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  1. Book ; Online ; E-Book: Assessing urban transportation with big data analysis

    Yang, DongYuan / Duan, Zhengyu

    (Urban Sustainability)

    2022  

    Author's details DongYuan Yang, Zhengyu Duan
    Series title Urban Sustainability
    Keywords Big data
    Subject code 170
    Language English
    Size 1 online resource (349 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-3338-3 ; 9789811933370 ; 978-981-19-3338-7 ; 9811933375
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Associations Between Temporomandibular Disorders and Brain Imaging-Derived Phenotypes.

    Lin, Jun / Cao, Dong-Yuan

    International dental journal

    2024  

    Abstract: Objective: Temporomandibular disorders (TMD) affect the temporomandibular joint and associated structures. Despite its prevalence and impact on quality of life, the underlying mechanisms of TMD remain unclear. Magnetic resonance imaging studies suggest ... ...

    Abstract Objective: Temporomandibular disorders (TMD) affect the temporomandibular joint and associated structures. Despite its prevalence and impact on quality of life, the underlying mechanisms of TMD remain unclear. Magnetic resonance imaging studies suggest brain abnormalities in patients with TMD. However, these lines of evidence are essentially observational and cannot infer a causal relationship. This study employs Mendelian randomisation (MR) to probe causal relationships between TMD and brain changes.
    Methods: Genome-wide association study (GWAS) summary statistics for TMD were collected, along with brain imaging-derived phenotypes (IDPs). Instrumental variables were selected from the GWAS summary statistics and used in bidirectional 2-sample MR analyses. The inverse-variance weighted analysis was chosen as the primary method. In addition, false discovery rate (FDR) correction of P value was used.
    Results: Eleven IDPs related to brain imaging alterations showed significant causal associations with TMD (P-FDR < .05), validated through sensitivity analysis. In forward MR, the mean thickness of left caudal middle frontal gyrus (OR, 0.76; 95% CI, 0.67-0.87; P-FDR = 1.15  ×  10
    Conclusions: This study provides genetic evidence supporting the bidirectional causal associations between TMD and brain IDPs, shedding light on potential neurobiological mechanisms underlying TMD development and its relationship with brain structure.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 218262-2
    ISSN 1875-595X ; 0020-6539
    ISSN (online) 1875-595X
    ISSN 0020-6539
    DOI 10.1016/j.identj.2024.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: NPFs-mediated actin cytoskeleton: a new viewpoint on autophagy regulation.

    Dong, Yuan / Quan, Chengshi

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 111

    Abstract: Macroautophagy/autophagy is a lysosome-dependent catabolic process induced by various cellular stress conditions, maintaining the homeostasis of cells, tissues and organs. Autophagy is a series of membrane-related events involving multiple autophagy- ... ...

    Abstract Macroautophagy/autophagy is a lysosome-dependent catabolic process induced by various cellular stress conditions, maintaining the homeostasis of cells, tissues and organs. Autophagy is a series of membrane-related events involving multiple autophagy-related (ATG) proteins. Most studies to date have focused on various signaling pathways affecting ATG proteins to control autophagy. However, mounting evidence reveals that the actin cytoskeleton acts on autophagy-associated membranes to regulate different events of autophagy. The actin cytoskeleton assists in vesicle formation and provides the mechanical forces for cellular activities that involve membrane deformation. Although the interaction between the actin cytoskeleton and membrane makes the role of actin in autophagy recognized, how the actin cytoskeleton is recruited and assembles on membranes during autophagy needs to be detailed. Nucleation-promoting factors (NPFs) activate the Arp2/3 complex to produce actin cytoskeleton. In this review, we summarize the important roles of the actin cytoskeleton in autophagy regulation and focus on the effect of NPFs on actin cytoskeleton assembly during autophagy, providing new insights into the occurrence and regulatory mechanisms of autophagy. Video Abstract.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actins/metabolism ; Cytoskeleton/metabolism ; Autophagy/physiology ; Actin-Related Protein 2-3 Complex/metabolism
    Chemical Substances Actins ; Actin-Related Protein 2-3 Complex
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01444-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SuSiE PCA

    Dong Yuan / Nicholas Mancuso

    iScience, Vol 26, Iss 11, Pp 108181- (2023)

    A scalable Bayesian variable selection technique for principal component analysis

    2023  

    Abstract: Summary: Latent factor models, like principal component analysis (PCA), provide a statistical framework to infer low-rank representation in various biological contexts. However, feature selection is challenging when this low-rank structure manifests from ...

