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  1. Article ; Online: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus.

    Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / Dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / Dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

    Viruses

    2021  Volume 13, Issue 9

    Abstract: The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile ...

    Abstract The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (
    MeSH term(s) Adult ; Biomarkers/blood ; Blood Coagulation Factors/classification ; Blood Coagulation Factors/immunology ; Brazil ; Chemokines/blood ; Chemokines/classification ; Chemokines/immunology ; Cytokines/blood ; Cytokines/classification ; Cytokines/immunology ; Dengue/blood ; Dengue/immunology ; Dengue Virus/immunology ; Female ; Humans ; Inflammation ; Male ; Middle Aged ; Severity of Illness Index
    Chemical Substances Biomarkers ; Blood Coagulation Factors ; Chemokines ; Cytokines
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus

    Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

    Viruses. 2021 Sept. 08, v. 13, no. 9

    2021  

    Abstract: The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile ...

    Abstract The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (p < 0.001), IL-6 (p = 0.005), IL-10 (p < 0.001), IL-18 (p = 0.001), CXCL8/IL-8 (p < 0.001), CCL2/MCP-1 (p < 0.001), CXCL10/IP-10 (p = 0.001), fibrinogen (p = 0.037), D-dimer (p = 0.01) and TFPI (p = 0.042) and lower levels of TF (p = 0.042) compared to healthy controls. A principal component analysis (PCA) distinguished between two profiles of mediators of inflammation and coagulation: protective (TNF-α, IL-1β and CXCL8/IL-8) and pathological (IL-6, TF and TFPI). Lastly, multivariate logistic regression analysis identified high aspartate aminotransferase-to-platelet ratio index (APRI) as independent risk factors associated with severity (adjusted OR: 1.33; 95% CI 1.03–1.71; p = 0.027), the area under the receiver operating characteristics curve (AUC) was 0.775 (95% CI 0.681–0.869) and an optimal cutoff value was 1.4 (sensitivity: 76%; specificity: 79%), so it could be a useful marker for the triage of patients attending primary care centers.
    Keywords Dengue virus ; aspartic acid ; biomarkers ; coagulation ; dengue ; fibrinogen ; inflammation ; interleukin-10 ; interleukin-18 ; interleukin-6 ; principal component analysis ; regression analysis ; Brazil ; Latin America
    Language English
    Dates of publication 2021-0908
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091789
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy.

    Familiar-Macedo, Débora / Amancio Paiva, Iury / Badolato-Corrêa da Silva, Jessica / de Carvalho, Fabiana Rabe / Dias, Helver Gonçalves / Pauvolid-Corrêa, Alex / Dos Santos, Caroline Fernandes / Gandini, Mariana / Silva, Andréa Alice / Baeta Cavalcanti, Silvia Maria / Artimos de Oliveira, Solange / Artimos de Oliveira Vianna, Renata / Leal de Azeredo, Elzinandes / Grifoni, Alba / Sette, Alessandro / Weiskopf, Daniela / Araújo Cardoso, Claudete Aparecida / de-Oliveira-Pinto, Luzia Maria

    Viruses

    2021  Volume 13, Issue 2

    Abstract: There have been reports of neurological abnormalities associated with the Zika virus (ZIKV), such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We investigated how the immune response to ZIKV during pregnancy is ...

    Abstract There have been reports of neurological abnormalities associated with the Zika virus (ZIKV), such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We investigated how the immune response to ZIKV during pregnancy is primed and conduct a thorough evaluation of the inflammatory and cytotoxic profiles as well as the expression of CCR5 and CX3CR1. We compared the reactivity of T cells to ZIKV peptides in convalescent mothers infected during pregnancy. The child's clinical outcome (i.e., born with or without CZS) was taken to be the variable. The cells were stimulated in vitro with ZIKV peptides and evaluated using the ELISPOT and flow cytometry assays. After in vitro stimulation with ZIKV peptides, we observed a tendency toward a higher Interferon gamma (IFN-γ)-producing T cell responses in mothers who had asymptomatic children and a higher CD107a expression in T cells in mothers who had children with CZS. We found a higher frequency of T cells expressing CD107a+ and co-expressing CX3CR1+CCR5+, which is much clearer in the T cells of mothers who had CZS children. We suggest that this differential profile influenced the clinical outcome of babies. These data need to be further investigated, including the evaluation of other ZIKV peptides and markers and functional assays.
    MeSH term(s) Adult ; CX3C Chemokine Receptor 1/metabolism ; Cross-Sectional Studies ; Cytotoxicity, Immunologic ; Female ; Humans ; Infant ; Interferon-gamma/metabolism ; Lysosomal Membrane Proteins/metabolism ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Pregnancy Outcome ; Receptors, CCR5/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Young Adult ; Zika Virus/immunology ; Zika Virus Infection/immunology
    Chemical Substances CCR5 protein, human ; CX3C Chemokine Receptor 1 ; CX3CR1 protein, human ; LAMP1 protein, human ; Lysosomal Membrane Proteins ; Receptors, CCR5 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13020191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-atherogenic effects of a new thienylacylhydrazone derivative, LASSBio-788, in rats fed a hypercholesterolemic diet.

