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Article ; Online: RNA-seq combined network pharmacology reveals that Fu-Gan-Wan (FGW) inhibits liver fibrosis via NF-κB/CCL2/CCR2 and lipid peroxidation via Nrf2/HMOX1 signaling pathway.

Shi, Hanlin / Duan, Xiaohong / Dong, Jingcheng / Tao, Yanyan / Lei, Yang

2024 Volume 326, Page(s) 117963

Abstract: Ethnopharmacological relevance: Liver fibrosis is a serious complication of liver disease characterized by excessive collagen deposition, without effective therapeutic agents in the clinic. Fu-Gan-Wan (FGW) is an empirical formula used for the clinical ... ...

Abstract	Ethnopharmacological relevance: Liver fibrosis is a serious complication of liver disease characterized by excessive collagen deposition, without effective therapeutic agents in the clinic. Fu-Gan-Wan (FGW) is an empirical formula used for the clinical treatment of hepatitis and cirrhosis. It has been shown to reverse experimental liver fibrosis. However, its corresponding mechanisms remain unclear. Aim of the review: This study aimed to elucidate the key pathways and target genes of FGW in attenuating liver fibrosis. Materials and methods: The therapeutic effects of different doses of FGW on liver fibrosis were investigated using a 2 mL/kg 15% CCl Results: We found that 19.5 g/kg FGW significantly down-regulated CCl Conclusions: This study demonstrated that FGW exhibits potential in mitigating CCl
MeSH term(s)	Mice ; Animals ; NF-kappa B/metabolism ; Transforming Growth Factor beta1/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Lipid Peroxidation ; Network Pharmacology ; RNA-Seq ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Signal Transduction ; Liver ; Collagen/metabolism ; Carbon Tetrachloride/pharmacology ; Hepatic Stellate Cells
Chemical Substances	NF-kappa B ; Transforming Growth Factor beta1 ; NF-E2-Related Factor 2 ; Collagen (9007-34-5) ; Carbon Tetrachloride (CL2T97X0V0)
Language	English
Publishing date	2024-02-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117963
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Zs.A 1494: Show issues

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Article ; Online: Network pharmacology prediction and molecular docking analysis reveal the mechanism of modified Bushen Yiqi formulas on chronic obstructive pulmonary disease.

Choi, Wenglam / Wu, Yueren / Li, Yifan / Dong, Jingcheng

The journal of gene medicine

2023 Volume 26, Issue 1, Page(s) e3607

Abstract: Background: The present study aimed to explore the mechanism of the modified Bushen Yiqi formula (MBYF) in the treatment of chronic obstructive pulmonary disease (COPD) based on network pharmacology and molecular docking.: Methods: First, the active ... ...

Abstract	Background: The present study aimed to explore the mechanism of the modified Bushen Yiqi formula (MBYF) in the treatment of chronic obstructive pulmonary disease (COPD) based on network pharmacology and molecular docking. Methods: First, the active ingredients and corresponding targets in MBYF were mined through the Traditional Chinese Medicine Systems Pharmacology database. Subsequently, Online Mendelian Inheritance in Man, DrugBank, and GeneCard were used to screen COPD-related targets. Cytoscape was used to construct a network of candidate components of MBYF in COPD treatment. The overlapping targets of COPD and MBYF were used to treat COPD, and then CytoHubba and CytoNAC plug-ins in Cytoscape were used for topology analysis to build the core network. In addition, core targets were used for Gene Ontology analysis and enrichment analysis of the Kyoto Encyclopedia of Genes and Genomes. Finally, AutoDock Vina software was used to conduct a molecular docking study on the core active ingredients and core targets to verify the above network pharmacological analysis. Results: Seventy-nine active components of MBYF were screened and 261 corresponding targets were found. At the same time, 1307 related targets corresponding to COPD were screened and 111 overlapping targets were matched. By bioinformatics analysis, 10 core targets were identified, and subsequently, enrichment analysis revealed 385 BP, two CC, eight MF and 78 related signaling pathways. The binding of the core active components in MBYF to the core target was further verified by molecular docking, and all showed good binding. Conclusions: The active components of MBYF, such as quercetin, kaempferol, luteolin, and baicalein, may be the material basis for the treatment of chronic obstructive pulmonary disease. They affect the expression of inflammatory cells and inflammatory factors, protein phosphorylation, and smooth muscle hyperplasia through tumor necrosis factor, interleukin-17, mitogen-activated protein kinase, nuclear factor-kappa B and other signaling pathways.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Network Pharmacology ; Computational Biology ; Databases, Genetic ; Pulmonary Disease, Chronic Obstructive/drug therapy
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3607
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Zs.A 5423: Show issues

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Article ; Online: Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity.

