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  1. Book ; Online ; Conference proceedings ; E-Book: Human Milk: Composition, Clinical Benefits and Future Opportunities

    Donovan, Sharon M.

    90th Nestlé Nutrition Institute Workshop, Lausanne, October-November 2017

    (Nestlé Nutrition Institute Workshop Series ; Vol.90)

    2019  

    Author's details editors, Sharon M. Donovan, J. Bruce German, Bo Lönnerdal, Alan Lucas
    Series title Nestlé Nutrition Institute Workshop Series ; Vol.90
    Keywords Nutrition ; Pediatrics ; Neonatology
    Language English
    Size 1 online resource (XVI + 234 pages), 32 figures, 5 in color, 18 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online ; Conference proceedings ; E-Book
    Note A timely review
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020436690
    ISBN 9783318063417 ; 9783318063400 ; 331806341X ; 3318063401
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: Emerging roles of bioactive components in pediatric nutrition

    Donovan, Sharon M.

    based on a symposium that was held in Boston, Massachusetts, April 22-24, 2015

    (The journal of pediatrics ; volume 173S, supplement (June 2016))

    2016  

    Author's details guest editors Sharon M. Donovan, PhD, RD; Bo Lönnerdal, PhD
    Series title The journal of pediatrics ; volume 173S, supplement (June 2016)
    Collection
    Language English
    Size A3, S65 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT019047418
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Um IV Zs 116 -173S- verfügbar in Königswinter Königswinter

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  3. Book ; Conference proceedings: Human milk: composition, clinical benefits and future opportunities

    Donovan, Sharon M. / German, J. Bruce / Lönnerdal, Bo / Lucas, Alan

    90th Nestlé Nutrition Institute Workshop, Lausanne, Oct. 30-Nov. 1, 2017

    (Nestlé Nutrition Institute workshop series ; vol. 90)

    2019  

    Event/congress Nestlé Nutrition Institute (90., 2017, Lausanne, Workshop)
    Author's details editors: Sharon M. Donovan, J. Bruce German, Bo Lönnerdal, Alan Lucas
    Series title Nestlé Nutrition Institute workshop series ; vol. 90
    Collection
    Keywords Nutrition ; Muttermilch ; Säuglingsnahrung
    Subject Muttermilch-Ersatznahrung ; Säuglings-Fertignahrung ; Vorgefertigte Säuglingsnahrung ; Babynahrung ; Frauenmilch ; Humanmilch
    Subject code 610
    Language English
    Size XIV, 233 Seiten, Illustrationen, 660 g
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT020027471
    ISBN 978-3-318-06340-0 ; 3-318-06340-1 ; 9783318063417 ; 331806341X
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    198/157 available for loan (reading room) Freihandmagazin (U1)

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  4. Book: Nutrition and gastrointestinal tract development and function

    Donovan, Sharon M.

    Cincinnati, Ohio, June 7 - 8, 2005

    (The journal of pediatrics ; 149,5, Suppl.)

    2006  

    Author's details guest ed.: Sharon M. Donovan
    Series title The journal of pediatrics ; 149,5, Suppl.
    Collection
    Language English
    Size S. S47 - S142 : Ill., graph. Darst.
    Publisher Mosby
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT014920270
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Um IV Zs 116 -149,5,Suppl.- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Evolution of the gut microbiome in infancy within an ecological context.

    Donovan, Sharon M

    Current opinion in clinical nutrition and metabolic care

    2020  Volume 23, Issue 3, Page(s) 223–227

    Abstract: Purpose of review: Humans and their commensal microbiota coexist in a complex ecosystem molded by evolutionary and ecological factors. Ecological opportunity is the prospective, lineage-specific characteristic of an environment that contains both niche ... ...

