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  1. Article ; Online: Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans - Los Angeles, California, 2020.

    Dora, Amy V / Winnett, Alexander / Jatt, Lauren P / Davar, Kusha / Watanabe, Mika / Sohn, Linda / Kern, Hannah S / Graber, Christopher J / Goetz, Matthew B

    MMWR. Morbidity and mortality weekly report

    2020  Volume 69, Issue 21, Page(s) 651–655

    Abstract: On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by ... ...

    Abstract On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by reverse transcription-polymerase chain reaction (RT-PCR) testing of nasopharyngeal specimens collected on March 26 and March 27. During March 29-April 23, all SNF residents, regardless of symptoms, underwent serial (approximately weekly) nasopharyngeal SARS-CoV-2 RT-PCR testing, and positive results were communicated to the county health department. All SNF clinical and nonclinical staff members were also screened for SARS-CoV-2 by RT-PCR during March 29-April 10. Nineteen of 99 (19%) residents and eight of 136 (6%) staff members had positive test results for SARS-CoV-2 during March 28-April 10; no further resident cases were identified on subsequent testing on April 13, April 22, and April 23. Fourteen of the 19 residents with COVID-19 were asymptomatic at the time of testing. Among these residents, eight developed symptoms 1-5 days after specimen collection and were later classified as presymptomatic; one of these patients died. This report describes an outbreak of COVID-19 in an SNF, with case identification accomplished by implementing several rounds of RT-PCR testing, permitting rapid isolation of both symptomatic and asymptomatic residents with COVID-19. The outbreak was successfully contained following implementation of this strategy.
    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks/prevention & control ; Female ; Humans ; Long-Term Care ; Los Angeles/epidemiology ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Skilled Nursing Facilities ; Veterans/statistics & numerical data ; Veterans Health Services
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6921e1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial Polymerase Chain Reaction Testing, and Cohorting of Positive Severe Acute Respiratory Syndrome Coronavirus 2 Patients in a Skilled Nursing Facility.

    Dora, Amy V / Winnett, Alexander / Fulcher, Jennifer A / Sohn, Linda / Calub, Feliza / Lee-Chang, Ian / Ghadishah, Elham / Schwartzman, William A / Beenhouwer, David O / Vallone, John / Graber, Christopher J / Goetz, Matthew Bidwell / Bhattacharya, Debika

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 3, Page(s) 545–548

    Abstract: We characterized serology following a nursing home outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where residents were serially tested by reverse-transcription polymerase chain reaction (RT-PCR) and positive residents were ... ...

    Abstract We characterized serology following a nursing home outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where residents were serially tested by reverse-transcription polymerase chain reaction (RT-PCR) and positive residents were cohorted. When tested 46-76 days later, 24 of 26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR-negative residents had confirmed seropositivity, supporting serial SARS-CoV-2 RT-PCR testing and cohorting in nursing homes.
    MeSH term(s) COVID-19 ; Disease Outbreaks ; Humans ; Polymerase Chain Reaction ; SARS-CoV-2 ; Skilled Nursing Facilities
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial PCR Testing, and Cohorting of Positive SARS-CoV-2 Patients in a Skilled Nursing Facility

    Dora, Amy V / Winnett, Alexander / Fulcher, Jennifer A / Sohn, Linda / Calub, Feliza / Lee-Chang, Ian / Ghadishah, Elham / Schwartzman, William A / Beenhouwer, David O / Vallone, John / Graber, Christopher J / Goetz, Matthew Bidwell / Bhattacharya, Debika

    Clin. infect. dis

    Abstract: We characterized serology following a nursing home outbreak where residents were serially tested by RT-PCR and positive residents were cohorted. When tested 46-76 days later, 24/26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR- ... ...

    Abstract We characterized serology following a nursing home outbreak where residents were serially tested by RT-PCR and positive residents were cohorted. When tested 46-76 days later, 24/26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR-negative residents had confirmed seropositivity, supporting serial SARS-CoV-2 RT-PCR testing and cohorting in nursing homes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733397
    Database COVID19

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  4. Article: Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans - Los Angeles, California, 2020

    Dora, Amy V / Winnett, Alexander / Jatt, Lauren P / Davar, Kusha / Watanabe, Mika / Sohn, Linda / Kern, Hannah S / Graber, Christopher J / Goetz, Matthew B

    MMWR Morb Mortal Wkly Rep

    Abstract: On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by ... ...

