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  1. Article ; Online: Clinicopathological analysis of 114 cases of typical Kaposi's sarcoma in Xinjiang Uygur autonomous region, China.

    Fan, Jun-Wei / Wan, Xue-Feng / Yi, Bian / Dong, Jin-Cheng / Abulize, Palida

    Molecular medicine reports

    2017  Volume 16, Issue 4, Page(s) 5495–5498

    Abstract: The present study aimed to investigate the clinicopathological features of cases of classic Kaposi's sarcoma (CKS) in Xinjiang Uygur Autonomous Region, China, and analyze its etiology and treatment. A total of 114 patients, who were clinicopathologically ...

    Abstract The present study aimed to investigate the clinicopathological features of cases of classic Kaposi's sarcoma (CKS) in Xinjiang Uygur Autonomous Region, China, and analyze its etiology and treatment. A total of 114 patients, who were clinicopathologically diagnosed with CKS at the First Affiliated Hospital of Xinjiang Medical University (Urumqi, China) between 1980 and 2015 were retrospectively analyzed. The clinicopathological features of CKS were summarized, and its demographic distribution, pathogenesis, etiology and treatment were examined. The results revealed that, among the 114 patients with CKS, 100 patients were men and 14 patients were women, with a respective ratio of 7:1. The average age of these patients was 57.5 years old, and 97 of the patients were from the Uygur Autonomous Region (85.1%). Among the 114 patients, 60 patients (52.6%) were from Southern Xinjiang, 50 patients (43.9%) were from Northern Xinjiang and four patients (3.5%) were from Eastern Xinjiang. It was found that CKS in the Uygur ethnic group of Xinjiang Uygur Autonomous Region had unique clinicopathological features. The occurrence of CKS in Xinjiang may be associated with human herpes virus 8 infection, ethnicity‑based susceptibility and lifestyle.
    Language English
    Publishing date 2017-10
    Publishing country Greece
    Document type Journal Article
    ISSN 1791-3004
    ISSN (online) 1791-3004
    DOI 10.3892/mmr.2017.7283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

    Wang, Li-Dong / Zhou, Fu-You / Li, Xue-Min / Sun, Liang-Dan / Song, Xin / Jin, Yan / Li, Jiang-Man / Kong, Guo-Qiang / Qi, Hong / Cui, Juan / Zhang, Lian-Qun / Yang, Jie-Zhi / Li, Ji-Lin / Li, Xing-Chuan / Ren, Jing-Li / Liu, Zhi-Cai / Gao, Wen-Jun / Yuan, Ling / Wei, Wu /
    Zhang, Yan-Rui / Wang, Wei-Peng / Sheyhidin, Ilyar / Li, Feng / Chen, Bao-Ping / Ren, Shu-Wei / Liu, Bin / Li, Dan / Ku, Jian-Wei / Fan, Zong-Min / Zhou, Sheng-Li / Guo, Zhi-Gang / Zhao, Xue-Ke / Liu, Na / Ai, Yong-Hong / Shen, Fang-Fang / Cui, Wen-Yan / Song, Shuang / Guo, Tao / Huang, Jing / Yuan, Chao / Huang, Jia / Wu, Yue / Yue, Wen-Bin / Feng, Chang-Wei / Li, Hong-Lei / Wang, Yan / Tian, Jin-Ya / Lu, Yue / Yuan, Yi / Zhu, Wen-Liang / Liu, Min / Fu, Wen-Jing / Yang, Xia / Wang, Han-Jing / Han, Suo-Li / Chen, Jie / Han, Min / Wang, Hai-Yan / Zhang, Peng / Li, Xiu-Min / Dong, Jin-Cheng / Xing, Guo-Lan / Wang, Ran / Guo, Ming / Chang, Zhi-Wei / Liu, Hai-Lin / Guo, Li / Yuan, Zhi-Qing / Liu, Hai / Lu, Qin / Yang, Liu-Qin / Zhu, Fu-Guo / Yang, Xiu-Feng / Feng, Xiao-Shan / Wang, Zhou / Li, Yin / Gao, She-Gan / Qige, Qirenwang / Bai, Long-Tang / Yang, Wen-Jun / Lei, Guang-Yan / Shen, Zhong-Ying / Chen, Long-Qi / Li, En-Min / Xu, Li-Yan / Wu, Zhi-Yong / Cao, Wei-Ke / Wang, Jian-Po / Bao, Zhi-Qin / Chen, Ji-Li / Ding, Guang-Cheng / Zhuang, Xiang / Zhou, Ying-Fa / Zheng, Hou-Feng / Zhang, Zheng / Zuo, Xian-Bo / Dong, Zi-Ming / Fan, Dong-Mei / He, Xin / Wang, Jin / Zhou, Qi / Zhang, Qin-Xian / Jiao, Xin-Ying / Lian, Shi-Yong / Ji, Ai-Fang / Lu, Xiao-Mei / Wang, Jin-Sheng / Chang, Fu-Bao / Lu, Chang-Dong / Chen, Zhi-Guo / Miao, Jian-Jun / Fan, Zeng-Lin / Lin, Ruo-Bai / Liu, Tai-Jiang / Wei, Jin-Chang / Kong, Qing-Peng / Lan, Yu / Fan, Yu-Jing / Gao, Fu-Sheng / Wang, Tian-Yun / Xie, Dong / Chen, Shu-Qing / Yang, Wan-Cai / Hong, Jun-Yan / Wang, Liang / Qiu, Song-Liang / Cai, Zhi-Ming / Zhang, Xue-Jun

    Nature genetics

    2010  Volume 42, Issue 9, Page(s) 759–763

    Abstract: We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 ... ...

