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Article ; Online: Succinylation-Alcian Blue Staining of Mucins on Polyvinylidene Difluoride Membrane.

Dong, Weijie / Kameyama, Akihiko

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2763, Page(s) 111–117

Abstract: Mucins are often stained with the basic dye Alcian blue, but mucins with a low acidic glycan content cannot be stained with it. Succinylation-Alcian blue staining is a method that temporarily modifies glycans with succinic acid to visualize mucins with ... ...

Abstract	Mucins are often stained with the basic dye Alcian blue, but mucins with a low acidic glycan content cannot be stained with it. Succinylation-Alcian blue staining is a method that temporarily modifies glycans with succinic acid to visualize mucins with low acidic glycan content. This method can be used to stain mucins on polyvinylidene difluoride (PVDF) membranes separated via supported molecular matrix electrophoresis (SMME) and mucins blotted onto PVDF membranes from gel electrophoreses. The succinyl groups of the modified glycans can be easily and completely removed by releasing O-glycan from the stained mucin bands. Therefore, the glycans can be analyzed using the same methods as those used for mucins with a high acidic glycan content.
MeSH term(s)	Mucins/analysis ; Alcian Blue ; Staining and Labeling ; Polysaccharides/analysis ; Fluorocarbon Polymers ; Polyvinyls
Chemical Substances	Mucins ; polyvinylidene fluoride (24937-79-9) ; Alcian Blue (P4448TJR7J) ; Polysaccharides ; Fluorocarbon Polymers ; Polyvinyls
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3670-1_9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis.

Li, Yuan / Lei, Guohua / Dong, Weijie / Lan, Tinglong / Fan, Jun / Qin, Shibing

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 50

Abstract: Background: Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, ...

Abstract	Background: Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, which limits the pharmacokinetic and pharmacodynamic studies of linezolid. This study aimed to evaluate the distribution of linezolid in diseased and nondiseased bones in patients with spinal TB. Methods: Spinal TB patients treated with linezolid-containing regimens and whose diseased and nondiseased bones were collected during surgery were enrolled retrospectively from January 2017 to February 2022. Blood, nondiseased bones, and diseased bones were collected simultaneously during the operation. Linezolid concentrations in the plasma, nondiseased bones, and diseased bones were subjected to high-performance liquid chromatography-tandem mass spectrometry. Results: Seven eligible spinal TB patients, including one rifampicin-resistant case, were enrolled. Following a 600 mg oral administration of linezolid before surgery, the median concentrations of linezolid in plasma, nondiseased bone, and diseased bone of the seven patients were 8.23, 1.01, and 2.13 mg/L, respectively. The mean ratios of linezolid concentration in nondiseased bones/plasma, diseased bones/plasma and diseased bones/nondiseased bones reached 0.26, 0.49, and 2.27, respectively. The diseased bones/plasma presented a higher mean ratio of linezolid concentration than nondiseased bones/plasma, and the difference was statistically significant (t = 2.55, p = 0.025). Pearson's correlation analysis showed the positively correlation of linezolid concentrations in diseased and nondiseased bones (r = 0.810, p = 0.027). Conclusions: Linezolid exhibits a higher concentration distribution in diseased bones than in nondiseased bones.
MeSH term(s)	Humans ; Linezolid/therapeutic use ; Tuberculosis, Spinal/drug therapy ; Retrospective Studies ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Mycobacterium tuberculosis
Chemical Substances	Linezolid (ISQ9I6J12J) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08970-x
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Article ; Online: High expression of ARPC1B correlates with immune infiltration and poor outcomes in glioblastoma.

Liao, Chuangxin / Chen, Wenli / Xu, Guixin / Wang, Jingshan / Dong, Weijie

Biochemistry and biophysics reports

2023 Volume 37, Page(s) 101619

Abstract: Objective: To investigate the role of ARPC1B in GBM and its prognostic value.: Methods: mRNA and protein expression of ARPC1B in GBM was analyzed using the TCGA; TIMER2 and the HPA databases, and protein expression differences were detected using ... ...

Abstract	Objective: To investigate the role of ARPC1B in GBM and its prognostic value. Methods: mRNA and protein expression of ARPC1B in GBM was analyzed using the TCGA; TIMER2 and the HPA databases, and protein expression differences were detected using immunohistochemistry. K-M analysis and Cox regression analysis were performed on high and low ARPC1B expression groups in the TCGA database. The relationship between immune cells and ARPC1B expression was explored using the TIMER2 database. GO and KEGG analyses were conducted to investigate the functions of ARPC1B-related genes in GBM. Results: ARPC1B was highly expressed in both GBM tissues and cell lines, and it was demonstrated as a prognostic biomarker for GBM. ARPC1B expression levels showed associations with immune cell populations within the GBM microenvironment. Conclusion: ARPC1B can regulating immune infiltration in the GBM microenvironment, indicating its potential as a novel therapeutic target for GBM.
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2023.101619
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Article ; Online: Perioperative nutrition management in patients with spinal tuberculosis taking ERAS measures.

