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  1. Article ; Online: Role of the RAAS in mediating the pathophysiology of COVID-19.

    Jasiczek, Jakub / Doroszko, Adrian / Trocha, Tymoteusz / Trocha, Małgorzata

    Pharmacological reports : PR

    2024  

    Abstract: The renin-angiotensin-aldosterone system (RAAS) holds a position of paramount importance as enzymatic and endocrine homeostatic regulator concerning the water-electrolyte and acid-base balance. Nevertheless, its intricacy is influenced by the presence of ...

    Abstract The renin-angiotensin-aldosterone system (RAAS) holds a position of paramount importance as enzymatic and endocrine homeostatic regulator concerning the water-electrolyte and acid-base balance. Nevertheless, its intricacy is influenced by the presence of various complementary angiotensins and their specific receptors, thereby modifying the primary RAAS actions. Angiotensin-converting enzyme 2 (ACE2) acts as a surface receptor for SARS-CoV-2, establishing an essential connection between RAAS and COVID-19 infection. Despite the recurring exploration of the RAAS impact on the trajectory of COVID-19 along with the successful resolution of many inquiries, its complete role in the genesis of delayed consequences encompassing long COVID and cardiovascular thrombotic outcomes during the post-COVID phase as well as post-vaccination, remains not fully comprehended. Particularly noteworthy is the involvement of the RAAS in the molecular mechanisms underpinning procoagulant processes throughout COVID-19. These processes significantly contribute to the pathogenesis of organ complications as well as determine clinical outcomes and are discussed in this manuscript.
    Language English
    Publishing date 2024-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-024-00596-3
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    Zs.A 861: Show issues Location:
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  2. Article ; Online: Coronary microvascular dysfunction in the context of long COVID-19: What is the effect of anti-inflammatory treatment? Author's reply.

    Doroszko, Adrian / Rola, Piotr / Włodarczak, Szymon / Lesiak, Maciej / Włodarczak, Adrian

    Kardiologia polska

    2023  Volume 81, Issue 3, Page(s) 320–321

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Myocardial Ischemia ; Anti-Inflammatory Agents
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2023-02-06
    Publishing country Poland
    Document type Letter ; Comment
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2023.0040
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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  3. Article: Use of the Shock Wave Therapy in Basic Research and Clinical Applications-From Bench to Bedsite.

    Rola, Piotr / Włodarczak, Adrian / Barycki, Mateusz / Doroszko, Adrian

    Biomedicines

    2022  Volume 10, Issue 3

    Abstract: Shock Waves (SW) are acoustic disturbances that propagate through a medium carrying the energy. These specific sonic pulses are composed of two phases—high positive pressure, a rise time < 10 ns, and a tensile wave. Originally Shock Waves were introduced ...

    Abstract Shock Waves (SW) are acoustic disturbances that propagate through a medium carrying the energy. These specific sonic pulses are composed of two phases—high positive pressure, a rise time < 10 ns, and a tensile wave. Originally Shock Waves were introduced to clinical practice as a part of the lithotripsy therapy focused on disrupting calcific deposits in the body. Since that time, shock wave therapy (SWT) has gone far beyond the original application related to the destruction of kidney stones. In this narrative Review, we present basic clinical applications of the SWT along with the potential therapeutic application in clinical practice.
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10030568
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  4. Article: Role of Erythrocytes in Nitric Oxide Metabolism and Paracrine Regulation of Endothelial Function.

    Gajecki, Damian / Gawryś, Jakub / Szahidewicz-Krupska, Ewa / Doroszko, Adrian

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Emerging studies provide new data shedding some light on the complex and pivotal role of red blood cells (RBCs) in nitric oxide (NO) metabolism and paracrine regulation of endothelial function. NO is involved in the regulation of vasodilatation, platelet ...

    Abstract Emerging studies provide new data shedding some light on the complex and pivotal role of red blood cells (RBCs) in nitric oxide (NO) metabolism and paracrine regulation of endothelial function. NO is involved in the regulation of vasodilatation, platelet aggregation, inflammation, hypoxic adaptation, and oxidative stress. Even though tremendous knowledge about NO metabolism has been collected, the exact RBCs' status still requires evaluation. This paper summarizes the actual knowledge regarding the role of erythrocytes as a mobile depot of amino acids necessary for NO biotransformation. Moreover, the complex regulation of RBCs' translocases is presented with a particular focus on cationic amino acid transporters (CATs) responsible for the NO substrates and derivatives transport. The main part demonstrates the intraerythrocytic metabolism of L-arginine with its regulation by reactive oxygen species and arginase activity. Additionally, the process of nitrite and nitrate turnover was demonstrated to be another stable source of NO, with its reduction by xanthine oxidoreductase or hemoglobin. Additional function of hemoglobin in NO synthesis and its subsequent stabilization in steady intermediates is also discussed. Furthermore, RBCs regulate the vascular tone by releasing ATP, inducing smooth muscle cell relaxation, and decreasing platelet aggregation. Erythrocytes and intraerythrocytic NO metabolism are also responsible for the maintenance of normotension. Hence, RBCs became a promising new therapeutic target in restoring NO homeostasis in cardiovascular disorders.
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050943
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  5. Article ; Online: Utilizing orbital atherectomy for stentablation following unsuccessful S-IVL of an underexpanded stent.

    Furtan, Łukasz / Rola, Piotr / Włodarczak, Szymon / Barycki, Mateusz / Włodarczak, Piotr / Doroszko, Adrian / Włodarczak, Adrian / Lesiak, Maciej

    Kardiologia polska

    2024  

    Language English
    Publishing date 2024-05-07
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/v.phj.100437
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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  6. Article ; Online: The bioresorbable magnesium scaffold (Magmaris)-State of the art: From basic concept to clinical application.