    da Motta, Nadia Alice Vieira / Kümmerle, Arthur Eugen / Marostica, Elisabeth / Dos Santos, Caroline Fernandes / Fraga, Carlos Alberto Manssour / Barreiro, Eliezer Jesus / de Miranda, Ana Luisa Palhares / de Brito, Fernanda Carla Ferreira

    Journal of pharmacological sciences

    2013  Volume 123, Issue 1, Page(s) 47–57

    Abstract: The compound LASSBio-788 (N-Allyl (2-thienylidene) 3,4-methylenedioxybenzoylhydrazine) is a thienylacylhydrazone derivative shown to have antiplatelet, vasodilatory, and anti-inflammatory properties in vitro. We hypothesize that LASSBio-788 may exert ... ...

    Abstract The compound LASSBio-788 (N-Allyl (2-thienylidene) 3,4-methylenedioxybenzoylhydrazine) is a thienylacylhydrazone derivative shown to have antiplatelet, vasodilatory, and anti-inflammatory properties in vitro. We hypothesize that LASSBio-788 may exert beneficial effects on atherosclerosis. Male wistar rats were divided into 4 groups: Control group received standard rat chow, hypercholesterolemic group (HC) and HC+788 (compound LASSBio-788 group) received hypercholesterolemic diet for 45 days. HC+788 group received compound LASSBio-788 (100 μmol/kg) once daily in the last 15 days. LASSBio-788 reduced the levels of total cholesterol (109.1 ± 4.3 vs. 361.0 ± 12.8 mg/dl), triglycerides (66.1 ± 1.1 vs. 186.9 ± 17.7 mg/dl), LDLc (63.2 ± 6.1 vs. 330.9 ± 9.7 mg/dl), VLDLc (9.8 ± 1.1 vs. 45.0 ± 4.6 mg/dl) and malondialdehyde (4.8 ± 0.3 vs. 9.4 ± 0.5 nmol/ml) compared to the HC group. LASSBio-788 presented antiplatelet properties and decreased inflammatory markers levels. LASSBio-788 promoted a decrease in contractile response to phenylephrine and an improvement in endothelium-dependent vasorelaxant response by increasing two-fold the expression of nitric oxide synthase (eNOS). Our results suggest that the compound LASSBio-788 represents a new multi-targeted drug candidate for the treatment of atherosclerosis.
    MeSH term(s) Animals ; Atherosclerosis/blood ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Cholesterol, LDL/blood ; Cholesterol, VLDL/blood ; Diet, Atherogenic/adverse effects ; Disease Models, Animal ; Hydrazones/administration & dosage ; Hydrazones/pharmacology ; Hydrazones/therapeutic use ; Male ; Malondialdehyde/blood ; Molecular Targeted Therapy ; Nitric Oxide Synthase/blood ; Rats ; Rats, Wistar ; Thiophenes/administration & dosage ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Triglycerides/blood
    Chemical Substances Cholesterol, LDL ; Cholesterol, VLDL ; Hydrazones ; LASSBio-788 ; Thiophenes ; Triglycerides ; Malondialdehyde (4Y8F71G49Q) ; Nitric Oxide Synthase (EC 1.14.13.39)
    Language English
    Publishing date 2013-09-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1254/jphs.13016fp
    Database MEDical Literature Analysis and Retrieval System OnLINE

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