    Abstract Purpose of review: Humans and their commensal microbiota coexist in a complex ecosystem molded by evolutionary and ecological factors. Ecological opportunity is the prospective, lineage-specific characteristic of an environment that contains both niche availability leading to persistence coupled with niche discordance that drives selection within that lineage. The newborn gut ecosystem presents vast ecological opportunity. Herein, factors affecting perinatal infant microbiome composition are discussed.
    Recent findings: Establishing a healthy microbiota in early life is required for immunological programming and prevention of both short-term and long-term health outcomes. The holobiont theory infers that host genetics contributes to microbiome composition. However, in most human studies, environmental factors are predominantly responsible for microbiome composition and function. Key perinatal elements are route of delivery, diet and the environment in which that infant resides. Vaginal delivery seeds an initial microbiome, and breastfeeding refines the community by providing additional microbes, human milk oligosaccharides and immunological proteins.
    Summary: Early life represents an opportunity to implement clinical practices that promote the optimal seeding and feeding of the gut microbial ecosystem. These include reducing nonemergent cesarean deliveries, avoiding the use of antibiotics, and promoting exclusive breastfeeding.
    MeSH term(s) Ecological and Environmental Phenomena/physiology ; Feeding Behavior/physiology ; Female ; Gastrointestinal Microbiome/physiology ; Humans ; Infant ; Infant, Newborn ; Male ; Pregnancy ; Prenatal Nutritional Physiological Phenomena
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Fructooligosaccharides are not the same as Fucosylated Human Milk Oligosaccharides.

    Bode, Lars / Donovan, Sharon M

    Advances in nutrition (Bethesda, Md.)

    2022  Volume 13, Issue 3, Page(s) 972–973

    MeSH term(s) Humans ; Milk, Human ; Oligosaccharides
    Chemical Substances Oligosaccharides ; fructooligosaccharide
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmac033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Summary on Clinical Aspects of Human Milk on Infant Health Outcomes.

    Donovan, Sharon M

    Nestle Nutrition Institute workshop series

    2019  Volume 90, Page(s) 175–178

    MeSH term(s) Brain/growth & development ; Breast Feeding ; Child Development/physiology ; Female ; Gastrointestinal Microbiome/physiology ; Humans ; Infant ; Infant Health ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Infant, Premature ; Intensive Care, Neonatal ; Milk, Human/physiology
    Language English
    Publishing date 2019-03-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1664-2155
    ISSN (online) 1664-2155
    DOI 10.1159/000490485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Human Milk Proteins: Composition and Physiological Significance.

    Donovan, Sharon M

    Nestle Nutrition Institute workshop series

    2019  Volume 90, Page(s) 93–101

    Abstract: Human milk (HM) contains hundreds of proteins with very diverse functions that likely contribute to the short- and long-term beneficial effects of breastfeeding. These functions include serving as a source of amino acids, improving the bioavailability of ...

    Abstract Human milk (HM) contains hundreds of proteins with very diverse functions that likely contribute to the short- and long-term beneficial effects of breastfeeding. These functions include serving as a source of amino acids, improving the bioavailability of micronutrients, including vitamins, minerals, and trace elements, providing immunologic defense, stimulating intestinal growth and maturation, shaping the microbiome, and enhancing learning and memory. Human milk proteins can be broadly classified into 3 categories: caseins, whey proteins, and mucins, which are present in the milk fat globule membrane. HM is whey predominant; however, the whey/casein ratio of HM changes from 90/10 in colostrum to 60/40 in mature HM. The whey proteins present in significant quantities in the whey fraction are α-lactalbumin, lactoferrin, IgA, osteopontin, and lysozyme. Additionally, bioactive peptides are formed during digestion of casein and whey, and glycans from glycoproteins are bifidogenic, adding further complexity to the functional properties of HM proteins. Recent advances in dairy technology have enabled isolation of bioactive milk proteins from bovine milk in sufficient quantities for clinical studies and, in some cases, addition to commercially available infant formula. Herein, the current evidence on HM protein composition and bioactivity of HM proteins is reviewed.
    MeSH term(s) Caseins/analysis ; Female ; Glycolipids/physiology ; Glycoproteins/physiology ; Humans ; Infant ; Infant, Newborn ; Lactoferrin/physiology ; Milk Proteins/chemistry ; Milk Proteins/metabolism ; Milk, Human/chemistry ; Milk, Human/physiology ; Mucins/analysis ; Mucins/physiology ; Nutritive Value ; Osteopontin/physiology ; Whey Proteins/analysis
    Chemical Substances Caseins ; Glycolipids ; Glycoproteins ; LTF protein, human ; Milk Proteins ; Mucins ; Whey Proteins ; milk fat globule ; Osteopontin (106441-73-0) ; Lactoferrin (EC 3.4.21.-)
    Language English
    Publishing date 2019-03-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1664-2155
    ISSN (online) 1664-2155
    DOI 10.1159/000490298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dietary supplementation of 3'-sialyllactose or 6'-sialyllactose elicits minimal influence on cognitive and brain development in growing pigs.

