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Article: Outcomes of Robot-Assisted Surgery in Rectal Cancer Compared with Open and Laparoscopic Surgery.

Khajeh, Elias / Aminizadeh, Ehsan / Dooghaie Moghadam, Arash / Nikbakhsh, Rajan / Goncalves, Gil / Carvalho, Carlos / Parvaiz, Amjad / Kulu, Yakup / Mehrabi, Arianeb

Cancers

2023 Volume 15, Issue 3

Abstract: With increasing trends for the adoption of robotic surgery, many centers are considering changing their practices from open or laparoscopic to robot-assisted surgery for rectal cancer. We compared the outcomes of robot-assisted rectal resection with ... ...

Abstract	With increasing trends for the adoption of robotic surgery, many centers are considering changing their practices from open or laparoscopic to robot-assisted surgery for rectal cancer. We compared the outcomes of robot-assisted rectal resection with those of open and laparoscopic surgery. We searched Medline, Web of Science, and CENTRAL databases until October 2022. All randomized controlled trials (RCTs) and prospective studies comparing robotic surgery with open or laparoscopic rectal resection were included. Fifteen RCTs and 11 prospective studies involving 6922 patients were included. The meta-analysis revealed that robotic surgery has lower blood loss, less surgical site infection, shorter hospital stays, and higher negative resection margins than open resection. Robotic surgery also has lower conversion rates, lower blood loss, lower rates of reoperation, and higher negative circumferential margins than laparoscopic surgery. Robotic surgery had longer operation times and higher costs than open and laparoscopic surgery. There were no differences in other complications, mortality, and survival between robotic surgery and the open or laparoscopic approach. However, heterogeneity between studies was moderate to high in some analyses. The robotic approach can be the method of choice for centers planning to change from open to minimally invasive rectal surgery. The higher costs of robotic surgery should be considered as a substitute for laparoscopic surgery (PROSPERO: CRD42022381468).
Language	English
Publishing date	2023-01-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030839
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Article: Comparison of the potency of nortriptyline and mirtazapine on gastrointestinal symptoms, the level of anxiety and depression in patients with functional dyspepsia.

Jamshidfar, Negin / Hamdieh, Mostafa / Eslami, Pegah / Batebi, Sepideh / Sadeghi, Amir / Rastegar, Reyhaneh / Dooghaie Moghadam, Arash / Masjedi Arani, Abbas

Gastroenterology and hepatology from bed to bench

2023 Volume 16, Issue 1, Page(s) 468–477

Abstract: Aim: In the current clinical trial study, the potency of mirtazapine and nortriptyline was compared in patients with Functional Dyspepsia (FD) who had anxiety or depression.: Background: FD usually accompanies other psychosocial disorders. According ... ...

Abstract	Aim: In the current clinical trial study, the potency of mirtazapine and nortriptyline was compared in patients with Functional Dyspepsia (FD) who had anxiety or depression. Background: FD usually accompanies other psychosocial disorders. According to previous studies, among these disorders, anxiety and depression have the most correlation. Methods: This randomized clinical trial was organized in Taleghani hospital (Tehran, Iran). In two parallel groups, 42 patients were treated for 12 weeks, with 22 patients receiving 7.5 mg of mirtazapine and 20 patients receiving 25 mg of nortriptyline per day. To gain robust results, the patients with a positive history of antidepressant therapy, organic diseases, alcohol abuse, pregnancy, and major psychiatric disorders were excluded from the study. The subjects were examined by three questionnaires, including Nepean and Hamilton questionnaires. The patients were asked to answer the questions three times during the study: once before the onset of the treatment, second during the treatment, and third at the end of the treatment. Results: Based on Gastrointestinal (GI) manifestations, mirtazapine, in comparison to nortriptyline could significantly suppress the signs and symptoms of FD, including epigastric pains (P=0.02), belching (P=0.004), and bloating (P=0.01). Although the results from the use of mirtazapine compared to the use of nortriptyline (P=0.002) showed a lower mean depression score on the Hamilton questionnaire, no significant differences were found between the effects of these drugs on the anxiety scale of patients (P=0.091). Conclusion: Mirtazapine is more effective for GI symptoms related to gastric emptying. Considering the level of anxiety, mirtazapine, compared to nortriptyline, revealed better outcomes in FD patients suffering from depression.
Language	English
Publishing date	2023-04-12
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
DOI	10.22037/ghfbb.v16i1.2513
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Article ; Online: How to overcome cardiovascular challenges in COVID-19 patients: a guide for common practice.

