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  1. AU="Dorjsuren, Bilguujin"
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  1. Article ; Online: RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.

    Santoriello, Cristina / Sporrij, Audrey / Yang, Song / Flynn, Ryan A / Henriques, Telmo / Dorjsuren, Bilguujin / Custo Greig, Eugenia / McCall, Wyatt / Stanhope, Meredith E / Fazio, Maurizio / Superdock, Michael / Lichtig, Asher / Adatto, Isaac / Abraham, Brian J / Kalocsay, Marian / Jurynec, Michael / Zhou, Yi / Adelman, Karen / Calo, Eliezer /
    Zon, Leonard I

    Nature cell biology

    2020  Volume 22, Issue 4, Page(s) 372–379

    Abstract: The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates the effective transcription ... ...

    Abstract The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates the effective transcription elongation of genes required for neural crest development and melanoma growth in vivo
    MeSH term(s) Animals ; Cell Line, Tumor ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Dihydroorotate Dehydrogenase ; Embryo, Nonmammalian ; Gene Expression Regulation, Developmental ; Humans ; Leflunomide/pharmacology ; Melanocytes/drug effects ; Melanocytes/metabolism ; Melanocytes/pathology ; Neural Crest/drug effects ; Neural Crest/growth & development ; Neural Crest/metabolism ; Nucleotides ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Progesterone/metabolism ; Protein Binding ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism ; Signal Transduction ; Stress, Physiological/genetics ; Transcription Elongation, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Dihydroorotate Dehydrogenase ; Nucleotides ; Phosphoproteins ; Receptors, Progesterone ; Transcription Factors ; Zebrafish Proteins ; Progesterone (4G7DS2Q64Y) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; DDX1 protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) ; ddx21 protein, zebrafish (EC 3.6.4.13) ; Leflunomide (G162GK9U4W)
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-020-0493-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 12: Show issues

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  2. Article ; Online: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.

    Rossmann, Marlies P / Hoi, Karen / Chan, Victoria / Abraham, Brian J / Yang, Song / Mullahoo, James / Papanastasiou, Malvina / Wang, Ying / Elia, Ilaria / Perlin, Julie R / Hagedorn, Elliott J / Hetzel, Sara / Weigert, Raha / Vyas, Sejal / Nag, Partha P / Sullivan, Lucas B / Warren, Curtis R / Dorjsuren, Bilguujin / Greig, Eugenia Custo /
    Adatto, Isaac / Cowan, Chad A / Schreiber, Stuart L / Young, Richard A / Meissner, Alexander / Haigis, Marcia C / Hekimi, Siegfried / Carr, Steven A / Zon, Leonard I

    Science (New York, N.Y.)

    2021  Volume 372, Issue 6543, Page(s) 716–721

    Abstract: Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been defined. We discovered, using a chemical suppressor screen, that inhibition of the pyrimidine ... ...

    Abstract Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been defined. We discovered, using a chemical suppressor screen, that inhibition of the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) rescues erythroid differentiation in bloodless zebrafish
    MeSH term(s) Animals ; Citric Acid Cycle ; DNA Methylation ; Dihydroorotate Dehydrogenase ; Electron Transport ; Embryo, Nonmammalian/metabolism ; Enzyme Inhibitors/pharmacology ; Erythropoiesis ; Gene Expression Regulation ; Histones/metabolism ; Leflunomide/pharmacology ; Metabolic Networks and Pathways ; Methylation ; Mitochondria/metabolism ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Oxygen Consumption ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Ubiquinone/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Dihydroorotate Dehydrogenase ; Enzyme Inhibitors ; Histones ; Transcription Factors ; Zebrafish Proteins ; transcriptional intermediary factor 1gamma, zebrafish ; Ubiquinone (1339-63-5) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; Leflunomide (G162GK9U4W)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz2740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  3. Article: A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis.

    Paik, Elizabeth J / Mahony, Shaun / White, Richard M / Price, Emily N / Dibiase, Anthony / Dorjsuren, Bilguujin / Mosimann, Christian / Davidson, Alan J / Gifford, David / Zon, Leonard I

    Stem cell reports

    2013  Volume 1, Issue 5, Page(s) 425–436

    Abstract: Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed ... ...

    Abstract Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed chromatin immunoprecipitation sequencing (ChIP-seq) combined with gene-expression profiling in zebrafish, and identified the transcription factor spalt-like 4 (sall4) as a Cdx4 target. ChIP-seq revealed that Sall4 bound to its own gene locus and the cdx4 locus. Expression profiling showed that Cdx4 and Sall4 coregulate genes that initiate hematopoiesis, such as hox, scl, and lmo2. Combined cdx4/sall4 gene knockdown impaired erythropoiesis, and overexpression of the Cdx4 and Sall4 target genes scl and lmo2 together rescued the erythroid program. These findings suggest that auto- and cross-regulation of Cdx4 and Sall4 establish a stable molecular circuit in the mesoderm that facilitates the activation of the blood-specific program as development proceeds.
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; Hematopoiesis ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Mesoderm/cytology ; Mesoderm/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Homeodomain Proteins ; LIM Domain Proteins ; Sall4 protein, zebrafish ; Transcription Factors ; Zebrafish Proteins ; cdx4 protein, zebrafish ; lmo2 protein, zebrafish
    Language English
    Publishing date 2013-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2013.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NMR detection of structures in the HIV-1 5'-leader RNA that regulate genome packaging.

    Lu, Kun / Heng, Xiao / Garyu, Lianko / Monti, Sarah / Garcia, Eric L / Kharytonchyk, Siarhei / Dorjsuren, Bilguujin / Kulandaivel, Gowry / Jones, Simonne / Hiremath, Atheeth / Divakaruni, Sai Sachin / LaCotti, Courtney / Barton, Shawn / Tummillo, Daniel / Hosic, Azra / Edme, Kedy / Albrecht, Sara / Telesnitsky, Alice / Summers, Michael F

    Science (New York, N.Y.)

    2010  Volume 334, Issue 6053, Page(s) 242–245

    Abstract: The 5'-leader of the HIV-1 genome regulates multiple functions during viral replication via mechanisms that have yet to be established. We developed a nuclear magnetic resonance approach that enabled direct detection of structural elements within the ... ...

    Abstract The 5'-leader of the HIV-1 genome regulates multiple functions during viral replication via mechanisms that have yet to be established. We developed a nuclear magnetic resonance approach that enabled direct detection of structural elements within the intact leader (712-nucleotide dimer) that are critical for genome packaging. Residues spanning the gag start codon (AUG) form a hairpin in the monomeric leader and base pair with residues of the unique-5' region (U5) in the dimer. U5:AUG formation promotes dimerization by displacing and exposing a dimer-promoting hairpin and enhances binding by the nucleocapsid (NC) protein, which is the cognate domain of the viral Gag polyprotein that directs packaging. Our findings support a packaging mechanism in which translation, dimerization, NC binding, and packaging are regulated by a common RNA structural switch.
    MeSH term(s) 5' Untranslated Regions ; Base Pairing ; Binding Sites ; Codon, Initiator ; Dimerization ; Genes, gag ; Genome, Viral ; HIV-1/genetics ; HIV-1/physiology ; Human Immunodeficiency Virus Proteins/metabolism ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Nucleic Acid Conformation ; Nucleocapsid Proteins/metabolism ; Protein Binding ; Protein Biosynthesis ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Virus Assembly ; gag Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances 5' Untranslated Regions ; Codon, Initiator ; Human Immunodeficiency Virus Proteins ; Nucleocapsid Proteins ; RNA, Viral ; gag Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2010-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1210460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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