    Golden, Rebecca K / Sutkus, Loretta T / Donovan, Sharon M / Dilger, Ryan N

    Frontiers in behavioral neuroscience

    2024  Volume 17, Page(s) 1337897

    Abstract: Sialylated human milk oligosaccharides (HMO), such as 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL), are abundant throughout lactation and at much higher concentrations than are present in bovine milk or infant formulas. Previous studies have ... ...

    Abstract Sialylated human milk oligosaccharides (HMO), such as 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL), are abundant throughout lactation and at much higher concentrations than are present in bovine milk or infant formulas. Previous studies have suggested that sialylated HMO may have neurocognitive benefits in early life. Recent research has focused on infant formula supplementation with key nutrients and bioactives to narrow the developmental gap between formula-fed and breastfed infants. Herein, we investigated the impact of supplemental 3'-SL or 6'-SL on cognitive and brain development at two time-points [postnatal days (PND) 33 and 61]. Two-day-old piglets (
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1337897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Review on the Impact of Milk Oligosaccharides on the Brain and Neurocognitive Development in Early Life.

    Fan, Yuting / McMath, Arden L / Donovan, Sharon M

    Nutrients

    2023  Volume 15, Issue 17

    Abstract: Milk Oligosaccharides (MOS), a group of complex carbohydrates found in human and bovine milk, have emerged as potential modulators of optimal brain development for early life. This review provides a comprehensive investigation of the impact of milk ... ...

    Abstract Milk Oligosaccharides (MOS), a group of complex carbohydrates found in human and bovine milk, have emerged as potential modulators of optimal brain development for early life. This review provides a comprehensive investigation of the impact of milk oligosaccharides on brain and neurocognitive development of early life by synthesizing current literature from preclinical models and human observational studies. The literature search was conducted in the PubMed search engine, and the inclusion eligibility was evaluated by three reviewers. Overall, we identified 26 articles for analysis. While the literature supports the crucial roles of fucosylated and sialylated milk oligosaccharides in learning, memory, executive functioning, and brain structural development, limitations were identified. In preclinical models, the supplementation of only the most abundant MOS might overlook the complexity of naturally occurring MOS compositions. Similarly, accurately quantifying MOS intake in human studies is challenging due to potential confounding effects such as formula feeding. Mechanistically, MOS is thought to impact neurodevelopment through modulation of the microbiota and enhancement of neuronal signaling. However, further advancement in our understanding necessitates clinical randomized-controlled trials to elucidate the specific mechanisms and long-term implications of milk oligosaccharides exposure. Understanding the interplay between milk oligosaccharides and cognition may contribute to early nutrition strategies for optimal cognitive outcomes in children.
    MeSH term(s) Child ; Humans ; Animals ; Milk ; Brain ; Oligosaccharides/pharmacology ; Cognition ; Executive Function
    Chemical Substances Oligosaccharides
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15173743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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