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Article ; Online: A comprehensive review of phytochemistry, pharmacology and clinical applications of Uncariae Ramulus Cum Uncis

Zi-long Zhang / Yu-ze Li / Guo-qing Wu / Yi-Ming Li / Dong-dong Zhang / Rui Wang

Arabian Journal of Chemistry, Vol 16, Iss 5, Pp 104638- (2023)

2023

Abstract: Objectives: Uncariae Ramulus Cum Uncis (URCU) belonging to the genus Uncaria is widely distributed in China and used in folk medicine, which has the effect of clearing heat and calming the liver, extinguishing wind and settling convulsion. So, it is used ...

Abstract	Objectives: Uncariae Ramulus Cum Uncis (URCU) belonging to the genus Uncaria is widely distributed in China and used in folk medicine, which has the effect of clearing heat and calming the liver, extinguishing wind and settling convulsion. So, it is used to treat hypertension and neurological diseases. Herein, we reported a review on botany, phytochemistry, pharmacology and clinical applications reported from 1973 up to 2022. All the information and studies concerning URCU were summarized from the library and digital databases (e.g. Sciencedirect, SciFinder, Medline PubMed, Google Scholar, and CNKI). Key findings: A total of 190 articles about URCU have been collected. The phytochemical investigations of URCU revealed the presence of more than 371 chemical components, including alkaloids, terpenoids, flavonoids, phenylpropanoids, phytosterols and phenolics. Moreover, the compounds isolated from URCU possessed a wide spectrum of pharmacology such as anti-hypertension, antiinflammation, anticancer, antioxidant, antiviral, anti-epilepsy, anti-depressant, ischemic brain injury, neuroprotection, anti-Alzheimer's disease, anti-Parkinson's disease and antiasthma. Summary: In this paper, the botany, phytochemistry, pharmacology and clinical applications of URCU were reviewed. As a source of traditional folk medicine, URCU has high medicinal value and are widely used in medicine. Therefore, we hope our review can help URCU get better development and utilization.
Keywords	Uncariae Ramulus Cum Uncis ; Phytochemistry ; Pharmacology ; Clinical Applications ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microsimulation Study on Energy Release and Rock Block Ejection Force of Granite under Different Unloading Conditions

Xin-Yuan Wang / Yan-Chun Yin / Ming-Lu Xing / Dong-Dong Zhang / Yang Chen / En-Chao Wang

Frontiers in Earth Science, Vol

2022 Volume 10

Abstract: Rock burst is one typical dynamic disaster caused by excavation in deep underground engineering. High-stress unloading test is a common research method for rock bursts. Due to the limitation of laboratory test conditions, it is difficult to monitor the ... ...

Abstract	Rock burst is one typical dynamic disaster caused by excavation in deep underground engineering. High-stress unloading test is a common research method for rock bursts. Due to the limitation of laboratory test conditions, it is difficult to monitor the energy release and dissipation information during rock bursts in the unloading test. But the study of energy evolution law is more helpful to reveal the essential characteristics of rock burst. Therefore, the energy evolution process and ejection failure characteristics of granite after unloading were analyzed through the unloading simulation test in this paper, and the influence of unloading velocity, lateral stress, and axial stress were researched. The microstructure numerical model of the granite was established by using digital image processing technology and PFC2D software, aiming to match the real granite. The energy evolution process of unloading granite can be divided into three stages, namely the whole energy rapid release stage, sidewall energy slow-release stage, and rock block ejection stage. The area near the unloading sidewall is the main energy release and rock block ejection area. In the whole energy rapid release stage, the energy release velocity and dissipation velocity show similar law, i.e., a positive power function correlation with unloading velocity, a negative power function correlation with lateral stress, and a positive linear function correlation with axial stress. In the rock block ejection stage, with increasing the unloading velocity and axial stress, the rock block ejection force increases as a power function, while it decreases with increasing lateral stress. This research is an important supplement to the laboratory unloading test. It has theoretical guiding significance for rock burst hazard assessment during excavation in deep underground engineering.
Keywords	rock burst ; microsimulation ; energy evolution ; energy release law ; rock block ejection characteristics ; Science ; Q
Subject code	690
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: m6A RNA Methylation Regulators Contribute to Predict and as a Therapy Target of Pulmonary Fibrosis

Meng-Sheng Deng / Kui-Jun Chen / Dong-Dong zhang / Guan-Hua Li / Chang-Mei Weng / Jian-Min Wang

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Background. Pulmonary fibrosis is difficult to treat. Early diagnosis and finding potential drug therapy targets of pulmonary fibrosis are particularly important. There were still various problems with existing pulmonary fibrosis markers, so it is ... ...

