Article ; Online: COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity.
2022 Volume 74, Issue 4, Page(s) 381–407
Abstract: COVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the ... ...
| Abstract | COVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the international scientific community is engaged in elucidating the molecular mechanisms of the pathophysiology of SARS-CoV-2 infection as a basis of scientific developments for the future control of COVID-19. Global exome and genome analysis efforts work to define the human genetics of protective immunity to SARS-CoV-2 infection. Here, we review the current knowledge regarding the SARS-CoV-2 infection, the implications of COVID-19 to Public Health and discuss genotype to phenotype association approaches that could be exploited through the selection of candidate genes to identify the genetic determinants of severe COVID-19. |
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| MeSH term(s) | COVID-19/genetics ; Genetic Predisposition to Disease ; Humans ; Pandemics ; Public Health ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2022-03-29 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 186560-2 | |||||
| ISSN | 1432-1211 ; 0093-7711 | |||||
| ISSN (online) | 1432-1211 | |||||
| ISSN | 0093-7711 | |||||
| DOI | 10.1007/s00251-022-01261-w | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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