Eslami, Pegah / Tabary, Mohammadreza / Dooghaie-Moghadam, Arash / Khaheshi, Isa

Acta bio-medica : Atenei Parmensis

2020 Volume 91, Issue 3, Page(s) e2020021

Abstract: The COVID-19 epidemic initially started in Wuhan, China in December 2019 due to SARS-CoV-2. SARS-CoV-2 is genetically similar to the bat beta-coronavirus genus, but the novel specie of this genus can infect humans. The most common clinical features of ... ...

Abstract	The COVID-19 epidemic initially started in Wuhan, China in December 2019 due to SARS-CoV-2. SARS-CoV-2 is genetically similar to the bat beta-coronavirus genus, but the novel specie of this genus can infect humans. The most common clinical features of COVID-19 are fever, cough, myalgia, fatigue, expectoration, and dyspnea. The primary reported mortality rate was about 2-3% in China; however, it reached up to 10% among patients with underlying cardiovascular diseases. The primary epidemiological investigations showed a high prevalence of underlying cardiovascular diseases in more than 40% of infected patients. A high prevalence of hypertension, ischemic heart disease, and diabetes were reported among deceased patients in Italy. Previous experiments in different pandemic situations showed that the cardiovascular system has been affected in many ways. Previous studies on SARS-CoV and MERS-CoV reported that cardiovascular co-morbidities had a direct correlation with the risk of infection, the severity of disease, and the mortality rate. Therefore, brief and available protocols for controlling the negative effects of this novel respiratory infection on the cardiovascular system, especially in a high-risk populations with underlying cardiovascular conditions, is one of the most serious concerns among healthcare providers. Herein, we aimed to review the available data on the cardiac manifestation of COVID-19. Besides, we described useful maps for the better treatment of COVID-19 infection in patients with underlying cardiovascular conditions, as a high-risk group of patients.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Cause of Death/trends ; Comorbidity ; Coronavirus Infections/epidemiology ; Global Health ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Risk Assessment/methods ; SARS-CoV-2 ; Survival Rate/trends
Keywords	covid19
Language	English
Publishing date	2020-09-07
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v91i3.9848
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Article: Comparison of endoscopic balloon dilatation potency using balloons size more or less than 15 mm in the treatment of large bile duct stones: a clinical trial study.

Sadeghi, Amir / Dooghaie Moghadam, Arash / Jamshidizade, Shaghayegh / Norouzinia, Mohsen / Jamshidfar, Negin / Hosseini, Parna

Gastroenterology and hepatology from bed to bench

2021 Volume 14, Issue Suppl1, Page(s) S112–S117

Abstract: Aim: The present study was performed on patients with large bile duct stones to compare clinical outcomes and complications of balloon dilatation treatment between two sizes of balloons, < 15 mm and ≥ 15 mm.: Background: in 1982, the endoscopic ... ...