Abstract	Background. Pulmonary fibrosis is difficult to treat. Early diagnosis and finding potential drug therapy targets of pulmonary fibrosis are particularly important. There were still various problems with existing pulmonary fibrosis markers, so it is particularly important to find new biomarkers and drug treatment targets. m6A (N6,2′-O-dimethyladenosine) RNA methylation was the cause of many diseases, and it is regulated by m6A methylation regulators. So, whether RNA methylation regulators can be a diagnostic marker and potential drug therapy target of early pulmonary fibrosis needs to be explored. Materials and Methods. Using GSE110147 and GSE33566 in the GEO database to predict the m6A methylation regulators that may be related to the development of pulmonary fibrosis, we used 10 mg/ml bleomycin to induce mouse pulmonary fibrosis models and human pulmonary fibrosis samples, to confirm whether this indicator can be an early diagnostic marker of pulmonary fibrosis. Results. According to the database prediction results, METTL3 can predict the occurrence and development of pulmonary fibrosis, and the results of MASSON and HE staining show that the fibrosis model of mice is successful, and the fibrosis of human samples is obvious. The results of immunohistochemistry showed that the expression of METTL3 was significantly reduced in pulmonary fibrosis. Conclusions. The m6A methylation regulator METTL3 can be considered as an important biomarker for diagnosing pulmonary fibrosis occurrence, furthermore it could be considered as a drug target because of its low expression in pulmonary fibrosis.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enhanced Mechanical Properties of Multiscale Carbon Fiber/Epoxy Unidirectional Composites with Different Dimensional Carbon Nanofillers

Yu Liu / Dong-Dong Zhang / Guang-Yuan Cui / Rui-Ying Luo / Dong-Lin Zhao

Nanomaterials, Vol 10, Iss 1670, p

2020 Volume 1670

Abstract: Ammonia modified graphene-carbon nanotubes/continuous carbon fiber reinforced epoxy unidirectional multiscale composites (AMGNS-MWCNT/CFEP) were prepared by adding ammonia modified graphene and carbon nanotubes to an epoxy matrix to reduce agglomeration ... ...

Abstract	Ammonia modified graphene-carbon nanotubes/continuous carbon fiber reinforced epoxy unidirectional multiscale composites (AMGNS-MWCNT/CFEP) were prepared by adding ammonia modified graphene and carbon nanotubes to an epoxy matrix to reduce agglomeration of carbon nanofillers in the epoxy matrix and improve composites properties. Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and universal testing machines were used to characterize the properties of carbon nanofillers, AMGNS-MWCNT/epoxy nanocomposites, and AMGNS-MWCNT/CFEP unidirectional composites. When the AMGNS-MWCNT content was 1.0 wt%, flexural strength, the flexural modulus and interlaminar shear strength of AMGNS-MWCNT/CFEP unidirectional composites reached the maximum value of 1520.3 MPa, 138.88 GPa, and 87.80 MPa, respectively, which were 12.5%, 9.42%, and 10.1% higher than that of carbon fiber reinforced epoxy unidirectional composites (CFEP). The synergistic mechanism of two carbon nanofillers in the matrix is discussed.
Keywords	graphene ; carbon nanotubes ; epoxy ; mechanical property ; composites ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alkaloids and flavonoids exert protective effects against UVB-induced damage in a 3D skin model using human keratinocytes

Yi-Fang Chen / Dong-Dong Zhang / Dong-Bao Hu / Xiao-Nian Li / Ji-Feng Luo / Xiao-Yan Duan / Yan-Ni Zhang / Yue-Hu Wang

Results in Chemistry, Vol 4, Iss , Pp 100298- (2022)

2022

Abstract: This study isolated six carboline alkaloids, (3S,4R)-1-(β-carbolin-1-yl)-3,4,5-trihydroxy-1-pentanone (1), β-carboline (2), 1-hydroxymethyl-β-carboline (3), perlolyrine (4), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (5) and (1R,3S) ...

