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Article: Behavioral Patterns in Special Education. Good Teaching Practices.

Rodríguez-Dorta, Manuela / Borges, África

2017 Volume 8, Page(s) 631

Abstract: Providing quality education means to respond to the diversity in the classroom. The teacher is a key figure in responding to the various educational needs presented by students. Specifically, special education professionals are of great importance as ... ...

Abstract	Providing quality education means to respond to the diversity in the classroom. The teacher is a key figure in responding to the various educational needs presented by students. Specifically, special education professionals are of great importance as they are the ones who lend their support to regular classroom teachers and offer specialized educational assistance to students who require it. Therefore, special education is different from what takes place in the regular classroom, demanding greater commitment by the teacher. There are certain behaviors, considered good teaching practices, which teachers have always been connected with to achieve good teaching and good learning. To ensure that these teachers are carrying out their educational work properly it is necessary to evaluate. This means having appropriate instruments. The Observational Protocol for Teaching Functions in Primary School and Special Education (PROFUNDO-EPE, v.3., in Spanish) allows to capture behaviors from these professionals and behavioral patterns that correspond to good teaching practices. This study evaluates the behavior of two special education teachers who work with students from different educational stages and educational needs. It reveals that the analyzed teachers adapt their behavior according the needs and characteristics of their students to the students responding more adequately to the needs presented by the students and showing good teaching practices. The patterns obtained indicate that they offer support, help and clear guidelines to perform the tasks. They motivate them toward learning by providing positive feedback and they check that students have properly assimilated the contents through questions or non-verbal supervision. Also, they provide a safe and reliable climate for learning.
Language	English
Publishing date	2017-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2017.00631
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Article ; Online: Pain location and widespread pain in youth with orthopaedic conditions: Exploration of the reliability and validity of a body map.

Foxen-Craft, E / Scott, E L / Kullgren, K A / Philliben, R / Hyman, C / Dorta, M / Murphy, A / Voepel-Lewis, T

European journal of pain (London, England)

2018 Volume 23, Issue 1, Page(s) 57–65

Abstract: Background: Pain location and widespread pain are important but underexamined dimensions of paediatric pain. Body map tools to assess pain location in youth have been used for several decades, but few studies have established reliability and validity of ...

Abstract	Background: Pain location and widespread pain are important but underexamined dimensions of paediatric pain. Body map tools to assess pain location in youth have been used for several decades, but few studies have established reliability and validity of these measures. The purpose of this study was to explore the reliability and validity of a pain body map among youth with orthopaedic conditions before surgery. Method: Youth ages 10-17 years completed the body map and other self-reported outcomes at their preoperative clinic visit and at their day of surgery. Results: Most (91.7%) youth had small discrepancy between body map scores at preoperative clinic visit (baseline) and day of surgery (second assessment), and site-to-site agreement ranged from 78% to 98%. Those with back and lower extremity diagnoses had high correspondence between body map sites and diagnostic sites. Body map scores and widespread pain were associated with other dimensions of pain, as well as other patient-reported outcomes. Higher pain intensity and widespread pain predicted greater discrepancy between body map scores. Conclusions: These results support the use of body map tools in further research examining widespread pain among youth by demonstrating adequate reliability, descriptive validity and associative validity. Significance: These results contribute to the limited information regarding psychometric properties of paediatric pain body maps, provide novel information about widespread pain among youth undergoing orthopaedic surgeries, and pave the way for improved assessment and treatment of paediatric pain.
MeSH term(s)	Adolescent ; Child ; Female ; Fractures, Bone/complications ; Fractures, Bone/surgery ; Humans ; Male ; Musculoskeletal Pain/diagnosis ; Musculoskeletal Pain/physiopathology ; Orthopedics ; Pain Measurement/methods ; Psychometrics ; Reproducibility of Results ; Scoliosis/complications ; Scoliosis/surgery
Language	English
Publishing date	2018-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.1282
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Article: COVID-19 impact and predictive factors for mortality in cancer patients

Sanz Garcia, E. / Peinado, P. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Rodriguez Pascual, J. / Ugidos, L. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

Annals of Oncology

Abstract: Background: SARS-CoV-2 is a novel coronavirus that has been responsible for the largest pandemic in the last century: COVID-19 This disease has widely affected Spain with a high lethality in ancient patients (pts) and with comorbidities Oncological pts ... ...

