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Article ; Online: Aspectos da educação integral no Brasil

Carlos Wagner Costa Araújo / Renata Gerhardt Barcelos / Luciana dos Santos Célia / Jaqueline Moll

Revista Educação e Políticas em Debate, Vol 12, Iss

disputas conceituais, ideológicas e políticas

2022 Volume 1

Abstract: A educação integral é objeto de estudo por vários educadores, grupos de pesquisa e interessados pelo tema, porém existem contradições e distopias conceituais. Este ensaio tem por objetivo analisar e dialogar com referenciais teóricos da educação integral, ...

Abstract	A educação integral é objeto de estudo por vários educadores, grupos de pesquisa e interessados pelo tema, porém existem contradições e distopias conceituais. Este ensaio tem por objetivo analisar e dialogar com referenciais teóricos da educação integral, a partir da produção e experiências de: Anísio Teixeira, Maria Nilde Mascellani, Paulo Freire, Darcy Ribeiro e Jaqueline Moll. Trata-se de uma pesquisa qualitativa e documental. Utilizou-se para análise: textos, artigos e documentos oficiais da educação brasileira que versam sobre o tema. Concluiu-se que as bases conceituais e históricas da educação integral precisam ser revisitadas, problematizadas e refletidas, para que não haja distorções nas políticas públicas implementadas ou em fase de implementação.
Keywords	Educação Integral ; Educação Científica ; História da Educação ; Political science (General) ; JA1-92 ; Education (General) ; L7-991 ; Political institutions and public administration (General) ; JF20-2112
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Maria Vieira Silva
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: From the Discovery of ADAMTS13 to Current Understanding of Its Role in Health and Disease.

Woods, Adriana Inés / Paiva, Juvenal / Dos Santos, Celia / Alberto, María Fabiana / Sánchez-Luceros, Analía

Seminars in thrombosis and hemostasis

2022 Volume 49, Issue 3, Page(s) 284–294

Abstract: ADAMTS13 (a disintegrin-like metalloprotease domain with thrombospondin type 1 motif, member 13) is a protease of crucial importance in the regulation of the size of von Willebrand factor multimers. Very low ADAMTS13 activity levels result in thrombotic ... ...

Abstract	ADAMTS13 (a disintegrin-like metalloprotease domain with thrombospondin type 1 motif, member 13) is a protease of crucial importance in the regulation of the size of von Willebrand factor multimers. Very low ADAMTS13 activity levels result in thrombotic thrombocytopenic purpura, a rare and life-threatening disease. The mechanisms involved can either be acquired (immune-mediated thrombotic thrombocytopenic purpura [iTTP]) or congenital (cTTP, Upshaw-Schulman syndrome) caused by the autosomal recessive inheritance of disease-causing variants (DCVs) located along the
MeSH term(s)	Humans ; ADAM Proteins/genetics ; ADAMTS13 Protein/genetics ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/genetics ; Purpura, Thrombotic Thrombocytopenic/therapy ; von Willebrand Factor
Chemical Substances	ADAM Proteins (EC 3.4.24.-) ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87) ; von Willebrand Factor
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0042-1758059
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Article: From the Discovery of ADAMTS13 to Current Understanding of Its Role in Health and Disease

Woods, Adriana Inés / Paiva, Juvenal / Dos Santos, Celia / Alberto, María Fabiana / Sánchez-Luceros, Analía

Seminars in Thrombosis and Hemostasis

(Celebrating 50 Years of Seminars in Thrombosis and Hemostasis–Part II)

