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  1. Book ; Online: Smart and Functional Soft Materials

    Dong, Xufeng

    2019  

    Keywords Spectrum analysis, spectrochemistry, mass spectrometry ; Polymer chemistry
    Size 1 electronic resource (146 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021045690
    ISBN 9781839627859 ; 1839627859
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Mechanisms affecting the biopharmacological properties of saffron active ingredients based on anti-inflammatory activity.

    Dong, Xiangmin

    Biotechnology & genetic engineering reviews

    2023  , Page(s) 1–22

    Abstract: To explore the mechanisms affecting the biopharmacological properties of the active components of saffron. Ultrasonic extraction technique was applied to extract the active components from safflower materials and combined with molecular docking technique ...

    Abstract To explore the mechanisms affecting the biopharmacological properties of the active components of saffron. Ultrasonic extraction technique was applied to extract the active components from safflower materials and combined with molecular docking technique to screen four safflower anti-inflammatory active components, naiophenol-3-0-rutinoside, kaempferol-3-O-glucoside, quercetin and lignan. In order to understand the mechanism of the influence of its biopharmaceutical properties, the changes of the solubility and permeability parameters of the anti-inflammatory active components of safflower were obtained by using the classical shaking bottle method and the body enteric irrigation method. The compound environment had a great influence on the solubility of single active ingredient. The calculated results of the dose number of all ingredients were greater than 1, and the solubility properties were all high solubility. The absorption parameters and osmotic coefficients of kaempferol-3-O-glucoside and lignan varied insignificantly under different concentration conditions, while each osmotic coefficient of kaempferol-3-O-rutinoside and quercetin showed a positive proportional decreasing trend. In addition, the osmotic coefficients of the three components except kaempferol-3-O-glucoside did not change with environmental changes, and the overall anti-inflammatory active ingredient absorption mechanisms included both passive diffusion and active transport. The two biopharmaceutical properties of the solubility and permeability of the active ingredients of Safflower can be changed under the influence of the application environment and drug concentration. In the pharmaceutical process, the preparation means can be optimized from this aspect to achieve the purpose of improving the clinical efficacy of Safflower anti-inflammatory drugs.
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2023.2184965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1012: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Editorial: Multi-modality imaging and multi-omics approach to pediatric neurogenetic disorders.

    Dong, Xinran

    Frontiers in neuroinformatics

    2023  Volume 17, Page(s) 1192211

    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2023.1192211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hideo Fukumi: Medical research in the shadow of biological warfare.

    Dong, Xianliang

    Journal of medical biography

    2023  , Page(s) 9677720231167784

    Abstract: Hideo Fukumi (1914-1998) is renowned for his position as the director of Japan's National Institute of Health and his scientific contributions to the fields of bacteriology, virology and epidemiology. This article introduces Fukumi's career cultivated ... ...

    Abstract Hideo Fukumi (1914-1998) is renowned for his position as the director of Japan's National Institute of Health and his scientific contributions to the fields of bacteriology, virology and epidemiology. This article introduces Fukumi's career cultivated over decades in the Japanese national medical system and focuses on his research on
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1177/09677720231167784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3995: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Fairy circle tales.

    Dong, Xiaoli

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 41, Page(s) e2314908120

    MeSH term(s) Psychoanalytic Interpretation
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2314908120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: Formation and Containment Control for High-order Linear Swarm Systems

    Dong, Xiwang

    (Springer Theses)

    2024  

    Series title Springer Theses
    Language English
    Size Online-Ressource (182 p)
    Publisher Springer Berlin Heidelberg
    Publishing place Berlin/Heidelberg
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783662478356 ; 3662478358
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Sirtuin 6-A Key Regulator of Hepatic Lipid Metabolism and Liver Health.

    Dong, X Charlie

    Cells

    2023  Volume 12, Issue 4

    Abstract: Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in hepatic lipid homeostasis and liver health. Hepatic lipogenesis is driven by several master ... ...

    Abstract Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in hepatic lipid homeostasis and liver health. Hepatic lipogenesis is driven by several master regulators including liver X receptor (LXR), carbohydrate response element binding protein (ChREBP), and sterol regulatory element binding protein 1 (SREBP1). Interestingly, these three transcription factors can be negatively regulated by SIRT6 through direct deacetylation. Fatty acid oxidation is regulated by peroxisome proliferator activated receptor alpha (PPARα) in the liver. SIRT6 can promote fatty acid oxidation by the activation of PPARα or the suppression of miR-122. SIRT6 can also directly modulate acyl-CoA synthetase long chain family member 5 (ACSL5) activity for fatty acid oxidation. SIRT6 also plays a critical role in the regulation of total cholesterol and low-density lipoprotein (LDL)-cholesterol through the regulation of SREBP2 and proprotein convertase subtilisin/kexin type 9 (PCSK9), respectively. Hepatic deficiency of Sirt6 in mice has been shown to cause hepatic steatosis, inflammation, and fibrosis, hallmarks of alcoholic and nonalcoholic steatohepatitis. SIRT6 can dampen hepatic inflammation through the modulation of macrophage polarization from M1 to M2 type. Hepatic stellate cells are a key cell type in hepatic fibrogenesis. SIRT6 plays a strong anti-fibrosis role by the suppression of multiple fibrogenic pathways including the transforming growth factor beta (TGFβ)-SMAD family proteins and Hippo pathways. The role of SIRT6 in liver cancer is quite complicated, as both tumor-suppressive and tumor-promoting activities have been documented in the literature. Overall, SIRT6 has multiple salutary effects on metabolic homeostasis and liver health, and it may serve as a therapeutic target for hepatic metabolic diseases. To date, numerous activators and inhibitors of SIRT6 have been developed for translational research.
    MeSH term(s) Animals ; Mice ; Cholesterol ; Fatty Acids/metabolism ; Inflammation ; Lipid Metabolism ; Non-alcoholic Fatty Liver Disease ; PPAR alpha/metabolism ; Proprotein Convertase 9/metabolism ; Sirtuins/metabolism ; Liver/metabolism
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Fatty Acids ; PCSK9 protein, human (EC 3.4.21.-) ; PPAR alpha ; Proprotein Convertase 9 (EC 3.4.21.-) ; Sirt6 protein, mouse (EC 2.4.2.31) ; Sirtuins (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-)
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Revealing the Mysterious Veil of Prion Diseases Under the Framework of China CDC.

