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  1. Article ; Online: Opportunities and Challenges in mRNA Therapeutics.

    Dong, Yizhou / Anderson, Daniel G

    Accounts of chemical research

    2022  Volume 55, Issue 1, Page(s) 1

    MeSH term(s) RNA, Messenger/genetics
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.1c00739
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  2. Article: mRNA delivery in cancer immunotherapy.

    Zhong, Yichen / Du, Shi / Dong, Yizhou

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 4, Page(s) 1348–1357

    Abstract: Messenger RNA (mRNA) has drawn much attention in the medical field. Through various treatment approaches including protein replacement therapies, gene editing, and cell engineering, mRNA is becoming a potential therapeutic strategy for cancers. However, ... ...

    Abstract Messenger RNA (mRNA) has drawn much attention in the medical field. Through various treatment approaches including protein replacement therapies, gene editing, and cell engineering, mRNA is becoming a potential therapeutic strategy for cancers. However, delivery of mRNA into targeted organs and cells can be challenging due to the unstable nature of its naked form and the low cellular uptake. Therefore, in addition to mRNA modification, efforts have been devoted to developing nanoparticles for mRNA delivery. In this review, we introduce four categories of nanoparticle platform systems: lipid, polymer, lipid-polymer hybrid, and protein/peptide-mediated nanoparticles, together with their roles in facilitating mRNA-based cancer immunotherapies. We also highlight promising treatment regimens and their clinical translation.
    Language English
    Publishing date 2023-03-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics.

    Kang, Diana D / Li, Haoyuan / Dong, Yizhou

    Advanced drug delivery reviews

    2023  Volume 199, Page(s) 114961

    Abstract: The accelerated progress and approval of two mRNA-based vaccines to address the SARS-CoV-2 virus were unprecedented. This record-setting feat was made possible through the solid foundation of research on in vitro transcribed mRNA (IVT mRNA) which could ... ...

    Abstract The accelerated progress and approval of two mRNA-based vaccines to address the SARS-CoV-2 virus were unprecedented. This record-setting feat was made possible through the solid foundation of research on in vitro transcribed mRNA (IVT mRNA) which could be utilized as a therapeutic modality. Through decades of thorough research to overcome barriers to implementation, mRNA-based vaccines or therapeutics offer many advantages to rapidly address a broad range of applications including infectious diseases, cancers, and gene editing. Here, we describe the advances that have supported the adoption of IVT mRNA in the clinics, including optimization of the IVT mRNA structural components, synthesis, and lastly concluding with different classes of IVT RNA. Continuing interest in driving IVT mRNA technology will enable a safer and more efficacious therapeutic modality to address emerging and existing diseases.
    MeSH term(s) Humans ; RNA, Messenger/genetics ; COVID-19 ; SARS-CoV-2/genetics ; Neoplasms ; Vaccines
    Chemical Substances RNA, Messenger ; Vaccines
    Language English
    Publishing date 2023-06-14
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2023.114961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Advances in engineering and delivery strategies for cytokine immunotherapy.

    Bohmer, Margaret / Xue, Yonger / Jankovic, Katarina / Dong, Yizhou

    Expert opinion on drug delivery

    2023  Volume 20, Issue 5, Page(s) 579–595

    Abstract: Introduction: Cytokine immunotherapy is a growing field for the treatment of cancer, infectious disease, autoimmunity, and other ailments. Therapeutic cytokines are a class of secreted, small proteins that play a pivotal role in regulating the innate ... ...

