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  1. Article: Introduction to the Special Issue on

    Granata, Guido / Donno, Davide Roberto

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: The Gram-positive, anaerobic ... ...

    Abstract The Gram-positive, anaerobic bacterium
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10101233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive scores for the diagnosis of Pulmonary Embolism in COVID-19: A systematic review.

    Rindi, Lorenzo Vittorio / Al Moghazi, Samir / Donno, Davide Roberto / Cataldo, Maria Adriana / Petrosillo, Nicola

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 115, Page(s) 93–100

    Abstract: Objectives: During the COVID-19 pandemic, several studies described an increased chance of developing pulmonary embolism (PE). Several scores have been used to predict the occurrence of PE. This systematic review summarizes the literature on predicting ... ...

    Abstract Objectives: During the COVID-19 pandemic, several studies described an increased chance of developing pulmonary embolism (PE). Several scores have been used to predict the occurrence of PE. This systematic review summarizes the literature on predicting rules for PE in hospitalized COVID-19 patients (HCPs).
    Methods: PUBMED and EMBASE databases were searched to identify articles (1 January 2020-28 April 2021) presenting data pertaining to the use of a prediction rule to assess the risk for PE in adult HCPs. The investigated outcome was the diagnosis of PE. Studies presenting data using a single laboratory assay for PE prediction were excluded. Included studies were appraised for methodological quality using the Newcastle - Ottawa Quality Assessment Scale for Cohort Studies (NOS).
    Results: We obtained a refined pool of twelve studies for five scoring systems (Wells score, Geneva score, CHADS2/CHA2DS2VASc/M-CHA2DS2VASc, CHOD score, Padua Prediction Score), and 4,526 patients. Only one score was designed explicitly for HCPs. Three and nine included studies were prospective and retrospective cohort studies, respectively. Among the examined scores, the CHOD score seems promising for predictive ability.
    Conclusion: New prediction rules, specifically developed and validated for estimating the risk of PE in HCP, differentiating ICU from non-ICU patients, and taking into account anticoagulation prophylaxis, comorbidities, and the time from COVID-19 diagnosis are needed.
    MeSH term(s) Adult ; COVID-19 ; COVID-19 Testing ; Humans ; Pandemics ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-11-27
    Publishing country Canada
    Document type Journal Article ; Systematic Review
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.11.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: How to Treat COVID-19 Patients at Home in the Italian Context: An Expert Opinion.

    Donno, Davide Roberto / Grattagliano, Ignazio / Rossi, Alessandro / Lora Aprile, Pierangelo / Medea, Gerardo / Lagolio, Erik / Granata, Guido / Petrosillo, Nicola / Cricelli, Claudio

    Infectious disease reports

    2021  Volume 13, Issue 1, Page(s) 251–258

    Abstract: The impact of the coronavirus disease (COVID-19), caused by the novel coronavirus SARS-CoV-2, continues to be widespread, with more than 100 million cases diagnosed in more than 220 countries since the virus was first identified in January 2020. Although ...

    Abstract The impact of the coronavirus disease (COVID-19), caused by the novel coronavirus SARS-CoV-2, continues to be widespread, with more than 100 million cases diagnosed in more than 220 countries since the virus was first identified in January 2020. Although patients with mild to moderate forms of COVID-19 could be efficiently managed at home, thus reducing the pressure on the healthcare system and minimizing socio-psychological impact on patients, no trial has been proposed, conducted, or even published on COVID-19 home therapy to date. These expert opinions provide indications on the therapeutical at home management of COVID-19 patients, based on the evidence from the literature and on current guidelines.
    Language English
    Publishing date 2021-03-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13010028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vaccine-Induced Subacute Thyroiditis (De Quervain's) after mRNA Vaccine against SARS-CoV-2: A Case Report and Systematic Review.

