to the adherence, biofilm formation, and pathogenicity of Streptococcus suis

Yu, Fei / Dong, Chunliu / Zhang, Yuefeng / Che, Ruixiang / Xie, Chunmei / Liu, Yanyan / Zhang, Zhiyun / Li, Lu / Chen, Xueying / Cai, Xuehui / Wang, Gang / Li, Yanhua

Arch Microbiol. 2023 Apr., v. 205, no. 4 p.159-159

2023

Abstract: Streptococcus suis is a major bacterial pathogen of swine and an emerging zoonotic agent that has to date resulted in substantial economic losses to the swine industry worldwide, and can cause persistent infection by forming biofilms. GrpE and histidine ... ...

Abstract	Streptococcus suis is a major bacterial pathogen of swine and an emerging zoonotic agent that has to date resulted in substantial economic losses to the swine industry worldwide, and can cause persistent infection by forming biofilms. GrpE and histidine protein kinase ComD are important proteins implicated in the pathogenicity of S. suis, although whether they play roles in adhesion and biofilm formation has yet to be sufficiently clarified. In this study, we constructed grpE and comD deletion strains of S. suis by homologous recombination, and examined their cell adhesion and biofilm formation capacities compared with those of the wild-type strain. The pathogenicity of the grpE and comD deletion strains was evaluated using a mouse infection model, which revealed that compared with the wild-type, these deletion strains induced milder symptoms and lower bacteremia, as well as comparatively minor organ (brain, spleen, liver, and lung) lesions, in the infected mice. Moreover, the deletion of grpE and comD significantly reduced the pro-inflammatory cytokine (IL-6, IL-1β, and TNF-α) induction capacity of S. suis. Collectively, the findings of this study indicate that the GrpE and ComD proteins of Streptococcus suis play key roles in the adherence to PK-15 cells and the formation of biofilms, thereby contributing to the virulence of this pathogen.
Keywords	Streptococcus suis ; adhesion ; bacteremia ; biofilm ; brain ; cell adhesion ; chronic diseases ; histidine ; homologous recombination ; interleukin-6 ; liver ; lungs ; mice ; models ; pathogens ; pork industry ; protein kinases ; spleen ; swine ; virulence
Language	English
Dates of publication	2023-04
Size	p. 159.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03503-1
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Article ; Online: Germanium Reduces Inflammatory Damage in Mammary Glands During Lipopolysaccharide-Induced Mastitis in Mice.

Wang, Yong-Sheng / Teng, Guo-Qing / Zhou, Han / Dong, Chun-Liu

Biological trace element research

2020 Volume 198, Issue 2, Page(s) 617–626

Abstract: Ge is a trace element needed for good nutrition and health protection in animals and humans. Ge can be consumed by drinking or eating or administered by injection and transferred with the blood to exert pharmacological activities. The blood is important ... ...

Abstract	Ge is a trace element needed for good nutrition and health protection in animals and humans. Ge can be consumed by drinking or eating or administered by injection and transferred with the blood to exert pharmacological activities. The blood is important in the formation of milk. Mastitis is a serious health hazard in animals and humans. The present study explored the effect of Ge on mastitis and the potential underlying mechanism. A mastitis mouse model was established with LPS. mMECs were prepared for study in vitro. Histopathological changes showed that Ge had a protective effect on mammary gland tissues. Ge inhibited MPO activity to reduce inflammatory cell infiltration during mastitis. ELISA and qPCR results for tissues and cells showed that the expression of TNF-α, IL-1β, and IL-6 was decreased and that of IL-10 was increased by Ge in a dose-dependent manner in mastitis. An analysis of protein phosphorylation was performed with sandwich ELISAs for both tissues and mMECs. The results showed that Ge significantly inhibited the phosphorylation of IκB, NF-κB p65, p38, ERK, and JNK, which was dramatically increased by LPS. These results demonstrate that Ge has an inhibitory effect on inflammation that protects mammary gland tissues by inhibiting NF-κB and MAPK pathway activation and reducing TNF-α, IL-1β, and IL-6 expression. Ge may be an effective clinical treatment for mastitis and other inflammatory diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Female ; Germanium ; Humans ; Lipopolysaccharides/toxicity ; Mammary Glands, Animal ; Mastitis/chemically induced ; Mastitis/drug therapy ; Mice ; Mice, Inbred BALB C ; NF-kappa B
Chemical Substances	Anti-Inflammatory Agents ; Lipopolysaccharides ; NF-kappa B ; Germanium (00072J7XWS)
Language	English
Publishing date	2020-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02106-x
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Article: Germanium Reduces Inflammatory Damage in Mammary Glands During Lipopolysaccharide-Induced Mastitis in Mice