    Dong, Xiaoping

    China CDC weekly

    2022  Volume 4, Issue 33, Page(s) 721–722

    Language English
    Publishing date 2022-10-20
    Publishing country China
    Document type Editorial
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2022.150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Surgical site infection in upper extremity fracture: Incidence and prognostic risk factors.

    Dong, Xin

    Medicine

    2022  Volume 101, Issue 35, Page(s) e30460

    Abstract: Upper extremity fractures (UEF) occurred in about 0.67% of males and females at some point in their lifetime. Surgical treatment has the advantage of good functional recovery, however, the occurrence of surgical site infection (SSI) affects the clinical ... ...

    Abstract Upper extremity fractures (UEF) occurred in about 0.67% of males and females at some point in their lifetime. Surgical treatment has the advantage of good functional recovery, however, the occurrence of surgical site infection (SSI) affects the clinical outcome of operation. Currently, there are few studies focused on SSI of UEF. Consecutive patients with UEF and underwent surgeries from January 2010 to February 2021 were recruited. Demographic data, surgical related variables and laboratory test index of these patients were extracted and collected from the electronic medical records and picture archiving and communication system by well-trained investigators. Receiver operating characteristic (ROC) analysis was performed to detect the optimum cut-off value for continuous variables. Multivariate logistic regression analysis was performed to identify independent risk factors of SSI. In total, 286 patients with a mean age of 44.4 ± 16.6 years were identified for inclusion, 59.8% patients diagnosed with fracture of radius and ulna and 40.2% fractures located in the humerus, closed and open fractures were occurred in 252 and 34 adult patients respectively. 7.3% UEF patients were encountered with SSI, incidence of superficial and deep infection was 6.3% and 1.0%. Open fracture (OR, 8.33; P, .000), operation time longer than 122 minutes (OR, 3.12; P, .036), intraoperative blood loss more than 135 mL (OR, 3.98; P, .009) and albumin (ALB) lower than 40.8 g/L (OR, 3.60; P, .015) were demonstrated as independent risk factors of SSI. Adequate preoperative evaluation, careful intraoperative manipulation, and timely and appropriate postoperative interventions should be formulated to reduce the incidence of SSI in patients with the above perioperative high-risk factors.
    MeSH term(s) Adult ; Arm Injuries ; Female ; Fractures, Open/complications ; Humans ; Incidence ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Surgical Wound Infection/etiology ; Upper Extremity/surgery
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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  10. Article ; Online: Evolution of Plant Niche Construction Traits in Biogeomorphic Landscapes.

    Dong, Xiaoli

    The American naturalist

    2022  Volume 199, Issue 6, Page(s) 758–775

    Abstract: AbstractBy virtue of their niche construction traits, plants play a significant role in shaping landscapes. The resultant outcome could change the selective environment, which then influences the evolution of these same plants. To date, almost all ... ...

    Abstract AbstractBy virtue of their niche construction traits, plants play a significant role in shaping landscapes. The resultant outcome could change the selective environment, which then influences the evolution of these same plants. To date, almost all biogeomorphic models have assumed that niche construction traits are invariant in time. Conversely, niche construction studies often assume that independent abiotic changes either are nonexistent or are simply linear. Here, I consider the concomitant evolution of plant niche construction traits during complex landscape development. I construct a geo-evolutionary model that couples a population genetic module with a landscape development module. Allowing plants to evolve always results in landforms different from those that appear when evolution is not included. The topographic difference between cases with and without evolution ranges from a small difference in steady-state elevation (topography) to pronounced differences in landforms. Furthermore, evolution of niche construction traits could introduce alternative stable states and hysteresis, modifying the responses of landscapes to environmental stress. Allowing the landscape to develop while evolution occurs alters evolutionary trajectories for niche construction traits. The system can even develop into states that suppress natural selection. Model results support the need to integrate niche construction theory and biogeomorphology to better understand both.
    MeSH term(s) Biological Evolution ; Ecosystem ; Phenotype ; Selection, Genetic
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207092-3
    ISSN 1537-5323 ; 0003-0147
    ISSN (online) 1537-5323
    ISSN 0003-0147
    DOI 10.1086/719425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/723: Show issues

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