    Abstract Summary: Latent factor models, like principal component analysis (PCA), provide a statistical framework to infer low-rank representation in various biological contexts. However, feature selection is challenging when this low-rank structure manifests from a sparse subspace. We introduce SuSiE PCA, a scalable sparse latent factor approach that evaluates uncertainty in contributing variables through posterior inclusion probabilities. We validate our model in extensive simulations and demonstrate that SuSiE PCA outperforms other approaches in signal detection and model robustness. We apply SuSiE PCA to multi-tissue expression quantitative trait loci (eQTLs) data from GTEx v8 and identify tissue-specific factors and their contributing eGenes. We further investigate its performance on the large-scale perturbation data and find that SuSiE PCA identifies modules with a higher enrichment of ribosome-related genes than sparse PCA (false discovery rate [FDR] =9.2×10−82 vs. 1.4×10−33), while being ∼ 18x faster. Overall, SuSiE PCA provides an efficient tool to identify relevant features in high-dimensional biological data.
    Keywords Biocomputational method ; Classification of bioinformatical subject ; data processing in systems biology ; Algorithms ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Synthesis of a CFD Benchmark Exercise: Examining Fluid Flow and Residence-Time Distribution in a Water Model of Tundish.

    Sheng, Dong-Yuan

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 18

    Abstract: Computational Fluid Dynamics (CFD) has become an indispensable tool that can potentially predict many phenomena of practical interest in the tundish. Model verification and validation (V&V) are essential parts of a CFD model development process if the ... ...

    Abstract Computational Fluid Dynamics (CFD) has become an indispensable tool that can potentially predict many phenomena of practical interest in the tundish. Model verification and validation (V&V) are essential parts of a CFD model development process if the models are to be used with sufficient confidence in real industrial tundish applications. The crucial aspects of CFD simulations in the tundish are addressed in this study, such as the selection of the turbulence models, meshing, boundary conditions, and selection of discretization schemes. A series of CFD benchmarking exercises are presented serving as selected examples of appropriate modelling strategies. A tundish database, initiated by German Steel Institute VDEH working group "Fluid Mechanics and Fluid Simulation", was revisited with the aim of establishing a comprehensive set of best practice guidelines (BPG) in CFD simulations for tundish applications. These CFD benchmark exercises yield important results for the sensible application of CFD models and contribute to further improving the reliability of CFD applications in metallurgical reactors.
    Language English
    Publishing date 2021-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14185453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microglial Calcium Homeostasis Modulator 2: Novel Anti-neuroinflammation Target for the Treatment of Neurodegenerative Diseases.

    Dong, Yuan / Tang, Li

    Neuroscience bulletin

    2023  Volume 40, Issue 4, Page(s) 553–556

    MeSH term(s) Calcium ; Homeostasis ; Inflammation/drug therapy ; Microglia ; Neurodegenerative Diseases/drug therapy ; Neuroinflammatory Diseases
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-11-23
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-023-01153-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6734: Show issues Location:
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  7. Article ; Online: Interleukins in Epilepsy: Friend or Foe.

    Dong, Yuan / Zhang, Xia / Wang, Ying

    Neuroscience bulletin

    2024  

    Abstract: Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures, affecting ~ 65 million worldwide. Evidence in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ... ...

    Abstract Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures, affecting ~ 65 million worldwide. Evidence in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of epilepsy. Interleukins (ILs), as one of the major contributors to neuroinflammation, are intensively studied for their association and modulatory effects on ictogenesis and epileptogenesis. ILs are commonly divided into pro- and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in epilepsy. However, both protective and destructive effects have been reported for many ILs. This may be due to the complex nature of ILs, and also possibly due to the different disease courses that those ILs are involved in. In this review, we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances, as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.
    Language English
    Publishing date 2024-01-24
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-023-01170-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Growth Differentiation Factor-15 Orchestrates Inflammation-Related Diseases via Macrophage Polarization.