    Abstract Introduction: Cytokine immunotherapy is a growing field for the treatment of cancer, infectious disease, autoimmunity, and other ailments. Therapeutic cytokines are a class of secreted, small proteins that play a pivotal role in regulating the innate and adaptive immune system by provoking or mitigating immune responses. In the clinic, cytokines are frequently combined with other treatments, such as small molecules and monoclonal antibodies. However, the clinical translation of cytokine therapies is hindered by their short half-life, pleiotropic nature, and off-target effects, which cause diminished efficacy and severe systemic toxicity. Such toxicity limits dosage, thus resulting in suboptimal doses. Accordingly, numerous efforts have been devoted to exploring strategies to promote cytokine therapies by improving their tissue specificity and pharmacokinetics.
    Areas covered: Preclinical and clinical research into bioengineering and delivery strategies for cytokines, consisting of bioconjugation, fusion proteins, nanoparticles, and scaffold-based systems.
    Expert opinion: These approaches pave the way for the development of next-generation cytokine treatments with greater clinical benefit and reduced toxicity, circumventing such issues currently associated with cytokine therapy.
    MeSH term(s) Humans ; Cytokines/therapeutic use ; Neoplasms/drug therapy ; Antibodies, Monoclonal ; Drug Delivery Systems ; Immunotherapy/methods
    Chemical Substances Cytokines ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2167286-6
    ISSN 1744-7593 ; 1742-5247
    ISSN (online) 1744-7593
    ISSN 1742-5247
    DOI 10.1080/17425247.2023.2208344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6012: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Adoptive cell therapy for cancer treatment.

    Du, Shi / Yan, Jingyue / Xue, Yonger / Zhong, Yichen / Dong, Yizhou

    Exploration (Beijing, China)

    2023  Volume 3, Issue 4, Page(s) 20210058

    Abstract: Adoptive cell therapy (ACT) is a rapidly growing anti-cancer strategy that has shown promise in treating various cancer types. The concept of ACT involves activating patients' own immune cells ex vivo and then transferring them back to the patients to ... ...

    Abstract Adoptive cell therapy (ACT) is a rapidly growing anti-cancer strategy that has shown promise in treating various cancer types. The concept of ACT involves activating patients' own immune cells ex vivo and then transferring them back to the patients to recognize and eliminate cancer cells. Currently, the commonly used ACT includes tumor-infiltrating lymphocytes (TILs), genetically engineered immune cells, and dendritic cells (DCs) vaccines. With the advancement of cell culture and genetic engineering techniques, ACT has been used in clinics to treat malignant hematological diseases and many new ACT-based regimens are in different stages of clinical trials. Here, representative ACT approaches are introduced and the opportunities and challenges for clinical translation of ACT are discussed.
    Language English
    Publishing date 2023-07-02
    Publishing country China
    Document type Journal Article
    ISSN 2766-2098
    ISSN (online) 2766-2098
    DOI 10.1002/EXP.20210058
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  6. Article ; Online: Recent advances of biomaterials in stem cell therapies.

    Xue, Yonger / Baig, Rafia / Dong, Yizhou

    Nanotechnology

    2022  Volume 33, Issue 13

    Abstract: Stem cells have been utilized as 'living drugs' in clinics for decades. Their self-renewal, differentiation, and immunomodulating properties provide potential solutions for a variety of malignant diseases and disorders. However, the pathological ... ...

    Abstract Stem cells have been utilized as 'living drugs' in clinics for decades. Their self-renewal, differentiation, and immunomodulating properties provide potential solutions for a variety of malignant diseases and disorders. However, the pathological environment may diminish the therapeutic functions and survival of the transplanted stem cells, causing failure in clinical translation. To overcome these challenges, researchers have developed biomaterial-based strategies that facilitate
    MeSH term(s) Animals ; Biocompatible Materials ; Cell Engineering ; Humans ; Stem Cell Transplantation ; Stem Cells/physiology
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Letter
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac4520
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  7. Article ; Online: Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.

    Cui, Zhifen / Wang, Hongyan / Dong, Yizhou / Liu, Shan-Lu / Wang, Qianben

    Frontiers in genome editing

    2023  Volume 5, Page(s) 1231656

    Abstract: Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as ... ...

    Abstract Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as identifying of virus-host dependencies, offers valuable insights into disease mechanisms and informs the development of effective therapeutic strategies against viral infections. This review delves into the key host factors that facilitate or hinder SARS-CoV-2 infection and replication, as identified by CRISPR/Cas9-based screening platforms. Furthermore, we explore CRISPR/Cas13-based gene therapy strategies aimed at targeting these host factors to inhibit viral infection, with the ultimate goal of eradicating SARS-CoV-2 and preventing and treating related coronaviruses for future outbreaks.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3439
    ISSN (online) 2673-3439
    DOI 10.3389/fgeed.2023.1231656
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  8. Article ; Online: Lipid Nanoparticle-mRNA Formulations for Therapeutic Applications.