Abstract	Aim: The present study was performed on patients with large bile duct stones to compare clinical outcomes and complications of balloon dilatation treatment between two sizes of balloons, < 15 mm and ≥ 15 mm. Background: in 1982, the endoscopic papillary balloon dilatation (EPBD) method was presented by Staritz to reduce bleeding and perforation risk of large bile duct stones. Methods: Patients with large bile duct stones admitted to Taleghani hospital from December 2018 to December 2019 who were the candidates for balloon dilation with limited sphincterotomy. Patients were randomly divided into two groups. In group B, a ≥ 15 mm balloon was used, and in group A, a balloon <15 mm was used. The clinical results of balloon dilation and its complications were recorded and compared. Results: Most patients had 1 or 2 large bile duct stones, and there was no significant difference in the number of stones. Extraction was successful in 92.8% of group B and 85.7% of group A without significant differences (P = 0.8). Pancreatitis, hemorrhage, cholangitis, and perfusion occurred in 8%, 4.2%, 1.4%, and 2.8% of group B subjects and also in 10%, 2.8%, 0%, and 1.4% of group A subjects, respectively, and the difference between the two groups was not significant. Conclusion: Generally, this study results showed that balloon size did not have a significant effect on the success rate of bile duct stones. Moreover, considering the lack of significant association between balloon dilatation size and the occurrence of post-endoscopic complications such as pancreatitis, it seems that large-size dilatation has no serious clinical risk.
Language	English
Publishing date	2021-07-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
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Article: Vasculopathy-related cutaneous lesions and intrahepatic cholestasis as synchronous manifestations in a COVID-19 patient; a case report.

Sadeghi, Amir / Dooghaie Moghadam, Arash / Eslami, Pegah / Pirsalehi, Ali / Salari, Sina / Roshandel, Elham

Gastroenterology and hepatology from bed to bench

2020 Volume 13, Issue 4, Page(s) 400–404

Abstract: Today, COVID-19 pneumonia causes global concern. The World Health Organization (WHO) has reported many mortalities from this disease all around the world. Therefore, recognizing new cases of COVID-19 is crucial during this pandemic. Many studies have ... ...

Abstract	Today, COVID-19 pneumonia causes global concern. The World Health Organization (WHO) has reported many mortalities from this disease all around the world. Therefore, recognizing new cases of COVID-19 is crucial during this pandemic. Many studies have shown that COVID-19 has a broad spectrum of signs and symptoms, including GI and cutaneous manifestations. Previous studies have reported liver enzyme changes as well as diarrhea as a common GI manifestation of COVID-19. However, there are few reports about COVID-19 synchronous cutaneous and liver involvement. Additionally, there are few reports about intrahepatic cholestasis in COVID-19 patients. In this article, a confirmed case of COVID-19 with vasculopathy-related cutaneous manifestation and liver cholestasis is reported. A 67-year-old Iranian woman was admitted to Taleghani Hospital with epigastric pain, vomiting, anosmia, rising liver enzyme levels, fever, itching, and skin rashes. Skin and liver biopsies were performed during the patient's admission; the results suggested vasculopathy-related cutaneous lesion and liver cholestasis. Plasmapheresis was initiated and all manifestations disappeared after treatment. All atypical presentations, including cutaneous lesions and liver manifestations, should be considered as COVID-19 and evaluated.
Language	English
Publishing date	2020-11-27
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
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Article ; Online: COVID-19 and telemedicine: Immediate action required for maintaining healthcare providers well-being.

Moazzami, Bobak / Razavi-Khorasani, Niloofar / Dooghaie Moghadam, Arash / Farokhi, Ermia / Rezaei, Nima

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2020 Volume 126, Page(s) 104345

Abstract: The well-being of the health care workforce is the cornerstone of every well-functioning health system. As a result of the pandemic, medical healthcare providers are under an enormous amount of workload pressure along with increased total health ... ...

Abstract	The well-being of the health care workforce is the cornerstone of every well-functioning health system. As a result of the pandemic, medical healthcare providers are under an enormous amount of workload pressure along with increased total health expenditures. The overwhelming burden of COVID-19 illness could lead to caregiver burnout. Direct-to-consumer telemedicine can enable patients to connect with their healthcare provider at a distance. This virtual platform could be used by smartphones or webcam-enabled computers and allows physicians to effectively screen patients with early signs of COVID-19 before they reach to hospital.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Health Personnel ; Humans ; Internet ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Smartphone ; Telemedicine
Keywords	covid19
Language	English
Publishing date	2020-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2020.104345
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Article ; Online: Bariatric surgery in patients with obesity and end-stage renal disease.