    Huang, Jingjing / Ding, Xinhuan / Dong, Yuan / Zhu, Haiyan

    Discovery medicine

    2024  Volume 36, Issue 181, Page(s) 248–255

    Abstract: Macrophage polarization is a critical determinant of disease progression and regression. Studies on macrophage plasticity and polarization can provide a theoretical basis for the tactics of diagnosis and treatment for macrophage-related diseases. These ... ...

    Abstract Macrophage polarization is a critical determinant of disease progression and regression. Studies on macrophage plasticity and polarization can provide a theoretical basis for the tactics of diagnosis and treatment for macrophage-related diseases. These include inflammation-related diseases, such as sepsis, tumors, and metabolic disorders. Growth differentiation factor-15 (GDF-15) or macrophage inhibitory cytokine-1, a 25 kDa secreted homodimeric protein, is a member of the transforming growth factor-β (TGF-β) superfamily that is released in response to external stressors. GDF-15 regulates biological effects such as tumor occurrence, inflammatory response, tissue damage, angiogenesis, and bone metabolism. It has been shown to exert anti-inflammatory and pro-inflammatory effects in inflammation-related diseases. Moreover, inflammatory stimuli can induce GDF-15 expression in immune and parenchymal cells. GDF-15 exhibits a feedback inhibitory effect by inhibiting tumor necrosis factor-α secretion during the macrophage activation anaphase, suggesting that there may be a close association between the two. GDF-15 directly induces CD14
    MeSH term(s) Humans ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/pharmacology ; Macrophage Activation ; Macrophages ; Transforming Growth Factor beta/metabolism ; Inflammation/metabolism ; Sepsis
    Chemical Substances Growth Differentiation Factor 15 ; Transforming Growth Factor beta
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2415544-5
    ISSN 1944-7930 ; 1944-7930
    ISSN (online) 1944-7930
    ISSN 1944-7930
    DOI 10.24976/Discov.Med.202436181.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Research progress on the cannabinoid type-2 receptor and Parkinson's disease.

    Yu, Xiaoqi / Jia, Yi / Dong, Yuan

    Frontiers in aging neuroscience

    2024  Volume 15, Page(s) 1298166

    Abstract: Parkinson's disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders. Previous ... ...

    Abstract Parkinson's disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders. Previous studies identify the associations between PD progression and factors such as α-synuclein aggregation, mitochondrial dysfunction, inflammation, and cell death. The cannabinoid type-2 receptor (CB
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1298166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Theoretical and experimental verification of wide-spectrum thermometry based on Taylor series de-integration method.

    Yu, Qiansong / Gu, Shengyu / Dong, Yuan

    Optics express

    2024  Volume 32, Issue 4, Page(s) 4954–4973

    Abstract: In response to the challenges encountered in solving the integral equations and the disadvantages of requiring additional calibration parameters in the existing three-channel wide-spectrum temperature measurement, a wavelength-based Taylor series de- ... ...

    Abstract In response to the challenges encountered in solving the integral equations and the disadvantages of requiring additional calibration parameters in the existing three-channel wide-spectrum temperature measurement, a wavelength-based Taylor series de-integration method is proposed. By combining the coefficient of determination, which characterizes the approximation effect, the selection criterion of characteristic wavelength (optimal expansion wavelength, OEW) is constructed. In the influence analysis of spectral emissivity on the de-integration method, the insensitivity of OEW to spectral emissivity is revealed. The feasibility of using blackbody OEW for de-integration processing is proved when the spectral emissivity is unknown, which provides necessary theoretical support for the selection of characteristic wavelengths in practical application. Based on this integration method, algebraic temperature measurement equations in the forms of graybody, three-channel fusion, and two-color are derived, and the theoretical errors of each form are discussed from both horizontal and longitudinal perspectives. Furthermore, thermometry experiments with multiple acquisition parameters and diverse samples were conducted corresponding to three solution forms, the universality of acquisition parameters and sample applicability are proven.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.512126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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