    Abstract We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.
    MeSH term(s) Aged ; Asian Continental Ancestry Group/genetics ; Carcinoma, Squamous Cell/ethnology ; Carcinoma, Squamous Cell/genetics ; Case-Control Studies ; Chromosomes, Human, Pair 10 ; Chromosomes, Human, Pair 20 ; Esophageal Neoplasms/ethnology ; Esophageal Neoplasms/genetics ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Membrane Proteins/genetics ; Membrane Transport Proteins ; Middle Aged ; Phosphoinositide Phospholipase C/genetics ; Polymorphism, Single Nucleotide/physiology
    Chemical Substances Membrane Proteins ; Membrane Transport Proteins ; SLC52A3 protein, human ; Phosphoinositide Phospholipase C (EC 3.1.4.11) ; phospholipase C epsilon (EC 3.1.4.11)
    Language English
    Publishing date 2010-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.

    Abnet, Christian C / Wang, Zhaoming / Song, Xin / Hu, Nan / Zhou, Fu-You / Freedman, Neal D / Li, Xue-Min / Yu, Kai / Shu, Xiao-Ou / Yuan, Jian-Min / Zheng, Wei / Dawsey, Sanford M / Liao, Linda M / Lee, Maxwell P / Ding, Ti / Qiao, You-Lin / Gao, Yu-Tang / Koh, Woon-Puay / Xiang, Yong-Bing /
    Tang, Ze-Zhong / Fan, Jin-Hu / Chung, Charles C / Wang, Chaoyu / Wheeler, William / Yeager, Meredith / Yuenger, Jeff / Hutchinson, Amy / Jacobs, Kevin B / Giffen, Carol A / Burdett, Laurie / Fraumeni, Joseph F / Tucker, Margaret A / Chow, Wong-Ho / Zhao, Xue-Ke / Li, Jiang-Man / Li, Ai-Li / Sun, Liang-Dan / Wei, Wu / Li, Ji-Lin / Zhang, Peng / Li, Hong-Lei / Cui, Wen-Yan / Wang, Wei-Peng / Liu, Zhi-Cai / Yang, Xia / Fu, Wen-Jing / Cui, Ji-Li / Lin, Hong-Li / Zhu, Wen-Liang / Liu, Min / Chen, Xi / Chen, Jie / Guo, Li / Han, Jing-Jing / Zhou, Sheng-Li / Huang, Jia / Wu, Yue / Yuan, Chao / Huang, Jing / Ji, Ai-Fang / Kul, Jian-Wei / Fan, Zhong-Min / Wang, Jian-Po / Zhang, Dong-Yun / Zhang, Lian-Qun / Zhang, Wei / Chen, Yuan-Fang / Ren, Jing-Li / Li, Xiu-Min / Dong, Jin-Cheng / Xing, Guo-Lan / Guo, Zhi-Gang / Yang, Jian-Xue / Mao, Yi-Ming / Yuan, Yuan / Guo, Er-Tao / Hou, Zhi-Chao / Liu, Jing / Li, Yan / Tang, Sa / Chang, Jia / Peng, Xiu-Qin / Han, Min / Yin, Wan-Li / Liu, Ya-Li / Hu, Yan-Long / Liu, Yu / Yang, Liu-Qin / Zhu, Fu-Guo / Yang, Xiu-Feng / Feng, Xiao-Shan / Wang, Zhou / Li, Yin / Gao, She-Gan / Liu, Hai-Lin / Yuan, Ling / Jin, Yan / Zhang, Yan-Rui / Sheyhidin, Ilyar / Li, Feng / Chen, Bao-Ping / Ren, Shu-Wei / Liu, Bin / Li, Dan / Zhang, Gao-Fu / Yue, Wen-Bin / Feng, Chang-Wei / Qige, Qirenwang / Zhao, Jian-Ting / Yang, Wen-Jun / Lei, Guang-Yan / Chen, Long-Qi / Li, En-Min / Xu, Li-Yan / Wu, Zhi-Yong / Bao, Zhi-Qin / Chen, Ji-Li / Li, Xian-Chang / Zhuang, Xiang / Zhou, Ying-Fa / Zuo, Xian-Bo / Dong, Zi-Ming / Wang, Lu-Wen / Fan, Xue-Pin / Wang, Jin / Zhou, Qi / Ma, Guo-Shun / Zhang, Qin-Xian / Liu, Hai / Jian, Xin-Ying / Lian, Sin-Yong / Wang, Jin-Sheng / Chang, Fu-Bao / Lu, Chang-Dong / Miao, Jian-Jun / Chen, Zhi-Guo / Wang, Ran / Guo, Ming / Fan, Zeng-Lin / Tao, Ping / Liu, Tai-Jing / Wei, Jin-Chang / Kong, Qing-Peng / Fan, Lei / Wang, Xian-Zeng / Gao, Fu-Sheng / Wang, Tian-Yun / Xie, Dong / Wang, Li / Chen, Shu-Qing / Yang, Wan-Cai / Hong, Jun-Yan / Wang, Liang / Qiu, Song-Liang / Goldstein, Alisa M / Yuan, Zhi-Qing / Chanock, Stephen J / Zhang, Xue-Jun / Taylor, Philip R / Wang, Li-Dong

    Human molecular genetics

    2012  Volume 21, Issue 9, Page(s) 2132–2141

    Abstract: Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously ... ...

    Abstract Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P< 5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19-1.40) and P= 7.63 × 10(-10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.
    MeSH term(s) Asian Continental Ancestry Group/genetics ; Carcinoma, Squamous Cell/genetics ; China ; Chromosomes, Human, Pair 10/genetics ; Chromosomes, Human, Pair 2/genetics ; Esophageal Neoplasms/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide ; Recombination, Genetic
    Language English
    Publishing date 2012-02-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/dds029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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