Ma, Jiaojie / Li, Zhuo / Chen, Yang / Zhang, Yachao / Wang, Qian / Yan, Guangxuan / Dong, Weijie / Li, Shanshan

Asia Pacific journal of clinical nutrition

2024 Volume 33, Issue 1, Page(s) 39–46

Abstract: Background and objectives: To explore the effect of nutrition management under ERAS concept in patients with spinal tuberculosis.: Methods and study design: The study was conducted in an orthopedic ward of a tertiary grade A special hospital in ... ...

Abstract	Background and objectives: To explore the effect of nutrition management under ERAS concept in patients with spinal tuberculosis. Methods and study design: The study was conducted in an orthopedic ward of a tertiary grade A special hospital in Beijing. The patients admitted from January 1, 2021 to June 27, 2023 were screened for inclusion. The qualified patients were randomized into experimental group or control group. The experimental group received perioperative nutrition management under the concept of ERAS while the control group received routine perioperative management in hospital. The data was collected on the next day of admission, the next day and the sixth day after operation, including laboratory indicators (lymphocyte count, hemoglobin level, etc), intraoperative bleeding volume, postoperative exhaust, defecation time, drainage volume, albumin infusion amount, nutritional risk score, length of stay, hospitalization costs, etc. Univariate analysis and multivariate analysis correcting for gender, age, and baseline values were performed using SPSS24.0. Results: A total of 127 patients with spinal tuberculosis completed the study. Compared with the control group, the intraoperative blood loss (p=0.028) in the experimental group was significantly reduced, the postoperative exhaust time (p=0.012) and defecation time (p=0.012) were significantly shortened, and the nutritional status (p<0.001) was significantly improved. Besides, the results of multivariate analysis are robust after correcting potential confounding factors. Conclusions: Nutrition management under the concept of ERAS is helpful to reduce intraoperative bleeding, promote postoperative flatus and defecation, and improve nutritional status in patients with spinal tuberculosis, which may further improve their clinical outcome and prognosis.
MeSH term(s)	Humans ; Tuberculosis, Spinal/surgery ; Length of Stay ; Perioperative Care/methods ; Prognosis ; Nutritional Status ; Postoperative Complications/prevention & control
Language	English
Publishing date	2024-03-17
Publishing country	China
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1460012-2
ISSN	1440-6047 ; 0964-7058
ISSN (online)	1440-6047
ISSN	0964-7058
DOI	10.6133/apjcn.202403_33(1).0005
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Article ; Online: Dynamic Fluctuations of Metastatic Pulmonary Lesions.

Dong, Weijie / You, Yan / Liu, Chunyi / Ma, Qing / Wang, Dan / Shi, Xinlin / Wang, Daoxin / Li, Changyi

American journal of respiratory and critical care medicine

2024 Volume 209, Issue 8, Page(s) 1013–1015

MeSH term(s)	Humans ; Female ; Lung/diagnostic imaging ; Lung/pathology ; Sarcoma, Endometrial Stromal/pathology ; Sarcoma, Endometrial Stromal/secondary
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202307-1135IM
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Book ; Online: Model Predictive Monitoring of Dynamical Systems for Signal Temporal Logic Specifications

Yu, Xinyi / Dong, Weijie / Yin, Xiang / Li, Shaoyuan

2022

Abstract: Online monitoring aims to evaluate or to predict, at runtime, whether or not the behaviors of a system satisfy some desired specification. It plays a key role in safety-critical cyber-physical systems. In this work, we propose a new monitoring approach, ... ...

Abstract	Online monitoring aims to evaluate or to predict, at runtime, whether or not the behaviors of a system satisfy some desired specification. It plays a key role in safety-critical cyber-physical systems. In this work, we propose a new monitoring approach, called model predictive monitoring, for specifications described by Signal Temporal Logic (STL) formulae. Specifically, we assume that the observed state traces are generated by an underlying dynamical system whose model is known but the control law is unknown. The main idea is to use the dynamic of the system to predict future states when evaluating the satisfaction of the STL formulae. To this end, effective approaches for the computation of feasible sets of STL formulae are provided. We show that, by explicitly utilizing the model information of the dynamical system, the proposed online monitoring algorithm can falsify or certify of the specification in advance compared with existing algorithms, where no model information is used. We also demonstrate the proposed monitoring algorithm by several real world case studies. Comment: This paper is accepted to Automatica. arXiv admin note: substantial text overlap with arXiv:2203.16267
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Computer Science - Formal Languages and Automata Theory
Publishing date	2022-09-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Online Monitoring of Dynamic Systems for Signal Temporal Logic Specifications with Model Information

Yu, Xinyi / Dong, Weijie / Yin, Xiang / Li, Shaoyuan

2022

Abstract	Online monitoring aims to evaluate or to predict, at runtime, whether or not the behaviors of a system satisfy some desired specification. It plays a key role in safety-critical cyber-physical systems. In this work, we propose a new model-based approach for online monitoring for specifications described by Signal Temporal Logic (STL) formulae. Specifically, we assume that the observed state traces are generated by an underlying dynamic system whose model is known. The main idea is to consider the dynamic of the system when evaluating the satisfaction of the STL formulae. To this end, effective approaches for the computation of feasible sets for STL formulae are provided. We show that, by explicitly utilizing the model information of the dynamic system, the proposed online monitoring algorithm can falsify or certify of the specification in advance compared with existing algorithms, where no model information is used. We also demonstrate the proposed monitoring algorithm by case studies.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	005
Publishing date	2022-03-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Fault Diagnosis of Discrete-Event Systems under Non-Deterministic Observations with Output Fairness

Dong, Weijie / Gao, Shang / Yin, Xiang / Li, Shaoyuan

2022

Abstract: In this paper, we revisit the fault diagnosis problem of discrete-event systems (DES) under non-deterministic observations. Non-deterministic observation is a general observation model that includes the case of intermittent loss of observations. In this ... ...