Khajeh, Elias / Aminizadeh, Ehsan / Dooghaie Moghadam, Arash / Sabetkish, Nastaran / Abbasi Dezfouli, Sepehr / Morath, Christian / Zeier, Martin / Nickel, Felix / Billeter, Adrian T / Müller-Stich, Beat Peter / Mehrabi, Arianeb

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2023 Volume 19, Issue 8, Page(s) 858–871

Abstract: Background: Bariatric surgery has been suggested as a treatment for obesity and end-stage renal disease (ESRD). Although the number of bariatric surgeries in patients with ESRD is increasing, its safety and effectiveness in these patients are still ... ...

Abstract	Background: Bariatric surgery has been suggested as a treatment for obesity and end-stage renal disease (ESRD). Although the number of bariatric surgeries in patients with ESRD is increasing, its safety and effectiveness in these patients are still controversial and the surgical method of choice in these patients is under debate. Objectives: To compare the outcomes of bariatric surgery between patients with and without ESRD and to assess different methods of bariatric surgery in patients with ESRD. Setting: Meta-analysis. Methods: A comprehensive search was conducted in Web of Science and Medline (via Pubmed) until May 2022. Tow meta-analyses were performed: A) to compare bariatric surgery outcomes among patients with and without ESRD, and B) to compare outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in patients with ESRD. Using a random-effect model, odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) were computed for surgical and weight loss outcomes. Results: Of 5895 articles, 6 studies were included in meta-analysis A and 8 studies in meta-analysis B. The risk of bias was moderate to serious among studies. Major postoperative complications (OR = 2.82; 95% CI = 1.66-4.77; P = .0001), reoperation (OR = 2.66; 95% CI = 1.99-3.56; P < .00001), readmission (OR = 2.37; 95% CI = 1.55-3.64; P < .0001), and in-hospital/90-d mortality (OR = 4.03; 95% CI = 1.80-9.03; P = .0007) were higher in patients with ESRD. Patients with ESRD also had a longer hospital stay (MD = 1.23; 95% CI = .32-2.14; P = .008). Bleeding, leakage, and total weight loss were comparable among groups. SG showed a 10% lower rate of overall complications and significantly shorter hospital stay than RYGB did. The quality of evidence was very low for the outcomes CONCLUSIONS: Bariatric surgery in patients with ESRD seems to have higher rates of major complications and perioperative mortality than in patients without ESRD, but a comparable rate of overall complications. SG has fewer postoperative complications and could be the method of choice in these patients. These findings should be interpreted cautiously in light of the moderate to high risk of bias in most included studies.
MeSH term(s)	Humans ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Treatment Outcome ; Bariatric Surgery/adverse effects ; Obesity/surgery ; Gastric Bypass/adverse effects ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Postoperative Complications/etiology ; Gastrectomy/methods ; Weight Loss ; Retrospective Studies
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2023.01.015
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Article: How to overcome cardiovascular challenges in COVID-19 patients: a guide for common practice

Eslami, Pegah / Tabary, Mohammadreza / Dooghaie-Moghadam, Arash / Khaheshi, Isa

Acta Biomed

Abstract	The COVID-19 epidemic initially started in Wuhan, China in December 2019 due to SARS-CoV-2. SARS-CoV-2 is genetically similar to the bat beta-coronavirus genus, but the novel specie of this genus can infect humans. The most common clinical features of COVID-19 are fever, cough, myalgia, fatigue, expectoration, and dyspnea. The primary reported mortality rate was about 2-3% in China; however, it reached up to 10% among patients with underlying cardiovascular diseases. The primary epidemiological investigations showed a high prevalence of underlying cardiovascular diseases in more than 40% of infected patients. A high prevalence of hypertension, ischemic heart disease, and diabetes were reported among deceased patients in Italy. Previous experiments in different pandemic situations showed that the cardiovascular system has been affected in many ways. Previous studies on SARS-CoV and MERS-CoV reported that cardiovascular co-morbidities had a direct correlation with the risk of infection, the severity of disease, and the mortality rate. Therefore, brief and available protocols for controlling the negative effects of this novel respiratory infection on the cardiovascular system, especially in a high-risk populations with underlying cardiovascular conditions, is one of the most serious concerns among healthcare providers. Herein, we aimed to review the available data on the cardiac manifestation of COVID-19. Besides, we described useful maps for the better treatment of COVID-19 infection in patients with underlying cardiovascular conditions, as a high-risk group of patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #761228
Database	COVID19

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Article: A new endoscopic submucosal resection -ligation technique for gastric tumors.