Abstract	Background: SARS-CoV-2 is a novel coronavirus that has been responsible for the largest pandemic in the last century: COVID-19 This disease has widely affected Spain with a high lethality in ancient patients (pts) and with comorbidities Oncological pts were not an exception Methods: We evaluated the association between COVID-19 mortality and clinical/laboratory/radiological parameters in cancer pts from March to April 2020 at our institution Past medical history and COVID-19-related parameters (symptoms, laboratory/x-ray findings and treatments) were retrospectively collected Univariate analysis (UA) has been done using Fisher exact and U-Mann-Withney test for qualitative and quantitative variables, respectively Multivariant analysis (MA) has been done using logistic regression Results: Forty three hospitalized pts were diagnosed with COVID-19;30 pts (69 8%) were symptomatic on admission and 13 pts (30 2%) were hospital-acquired cases Median age was 68 8 ± 7 8 years Most part of the pts had gastrointestinal (GI) (13;30 2%), thoracic (Tx) (12;27 9%) and breast (6;14%) cancer A higher prevalence of Tx tumours compared to our new pts prevalence is observed (9%) Fever was the most common symptom (27;62 8%) and bilateral pneumonia was observed in 24 pts (55 8%) SARS-Co-V-2 PCR was positive in 34 pts (79 1%) Hydroxychloroquine was administered in 35 pts (81 4%), steroids and antiretrovirals in 19 pts (44 1%) and tocilizumab in 12 pts (27 9%) Mortality rate due to COVID-19 was 30 23% (13 pts) and 8 pts could resume oncological treatment Hypertension (HTA) and previous daily steroids given during last month before admission;as well as performance status, fever, Curb-65, SOFA score and D-Dimer (DD) at admission were associated with COVID-19 mortality in UA Similarly, high flow oxygen requirements during hospitalization and DD at 72 hours are predictors of mortality HTA [OR: 8 3 (1-5-70 1)], steroids [OR: 10 7 (1 3 – 143 8)] and fever [OR: 0 09 (0 01 – 0 55)]were also associated in MA Conclusions: COVID-19 showed a relative higher incidence in pts with Tx and GI tumours Some clinical and laboratory parameters were found to be predictive factors for mortality as previously reported in non-cancer pts Further investigations with larger number of pts are needed Legal entity responsible for the study: HM Hospitales Funding: Has not received any funding Disclosure: All authors have declared no conflicts of interest
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #806039
Database	COVID19

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Article ; Online: 1760P COVID-19 severe pneumonia in cancer patients

Peinado, P. / Sanz Garcia, E. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Ugidos, L. / Rodriguez Pascual, J. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

Annals of Oncology

Impact and predictive factors

2020 Volume 31, Page(s) S1024

Keywords	Oncology ; Hematology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2020.08.1824
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 1749P COVID-19 impact and predictive factors for mortality in cancer patients

Sanz Garcia, E. / Peinado, P. / Moreno, I. / Dorta, M. / Alvarez, B. / Alvarez Gallego, R. / Madurga, R. / Rodriguez Pascual, J. / Ugidos, L. / Muñoz, C. / Garcia-Rico, E. / Cubillo, A.

Annals of Oncology

2020 Volume 31, Page(s) S1021

Keywords	Oncology ; Hematology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2020.08.1813
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Article ; Online: Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes.

Ayra-Plasencia, Jessel / Ramos-Pérez, Cristina / Santana-Sosa, Silvia / Quevedo, Oliver / Medina-Suárez, Sara / Matos-Perdomo, Emiliano / Zamora-Dorta, Marcos / Brown, Grant W / Lisby, Michael / Machín, Félix

Scientific reports

2021 Volume 11, Issue 1, Page(s) 14940

Abstract: The key role of Topoisomerase II (Top2) is the removal of topological intertwines between sister chromatids. In yeast, inactivation of Top2 brings about distinct cell cycle responses. In the case of the conditional top2-5 allele, interphase and mitosis ... ...

Abstract	The key role of Topoisomerase II (Top2) is the removal of topological intertwines between sister chromatids. In yeast, inactivation of Top2 brings about distinct cell cycle responses. In the case of the conditional top2-5 allele, interphase and mitosis progress on schedule but cells suffer from a chromosome segregation catastrophe. We here show that top2-5 chromosomes fail to enter a Pulsed-Field Gel Electrophoresis (PFGE) in the first cell cycle, a behavior traditionally linked to the presence of replication and recombination intermediates. We distinguished two classes of affected chromosomes: the rDNA-bearing chromosome XII, which fails to enter a PFGE at the beginning of S-phase, and all the other chromosomes, which fail at a postreplicative stage. In synchronously cycling cells, this late PFGE retention is observed in anaphase; however, we demonstrate that this behavior is independent of cytokinesis, stabilization of anaphase bridges, spindle pulling forces and, probably, anaphase onset. Strikingly, once the PFGE retention has occurred it becomes refractory to Top2 re-activation. DNA combing, two-dimensional electrophoresis, genetic analyses, and GFP-tagged DNA damage markers suggest that neither recombination intermediates nor unfinished replication account for the postreplicative PFGE shift, which is further supported by the fact that the shift does not trigger the G
MeSH term(s)	Cell Cycle ; Chromosome Segregation ; Chromosomes, Fungal/genetics ; DNA Topoisomerases, Type II/deficiency ; DNA Topoisomerases, Type II/genetics ; Electrophoresis, Gel, Pulsed-Field ; Gene Knockout Techniques ; Mitosis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/physiology ; Saccharomyces cerevisiae Proteins/genetics
Chemical Substances	Saccharomyces cerevisiae Proteins ; TOP2 protein, S cerevisiae ; DNA Topoisomerases, Type II (EC 5.99.1.3)
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-93875-5
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Article ; Online: Clinical Utility and Outcomes Impact of Crystal Digital PCR of Sensitizing and Resistance EGFR Mutations in Patients With Advanced Non-Small Cell Lung Cancer.