Wang, Yong-sheng / Teng, Guo-qing / Zhou, Han / Dong, Chun-liu

Biological trace element research. 2020 Dec., v. 198, no. 2

2020

Abstract	Ge is a trace element needed for good nutrition and health protection in animals and humans. Ge can be consumed by drinking or eating or administered by injection and transferred with the blood to exert pharmacological activities. The blood is important in the formation of milk. Mastitis is a serious health hazard in animals and humans. The present study explored the effect of Ge on mastitis and the potential underlying mechanism. A mastitis mouse model was established with LPS. mMECs were prepared for study in vitro. Histopathological changes showed that Ge had a protective effect on mammary gland tissues. Ge inhibited MPO activity to reduce inflammatory cell infiltration during mastitis. ELISA and qPCR results for tissues and cells showed that the expression of TNF-α, IL-1β, and IL-6 was decreased and that of IL-10 was increased by Ge in a dose-dependent manner in mastitis. An analysis of protein phosphorylation was performed with sandwich ELISAs for both tissues and mMECs. The results showed that Ge significantly inhibited the phosphorylation of IκB, NF-κB p65, p38, ERK, and JNK, which was dramatically increased by LPS. These results demonstrate that Ge has an inhibitory effect on inflammation that protects mammary gland tissues by inhibiting NF-κB and MAPK pathway activation and reducing TNF-α, IL-1β, and IL-6 expression. Ge may be an effective clinical treatment for mastitis and other inflammatory diseases.
Keywords	blood ; dose response ; enzyme-linked immunosorbent assay ; germanium ; health hazards ; health promotion ; histopathology ; inflammation ; interleukin-10 ; interleukin-6 ; mammary glands ; mice ; milk ; nutrition ; protective effect ; protein phosphorylation ; research ; trace elements
Language	English
Dates of publication	2020-12
Size	p. 617-626.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02106-x
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Article ; Online: Effects of l-Serine on Macrolide Resistance in Streptococcus suis.

Wu, Tong / Wang, Xiaozhen / Dong, Yue / Xing, Chen / Chen, Xueying / Li, Lu / Dong, Chunliu / Li, Yanhua

Microbiology spectrum

2022 Volume 10, Issue 4, Page(s) e0068922

Abstract: Streptococcus suis is an important zoonotic pathogen. Due to the indiscriminate use of macrolides, S. suis has developed a high level of drug resistance, which has led to a serious threat to human and animal health. However, it takes a long time to ... ...

Abstract	Streptococcus suis is an important zoonotic pathogen. Due to the indiscriminate use of macrolides, S. suis has developed a high level of drug resistance, which has led to a serious threat to human and animal health. However, it takes a long time to develop new antibacterial drugs. Therefore, we consider the perspective of bacterial physiological metabolism to ensure that the development of bacterial resistance to existing drugs is alleviated and bacterial susceptibility to drugs is restored. In the present study, an untargeted metabolomics analysis showed that the serine catabolic pathway was inhibited in drug-resistant S. suis. The addition of l-serine restored the fungicidal effect of macrolides on S. suis
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Humans ; Macrolides/pharmacology ; Macrolides/therapeutic use ; Microbial Sensitivity Tests ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Reactive Oxygen Species/therapeutic use ; Serine/metabolism ; Serine/pharmacology ; Serine/therapeutic use ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus suis/genetics ; Streptococcus suis/metabolism
Chemical Substances	Anti-Bacterial Agents ; Macrolides ; Reactive Oxygen Species ; Serine (452VLY9402)
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00689-22
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Article ; Online: Relationship between L-lactate dehydrogenase and multidrug resistance in Staphylococcus xylosus

Yuan, Zhongwei / Wang, Jinpeng / Che, Ruixiang / God’spower, Bello-Onaghise / Zhou, Yonghui / Dong, Chunliu / Li, Lu / Chen, Mingri / Eliphaz, Nsabimana / Liu, Xin / Li, Yanhua

Arch Microbiol. 2022 Jan., v. 204, no. 1 p.91-91

2022

Abstract: Staphylococcus xylosus is a gram-positive bacterium that has attracted much attention due to its increasing clinical appearance, frequently associated with serious multidrug resistance cases. L-lactate dehydrogenase (LDH) has been related to drug ... ...