2022 Volume 49, Issue 03, Page(s) 284–294

Series title	Celebrating 50 Years of Seminars in Thrombosis and Hemostasis–Part II
Abstract	ADAMTS13 (a disintegrin-like metalloprotease domain with thrombospondin type 1 motif, member 13) is a protease of crucial importance in the regulation of the size of von Willebrand factor multimers. Very low ADAMTS13 activity levels result in thrombotic thrombocytopenic purpura, a rare and life-threatening disease. The mechanisms involved can either be acquired (immune-mediated thrombotic thrombocytopenic purpura [iTTP]) or congenital (cTTP, Upshaw–Schulman syndrome) caused by the autosomal recessive inheritance of disease-causing variants (DCVs) located along the ADAMTS13 gene, which is located in chromosome 9q34. Apart from its role in TTP, and as a regulator of microthrombosis, ADAMTS13 has begun to be identified as a prognostic and/or diagnostic marker of other diseases, such as those related to inflammatory processes, liver damage, metastasis of malignancies, sepsis, and different disorders related to angiogenesis. Since its first description almost 100 years ago, the improvement of laboratory tests and the description of novel DCVs along the ADAMTS13 gene have contributed to a better and faster diagnosis of patients under critical conditions. The ability of ADAMTS13 to dissolve platelet aggregates in vitro and its antithrombotic properties makes recombinant human ADAMTS13 treatment a potential therapeutic approach targeting not only patients with cTTP but also other medical conditions.
Keywords	ADAMTS13 ; thrombotic thrombocytopenic purpura ; Upshaw–Schulman syndrome ; genotypic studies ; phenotypic studies
Language	English
Publishing date	2022-11-11
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0042-1758059
Database	Thieme publisher's database

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Article ; Online: Thrombocytopenic thrombotic purpura related to COVID-19 vaccine: apropos of 4 cases.

Dos Santos, Célia / Castera, Santiago / Fernandez, José / Rosales, Julieta Soledad / Crescitelli, Franco / Boughen, Santiago / Iastrebner, Marcelo / Guerrero, Osvaldo / Amell Menco, Carlos / Gomez, Mariela / Gonzalez, Jacqueline / Alberto, Maria Fabiana / Sanchez-Luceros, Analía

Hematology, transfusion and cell therapy

2023

Language	English
Publishing date	2023-12-30
Publishing country	Brazil
Document type	Case Reports
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.11.008
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Article: The Influence of Sex, Age, and Race on Coronary Artery Disease: A Narrative Review.

Lima Dos Santos, Célia C / Matharoo, Arshveer S / Pinzón Cueva, Emilio / Amin, Uzma / Perez Ramos, Aida A / Mann, Navpreet K / Maheen, Sara / Butchireddy, Jyothsna / Falki, Vaibhavkumar B / Itrat, Abeeha / Rajkumar, Nithyalakshmi / Zia Ul Haq, Muhammad

Cureus

2023 Volume 15, Issue 10, Page(s) e47799

Abstract: Cardiovascular disease has remained one of the leading causes of mortality in the world. The basic pathophysiology of coronary artery disease (CAD) is a reduction of the blood flow in coronary vessels, leading to restricted blood flow to the heart muscle. ...

Abstract	Cardiovascular disease has remained one of the leading causes of mortality in the world. The basic pathophysiology of coronary artery disease (CAD) is a reduction of the blood flow in coronary vessels, leading to restricted blood flow to the heart muscle. Both modifiable and non-modifiable risk factors contribute to its multifactorial etiology. The clinical presentation ranges from asymptomatic to typical symptoms like chest pain, shortness of breath, and left arm or jaw pain. The purpose of this review is to investigate and analyze the variation of CAD depending on the biological sex, age, race, or ethnicity and how it might differ in the studied population while comparing the symptoms and prognosis of CAD. For this research, PubMed's database was used. A total of 926 articles were selected using pre-determined inclusion and exclusion criteria, with 74 articles eligible to be included in the narrative review. Studies were selected from the general population of patients with CAD, regardless of their severity, stage of diagnosis, and treatment plan. The scale for the assessment of non-systematic review articles (SANRA) was used to assess the quality of the study. As humans age, the incidence of CAD increases, and people over 75 are more likely to have multiple-vessel CAD. It has been observed that South Asians have the highest rate of CAD at 24%, while the White population has the lowest at 8%. The prevalence of CAD also depends on race, with the White population having the lowest rate at 3.2%, followed by Hispanics at 5%, Black women at 5.2%, and Black men at 5.7%. Younger Black women tend to have more chest pain. Men with CAD commonly experience chest pain, and women are more likely to present with atypical symptoms. Modifiable risk factors such as smoking and alcoholism are more commonly observed in young men than in young women. Coronary artery disease in the elderly, female, minority, and Black patients is associated with a higher mortality rate. Acknowledging the prevalence of certain risk factors, signs, results, and responses to treatment in certain socio-demographic groups, as well as the provision and accessibility of diagnosis and treatment, would lead to a better outcome for all individuals. The impact of this shift can range from an earlier diagnosis of CAD to a faster and more customized treatment plan tailored to each patient's individual requirements.
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47799
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Article ; Online: Thrombotic microangiopathies: First report of 294 cases from a single institution experience in Argentina.

