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  1. Article ; Online: Research Progress on the Role and Mechanism of GDF15 in Body Weight Regulation.

    Dong, Xiao-Chen / Xu, Dan-Yan

    Obesity facts

    2023  Volume 17, Issue 1, Page(s) 1–11

    Abstract: Background: Growth differentiation factor-15 (GDF15) is a member of the growth differentiation factor subfamily in the transforming growth factor beta superfamily. GDF15 has multiple functions and can regulate biological processes. High levels of GDF15 ... ...

    Abstract Background: Growth differentiation factor-15 (GDF15) is a member of the growth differentiation factor subfamily in the transforming growth factor beta superfamily. GDF15 has multiple functions and can regulate biological processes. High levels of GDF15 in the circulation can affect metabolic processes. Studies have shown that GDF15 is associated with changes in body weight.
    Summary: This review reviews the current knowledge on the relationship between GDF15 and body weight change, focusing on the role and mechanism of GDF15 in body weight regulation. GDF15 plays an important role in reducing food intake, improving insulin resistance, and breaking down fat, suggesting that GDF15 has an important regulatory effect on body weight. The mechanism by which GDF15 causes reduced food intake may be related to changes in food preference, delayed gastric emptying, and conditioned taste aversion. GDF15 can combat insulin resistance induced by inflammation or protect β cell from apoptosis. GDF15 probably promotes lipolysis through a brain-somatic tissue circuit. Several factors and related signaling pathways are also mentioned that can contribute to the effects of GDF15 on reducing weight.
    Key message: GDF15 plays an important role in weight regulation and provides a new direction for the treatment of obesity. Its effects on resisting obesity are of great significance to inhibiting the progression of metabolic diseases. It is expected to become a new target for regulating body weight, improving obesity, and treating metabolic diseases such as diabetes.
    MeSH term(s) Humans ; Insulin Resistance ; Obesity/metabolism ; Food Preferences ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/pharmacology ; Metabolic Diseases/complications ; Body Weight
    Chemical Substances Growth Differentiation Factor 15 ; GDF15 protein, human
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2417831-7
    ISSN 1662-4033 ; 1662-4025
    ISSN (online) 1662-4033
    ISSN 1662-4025
    DOI 10.1159/000535089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Optimization of Hole Injection Layer in Organic Light-Emitting Diodes.

    Xing, Xiaolin / Wu, Ziye / Sun, Yingying / Liu, Yunlong / Dong, Xiaochen / Li, Shuhong / Wang, Wenjun

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Organic light-emitting diodes (OLEDs) are widely recognized as the forefront technology for displays and lighting technology. Now, the global OLED market is nearly mature, driven by the rising demand for superior displays in smartphones. In recent years, ...

    Abstract Organic light-emitting diodes (OLEDs) are widely recognized as the forefront technology for displays and lighting technology. Now, the global OLED market is nearly mature, driven by the rising demand for superior displays in smartphones. In recent years, numerous strategies have been introduced and demonstrated to optimize the hole injection layer to further enhance the efficiency of OLEDs. In this paper, different methods of optimizing the hole injection layer were elucidated, including using a suitable hole injection material to minimize the hole injection barrier and match the energy level with the emission layer, exploring new preparation methods to optimize the structure of hole injection layer, and so on. Meanwhile, this article can help people to understand the current research progress and the challenges still faced in relation to the hole injection layer in OLEDs, providing future research directions to enhance the properties of OLEDs.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics.

    Wang, Leichen / Li, Na / Wang, Weili / Mei, Anqing / Shao, Jinjun / Wang, Wenjun / Dong, Xiaochen

    ACS nano

    2024  Volume 18, Issue 6, Page(s) 4683–4703

    Abstract: Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely ... ...

    Abstract Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation in cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), with high electron affinity, is widely utilized as the electron acceptor in constructing donor-acceptor-donor (D-A-D) structured fluorophores with intensive near-infrared (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based NIR-II dyes have been employed in tumor phototheranostics due to their exceptional structure tunability, biocompatibility, and photophysical properties. This review systematically overviews the research progress of BBT-based small molecular NIR-II dyes and focuses on molecule design and bioapplications. First, the molecular engineering strategies to fine-tune the photophysical properties in constructing the high-performance BBT-based NIR-II fluorophores are discussed in detail. Then, their biological applications in optical imaging and phototherapy are highlighted. Finally, the current challenges and future prospects of BBT-based NIR-II fluorescent dyes are also summarized. This review is believed to significantly promote the further progress of BBT-derived NIR-II fluorophores for cancer phototheranostics.
    MeSH term(s) Humans ; Fluorescent Dyes/chemistry ; Phototherapy ; Fluorescence ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Optical Imaging/methods ; Nanoparticles/chemistry
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c12316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: FDPP-HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy.

    Liang, Pingping / Shao, Jinjun / Tang, Qianyun / Si, Weili / Wang, Qiang / Zhang, Qi / Dong, Xiaochen

    RSC advances

    2023  Volume 13, Issue 26, Page(s) 17621

    Abstract: This corrects the article DOI: 10.1039/C7RA06551E.]. ...

    Abstract [This corrects the article DOI: 10.1039/C7RA06551E.].
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90050a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ultrabright Green-Emissive Nanodots for Precise Biological Visualization.

    Guo, Yuxin / Wang, Zihao / Chen, Yu / Chao, Furong / Xu, Yin / Qu, Lu-Lu / Wu, Fu-Gen / Dong, Xiaochen

    Nano letters

    2024  Volume 24, Issue 7, Page(s) 2264–2272

    Abstract: Developing general methods to fabricate water-dispersible and biocompatible fluorescent probes will promote different biological visualization applications. Herein, we report a metal-facilitated method to fabricate ultrabright green-emissive nanodots via ...