    Rola, Piotr / Włodarczak, Szymon / Doroszko, Adrian / Lesiak, Maciej / Włodarczak, Adrian

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2022  Volume 100, Issue 6, Page(s) 1051–1058

    Abstract: Since its introduction to clinical practice, coronary artery stent implantation has become a crucial part of the therapy of coronary artery disease (CAD). Despite the undeniable evolution of percutaneous coronary revascularization procedures, drug- ... ...

    Abstract Since its introduction to clinical practice, coronary artery stent implantation has become a crucial part of the therapy of coronary artery disease (CAD). Despite the undeniable evolution of percutaneous coronary revascularization procedures, drug-eluting stent (DES) technology shows some limitations. To overcome these limitations bioresorbable vascular scaffolds (BRS) were designed as a vessel-supporting technology allowing for anatomical and functional restoration of the vessel after the scaffold intended resorption. Various materials have been proposed as the basis of the scaffold backbone. In this narrative review, we present second-generation magnesium-alloy bioresorbable scaffold devices (Magmaris; Biotronik). Additionally, we discuss available preclinical and clinical data regarding this new magnesium BRS.
    MeSH term(s) Humans ; Drug-Eluting Stents ; Magnesium ; Absorbable Implants ; Treatment Outcome ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Percutaneous Coronary Intervention/adverse effects ; Prosthesis Design
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30435
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    Zs.A 1226: Show issues Location:
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  7. Article ; Online: Coronary sinus reducer implantation in a patient after previous CABG, PCI, TAVI, MitraClip, and CRT-D.

    Włodarczak, Szymon / Rola, Piotr / Jastrzębski, Artur / Woitek, Felix / Doroszko, Adrian / Lesiak, Maciej

    Polish archives of internal medicine

    2023  Volume 133, Issue 7-8

    MeSH term(s) Humans ; Coronary Sinus ; Percutaneous Coronary Intervention ; Coronary Artery Disease ; Heart ; Coronary Artery Bypass ; Treatment Outcome
    Language English
    Publishing date 2023-07-04
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16523
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    Zs.A 360: Show issues Location:
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  8. Article ; Online: Role of the eNOS Uncoupling and the Nitric Oxide Metabolic Pathway in the Pathogenesis of Autoimmune Rheumatic Diseases.

    Łuczak, Anna / Madej, Marta / Kasprzyk, Agata / Doroszko, Adrian

    Oxidative medicine and cellular longevity

    2020  Volume 2020, Page(s) 1417981

    Abstract: Atherosclerosis and its clinical complications constitute the major healthcare problems of the world population. Due to the central role of endothelium throughout the atherosclerotic disease process, endothelial dysfunction is regarded as a common ... ...

    Abstract Atherosclerosis and its clinical complications constitute the major healthcare problems of the world population. Due to the central role of endothelium throughout the atherosclerotic disease process, endothelial dysfunction is regarded as a common mechanism for various cardiovascular (CV) disorders. It is well established that patients with rheumatic autoimmune diseases are characterized by significantly increased prevalence of cardiovascular morbidity and mortality compared with the general population. The current European guidelines on cardiovascular disease (CVD) prevention in clinical practice recommend to use a 1,5-factor multiplier for CV risk in rheumatoid arthritis as well as in other autoimmune inflammatory diseases. However, mechanisms of accelerated atherosclerosis in these diseases, especially in the absence of traditional risk factors, still remain unclear. Oxidative stress plays the major role in the endothelial dysfunction and recently is strongly attributed to endothelial NO synthase dysfunction (eNOS uncoupling). Converted to a superoxide-producing enzyme, uncoupled eNOS not only leads to reduction of the nitric oxide (NO) generation but also potentiates the preexisting oxidative stress, which contributes significantly to atherogenesis. However, to date, there are no systemic analyses on the role of eNOS uncoupling in the excess CV mortality linked with autoimmune rheumatic diseases. The current review paper addresses this issue.
    MeSH term(s) Animals ; Autoimmune Diseases/enzymology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Humans ; Metabolic Networks and Pathways ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Rheumatic Diseases/enzymology ; Rheumatic Diseases/immunology ; Rheumatic Diseases/metabolism ; Signal Transduction
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2020/1417981
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  9. Article ; Online: Novel Approaches for Diagnosing and Management of Cardiovascular Disorders Mediated by Oxidative Stress.

    Doroszko, Adrian / Radziwon-Balicka, Aneta / Skomro, Robert

    Oxidative medicine and cellular longevity

    2020  Volume 2020, Page(s) 7096727

    MeSH term(s) Animals ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Diabetes Complications/diagnosis ; Diabetes Complications/therapy ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Humans ; Molecular Targeted Therapy ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Vascular Calcification
    Chemical Substances GPBAR1 protein, human ; Reactive Oxygen Species ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2020/7096727
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  10. Article: First experience with orbital atherectomy in calcified unprotected left main percutaneous coronary intervention.

    Rola, Piotr / Włodarczak, Szymon / Furtan, Łukasz / Doroszko, Adrian / Lesiak, Maciej / Włodarczak, Adrian

    Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

    2022  Volume 19, Issue 1, Page(s) 64–66

    Language English
    Publishing date 2022-12-22
    Publishing country Poland
    Document type Journal Article
    ISSN 1734-9338
    ISSN 1734-9338
    DOI 10.5114/aic.2022.121990
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