    Pipitone, Giuseppe / Rindi, Lorenzo Vittorio / Petrosillo, Nicola / Foti, Nunzio Adalberto Maria / Caci, Grazia / Iaria, Chiara / Donno, Davide Roberto / Boumis, Evangelo / Paviglianiti, Giuseppe / Taglietti, Fabrizio

    Infectious disease reports

    2022  Volume 14, Issue 1, Page(s) 142–154

    Abstract: De Quervain's thyroiditis, sometimes referred to as subacute thyroiditis (SAT), is the most common granulomatous disease of the thyroid, typically found after a viral infection in middle-aged women. The mRNA encoding for the angiotensin-converting enzyme- ...

    Abstract De Quervain's thyroiditis, sometimes referred to as subacute thyroiditis (SAT), is the most common granulomatous disease of the thyroid, typically found after a viral infection in middle-aged women. The mRNA encoding for the angiotensin-converting enzyme-2 (ACE-2) receptor is expressed in follicular thyroid cells, making them a potential target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides infection, SARS-CoV-2 vaccines have also been implicated in SAT pathogenesis. We present a case of a woman developing SAT following vaccination with Comirnaty by Pfizer Inc. (New-York, USA). We performed a systematic review of similar cases available in the literature to provide a better understanding of the topic. We searched the databases PubMed and Embase and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Patient records were then sorted according to the type of administered vaccine and a statistical analysis of the extracted data was performed. No statistically significant difference between mRNA vaccines and other vaccines in inducing SAT was found, nor was any found in terms of patient demographics, symptoms at presentation, initial, or follow-up blood tests. In our case report, we described the possible association between SARS-CoV-2 mRNA-based vaccine Comirnaty and SAT.
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr14010018
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  5. Article ; Online: Spontaneous ilio-psoas haematomas (IPHs): a warning for COVID-19 inpatients.

    Vergori, Alessandra / Pianura, Elisa / Lorenzini, Patrizia / D'Abramo, Alessandra / Di Stefano, Federica / Grisetti, Susanna / Vita, Serena / Pinnetti, Carmela / Donno, Davide Roberto / Marini, Maria Cristina / Nicastri, Emanuele / Ianniello, Stefania / Antinori, Andrea

    Annals of medicine

    2021  Volume 53, Issue 1, Page(s) 295–301

    Abstract: Introduction: Critically ill patients with COVID-19 are at increased risk of developing a hypercoagulable state due to haemostatic changes directly related to the SARS-CoV-2 infection or to the consequence of the cytokine storm. Anticoagulation is now ... ...

    Abstract Introduction: Critically ill patients with COVID-19 are at increased risk of developing a hypercoagulable state due to haemostatic changes directly related to the SARS-CoV-2 infection or to the consequence of the cytokine storm. Anticoagulation is now recommended to reduce the thrombotic risk. Ilio-psoas haematoma (IPH) is a potentially lethal condition that can arise during the hospitalization, especially in intensive care units (ICUs) and frequently reported as a complication of anticoagulation treatment.
    Materials and methods: We report a case series of seven subjects with SARS-CoV-2 pneumonia complicated by Ilio-psoas haematomas (IPHs) at our COVID-Hospital in Rome, Italy.
    Results: Over the observation period, 925 subjects with confirmed SARS-CoV-2 infection were admitted to our COVID-hospital. Among them, we found seven spontaneous IPHs with an incidence of 7.6 cases per 1000 hospitalization. All the reported cases had a severe manifestation of COVID-19 pneumonia, with at least one comorbidity and 5/7 were on treatment with low weight molecular heparin for micro or macro pulmonary thrombosis.
    Conclusions: Given the indications to prescribe anticoagulant therapy in COVID-19 and the lack of solid evidences on the optimal dose and duration, it is important to be aware of the iliopsoas haematoma as a potentially serious complication in COVID-19 inpatients. KEY MESSAGE Critically ill patients with COVID-19 are at increased risk of hypercoagulability state and anticoagulation therapy is recommended. Ilio-psoas haematoma (IPH) is found to be a complication of anticoagulation regimen especially in severe COVID-19 cases. An incidence of 7.6 cases per 1000 admission of IPHs was reported. Hypoesthesia of the lower limbs, pain triggered by femoral rotation, hypovolaemia and anaemia are the most common symptoms and signs of IPHs that should alert physician.
    MeSH term(s) Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; Critical Illness/mortality ; Critical Illness/therapy ; Female ; Glucocorticoids/therapeutic use ; Hematoma/chemically induced ; Hematoma/diagnosis ; Hematoma/drug therapy ; Hematoma/epidemiology ; Heparin, Low-Molecular-Weight ; Hospital Mortality ; Humans ; Incidence ; Intensive Care Units ; Italy/epidemiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscular Diseases ; Psoas Muscles/diagnostic imaging ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Thrombophilia/drug therapy ; Thrombophilia/etiology ; Tomography, X-Ray Computed ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Anticoagulants ; Glucocorticoids ; Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2021-01-24
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2021.1875498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia.