Huang, Muhua / Dong, Jingcheng

Journal of immunology research

2021 Volume 2021, Page(s) 8816055

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Animals ; Homeostasis ; Humans ; Immunity ; Inflammation/immunology ; Interleukin-9/metabolism ; Neoplasms/immunology ; Respiratory Hypersensitivity/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Interleukin-9
Language	English
Publishing date	2021-03-01
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2021/8816055
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Article: Protective effects of Qing-Re-Huo-Xue formula on bleomycin-induced pulmonary fibrosis through the p53/IGFBP3 pathway.

Yang, Fangyong / Du, Wenjing / Tang, Zhao / Wei, Ying / Dong, Jingcheng

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 33

Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing lung disease with high mortality. Inflammation and epithelial mesenchymal transformation (EMT) may play an important role in the occurrence and development of IPF. Qing- ... ...

Abstract	Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing lung disease with high mortality. Inflammation and epithelial mesenchymal transformation (EMT) may play an important role in the occurrence and development of IPF. Qing-Re-Huo-Xue formula (QRHXF) has been used clinically by our team for half a century and has obvious therapeutic effects on lung disease. Nevertheless, the role and mechanism of QRHXF in the treatment of IPF have never been studied. Methods: A mouse pulmonary fibrosis model was established by intratracheal injection of BLM. The effects of QRHXF on the treatment of pulmonary fibrosis were studied by pulmonary function testing, imaging examination, pathological staining, transmission electron microscopy (TEM) observation and mRNA expression. Tandem mass tag (TMT)-based quantitative proteomics was carried out to analyse the lung protein expression profiles between the control (CTL), bleomycin (BLM) and QRHXF (BLM + QRHXF) groups. Immunohistochemistry and qRT-PCR were used to verify the possible existence of drug target proteins and signalling pathways. Results: The results of pulmonary function, lung pathology and imaging examinations showed that QRHXF could significantly alleviate BLM-induced pulmonary fibrosis in vivo. Additionally, inflammatory cell infiltration and EMT were markedly reduced in BLM-induced PF mice administered QRHXF. Proteomics detected a total of 35 proteins, of which 17 were upregulated and 18 were downregulated. A total of 19 differentially expressed proteins (DEPs) overlapped between the BLM versus CTL groups and the BLM + QRHXF versus BLM groups. The expression of p53 and IGFBP3 was reversed in the QRHXF intervention group, which was verified by immunohistochemistry and qRT-PCR. Conclusions: QRHXF attenuated BLM-induced pulmonary fibrosis, and regulation of the p53/IGFBP3 pathway might be associated with its efficacy, which holds promise as a novel treatment strategy for pulmonary fibrosis patients.
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00730-y
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Article ; Online: Identification of immune-related gene signatures for chronic obstructive pulmonary disease with metabolic syndrome: evidence from integrated bulk and single-cell RNA sequencing data.

Wu, Yueren / Ma, Mengyu / Choi, Wenglam / Xu, Weifang / Dong, Jingcheng

International immunology

2023 Volume 36, Issue 1, Page(s) 17–32

Abstract: Chronic obstructive pulmonary disease (COPD) is closely related to innate and adaptive inflammatory immune responses. It is increasingly becoming evident that metabolic syndrome (MetS) affects a significant portion of COPD patients. Through this ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is closely related to innate and adaptive inflammatory immune responses. It is increasingly becoming evident that metabolic syndrome (MetS) affects a significant portion of COPD patients. Through this investigation, we identify shared immune-related candidate biological markers. The Weighted Gene Co-Expression Network Analysis (WGCNA) was utilized to reveal the co-expression modules linked to COPD and MetS. The commonly expressed genes in the COPD and MetS were utilized to conduct an enrichment analysis. We adopted machine-learning to screen and validate hub genes. We also assessed the relationship between hub genes and immune cell infiltration in COPD and MetS, respectively. Moreover, associations across hub genes and metabolic pathways were also explored. Finally, we chose a single-cell RNA sequencing (scRNA-seq) dataset to investigate the hub genes and shared mechanisms at the level of the cells. We also applied cell trajectory analysis and cell-cell communication analysis to focus on the vital immune cell we were interested in. As a result, we selected and validated 13 shared hub genes for COPD and MetS. The enrichment analysis and immune infiltration analysis illustrated strong associations between hub genes and immunology. Additionally, we applied metabolic pathway enrichment analysis, indicating the significant role of reactive oxygen species (ROS) in COPD with MetS. Through scRNA-seq analysis, we found that ROS might accumulate the most in the alveolar macrophages. In conclusion, the 13 hub genes related to the immune response and metabolism may serve as diagnostic biomarkers and treatment targets of COPD with MetS.
MeSH term(s)	Humans ; Metabolic Syndrome/genetics ; Reactive Oxygen Species ; Cell Communication ; Pulmonary Disease, Chronic Obstructive/genetics ; Sequence Analysis, RNA
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxad043
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

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Article ; Online: Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma.

