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  1. Article ; Online: Gram-positive bacterial membrane lipids at the host-pathogen interface.

    Joyce, Luke R / Doran, Kelly S

    PLoS pathogens

    2023  Volume 19, Issue 1, Page(s) e1011026

    MeSH term(s) Membrane Lipids ; Virulence ; Bacterial Outer Membrane Proteins ; Gram-Positive Bacteria ; Host-Pathogen Interactions
    Chemical Substances Membrane Lipids ; Bacterial Outer Membrane Proteins
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complete m6A and m4C methylomes for group B streptococcal clinical isolates CJB111, A909, COH1, and NEM316.

    Manzer, Haider S / Doran, Kelly S

    Microbiology resource announcements

    2023  Volume 13, Issue 1, Page(s) e0073323

    Abstract: ... Group ... ...

    Abstract Group B
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00733-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Group B Streptococcus and diabetes: Finding the sweet spot.

    Keogh, Rebecca A / Doran, Kelly S

    PLoS pathogens

    2023  Volume 19, Issue 2, Page(s) e1011133

    MeSH term(s) Humans ; Diabetes Mellitus ; Streptococcus agalactiae
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of interkingdom microbial interactions in the vaginal tract.

    Cohen, Shirli / Ost, Kyla S / Doran, Kelly S

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012018

    MeSH term(s) Female ; Humans ; Microbial Interactions ; Vagina
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012018
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  5. Article ; Online: Human Milk Oligosaccharides versus Streptococcus: How a Human-Made Natural Product Protects Us from Pathogens.

    Lyon, Laurie M / Doran, Kelly S

    mSphere

    2022  Volume 7, Issue 1, Page(s) e0004922

    Abstract: Group B Streptococcus (GBS) is a Gram-positive bacterium that colonizes the lower gastrointestinal tract, and in females, the urogenital tract, in up to 30% of healthy adults. However, GBS is a leading cause of mortality and morbidity in newborns due to ... ...

    Abstract Group B Streptococcus (GBS) is a Gram-positive bacterium that colonizes the lower gastrointestinal tract, and in females, the urogenital tract, in up to 30% of healthy adults. However, GBS is a leading cause of mortality and morbidity in newborns due to ascending infection of the womb or by neonatal acquisition during vaginal passage. GBS neonatal disease manifests as pneumonia, sepsis, or meningitis, and an estimated 4 million newborns die each year globally. This commentary reflects on recent work by Mejia and colleagues (M. E. Mejia, S. Ottinger, A. Vrbanac, P. Babu, et al., mSphere 6:e00885-21, 2022, https://doi.org/10.1128/msphere.00885-21) that has examined human milk oligosaccharides (HMOs) as a natural product with anti-GBS activity. They show that HMOs reduce GBS vaginal colonization without impacting the normal vaginal microbiota. This study advances the possibility of using novel therapeutics to limit GBS maternal colonization and subsequent neonatal disease.
    MeSH term(s) Adult ; Biological Products ; Female ; Humans ; Infant, Newborn ; Milk, Human ; Oligosaccharides ; Streptococcus ; Streptococcus agalactiae
    Chemical Substances Biological Products ; Oligosaccharides
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00049-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evolving understanding of the type VII secretion system in Gram-positive bacteria.

    Spencer, Brady L / Doran, Kelly S

    PLoS pathogens

    2022  Volume 18, Issue 7, Page(s) e1010680

    MeSH term(s) Bacterial Proteins ; Gram-Positive Bacteria ; Type VII Secretion Systems
    Chemical Substances Bacterial Proteins ; Type VII Secretion Systems
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Identification of a DNA-cytosine methyltransferase that impacts global transcription to promote group B streptococcal vaginal colonization.

    Manzer, Haider S / Brunetti, Tonya / Doran, Kelly S

    mBio

    2023  , Page(s) e0230623

    Abstract: ... Group ... ...

    Abstract Group B
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02306-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis.

    Manzer, Haider S / Villarreal, Ricardo I / Doran, Kelly S

    PLoS pathogens

    2022  Volume 18, Issue 3, Page(s) e1010397

    Abstract: Bacterial infections are a major cause of morbidity and mortality worldwide and the rise of antibiotic resistance necessitates development of alternative treatments. Pathogen adhesins that bind to host cells initiate disease pathogenesis and represent ... ...

    Abstract Bacterial infections are a major cause of morbidity and mortality worldwide and the rise of antibiotic resistance necessitates development of alternative treatments. Pathogen adhesins that bind to host cells initiate disease pathogenesis and represent potential therapeutic targets. We have shown previously that the BspC adhesin in Group B Streptococcus (GBS), the leading cause of bacterial neonatal meningitis, interacts with host vimentin to promote attachment to brain endothelium and disease development. Here we determined that the BspC variable (V-) domain contains the vimentin binding site and promotes GBS adherence to brain endothelium. Site directed mutagenesis identified a binding pocket necessary for GBS host cell interaction and development of meningitis. Using a virtual structure-based drug screen we identified compounds that targeted the V-domain binding pocket, which blocked GBS adherence and entry into the brain in vivo. These data indicate the utility of targeting the pathogen-host interface to develop anti-virulence therapeutics.
    MeSH term(s) Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Humans ; Infant, Newborn ; Meningitis, Bacterial/metabolism ; Streptococcal Infections/microbiology ; Streptococcus agalactiae ; Vimentin/metabolism ; Virulence
    Chemical Substances Adhesins, Bacterial ; Vimentin
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Metal Homeostasis in Pathogenic Streptococci.

    Akbari, Madeline S / Doran, Kelly S / Burcham, Lindsey R

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: ... ...

    Abstract Streptococcus
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Staphylococcus aureus

    Lyon, Laurie M / Doran, Kelly S / Horswill, Alexander R

    Infection and immunity

    2022  Volume 91, Issue 1, Page(s) e0046022

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and frequent colonizer of human skin and mucosal membranes, including the vagina, with vaginal colonization reaching nearly 25% in some pregnant populations. MRSA vaginal ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and frequent colonizer of human skin and mucosal membranes, including the vagina, with vaginal colonization reaching nearly 25% in some pregnant populations. MRSA vaginal colonization can lead to aerobic vaginitis (AV), and during pregnancy, bacterial ascension into the upper reproductive tract can lead to adverse birth outcomes. USA300, the most prominent MRSA lineage to colonize pregnant individuals, is a robust biofilm former and causative agent of invasive infections; however, little is known about how it colonizes and ascends in the female reproductive tract (FRT). Our previous studies showed that a MRSA mutant of seven fibrinogen-binding adhesins was deficient in FRT epithelial attachment and colonization. Using both monolayer and multilayer air-liquid interface cell culture models, we determine that one class of these adhesins, the fibronectin binding proteins (FnBPA and FnBPB), are critical for association with human vaginal epithelial cells (hVECs) and hVEC invasion through interactions with α
    MeSH term(s) Female ; Humans ; Animals ; Mice ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Carrier Proteins/metabolism ; Fibronectins/genetics ; Fibronectins/metabolism ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Staphylococcal Infections/microbiology
    Chemical Substances Carrier Proteins ; Fibronectins ; Adhesins, Bacterial
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00460-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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