    Abstract Developing general methods to fabricate water-dispersible and biocompatible fluorescent probes will promote different biological visualization applications. Herein, we report a metal-facilitated method to fabricate ultrabright green-emissive nanodots via the one-step solvothermal treatment of rose bengal, ethanol, and various metal ions. These metal-doped nanodots show good water dispersity, ultrahigh photoluminescence quantum yields (PLQYs) (e.g., the PLQY of Fe-doped nanodots (FeNDs) was ∼97%), and low phototoxicity. Owing to the coordination effect of metal ions, the FeNDs realize glutathione detection with outstanding properties. Benefiting from the high endoplasmic reticulum (ER) affinity of the chloride group, the FeNDs can act as an ER tracker with long ER imaging capacity (FeNDs: >24 h; commercial ER tracker: ∼1 h) and superb photostability and can achieve tissue visualization in living
    MeSH term(s) Quantum Dots ; Carbon ; Fluorescent Dyes ; Ions ; Water
    Chemical Substances Carbon (7440-44-0) ; Fluorescent Dyes ; Ions ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Pyrrolopyrrole aza-BODIPY near-infrared photosensitizer for dual-mode imaging-guided photothermal cancer therapy.

    Wu, Chaolong / Huang, Xiaoyu / Tang, Yunyun / Xiao, Wanyue / Sun, Liguo / Shao, Jinjun / Dong, Xiaochen

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 57, Page(s) 8866

    Abstract: Correction for 'Pyrrolopyrrole aza-BODIPY near-infrared photosensitizer for dual-mode imaging-guided photothermal cancer therapy' by Chaolong ... ...

    Abstract Correction for 'Pyrrolopyrrole aza-BODIPY near-infrared photosensitizer for dual-mode imaging-guided photothermal cancer therapy' by Chaolong Wu
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc90217j
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  7. Article ; Online: Ionic Liquid/Water Binary Solvent Anti-Freezing Hydrogel for Strain and Temperature Sensors.

    Liu, Jingying / Zhang, Xinyi / Cui, Ying / Liu, Yunlong / Wang, Wenjun / Guo, Yuxin / Wang, Qian / Dong, Xiaochen

    ACS applied materials & interfaces

    2024  Volume 16, Issue 4, Page(s) 5208–5216

    Abstract: Hydrogels are widely applied in the flexible wearable electronic devices field owing to their skin-like stretchability, superb biocompatibility, and high conductivity retention under mechanical deformations. Nevertheless, hydrogels are prone to freezing ... ...

    Abstract Hydrogels are widely applied in the flexible wearable electronic devices field owing to their skin-like stretchability, superb biocompatibility, and high conductivity retention under mechanical deformations. Nevertheless, hydrogels are prone to freezing at low temperatures and losing water at high temperatures, which seriously limits their practical applications. Herein, a binary solvent system of ionic liquid (1-ethyl-3-methylimidazolium chloride) and water was prepared to endow the ionic hydrogel high ionic conductivity (0.28 S m
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c19136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction to "Diketopyrrolopyrrole-Based Photosensitizers Conjugated with Chemotherapeutic Agents for Multimodal Tumor Therapy".

    Cai, Yu / Liang, Pingping / Tang, Qianyun / Si, Weili / Chen, Peng / Zhang, Qi / Dong, Xiaochen

    ACS applied materials & interfaces

    2023  Volume 15, Issue 21, Page(s) 26225

    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Published Erratum
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c06523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The insightful water quality analysis and predictive model establishment via machine learning in dual-source drinking water distribution system.

    Li, Huiping / Zhou, Baiqin / Xu, Xiaoyan / Huo, Ranran / Zhou, Ting / Dong, Xiaochen / Ye, Cheng / Li, Tian / Xie, Li / Pang, Weihai

    Environmental research

    2024  Volume 250, Page(s) 118474

    Abstract: Dual-source drinking water distribution systems (DWDS) over single-source water supply systems are becoming more practical in providing water for megacities. However, the more complex water supply problems are also generated, especially at the hydraulic ... ...

    Abstract Dual-source drinking water distribution systems (DWDS) over single-source water supply systems are becoming more practical in providing water for megacities. However, the more complex water supply problems are also generated, especially at the hydraulic junction. Herein, we have sampled for a one-year and analyzed the water quality at the hydraulic junction of a dual-source DWDS. The results show that visible changes in drinking water quality, including turbidity, pH, UV
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reversing the Interfacial Electric Field in Metal Phosphide Heterojunction by Fe-Doping for Large-Current Oxygen Evolution Reaction.

    Li, Zhong / Xu, Chengshuang / Zhang, Zheye / Xia, Shan / Li, Dongsheng / Liu, Liren / Chen, Peng / Dong, Xiaochen

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2308477

    Abstract: Developing non-precious-metal electrocatalysts that can operate with a low overpotential at a high current density for industrial application is challenging. Heterogeneous bimetallic phosphides have attracted much interest. Despite high hydrogen ... ...

    Abstract Developing non-precious-metal electrocatalysts that can operate with a low overpotential at a high current density for industrial application is challenging. Heterogeneous bimetallic phosphides have attracted much interest. Despite high hydrogen evolution reaction (HER) performance, the ordinary oxygen evolution reaction (OER) performance hinders their practical use. Herein, it is shown that Fe-doping reverses and enlarges the interfacial electrical field at the heterojunction, turning the H intermediate favorable binding sites for HER into O intermediate favorable sites for OER. Specifically, the self-supported heterojunction catalysts on nickel foam (CoP@Ni
    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202308477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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