Abstract	Staphylococcus xylosus is a gram-positive bacterium that has attracted much attention due to its increasing clinical appearance, frequently associated with serious multidrug resistance cases. L-lactate dehydrogenase (LDH) has been related to drug resistance in several bacterial species. However, the mechanism of multidrug resistance in S. xylosus remains unclear as well as the involvement of LDH in such resistance. To explore the relationship between multidrug resistance and LDH in S. xylosus, we used tylosin-resistant S. xylosus as the parent strain to construct ldh knockout and complemented strains. Then, we tested their resistance to macrolides, lincosamides, tetracyclines, and aminoglycosides. In addition, the enzyme activity, metabolite content, and transcriptional level of key genes involved in the TCA cycle and thioredoxin system were determined to clarify the mechanism of resistance. We observed that the resistance to multiple antibiotics increased significantly after ldh knockout, especially that to lincomycin, whereas antibiotic sensitivity was partially restored in the complemented strain. The levels of pyruvate, nicotinamide adenine dinucleotide, and reactive oxygen species decreased significantly upon ldh knockout, and the activity of isocitrate dehydrogenase and malate dehydrogenase decreased. These results indicate that the lack of LDH promotes multidrug resistance in S. xylosus by inhibiting the TCA cycle and regulating the thioredoxin system.
Keywords	Gram-positive bacteria ; NAD (coenzyme) ; Staphylococcus xylosus ; aminoglycosides ; enzyme activity ; isocitrate dehydrogenase ; lactate dehydrogenase ; lincomycin ; macrolides ; malate dehydrogenase ; metabolites ; multiple drug resistance ; pyruvic acid ; reactive oxygen species ; thioredoxins ; transcription (genetics) ; tricarboxylic acid cycle
Language	English
Dates of publication	2022-01
Size	p. 91.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02625-8
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Article ; Online: Celastrol Combats Methicillin-Resistant Staphylococcus aureus by Targeting Δ

Yuan, Zhongwei / Wang, Jun / Qu, Qianwei / Zhu, Zhenxin / Xu, Marc / Zhao, Mengmeng / Sun, Chongxiang / Peng, Haixin / Huang, Xingyu / Dong, Yue / Dong, Chunliu / Zheng, Yadan / Yuan, Shuguang / Li, Yanhua

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 25, Page(s) e2302459

Abstract: The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) raise a critical need for alternative therapeutic options. New antibacterial drugs and targets are required to combat MRSA-associated infections. Based on this study, ... ...

Abstract	The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) raise a critical need for alternative therapeutic options. New antibacterial drugs and targets are required to combat MRSA-associated infections. Based on this study, celastrol, a natural product from the roots of Tripterygium wilfordii Hook. f., effectively combats MRSA in vitro and in vivo. Multi-omics analysis suggests that the molecular mechanism of action of celastrol may be related to Δ
MeSH term(s)	Methicillin-Resistant Staphylococcus aureus ; 1-Pyrroline-5-Carboxylate Dehydrogenase/chemistry ; 1-Pyrroline-5-Carboxylate Dehydrogenase/genetics ; 1-Pyrroline-5-Carboxylate Dehydrogenase/metabolism ; Molecular Docking Simulation
Chemical Substances	delta-1-pyrroline-5-carboxylate (2906-39-0) ; 1-Pyrroline-5-Carboxylate Dehydrogenase (EC 1.2.1.88) ; celastrol (L8GG98663L)
Language	English
Publishing date	2023-06-28
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202302459
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Article: New Characterization of Multi-Drug Resistance of

Dong, Chun-Liu / Che, Rui-Xiang / Wu, Tong / Qu, Qian-Wei / Chen, Mo / Zheng, Si-Di / Cai, Xue-Hui / Wang, Gang / Li, Yan-Hua

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 1

Abstract: The aim of this study was to investigate the antimicrobial resistance profiles and genotypes ... ...

Abstract	The aim of this study was to investigate the antimicrobial resistance profiles and genotypes of
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12010132
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Article ; Online: Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities.

