LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 111

Search options

  1. Article ; Online: Gantenerumab in Early Alzheimer's Disease. Reply.

    Bateman, Randall J / Smith, Janice / Doody, Rachelle S

    The New England journal of medicine

    2024  Volume 390, Issue 9, Page(s) 867

    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances gantenerumab (4DF060P933) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2314291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Concern about Tominersen in Patients with Huntington's Disease. Reply.

    McColgan, Peter / Tabrizi, Sarah J / Doody, Rachelle S

    The New England journal of medicine

    2024  Volume 390, Issue 11, Page(s) 1059

    MeSH term(s) Adult ; Humans ; Huntington Disease ; Patients ; Oligonucleotides
    Chemical Substances tominersen (7QI41X9QWC) ; Oligonucleotides
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2400161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Conference proceedings: Impact of new therapies on Alzheimer's disease management

    Doody, Rachelle S.

    7 tables ; [proceedings of a satellite symposium held at the 13th International Conference of Alzheimer's Disease International, 29th September 1997, Helsinki, Finland]

    (Gerontology ; 45, Suppl. 1)

    1999  

    Event/congress International Conference of Alzheimer's Disease International (13, 1997, Helsinki)
    Author's details guest ed. Rachelle S. Doody
    Series title Gerontology ; 45, Suppl. 1
    Collection
    Keywords Alzheimerkrankheit ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease
    Language English
    Size 38 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT009633163
    ISBN 3-8055-6817-7 ; 978-3-8055-6817-3
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 201 -45,Suppl.1- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Mitochondria

    Salloway, Stephen P. / Reddy, P. Hemachandra / Doody, Rachelle S.

    an emerging therapeutic focus in Alzheimer's disease therapy

    (CNS spectrums ; 14,8, Suppl. 7 : Expert panel supplement)

    2009  

    Author's details authors Stephen Salloway ; P. Hemachandra Reddy ; Rachelle S. Doody
    Series title CNS spectrums ; 14,8, Suppl. 7 : Expert panel supplement
    Collection
    Language English
    Size 20 S. : Ill., graph. Darst.
    Publisher MBL Communications
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016099844
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5171 -14,Suppl.8- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: [Clinical trials in AD].

    Doody, Rachelle S

    Rinsho shinkeigaku = Clinical neurology

    2011  Volume 50, Issue 11, Page(s) 835

    MeSH term(s) Alzheimer Disease/drug therapy ; Clinical Trials as Topic ; Cognitive Dysfunction/drug therapy ; Drug Discovery ; Humans ; International Cooperation
    Language Japanese
    Publishing date 2011-09-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.50.835
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 223: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Centers of excellence in Alzheimer's disease: it is time to better integrate patient care and clinical research to improve the prevention and treatment of Alzheimer's disease.

    Doody, Rachelle S

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2009  Volume 5, Issue 2, Page(s) 133–136

    Abstract: Despite enormous worldwide public and private interest in improving the prevention and treatment of Alzheimer's disease (AD), we have not made as much of an impact as we would like, and the number of affected individuals continues to grow. Even more ... ...

    Abstract Despite enormous worldwide public and private interest in improving the prevention and treatment of Alzheimer's disease (AD), we have not made as much of an impact as we would like, and the number of affected individuals continues to grow. Even more alarmingly, whereas global efforts to identify AD cases and to develop new treatments are increasing, patient-care options are disappearing, so that even if a highly efficacious therapy or prevention approach arose, it would not be used effectively. As a first step toward organizing a better way forward, we should establish AD centers of excellence that mandate both patient care and research in the same setting. These centers would benefit from changes in public health policies related to chronic-disease surveillance, Center for Medicare and Medicaid Services funding for the care of chronic diseases, institutional review boards, good clinical practice guidelines, National Institutes of Health regulations for the use of research funds, Food and Drug Administration guidelines for the approval of AD drugs, and Department of Commerce regulations related to patent protection of AD diagnostic aids and treatments. This new form of AD centers of excellence would also provide direct care to many patients and their families, model care for communities and medical trainees, enhance the voluntary recruitment of AD patients to clinical trials, and improve our understanding of AD and its management.
    MeSH term(s) Academic Medical Centers/standards ; Academic Medical Centers/trends ; Aged ; Alzheimer Disease/drug therapy ; Alzheimer Disease/prevention & control ; Biomedical Research/standards ; Biomedical Research/trends ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/trends ; Government Agencies/standards ; Government Agencies/trends ; Health Policy/legislation & jurisprudence ; Health Policy/trends ; Health Services Administration/standards ; Health Services Administration/trends ; Humans ; Patient Care/standards ; Patient Care/trends ; Public Policy ; United States
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1016/j.jalz.2009.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Dimebon as a potential therapy for Alzheimer's disease.