Abstract	This study isolated six carboline alkaloids, (3S,4R)-1-(β-carbolin-1-yl)-3,4,5-trihydroxy-1-pentanone (1), β-carboline (2), 1-hydroxymethyl-β-carboline (3), perlolyrine (4), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (5) and (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (6) from the leaves of Dendrobium officinale Kimura et Migo (Orchidaceae). These alkaloids, along with 14 flavonoids, vicenin-2 (7), vicenin-1 (8), isoschaftoside (9), schaftoside (10), neoschaftoside (11), violanthin (12), isoviolanthin (13), vicenin-3 (14), apigenin 6-C-α-l-arabinopyranosyl-8-C-β-d-xylopyranoside (15), vitexin 2″-O-glucoside (16), vitexin 2″-O-rhamnoside (17), rutin (18) and quercetin (19), which were previously found in D. officinale leaves by other researchers, and apigenin (20), which is the aglycone of flavone C-glycosides 7–17, were bioassayed to determine their protective effects on UVB-induced damage in human keratinocytes. Carboline alkaloids 1 and 3 and flavonoids 8 and 20 significantly increased cell viability in human keratinocytes irradiated by UVB. In a 3D skin model, compounds 1 and 8 showed promising protective effects, maintained reasonable skin structures and increased the expression of filaggrin and claudin-1, which was inhibited by UVB irradiation. The anti-UVB activities of compounds 1, 3 and 8 were reported for the first time, and these three compounds exhibit potential for application in sunscreen cosmetics.
Keywords	Dendrobium officinale ; Carboline alkaloids ; Flavonoid C-glycosides ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Erythrocyte membrane bioinspired near-infrared persistent luminescence nanocarriers for in vivo long-circulating bioimaging and drug delivery

Liu, Jing-Min / Dong-Dong Zhang / Guo-Zhen Fang / Shuo Wang

Biomaterials. 2018 May, v. 165

2018

Abstract: Combination of biological entities with functional nanostructure would produce the excellent systemic drug-delivery vehicles that possess the ability to cross the biological barriers. Herein, from a biomimetic point of view, erythrocyte membrane ... ...

Abstract	Combination of biological entities with functional nanostructure would produce the excellent systemic drug-delivery vehicles that possess the ability to cross the biological barriers. Herein, from a biomimetic point of view, erythrocyte membrane bioinspired optical nanocarrier is fabricated by integrating Red blood cell (RBC) membrane vesicle with near-infrared persistent luminescence nanophosphors (PLNPs). The triple-doped zinc gallogermanate nanostructures with super-long near-infrared persistent luminescence (ZGGO) are used as optical emission center, mesoporous silica coated on the PLNPs (ZGGO@mSiO2) is employed for drug delivery, and the RBC membrane vesicle is introduced for biomimetic functionalization to ensure the developed nanocarriers bypass macrophage uptake and systemic clearance. Owing to the coating of natural erythrocyte membrane along with membrane lipids and associated membrane proteins, the proposed bioinspired nanocarriers have exhibited cell-mimicking property. Retaining the applicability of PLNPs core that favored in vitro excitation, the developed RBC-ZGGO@mSiO2 biomimetic nanocarriers have demonstrated intense fluorescence, super-long persistent luminescence, monodispersed nanosize, red light renewability, and excellent biocompatibility. In vivo mice bioimaging and biodistribution study demonstrate the erythrocyte membrane bioinspired nanoprobe loaded with doxorubicin as ideal nanocarriers for long-circulating bioimaging, in situ real-time monitoring and drug delivery. We believe the PLNPs-based biomimetic nanocarriers offer a promising nano-platform for diagnostics and therapeutics application.
Keywords	biocompatibility ; biomimetics ; coatings ; diagnostic techniques ; doxorubicin ; erythrocytes ; fluorescence ; lipids ; macrophages ; membrane proteins ; mice ; monitoring ; nanocarriers ; porous media ; red light ; silica ; zinc
Language	English
Dates of publication	2018-05
Size	p. 39-47.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2018.02.042
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The incubation period of COVID-19

Cheng Cheng / DongDong Zhang / Dejian Dang / Juan Geng / Peiyu Zhu / Mingzhu Yuan / Ruonan Liang / Haiyan Yang / Yuefei Jin / Jing Xie / Shuaiyin Chen / Guangcai Duan

Infectious Diseases of Poverty, Vol 10, Iss 1, Pp 1-

a global meta-analysis of 53 studies and a Chinese observation study of 11 545 patients

2021 Volume 13

Abstract: Abstract Background The incubation period is a crucial index of epidemiology in understanding the spread of the emerging Coronavirus disease 2019 (COVID-19). In this study, we aimed to describe the incubation period of COVID-19 globally and in the ... ...