Riudavets, Mariona / Lamberts, Virginie / Vasseur, Damien / Auclin, Edouard / Aldea, Mihaela / Jovelet, Cécile / Naltet, Charles / Lavaud, Pernelle / Gazzah, Anas / Aboubakar, Frank / Dorta, Miriam / Remon, Jordi / Rouleau, Etienne / Ngocamus, Maud / Nicotra, Claudio / Lacroix, Ludovic / Besse, Benjamin / Mezquita, Laura / Planchard, David

Clinical lung cancer

2022 Volume 23, Issue 6, Page(s) e377–e383

Abstract: Background: EGFRm represent 15% of advanced NSCLC in European patients. LB for molecular profiling offers a non-invasive alternative to tissue. cdPCR is a high-sensitive and low-cost LB to detect molecular alterations. We aimed to describe cdPCR ... ...

Abstract	Background: EGFRm represent 15% of advanced NSCLC in European patients. LB for molecular profiling offers a non-invasive alternative to tissue. cdPCR is a high-sensitive and low-cost LB to detect molecular alterations. We aimed to describe cdPCR clinical utility for EGFRm detection in advanced NSCLC. Methods: Prospective blood sample collection in patients with advanced NSCLC harbouring EGFRm either at diagnosis, under response or at PD between January 16 and September 20 at Gustave Roussy. LB was performed by cdPCR (Stilla): sensitizing (exon19; exon21 [p.L858R]) and exon 20 p.T790M resistance EGFRm. We defined high tumour burden (high-TB) as >2 metastatic sites. We analysed EGFRm detection by cdPCR and its correlation with progression-free and overall survival (PFS, OS). Results: A total of 252 blood samples were collected in 140 patients. At baseline (n=25), sensitizing EGFRm were detected in 64% of samples, 88% in patients with high-TB (n=8) and 40% among those with intracranial/intrathoracic isolated lesions (n=5). At PD to tyrosine-kinase inhibitors (TKI) (n=117), detection rate (sensitizing EGFRm) was 56%; 30% in patients with intracranial/thoracic isolated lesions (n=37) vs. 67% in those with high-TB (n=63). At PD to first/second generation TKI (n=81), the p.T790M mutation was found in 22% (18/81); detection rate was 9% for intracranial/thoracic (n=23) vs. 32% for high-TB (n=41) cases. The clearance of EGFRm allelic frequency was correlated with radiological response. The absence of EGFRm detection at TKI-failure was associated with longer OS (39.1 vs. 18.4 months; P=.02). Conclusions: cdPCR is a sensitive LB for sensitizing and resistance EGFRm detection. cdPCR positivity was more likely observed in systemic PD cases with high-TB. It is a low-cost EGFRm detecting approach to guide treatment in NSCLC, however metastatic profile should be taken into account.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation/genetics ; Polymerase Chain Reaction ; Prospective Studies ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2022.05.010
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Gefitinib plus tremelimumab combination in refractory non-small cell lung cancer patients harbouring EGFR mutations: The GEFTREM phase I trial.

Riudavets, Mariona / Naigeon, Marie / Texier, Matthieu / Dorta, Miriam / Barlesi, Fabrice / Mazieres, Julien / Varga, Andrea / Cassard, Lydie / Boselli, Lisa / Grivel, Jonathan / NgoCamus, Maud / Lacroix, Ludovic / Mezquita, Laura / Besse, Benjamin / Chaput, Nathalie / Planchard, David

Lung cancer (Amsterdam, Netherlands)

2021 Volume 166, Page(s) 255–264

Abstract: Introduction: A phase I open-label multicentre study was initiated to evaluate the association of tremelimumab with gefitinib in EGFR-mutant NSCLC patients who progressed after first-generation EGFR-TKI. Here we provide the efficacy data from the entire ...