Song, Xuejiao / Liu, Chang / Zhang, Yang / Xiao, Xiaoyue / Han, Guorui / Sun, Kedi / Liu, Shuoqi / Zhang, Zhiyun / Dong, Chunliu / Zheng, Yadan / Chen, Xueying / Xu, Tong / Liu, Yanyan / Li, Yanhua

Ultrasonics sonochemistry

2023 Volume 94, Page(s) 106344

Abstract: The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, in the extraction methods of compounds from medicinal plants and herbs, there is an urgent to reduce the use of organic ... ...

Abstract	The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, in the extraction methods of compounds from medicinal plants and herbs, there is an urgent to reduce the use of organic solvents and increase the energy efficiency of these methods. Therefore, a sustainable extraction method (enzyme and ultrasonic co-assisted aqueous two-phase extraction, EUA-ATPE) of simultaneous extraction and separation of ferulic acid and ligustilide from Angelicae Sinensis Radix (ASR) was developed by integrating enzyme-assisted extraction (EAE) with ultrasonic-assisted aqueous two-phase extraction (UAE- ATPE). The effects of different enzymes, extraction temperature, pH, ultrasonic time, liquid-to-materials ratio, etc., were optimized by single-factor experiments and central composite design (CCD). Under the optimum conditions, the highest comprehensive evaluation value (CEV) and extraction yield were obtained by EUA-ATPE. Furthermore, recovery (R), partition coefficient (K), and scanning electron microscopy (SEM) analysis revealed that enzyme and ultrasonic treatment improved mass transfer diffusion and increased the degree of cell disruption. Besides, the EUA-ATPE extracts have shown great antioxidant and anti-inflammatory activity in vitro. Finally, compared to different extraction methods, EUA-ATPE achieved higher extraction efficiency and higher energy efficiency due to the synergistic effect between EAE and UAE-ATPE. Therefore, the EUA-ATPE provides a sustainable method for extracting bioactive compounds from medicinal plants and herbs, contributing to Sustainable Development Goals (SDG), including SDG-6, SDG-7, SDG-9, SDG-12, and SDG-15.
MeSH term(s)	Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Antioxidants/pharmacology ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	ligustilide (4431-01-0) ; Plant Extracts ; Antioxidants ; ferulic acid (AVM951ZWST) ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2023.106344
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Article ; Online: GrpE and ComD contribute to the adherence, biofilm formation, and pathogenicity of Streptococcus suis.

Yu, Fei / Dong, Chunliu / Zhang, Yuefeng / Che, Ruixiang / Xie, Chunmei / Liu, Yanyan / Zhang, Zhiyun / Li, Lu / Chen, Xueying / Cai, Xuehui / Wang, Gang / Li, Yanhua

Archives of microbiology

2023 Volume 205, Issue 4, Page(s) 159

Abstract	Streptococcus suis is a major bacterial pathogen of swine and an emerging zoonotic agent that has to date resulted in substantial economic losses to the swine industry worldwide, and can cause persistent infection by forming biofilms. GrpE and histidine protein kinase ComD are important proteins implicated in the pathogenicity of S. suis, although whether they play roles in adhesion and biofilm formation has yet to be sufficiently clarified. In this study, we constructed grpE and comD deletion strains of S. suis by homologous recombination, and examined their cell adhesion and biofilm formation capacities compared with those of the wild-type strain. The pathogenicity of the grpE and comD deletion strains was evaluated using a mouse infection model, which revealed that compared with the wild-type, these deletion strains induced milder symptoms and lower bacteremia, as well as comparatively minor organ (brain, spleen, liver, and lung) lesions, in the infected mice. Moreover, the deletion of grpE and comD significantly reduced the pro-inflammatory cytokine (IL-6, IL-1β, and TNF-α) induction capacity of S. suis. Collectively, the findings of this study indicate that the GrpE and ComD proteins of Streptococcus suis play key roles in the adherence to PK-15 cells and the formation of biofilms, thereby contributing to the virulence of this pathogen.
MeSH term(s)	Animals ; Swine ; Virulence ; Streptococcus suis/genetics ; Biofilms ; Cytokines/metabolism ; Brain ; Disease Models, Animal ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
Chemical Substances	Cytokines ; Bacterial Proteins
Language	English
Publishing date	2023-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03503-1
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