Abstract	Abstract Background The incubation period is a crucial index of epidemiology in understanding the spread of the emerging Coronavirus disease 2019 (COVID-19). In this study, we aimed to describe the incubation period of COVID-19 globally and in the mainland of China. Methods The searched studies were published from December 1, 2019 to May 26, 2021 in CNKI, Wanfang, PubMed, and Embase databases. A random-effect model was used to pool the mean incubation period. Meta-regression was used to explore the sources of heterogeneity. Meanwhile, we collected 11 545 patients in the mainland of China outside Hubei from January 19, 2020 to September 21, 2020. The incubation period fitted with the Log-normal model by the coarseDataTools package. Results A total of 3235 articles were searched, 53 of which were included in the meta-analysis. The pooled mean incubation period of COVID-19 was 6.0 days (95% confidence interval [CI] 5.6–6.5) globally, 6.5 days (95% CI 6.1–6.9) in the mainland of China, and 4.6 days (95% CI 4.1–5.1) outside the mainland of China (P = 0.006). The incubation period varied with age (P = 0.005). Meanwhile, in 11 545 patients, the mean incubation period was 7.1 days (95% CI 7.0–7.2), which was similar to the finding in our meta-analysis. Conclusions For COVID-19, the mean incubation period was 6.0 days globally but near 7.0 days in the mainland of China, which will help identify the time of infection and make disease control decisions. Furthermore, attention should also be paid to the region- or age-specific incubation period. Graphic Abstract
Keywords	COVID-19 ; Incubation period ; Meta-analysis ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	950
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of the infectious triggers with childhood Henoch–Schonlein purpura in Anhui province, China

Jing Jing Wang / Yao Xu / Fei Fei Liu / Yue Wu / Sama Samadli / Yang Fang Wu / Huang Huang Luo / Dong Dong Zhang / Peng Hu

Journal of Infection and Public Health, Vol 13, Iss 1, Pp 110-

2020 Volume 117

Abstract: Background: Although the specific etiology of Henoch–Schonlein purpura (HSP) is still unknown, several kinds of infectious triggers have been proved to participate in its pathogenesis. The objectives of present study were to analyze the association of ... ...

Abstract	Background: Although the specific etiology of Henoch–Schonlein purpura (HSP) is still unknown, several kinds of infectious triggers have been proved to participate in its pathogenesis. The objectives of present study were to analyze the association of the infectious triggers with childhood HSP in Anhui province, China. Methods: 1200 HSP children were recruited from January 2015 to December 2017. Serum antistreptolysin O titer, TORCH, Epstein-Barr virus, helicobacter pylori (HP), Mycoplasma antibodies (MP-Ab), tubercle bacillus antibody (TB-Ab), respiratory pathogens (legionella pneumophila, chlamydia pneumoniae, adenovirus, respiratory syncytial virus, influenza A virus, influenza B virus, rickettsia, parainfluenza virus) were determined. Patients’ histories were obtained by interviews and questionnaires. Results: The annual incidence of HSP was 8.13–9.17 per 100,000. HSP occurred more commonly in spring and winter than in summer with an obvious west-to-east gradient. On admission, several potential infections were identified in 611 cases (50.92%). The infectious agents including streptococcus, HP, MP, parainfluenza, respiratory syncytial virus, TB and toxoplasma gondii were identified in 205 cases (17.08%), 71 cases (5.92%), 58 cases (4.83%), 6 cases (0.5%), 1 case (0.08%), 1 case (0.08%) and 1 case (0.08%) respectively. 123 cases (10.25%) relapsed or recurred more than one time; the mean number was 2.92, and the mean interval was 11.4 weeks. The infection was the most frequent trigger regardless of clinical phenotypes and relapse/recurrence. Symptomatic treatment plus adjunctive anti-infectious agents could significantly improve the remission rate of purpura in the infectious cases (x2 = 24.60, p < 0.01). Conclusions: Streptococcus is the most frequent infectious agent in HSP children regardless of clinical phenotype or relapse/recurrence. The complete elimination of infectious triggers may help relieve cutaneous purpura. Keywords: Children, Henoch–Schonlein, Purpura, Infection, Prednisone, Streptococcus
Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	616 ; 630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Incidence and survey of polycyclic aromatic hydrocarbons in edible vegetable oils in China

Shi, Long-Kai / Dong-Dong Zhang / Yu-Lan Liu

Food control. 2016 Apr., v. 62

2016

Abstract: Polycyclic aromatic hydrocarbons (PAHs) occurrence in eighty-five samples of edible vegetable oils from China was described for the first time. Analytes were determined based on a simplified solvent extraction and liquid chromatography-atmospheric ... ...