Asadzadeh Aghdaei, Hamid / Sadeghi, Amir / Ghorbanpour Nouri, Ahmad / Nouri, Gholam Reza / Dooghaie Moghadam, Arash / Azizi, Mohammad Reza / Eslami, Pegah

Gastroenterology and hepatology from bed to bench

2021 Volume 13, Issue Suppl1, Page(s) S149–S153

Abstract: Although most subepithelial lesions are benign, the malignant forms could present as serious life-threating cancers. Their accurate diagnosis depends on complete surgical resection. Different endoscopic methods have been recommended for the resection. ... ...

Abstract	Although most subepithelial lesions are benign, the malignant forms could present as serious life-threating cancers. Their accurate diagnosis depends on complete surgical resection. Different endoscopic methods have been recommended for the resection. Recently, the EMR has been considered as a safe and effective technique, while various revised EMR techniques have been introduced. In this study, a new version of EMR has been evaluated in two patients. Two middle-aged cases with gastric subepithelial tumors were admitted to Taleghani gastrointestinal department. The polyps were resected via our new Endoscopic Mucosal Resection (EMR) technique. In this technique, the needle knife was used for un-roofing the mucosal surface. Then, the polyps were resected with hot snares. The hemoclips were applied for ligation too. We found no early or delayed complications. Furthermore, the microscopic margins of the lesions were free. Our study represented a safe and cost-beneficial technique for subepithelial lesions and no complications was found and the margins were free. However, further investigations are required for confirming the validity of this new EMR technique.
Language	English
Publishing date	2021-02-09
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
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Article: The potential of endoscopic ultrasound sonography (EUS)-elastography in determining the stage of pancreatic tumor.

Saffarian, Afsaneh / Eslami, Pegah / Dooghaie Moghadam, Arash / Almasi, Faezeh / Pourhoseingholi, Mohamad Amin / Asadzadeh Aghdaei, Hamid / Sadeghi, Amir / Zali, Mohammad Reza

Gastroenterology and hepatology from bed to bench

2021 Volume 14, Issue 3, Page(s) 215–220

Abstract: Aim: The current study was designed to evaluate the role of semi-quantitative EUS- elastography (strain ratio) in staging malignant pancreatic lesions.: Background: Pancreatic cancer is considered one of the most lethal malignancies with a survival ... ...

Abstract	Aim: The current study was designed to evaluate the role of semi-quantitative EUS- elastography (strain ratio) in staging malignant pancreatic lesions. Background: Pancreatic cancer is considered one of the most lethal malignancies with a survival rate of only 5% worldwide. Pancreatic lesions include a wide range of diagnoses from benign to malignant forms. Biopsy and pathological study are the gold standard for the differentiation of malignant lesions and staging of tumors. Recently, endoscopic ultrasound sonography (EUS) elastography has been noticed as a non-invasive diagnosis modality. Nevertheless, no evidence of its potential to determine different stages of malignant tumors is available. Methods: This prospective study included 81 adult patients with a confirmed diagnosis of malignant pancreatic lesion in different clarified stages. All diagnoses were confirmed after endoscopic ultrasound sonography via pathological investigation of surgical specimens or needle biopsies. The results of EUS-elastography based on tumor size (T staging), involved lymph nodes (N staging), and metastasis (M staging) were compared with the gold standard. Results: The mean age of patients was 60.11±13.57 years. The mean SR elastography value was 52.78±48.97. Elastography could not significantly discriminate T stage, N stage, or M stage of tumors ( Conclusion: The non-invasive modality EUS-elastography cannot replace the gold standard in staging tumors; however, EUS-elastography seemed to differentiate benign lesions from malignant ones.
Language	English
Publishing date	2021-06-14
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
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