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  1. Article: Cockroaches and Food-borne Pathogens.

    Donkor, Eric S

    Environmental health insights

    2020  Volume 14, Page(s) 1178630220913365

    Abstract: Food-borne disease is a widespread and escalating public health problem globally. About a quarter of the microorganisms isolated from cockroaches are food-borne pathogens ... ...

    Abstract Food-borne disease is a widespread and escalating public health problem globally. About a quarter of the microorganisms isolated from cockroaches are food-borne pathogens including
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2452946-1
    ISSN 1178-6302
    ISSN 1178-6302
    DOI 10.1177/1178630220913365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nosocomial Pathogens: An In-Depth Analysis of the Vectorial Potential of Cockroaches.

    Donkor, Eric S

    Tropical medicine and infectious disease

    2019  Volume 4, Issue 1

    Abstract: Nosocomial or healthcare-associated infections are regarded as the most frequent adverse event that threatens patients' safety and has serious economic and social consequences. Cockroach infestation is common in many hospitals, especially in the ... ...

    Abstract Nosocomial or healthcare-associated infections are regarded as the most frequent adverse event that threatens patients' safety and has serious economic and social consequences. Cockroach infestation is common in many hospitals, especially in the developing world. Common nosocomial pathogens isolated from cockroaches include
    Language English
    Publishing date 2019-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed4010014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stroke in the 21

    Donkor, Eric S

    Stroke research and treatment

    2018  Volume 2018, Page(s) 3238165

    Abstract: Stroke is ranked as the second leading cause of death worldwide with an annual mortality rate of about 5.5 million. Not only does the burden of stroke lie in the high mortality but the high morbidity also results in up to 50% of survivors being ... ...

    Abstract Stroke is ranked as the second leading cause of death worldwide with an annual mortality rate of about 5.5 million. Not only does the burden of stroke lie in the high mortality but the high morbidity also results in up to 50% of survivors being chronically disabled. Thus stroke is a disease of immense public health importance with serious economic and social consequences. The public health burden of stroke is set to rise over future decades because of demographic transitions of populations, particularly in developing countries. This paper provides an overview of stroke in the 21
    Language English
    Publishing date 2018-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573724-7
    ISSN 2042-0056 ; 2090-8105
    ISSN (online) 2042-0056
    ISSN 2090-8105
    DOI 10.1155/2018/3238165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Sepsis-Related Lung Injury and the Complication of Extrapulmonary Pneumococcal Pneumonia.

    Darkwah, Samuel / Kotey, Fleischer C N / Ahenkorah, John / Adutwum-Ofosu, Kevin Kofi / Donkor, Eric S

    Diseases (Basel, Switzerland)

    2024  Volume 12, Issue 4

    Abstract: Globally, sepsis and pneumonia account for significant mortality and morbidity. A complex interplay of immune-molecular pathways underlies both sepsis and pneumonia, resulting in similar and overlapping disease characteristics. Sepsis could result from ... ...

    Abstract Globally, sepsis and pneumonia account for significant mortality and morbidity. A complex interplay of immune-molecular pathways underlies both sepsis and pneumonia, resulting in similar and overlapping disease characteristics. Sepsis could result from unmanaged pneumonia. Similarly, sepsis patients have pneumonia as a common complication in the intensive care unit. A significant percentage of pneumonia is misdiagnosed as septic shock. Therefore, our knowledge of the clinical relationship between pneumonia and sepsis is imperative to the proper management of these syndromes. Regarding pathogenesis and etiology, pneumococcus is one of the leading pathogens implicated in both pneumonia and sepsis syndromes. Growing evidence suggests that pneumococcal pneumonia can potentially disseminate and consequently induce systemic inflammation and severe sepsis. Streptococcus pneumoniae could potentially exploit the function of dendritic cells (DCs) to facilitate bacterial dissemination. This highlights the importance of pathogen-immune cell crosstalk in the pathophysiology of sepsis and pneumonia. The role of DCs in pneumococcal infections and sepsis is not well understood. Therefore, studying the immunologic crosstalk between pneumococcus and host immune mediators is crucial to elucidating the pathophysiology of pneumonia-induced lung injury and sepsis. This knowledge would help mitigate clinical diagnosis and management challenges.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12040072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Methicillin-Resistant

    Donkor, Eric S / Kotey, Fleischer Cn

    Infectious diseases

    2020  Volume 13, Page(s) 1178633720976581

    Abstract: The oral cavity harbors a multitude of commensal flora, which may constitute a repository of antibiotic resistance determinants. In the oral cavity, bacteria form biofilms, and this facilitates the acquisition of antibiotic resistance genes through ... ...