Abstract	Polycyclic aromatic hydrocarbons (PAHs) occurrence in eighty-five samples of edible vegetable oils from China was described for the first time. Analytes were determined based on a simplified solvent extraction and liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry method. PAHs were detected in all of the oil samples and the concentrations of BaP, PAH4 and PAH16 were 0.12–6.28, 1.48–27.84 and 9.25–154.27 μg/kg, respectively. Levels of BaP were all conformed to the upper limit 10 μg/kg set by China. However, each had 13% of oil samples (11 samples) exceeded the maximum limit 2 and 10 μg/kg set for BaP and PAH4 by EU. The light PAHs were primary in oil samples, and the contribution of the heavy PAHs was much less significant. A high variability of PAH levels between different oil types was observed, and peanut oils and sesame oils were two types of oils that were highly contaminated. The relationship between BaP and PAH4, BaP and PAH16 and PAH4 and PAH16 suggested that PAH4 was more suitable than BaP acted as a surrogate for the contamination level of PAHs in edible oils.
Keywords	cooking fats and oils ; European Union ; mass spectrometry ; peanuts ; polycyclic aromatic hydrocarbons ; solvents ; surveys ; vegetable oil ; China
Language	English
Dates of publication	2016-04
Size	p. 165-170.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1027805-9
ISSN	0956-7135
ISSN	0956-7135
DOI	10.1016/j.foodcont.2015.10.037
Database	NAL-Catalogue (AGRICOLA)

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Article: Survey of polycyclic aromatic hydrocarbons of vegetable oils and oilseeds by GC-MS in China

Shi, Long-Kai / Dong-Dong Zhang / Yu-Lan Liu

Food additives & contaminants. 2016 Apr. 2, v. 33, no. 4

2016

Abstract: There is a lack of information regarding the occurrence and content of contamination of polycyclic aromatic hydrocarbon (PAH) in edible vegetable oils and oilseeds used for oil production in China. By combining the advantages of ultrasound-assisted ... ...

Abstract	There is a lack of information regarding the occurrence and content of contamination of polycyclic aromatic hydrocarbon (PAH) in edible vegetable oils and oilseeds used for oil production in China. By combining the advantages of ultrasound-assisted extraction, low temperature separation and silica SPE purification, a method for the determination of the USEPA, 16 PAHs was developed based on GC-MS to fill this gap. The method recoveries for oils and oilseeds were 84.4â113.8% and 84.3â115.3%, respectively. The LODs and LOQs for 16 PAHs were ranged from 0.06â0.17 and 0.19â0.56Â Î¼gÂ kg âÂ¹, respectively. Based on the established method, PAH concentrations in 21 edible oils and 17 oilseeds were determined. Almost all the PAHs were found in all the samples tested, especially the light PAHs (LPAHs). Three oil samples exceeded the maximum level of 10Â Î¼gÂ kg âÂ¹ for BaP set by China. However, five and six oil samples, respectively, exceeded the maximum limits of 2 and 10Â Î¼gÂ kg âÂ¹ set for BaP and PAH4 by the European Union. The concentrations of PAH16 in oilseed samples were 1.5 times higher than corresponding oil samples. The relationships between PAH4 and PAH8, PAH4 and PAH16 as well as PAH8 and PAH16 indicates that PAH4 is a sufficient surrogate for the contamination level of PAHs in edible oils when compared with PAH8.
Keywords	cooking fats and oils ; European Union ; gas chromatography-mass spectrometry ; oilseeds ; polycyclic aromatic hydrocarbons ; silica ; surveys ; temperature ; ultrasonic treatment ; United States Environmental Protection Agency ; vegetable oil ; China
Language	English
Dates of publication	2016-0402
Size	p. 603-611.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2016.1144935
Database	NAL-Catalogue (AGRICOLA)

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