    Vergori, Alessandra / Lorenzini, Patrizia / Cozzi-Lepri, Alessandro / Donno, Davide Roberto / Gualano, Gina / Nicastri, Emanuele / Iacomi, Fabio / Marchioni, Luisa / Campioni, Paolo / Schininà, Vincenzo / Cicalini, Stefania / Agrati, Chiara / Capobianchi, Maria Rosaria / Girardi, Enrico / Ippolito, Giuseppe / Vaia, Francesco / Petrosillo, Nicola / Antinori, Andrea / Taglietti, Fabrizio

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11334

    Abstract: Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical ... ...

    Abstract Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50-77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2-26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7-15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO
    MeSH term(s) Aged ; COVID-19/diagnostic imaging ; COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/physiopathology ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Intubation, Intratracheal/statistics & numerical data ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; Risk Assessment ; Rome ; Severity of Illness Index
    Chemical Substances Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90713-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.

    De Rienzo, Mafalda / Foddai, Maria Laura / Conti, Laura / Mandoj, Chiara / Iaboni, Stefano / Saladini, Ilenia / Castilletti, Concetta / Matusali, Giulia / Donno, Davide Roberto / Marchioni, Luisa / Ianniello, Stefania / Corpolongo, Angela / Palange, Maria / Ciliberto, Gennaro / Piaggio, Giulia / De Marco, Federico

    Frontiers in immunology

    2021  Volume 12, Page(s) 690322

    Abstract: A convalescent, non-severe, patient with COVID-19 was enrolled as a hyper-immune plasma voluntary donor by the Immuno-Hematology and Transfusion Unit of the Regina Elena National Cancer Institute in Rome, under the TSUNAMI national study criteria. During ...

    Abstract A convalescent, non-severe, patient with COVID-19 was enrolled as a hyper-immune plasma voluntary donor by the Immuno-Hematology and Transfusion Unit of the Regina Elena National Cancer Institute in Rome, under the TSUNAMI national study criteria. During a nearly 6-month period (May-October 2020), the patient was closely monitored and underwent four hyperimmune plasma collections. Serum SARS-CoV-2 (anti-S + anti-N) IgG and IgM, anti-S1 IgA, and neutralizing titers (NTs) were measured. Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. Conversely, NTs directly correlated with anti-S1 IgA levels. Hyperimmune donor plasma, administered to five SARS-CoV-2 patients with persistent, severe COVID-19 symptoms, induced short-term clinical and pathological improvement. Reported data suggest that high NTs can persist longer than expected, thus widening hyperimmune plasma source, availability, and potential use.
    MeSH term(s) Aged ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Blood Donors ; COVID-19/immunology ; COVID-19/therapy ; COVID-19/virology ; Humans ; Immunization, Passive ; Immunoglobulin A/administration & dosage ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Time Factors ; Treatment Outcome ; COVID-19 Serotherapy
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin A ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.690322
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