Abstract	In this paper, we revisit the fault diagnosis problem of discrete-event systems (DES) under non-deterministic observations. Non-deterministic observation is a general observation model that includes the case of intermittent loss of observations. In this setting, upon the occurrence of an event, the sensor reading may be non-deterministic such that a set of output symbols are all possible. Existing works on fault diagnosis under non-deterministic observations require to consider all possible observation realizations. However, this approach includes the case where some possible outputs are permanently disabled. In this work, we introduce the concept of output fairness by requiring that, for any output symbols, if it has infinite chances to be generated, then it will indeed be generated infinite number of times. We use an assume-guarantee type of linear temporal logic formulas to formally describe this assumption. A new notion called output-fair diagnosability (OF-diagnosability) is proposed. An effective approach is provided for the verification of OF-diagnosability. We show that the proposed notion of OF-diagnosability is weaker than the standard definition of diagnosability under non-deterministic observations, and it better captures the physical scenario of observation non-determinism or intermittent loss of observations.
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Computer Science - Formal Languages and Automata Theory
Publishing date	2022-04-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: A Uniform Framework for Diagnosis of Discrete-Event Systems with Unreliable Sensors using Linear Temporal Logic

Dong, Weijie / Yin, Xiang / Li, Shaoyuan

2022

Abstract: In this paper, we investigate the diagnosability verification problem of partially-observed discrete-event systems (DES) subject to unreliable sensors. In this setting, upon the occurrence of each event, the sensor reading may be non-deterministic due to ...

Abstract	In this paper, we investigate the diagnosability verification problem of partially-observed discrete-event systems (DES) subject to unreliable sensors. In this setting, upon the occurrence of each event, the sensor reading may be non-deterministic due to measurement noises or possible sensor failures. Existing works on this topic mainly consider specific types of unreliable sensors such as the cases of intermittent sensors failures, permanent sensor failures or their combinations. In this work, we propose a novel \emph{uniform framework} for diagnosability of DES subject to, not only sensor failures, but also a very general class of unreliable sensors. Our approach is to use linear temporal logic (LTL) with semantics on infinite traces to describe the possible behaviors of the sensors. A new notion of $\varphi$-diagnosability is proposed as the necessary and sufficient condition for the existence of a diagnoser when the behaviors of sensors satisfy the LTL formula $\varphi$. Effective approach is provided to verify this notion. We show that, our new notion of $\varphi$-diagnosability subsumes all existing notions of robust diagnosability of DES subject to sensor failures. Furthermore, the proposed framework is user-friendly and flexible since it supports an arbitrary user-defined unreliable sensor type based on the specific scenario of the application. As examples, we provide two new notions of diagnosability, which have never been investigated in the literature, using our uniform framework.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	006
Publishing date	2022-04-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Self-scheduling of a novel hybrid GTSOFC unit in day-ahead energy and spinning reserve markets within ancillary services using a novel energy storage

Dong, Weijie / He, Guoqing / Cui, Quansheng / Sun, Wenwen / Hu, Zhenlong / Ahli raad, Erfan

Energy. 2022 Jan. 15, v. 239

2022

Abstract: Solid oxide fuel cell (SOFC) and gas turbine (GT) systems are the capability to achieve 75% efficiency of their potential, because of the high flexibility of fuel and load efficiency. So, by integrating the SOFC and GT, a novel hybrid framework with high ...

Abstract	Solid oxide fuel cell (SOFC) and gas turbine (GT) systems are the capability to achieve 75% efficiency of their potential, because of the high flexibility of fuel and load efficiency. So, by integrating the SOFC and GT, a novel hybrid framework with high efficiency is created for implementation in the power plant systems to minimizing operating costs in the energy market. In most of the paper, only the energy market of the day-ahead is considered and the ancillary service and participation in these markets are not seen. However, one of the biggest advantages of limited energy resources is the possibility of their presence in the ancillary services markets. In this paper, at first, a novel structure of hybrid a GTSOFC and new energy storage based on a reversible solid oxide fuel cell coupled with metal hydrides and waste steam is employed in power system for selling and buying energy from the energy market and ancillary services market then to increase the efficiency a new method based on the self-scheduling method is proposed for obtaining the best result. Finally, the proposed method is implemented in a sample unit and the results proved that the proposed method is suitable for the optimization problems.
Keywords	energy ; fuel cells ; markets ; power plants ; steam
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2021.122355
Database	NAL-Catalogue (AGRICOLA)

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