    Doody, Rachelle S

    CNS spectrums

    2009  Volume 14, Issue 8 Suppl 7, Page(s) 14–6; discussion 16–8

    Abstract: Excellent treatment for Alzheimer's disease remains an unmet medical need. Although current therapies improve patients' abilities compared to placebo and temporarily maintain performance above baseline on a number of outcome measures, additional ... ...

    Abstract Excellent treatment for Alzheimer's disease remains an unmet medical need. Although current therapies improve patients' abilities compared to placebo and temporarily maintain performance above baseline on a number of outcome measures, additional therapies are needed to augment the benefits over baseline and to prolong these improvements.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/physiopathology ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Randomized Controlled Trials as Topic
    Chemical Substances Histamine Antagonists ; Indoles ; latrepirdine (OD9237K1Z6)
    Language English
    Publishing date 2009-09-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900024913
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 340: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: We should not distinguish between symptomatic and disease-modifying treatments in Alzheimer's disease drug development.

    Doody, Rachelle S

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2008  Volume 4, Issue 1 Suppl 1, Page(s) S21–5

    Abstract: The terms symptomatic and disease-modifying have become standard in discussions of Alzheimer's disease therapeutics, yet there is little justification for their use. Currently marketed drugs are presumed to be symptomatic because they lead to some degree ...

    Abstract The terms symptomatic and disease-modifying have become standard in discussions of Alzheimer's disease therapeutics, yet there is little justification for their use. Currently marketed drugs are presumed to be symptomatic because they lead to some degree of mean improvement over baseline and because of the widespread belief that their mechanisms are limited and their effects are completely reversible. Current trial methodologies cannot distinguish between symptomatic and disease-modifying effects. Furthermore, it is highly likely that many trials will demonstrate a combination of such effects at the level of the trial or at the level of the individual. The forces that drive this distinction are largely social, as opposed to scientific. It would be preferable for drugs to first seek an antidementia claim, preferably on the background of conventional therapies when possible, in trials that are as small and as short in duration as possible. Further refinements would come by demonstration of how substantial and how enduring the antidementia benefits are.
    MeSH term(s) Alzheimer Disease/drug therapy ; Brain/drug effects ; Clinical Trials as Topic ; Humans
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1016/j.jalz.2007.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Cholinesterase inhibitors and memantine: best practices.

    Doody, Rachelle S

    CNS spectrums

    2008  Volume 13, Issue 10 Suppl 16, Page(s) 34–35

    MeSH term(s) Aging ; Alzheimer Disease/drug therapy ; Cholinesterase Inhibitors/therapeutic use ; Humans ; Memantine/therapeutic use ; Practice Patterns, Physicians'
    Chemical Substances Cholinesterase Inhibitors ; Memantine (W8O17SJF3T)
    Language English
    Publishing date 2008-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900027048
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 340: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Prevalence and correlates of cognitive asymmetry in a large sample of Alzheimer's disease patients.

    Alverson, W Alexander / Massman, Paul J / Doody, Rachelle S

    Journal of clinical and experimental neuropsychology

    2016  Volume 38, Issue 5, Page(s) 516–526

    Abstract: Previous research has suggested that a significant minority of patients with Alzheimer's disease (AD) exhibit asymmetric cognitive profiles (greater verbal than visuospatial impairment or vice versa) and that these patient subgroups may differ in ... ...

    Abstract Previous research has suggested that a significant minority of patients with Alzheimer's disease (AD) exhibit asymmetric cognitive profiles (greater verbal than visuospatial impairment or vice versa) and that these patient subgroups may differ in demographic and other characteristics. Prior studies have been relatively small, and this investigation sought to examine correlates of asymmetry in a large patient sample (N = 438). Patients were classified into the following cognitive profile groups: low verbal, symmetric, and low visuospatial. Consistent with past research, 28.3% of participants were classified as having asymmetric cognitive profiles, with more participants in the low visuospatial subgroup. Low visuospatial participants were younger than members of the other subgroups, and low verbal participants performed worse on a measure estimating premorbid verbal intelligence. Findings regarding apolipoprotein E (ApoE) ε4 genotype were equivocal, although results provided some evidence for an effect of the ɛ4 allele on cognitive asymmetry. These results suggest systematic differences between neuropsychological asymmetry profiles that support the possibility of distinct subgroups of the disease.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/epidemiology ; Apolipoprotein E4/genetics ; Cognition Disorders/complications ; Cognition Disorders/epidemiology ; Female ; Humans ; Male ; Neuropsychological Tests ; Prevalence ; Psychiatric Status Rating Scales ; Statistics as Topic
    Chemical Substances Apolipoprotein E4
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 605982-x
    ISSN 1744-411X ; 0168-8634 ; 1380-3395
    ISSN (online) 1744-411X
    ISSN 0168-8634 ; 1380-3395
    DOI 10.1080/13803395.2015.1127897
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2393: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top