    Abstract The oral cavity harbors a multitude of commensal flora, which may constitute a repository of antibiotic resistance determinants. In the oral cavity, bacteria form biofilms, and this facilitates the acquisition of antibiotic resistance genes through horizontal gene transfer. Recent reports indicate high methicillin-resistant
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2551443-X
    ISSN 1178-6337
    ISSN 1178-6337
    DOI 10.1177/1178633720976581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Microbial Contamination of Herbal Preparations on the Ghanaian Market, Accra.

    Darkwah, Samuel / Agbettor, Doris / Codjoe, Francis / Donkor, Eric S

    Microbiology insights

    2022  Volume 15, Page(s) 11786361221139602

    Abstract: In developing countries, an estimated 80% of the population use traditional herbal medicines as part of their primary health care. As the market for herbal medicine expands in many African countries, partly due to their use in the treatment of COVID-19, ... ...

    Abstract In developing countries, an estimated 80% of the population use traditional herbal medicines as part of their primary health care. As the market for herbal medicine expands in many African countries, partly due to their use in the treatment of COVID-19, there is the need to address all the associated safety issues. The aim of the study was to evaluate the microbial contamination of locally prepared, as well as imported foreign herbal products sold in Accra. Standard microbiological methods were employed in the enumeration of coliforms and the identification of pathogenic microbes in 60 herbal preparations that were sampled. A larger proportion (76.7%) of local herbal preparations was contaminated with bacteria as compared with imported ones (63.3%).
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455264-1
    ISSN 1178-6361
    ISSN 1178-6361
    DOI 10.1177/11786361221139602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Making a Case for Infection Control at Public Places of Convenience in Accra, Ghana.

    Donkor, Eric S / S Anyen, Nana Esi / Akumwena, Amos

    Environmental health insights

    2020  Volume 14, Page(s) 1178630220938414

    Abstract: In Ghana, environmental hygiene remains a major problem and infection control measures are hardly practised, particularly outside of the hospital. To provide evidence for infection control measures at public places of convenience in Accra (capital city ... ...

    Abstract In Ghana, environmental hygiene remains a major problem and infection control measures are hardly practised, particularly outside of the hospital. To provide evidence for infection control measures at public places of convenience in Accra (capital city of Ghana), this study was performed. The aim of the study was to evaluate microbial contamination of door handles at public places of convenience in Accra and assess the public health risk. A total of 183 swab specimens were collected aseptically from door handles of public places of convenience of shops, schools, hospitals, lorry stations, churches, and markets. The samples were cultured on bacteriological media, and the isolated organisms were identified. The most prevalent bacterial agent isolated was
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452946-1
    ISSN 1178-6302
    ISSN 1178-6302
    DOI 10.1177/1178630220938414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Molecular typing of the pneumococcus and its application in epidemiology in sub-Saharan Africa.

    Donkor, Eric S

    Frontiers in cellular and infection microbiology

    2013  Volume 3, Page(s) 12

    Abstract: Molecular typing of the pneumococcus has played a crucial role in understanding the epidemiology of the organism. However, most of what is known about molecular epidemiology of the pneumococcus pertains to the developed world. The brunt of pneumococcal ... ...