Luo, Weihang / Hu, Jindong / Xu, Weifang / Dong, Jingcheng

Frontiers in immunology

2022 Volume 13, Page(s) 974066

Abstract: Immune response in the asthmatic respiratory tract is mainly driven by ... ...

Abstract	Immune response in the asthmatic respiratory tract is mainly driven by CD4
MeSH term(s)	Asthma/immunology ; Cytokines ; Humans ; Th1 Cells/immunology ; Th17 Cells/immunology ; Th2 Cells/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2022-08-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.974066
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Article ; Online: Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways.

Luo, Zhuyu / Dong, Jingcheng / Wu, Jinfeng

International immunopharmacology

2022 Volume 108, Page(s) 108861

Abstract: Herba Epimedii is a famous herb collected from China and Korea. It has been used for impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical flavonoid compound isolated from Herba Epimedii, was reported as a potential ... ...

Abstract	Herba Epimedii is a famous herb collected from China and Korea. It has been used for impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical flavonoid compound isolated from Herba Epimedii, was reported as a potential anti-inflammatory drug. Icariside and icaritin are the two metabolites of icariin. Icariin and its metabolites have been used to treat a wide range of inflammatory diseases, such as atherosclerosis, Alzheimer's disease, depression, osteoarthritis, and asthma. They exert powerful suppression of proinflammatory signaling, such as NF-κB and MAPKs. More importantly, they can upregulate anti-inflammatory signaling, such as GR and Nrf2. In this study, we review the therapeutic effects and mechanisms of icariin and its metabolites in inflammatory diseases and provide novel insights into these potential anti-inflammatory drugs.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; NF-kappa B/metabolism ; Signal Transduction
Chemical Substances	Anti-Inflammatory Agents ; Flavonoids ; NF-kappa B ; icariin (VNM47R2QSQ)
Language	English
Publishing date	2022-05-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.108861
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Zs.A 5408: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Astragaloside IV targeting autophagy of T cells improves inflammation of asthma.

Yang, Qing-Qing / Zhang, Hong-Ying / Duan, Xiao-Hong / Li, Mi-Hui / Sun, Jing / Tian, Li-Xia / Dong, Jing-Cheng / Kong, Ling-Wen

Journal of Asian natural products research

2024 , Page(s) 1–15

Abstract: Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of memory T cells. AST treatment significantly decreased ... ...

Abstract	Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of memory T cells. AST treatment significantly decreased the number of T effector cells in asthma mice blood and the
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2023.2294069
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Article ; Online: A Mouse Model of Lumbar Spine Instability.

Liu, Shufen / Sun, Yueli / Dong, Jingcheng / Bian, Qin

Journal of visualized experiments : JoVE

2021 , Issue 170

Abstract: Intervertebral disc degeneration (IDD) is a common pathological change leading to low back pain. Appropriate animal models are desired for understanding the pathological processes and evaluating new drugs. Here, we introduced a surgically induced lumbar ... ...

Abstract	Intervertebral disc degeneration (IDD) is a common pathological change leading to low back pain. Appropriate animal models are desired for understanding the pathological processes and evaluating new drugs. Here, we introduced a surgically induced lumbar spine instability (LSI) mouse model that develops IDD starting from 1 week post operation. In detail, the mouse under anesthesia was operated by low back skin incision, L3-L5 spinous processes exposure, detachment of paraspinous muscles, resection of processes and ligaments, and skin closure. L4-L5 IVDs were chosen for the observation. The LSI model develops lumbar IDD by porosity and hypertrophy in endplates at an early stage, decrease in intervertebral disc volume, shrinkage in nucleus pulposus at an intermediate stage, and bone loss in lumbar vertebrae (L5) at a later stage. The LSI mouse model has the advantages of strong operability, no requirement of special equipment, reproducibility, inexpensive, and relatively short period of IDD development. However, LSI operation is still a trauma that causes inflammation within the first week post operation. Thus, this animal model is suitable for study of lumbar IDD.
MeSH term(s)	Animals ; Disease Models, Animal ; Low Back Pain/pathology ; Low Back Pain/surgery ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/surgery ; Male ; Mice
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61722
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Article ; Online: The Mechanisms of Effector Th Cell Responses Contribute to Treg Cell Function: New Insights into Pathogenesis and Therapy of Asthma.

Chen, Wenjing / Cao, Yuxue / Zhong, Yuanyuan / Sun, Jing / Dong, Jingcheng

Frontiers in immunology

2022 Volume 13, Page(s) 862866

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Asthma/therapy ; Cytokines ; Humans ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; T-Lymphocytes, Regulatory ; Th17 Cells
Chemical Substances	Cytokines ; Nuclear Receptor Subfamily 1, Group F, Member 3
Language	English
Publishing date	2022-07-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.862866
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