    Abstract On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by reverse transcription-polymerase chain reaction (RT-PCR) testing of nasopharyngeal specimens collected on March 26 and March 27. During March 29-April 23, all SNF residents, regardless of symptoms, underwent serial (approximately weekly) nasopharyngeal SARS-CoV-2 RT-PCR testing, and positive results were communicated to the county health department. All SNF clinical and nonclinical staff members were also screened for SARS-CoV-2 by RT-PCR during March 29-April 10. Nineteen of 99 (19%) residents and eight of 136 (6%) staff members had positive test results for SARS-CoV-2 during March 28-April 10; no further resident cases were identified on subsequent testing on April 13, April 22, and April 23. Fourteen of the 19 residents with COVID-19 were asymptomatic at the time of testing. Among these residents, eight developed symptoms 1-5 days after specimen collection and were later classified as presymptomatic; one of these patients died. This report describes an outbreak of COVID-19 in an SNF, with case identification accomplished by implementing several rounds of RT-PCR testing, permitting rapid isolation of both symptomatic and asymptomatic residents with COVID-19. The outbreak was successfully contained following implementation of this strategy.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #343466
    Database COVID19

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  5. Article ; Online: Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial Polymerase Chain Reaction Testing, and Cohorting of Positive Severe Acute Respiratory Syndrome Coronavirus 2 Patients in a Skilled Nursing Facility

    Dora, Amy V / Winnett, Alexander / Fulcher, Jennifer A / Sohn, Linda / Calub, Feliza / Lee-Chang, Ian / Ghadishah, Elham / Schwartzman, William A / Beenhouwer, David O / Vallone, John / Graber, Christopher J / Goetz, Matthew Bidwell / Bhattacharya, Debika

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Abstract: Abstract We characterized serology following a nursing home outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where residents were serially tested by reverse-transcription polymerase chain reaction (RT-PCR) and positive residents ... ...

    Abstract Abstract We characterized serology following a nursing home outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where residents were serially tested by reverse-transcription polymerase chain reaction (RT-PCR) and positive residents were cohorted. When tested 46–76 days later, 24 of 26 RT-PCR–positive residents were seropositive; none of the 124 RT-PCR–negative residents had confirmed seropositivity, supporting serial SARS-CoV-2 RT-PCR testing and cohorting in nursing homes.
    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1286
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Universal and Serial Laboratory Testing for SARS-CoV-2 at a Long-Term Care Skilled Nursing Facility for Veterans - Los Angeles, California, 2020.

    Dora, Amy V / Winnett, Alexander / Jatt, Lauren P / Davar, Kusha / Watanabe, Mika / Sohn, Linda / Kern, Hannah S / Graber, Christopher J / Goetz, Matthew B

    MMWR. Morbidity and mortality weekly report, vol 69, iss 21

    2020  

    Abstract: On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by ... ...

    Abstract On March 28, 2020, two residents of a long-term care skilled nursing facility (SNF) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) had positive test results for SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), by reverse transcription-polymerase chain reaction (RT-PCR) testing of nasopharyngeal specimens collected on March 26 and March 27. During March 29-April 23, all SNF residents, regardless of symptoms, underwent serial (approximately weekly) nasopharyngeal SARS-CoV-2 RT-PCR testing, and positive results were communicated to the county health department. All SNF clinical and nonclinical staff members were also screened for SARS-CoV-2 by RT-PCR during March 29-April 10. Nineteen of 99 (19%) residents and eight of 136 (6%) staff members had positive test results for SARS-CoV-2 during March 28-April 10; no further resident cases were identified on subsequent testing on April 13, April 22, and April 23. Fourteen of the 19 residents with COVID-19 were asymptomatic at the time of testing. Among these residents, eight developed symptoms 1-5 days after specimen collection and were later classified as presymptomatic; one of these patients died. This report describes an outbreak of COVID-19 in an SNF, with case identification accomplished by implementing several rounds of RT-PCR testing, permitting rapid isolation of both symptomatic and asymptomatic residents with COVID-19. The outbreak was successfully contained following implementation of this strategy.
    Keywords Humans ; Pneumonia ; Viral ; Coronavirus Infections ; Long-Term Care ; Clinical Laboratory Techniques ; Reverse Transcriptase Polymerase Chain Reaction ; Disease Outbreaks ; Aged ; 80 and over ; Veterans ; Skilled Nursing Facilities ; Los Angeles ; Female ; Male ; Pandemics ; Betacoronavirus ; Veterans Health Services ; General & Internal Medicine ; covid19
    Publishing date 2020-05-29
    Publisher eScholarship, University of California
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial PCR Testing, and Cohorting of Positive SARS-CoV-2 Patients in a Skilled Nursing Facility.

    Dora, Amy V / Winnett, Alexander / Fulcher, Jennifer A / Sohn, Linda / Calub, Feliza / Lee-Chang, Ian / Ghadishah, Elham / Schwartzman, William A / Beenhouwer, David O / Vallone, John / Graber, Christopher J / Goetz, Matthew Bidwell / Bhattacharya, Debika

    2020  

    Abstract: We characterized serology following a nursing home outbreak where residents were serially tested by RT-PCR and positive residents were cohorted. When tested 46-76 days later, 24/26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR- ... ...

    Abstract We characterized serology following a nursing home outbreak where residents were serially tested by RT-PCR and positive residents were cohorted. When tested 46-76 days later, 24/26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR-negative residents had confirmed seropositivity, supporting serial SARS-CoV-2 RT-PCR testing and cohorting in nursing homes.
    Keywords COVID-19 ; SARS-CoV-2 serology ; infection control ; long-term care facility ; Biological Sciences ; Medical and Health Sciences ; Microbiology ; covid19
    Publishing date 2020-08-28
    Publisher eScholarship, University of California
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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