Abstract	Introduction: A phase I open-label multicentre study was initiated to evaluate the association of tremelimumab with gefitinib in EGFR-mutant NSCLC patients who progressed after first-generation EGFR-TKI. Here we provide the efficacy data from the entire cohort. Material and methods: Patients with advanced EGFR-mutant NSCLC with progression after response to EGFR-TKI were enrolled. Study treatment was gefitinib 250 mg daily and tremelimumab at 3 dose levels: 3, 6 and 10 mg/kg IV Q4W for 6 cycles followed by Q12W until progression or unacceptable toxicity. The primary objective was safety and tolerability, and to establish a RP2D. Results: Between January 2014 and July 2015, 27 patients (21 in the escalating dose cohort and 6 in expansion cohort) received at least one dose of tremelimumab. DLTs occurred in 4 patients: 1 at 3 mg/kg (one grade 3 diarrhoea), 1 at 6 mg/kg (one grade 3 diarrhoea) and 2 at 10 mg/kg (one grade 3 diarrhoea and one grade 3 AST/ALT increase) of tremelimumab. Grade 3 TRAE occurred in 22 patients (81%), most frequently diarrhoea (30%) and ALT/AST increase (15%). Stable disease was the best overall response in 72% patients, with median PFS of 2.2 months (95% CI, 1.8-4.2). All patients discontinued treatment, most frequently due to disease progression (63% of patients). Conclusion: The recommended dose of tremelimumab in combination with gefitinib in EGFR-mutant NSCLC patients was 3 mg/kg. The gastrointestinal toxicity and the limited efficacy data prevented further evaluation of this combination. (GEFTREM; clinical trial number NCT02040064).
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Diarrhea/chemically induced ; ErbB Receptors/genetics ; Gefitinib/therapeutic use ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation
Chemical Substances	Antibodies, Monoclonal, Humanized ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; tremelimumab (QEN1X95CIX) ; Gefitinib (S65743JHBS)
Language	English
Publishing date	2021-12-03
Publishing country	Ireland
Document type	Clinical Trial, Phase I ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2021.11.018
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: A Multicenter Analysis of the Outcome of Cancer Patients with Neutropenia and COVID-19 Optionally Treated with Granulocyte-Colony Stimulating Factor (G-CSF): A Comparative Analysis.

Cancers

2021 Volume 13, Issue 16

Abstract: Background: Approximately 15% of patients infected by SARS-CoV-2 develop a distress syndrome secondary to a host hyperinflammatory response induced by a cytokine storm. Myelosuppression is associated with a higher risk of infections and mortality. There ...

Abstract	Background: Approximately 15% of patients infected by SARS-CoV-2 develop a distress syndrome secondary to a host hyperinflammatory response induced by a cytokine storm. Myelosuppression is associated with a higher risk of infections and mortality. There are data to support methods of management for neutropenia and COVID-19. We present a multicenter experience during the first COVID-19 outbreak in neutropenic cancer patients infected by SARS-CoV-2. Methods: Clinical retrospective data were collected from neutropenic cancer patients with COVID-19. Comorbidities, tumor type, stage, treatment, neutropenia severity, G-CSF, COVID-19 parameters, and mortality were analyzed. A bivariate analysis of the impact on mortality was carried out. Additionally, we performed a multivariable logistic regression to predict respiratory failure and death. Results: Among the 943 cancer patients screened, 83 patients (11.3%) simultaneously had neutropenia and an infection with COVID-19. The lungs (26%) and breasts (22%) were the primary locations affected, and most patients had advanced disease (67%). In the logistic model, as adjusted covariates, sex, age, treatment (palliative vs. curative), tumor type, and the lowest level of neutrophils were used. A significant effect was obtained for the number of days of G-CSF treatment (OR = 1.4, 95% CI [1,1,03,92], Conclusions: Our findings suggest that a prolonged G-CSF treatment could be disadvantageous for these cancer patients with infections by COVID-19, with a higher probability of worse outcome.
Language	English
Publishing date	2021-08-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13164205
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Article ; Online: Authors' reply to the letter to the editor by Sabour.

Foxen-Craft, Emily / Thompson, Aleda M / Scott, Eric L / Kullgren, Kristin A / Philliben, Reilly / Hyman, Caroline / Dorta, Marianna / Murphy, Anne / Voepel-Lewis, Terri

European journal of pain (London, England)

2018 Volume 23, Issue 1, Page(s) 199–200

MeSH term(s)	Humans ; Orthopedics ; Pain ; Reproducibility of Results
Language	English
Publishing date	2018-12-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.1345
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