    Abstract Molecular typing of the pneumococcus has played a crucial role in understanding the epidemiology of the organism. However, most of what is known about molecular epidemiology of the pneumococcus pertains to the developed world. The brunt of pneumococcal infections is borne by sub-Saharan African countries, which makes epidemiological monitoring of the pneumococcus essential in this region of the world. This review paper focuses on molecular typing of the pneumococcus and what is known about epidemiology of the organism in sub-Saharan Africa based on the various typing methods. Several molecular typing methods are available for typing the pneumococcus and the major ones include multilocus sequence typing (MLST), multilocus enzyme electrophoresis (MLEE), serotyping and DNA fingerprinting methods such as pulsed field gel electrophoresis (PFGE) and amplified fragment length polymorphism (AFLP). Currently, MLST is the most suitable method for typing the pneumococcus. The pneumococcal population structure in sub-Saharan Africa appears to be quite different from that of the developed world, and pneumococcal serotype 1 related to the ST 618 clone and clones of the ST 217 clonal complex are responsible for outbreaks in sub-Saharan Africa.
    MeSH term(s) Africa South of the Sahara/epidemiology ; Humans ; Molecular Epidemiology/methods ; Molecular Typing/methods ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/isolation & purification
    Language English
    Publishing date 2013-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2013.00012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Understanding the pneumococcus: transmission and evolution.

    Donkor, Eric S

    Frontiers in cellular and infection microbiology

    2013  Volume 3, Page(s) 7

    Abstract: Streptococcus pneumoniae is part of the normal bacterial flora of the narsopharynx, but is also associated with several invasive and non-invasive diseases. Recently, there has been a plethora of research information on the pneumococcus, however, there ... ...

    Abstract Streptococcus pneumoniae is part of the normal bacterial flora of the narsopharynx, but is also associated with several invasive and non-invasive diseases. Recently, there has been a plethora of research information on the pneumococcus, however, there are few comprehensive review papers discussing the research information. This paper provides a review of the pneumococcus in two vital areas related to its biology including transmission and evolution. Transmission of the pneumococcus is a highly efficient process that usually occurs through respiratory droplets from asymptomatic carriers. Following acquisition, the pneumococcus may only establish in the nasopharynx of the new host, or further progress to sites such as the lungs and cause disease. Pneumococcus transmission risk factors, as well as factors involved in its translocation from the nasophyarnx to diseases sites are still not fully understood. Pneumococcal evolution is dominated by recombination. The recombinational events usually involve genetic exchange with streptococci of the mitis group and some pneumococci are thought to exhibit hyper-recombination.
    MeSH term(s) Biological Evolution ; Carrier State/microbiology ; Carrier State/transmission ; Humans ; Nasopharynx/microbiology ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/transmission ; Recombination, Genetic ; Risk Factors ; Streptococcus pneumoniae/genetics
    Language English
    Publishing date 2013-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2013.00007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sequencing of bacterial genomes: principles and insights into pathogenesis and development of antibiotics.

    Donkor, Eric S

    Genes

    2013  Volume 4, Issue 4, Page(s) 556–572

    Abstract: The impact of bacterial diseases on public health has become enormous, and is partly due to the increasing trend of antibiotic resistance displayed by bacterial pathogens. Sequencing of bacterial genomes has significantly improved our understanding about ...

    Abstract The impact of bacterial diseases on public health has become enormous, and is partly due to the increasing trend of antibiotic resistance displayed by bacterial pathogens. Sequencing of bacterial genomes has significantly improved our understanding about the biology of many bacterial pathogens as well as identification of novel antibiotic targets. Since the advent of genome sequencing two decades ago, about 1,800 bacterial genomes have been fully sequenced and these include important aetiological agents such as Streptococcus pneumoniae, Mycobacterium tuberculosis, Escherichia coli O157:H7, Vibrio cholerae, Clostridium difficile and Staphylococcus aureus. Very recently, there has been an explosion of bacterial genome data and is due to the development of next generation sequencing technologies, which are evolving so rapidly. Indeed, the field of microbial genomics is advancing at a very fast rate and it is difficult for researchers to be abreast with the new developments. This highlights the need for regular updates in microbial genomics through comprehensive reviews. This review paper seeks to provide an update on bacterial genome sequencing generally, and to analyze insights gained from sequencing in two areas, including bacterial pathogenesis and the development of antibiotics.
    Language English
    Publishing date 2013-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes4040556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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