    Wang, Chang / Zhang, Yuebao / Dong, Yizhou

    Accounts of chemical research

    2021  Volume 54, Issue 23, Page(s) 4283–4293

    Abstract: After decades of extensive fundamental studies and clinical trials, lipid nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and Pfizer-BioNTech vaccines fighting against COVID-19. Moreover, researchers and clinicians have ...

    Abstract After decades of extensive fundamental studies and clinical trials, lipid nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and Pfizer-BioNTech vaccines fighting against COVID-19. Moreover, researchers and clinicians have been investigating mRNA therapeutics for a variety of therapeutic indications including protein replacement therapy, genome editing, and cancer immunotherapy. To realize these therapeutics in the clinic, there are many formidable challenges. First, novel delivery systems such as LNPs with high delivery efficiency and low toxicity need to be developed for different cell types. Second, mRNA molecules need to be engineered for improved pharmaceutical properties. Lastly, the LNP-mRNA nanoparticle formulations need to match their therapeutic applications.In this Account, we summarize our recent advances in the design and development of various classes of lipids and lipid derivatives, which can be formulated with multiple types of mRNA molecules to treat diverse diseases. For example, we conceived a series of ionizable lipid-like molecules based on the structures of a benzene core, an amide linker, and hydrophobic tails. We identified
    MeSH term(s) Animals ; Benzamides/chemistry ; Biomimetic Materials/chemistry ; Communicable Diseases/immunology ; Communicable Diseases/therapy ; Disease Models, Animal ; Drug Carriers/chemistry ; Genetic Diseases, Inborn/immunology ; Genetic Diseases, Inborn/therapy ; Humans ; Liposomes/chemistry ; Mice ; Nanoparticles/chemistry ; Neoplasms/immunology ; Neoplasms/therapy ; Phospholipids/chemistry ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA, Messenger/therapeutic use ; Untranslated Regions ; Vitamins/chemistry
    Chemical Substances Benzamides ; Drug Carriers ; Lipid Nanoparticles ; Liposomes ; Phospholipids ; RNA, Messenger ; Untranslated Regions ; Vitamins ; benzene-1,3,5-tricarboxamide
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.1c00550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Harnessing lipid nanoparticles for efficient CRISPR delivery.

    Yan, Jingyue / Kang, Diana D / Dong, Yizhou

    Biomaterials science

    2021  Volume 9, Issue 18, Page(s) 6001–6011

    Abstract: The CRISPR-Cas system has revolutionized the biomedical research field with its simple and flexible genome editing method. In October 2020, Emmanuelle Charpentier and Jennifer A. Doudna were awarded the 2020 Nobel Prize in chemistry in recognition of ... ...

    Abstract The CRISPR-Cas system has revolutionized the biomedical research field with its simple and flexible genome editing method. In October 2020, Emmanuelle Charpentier and Jennifer A. Doudna were awarded the 2020 Nobel Prize in chemistry in recognition of their outstanding contributions to the discovery of CRISPR-Cas9 genetic scissors, which allow scientists to alter DNA sequences with high precision. Recently, the first phase I clinical trials in cancer patients affirmed the safety and feasibility of
    MeSH term(s) CRISPR-Cas Systems/genetics ; DNA ; Gene Editing ; Humans ; Lipids ; Nanoparticles
    Chemical Substances Lipids ; DNA (9007-49-2)
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm00537e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Lipid nanoparticles for mRNA delivery.

    Hou, Xucheng / Zaks, Tal / Langer, Robert / Dong, Yizhou

    Nature reviews. Materials

    2021  Volume 6, Issue 12, Page(s) 1078–1094

    Abstract: Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow ... ...

    Abstract Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle-mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics. In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle-mRNA systems. We then consider key points for the clinical translation of lipid nanoparticle-mRNA formulations, including good manufacturing practice, stability, storage and safety, and highlight preclinical and clinical studies of lipid nanoparticle-mRNA therapeutics for infectious diseases, cancer and genetic disorders. Finally, we give an outlook to future possibilities and remaining challenges for this promising technology.
    Language English
    Publishing date 2021-08-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-021-00358-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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