Dos Santos, Célia / Paiva, Juvenal / Romero, María Lucila / Agazzoni, Mara / Kempfer, Ana Catalina / Rotondo, Sabrina / Casinelli, María Marta / Alberto, María Fabiana / Sánchez-Luceros, Analía

EJHaem

2021 Volume 2, Issue 2, Page(s) 149–156

Abstract: Introduction: Introduction: Thrombotic microangiopathies (TMAs) are rare disorders associated with fatal outcomes if left uncared for. However, healthcare problems in developing countries tend to limit medical assistance to patients.: Methods: ... ...

Abstract	Introduction: Introduction: Thrombotic microangiopathies (TMAs) are rare disorders associated with fatal outcomes if left uncared for. However, healthcare problems in developing countries tend to limit medical assistance to patients. Methods: Methods: We prospectively studied an Argentine cohort of 294 consecutive patients from 2013 to 2016. Patients' subcategory classification relied on clinical symptoms and presence or absence of trigger events associated with TMA. Results: Main suspected disorders were the primary TMAs known as thrombotic thrombocytopenic purpura (TTP) (n = 72/294, 24%) and atypical haemolytic uraemic syndrome (aHUS) (n = 94/294, 32%). In acute phase, demographic parameters for acquired TTP (aTTP) (n = 28) and aHUS (n = 47) showed that both groups were characterised by a young median age (37 and 25 years, respectively) and female predominance (60% and 86%). Median of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity was significantly lower in aTTP than in aHUS group (1.4% vs 83%) and was associated with a more severe thrombocytopenia (15 × 10 Conclusion: The first description of a TMA cohort in Argentina revealed similar clinical presentations to those of other countries.
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.154
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Article: Factors Associated with Gastrointestinal Parasitic Infections among Young Population in Northeast Brazil.

da Silva, Juliana Vasconcelos Lyra / Fontes, Gilberto / Dos Santos, Célia Dias / Dos Santos, Rafael Vital / da Rocha, Eliana Maria Mauricio

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2016 Volume 2016, Page(s) 6239434

Abstract: Background. Intestinal parasitic infections constitute a major public health problem that is frequently associated with poverty, inadequate sanitation, and the nutritional status of the population. Objective. The aim of the present study is to ... ...

Abstract	Background. Intestinal parasitic infections constitute a major public health problem that is frequently associated with poverty, inadequate sanitation, and the nutritional status of the population. Objective. The aim of the present study is to investigate the possible association of parasitic infections, sanitary conditions, hygiene practices, and the nutritional and socioeconomic status of a poor youth population. Methods. A cross-sectional study was conducted with 367 children and adolescents inhabiting a substandard settlement in the urban area of Maceió (Alagoas State, Brazil). Data collection included socioeconomic status, anthropometric measurements, fecal sample examinations, and laboratory blood analysis. The identification of factors associated with gastrointestinal parasitic infections was undertaken through bi- and multivariate analyses. Results. Stool sample analysis obtained from 300 individuals revealed that 204 (68%) were infected with at least one parasite species and of these 130 (63.7%) were polyparasitized. No significant associations were identified between low height for age (stunted), parasitic infections, and polyparasitism. There was also no association between family income and parasitosis. However, low socioeconomic status proved to be a potential risk factor for parasitic infections. Conclusion. Actions must be taken to improve sanitation, housing, and environmental conditions in order to eliminate the risk factors for parasitic infections, and thereby guarantee a better quality of life for this population.
Language	English
Publishing date	2016-07-26
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2016/6239434
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Article ; Online: Additivity of optical emissions applied to neodymium and praseodymium quantification in metallic didymium and (Nd,Pr)-Fe-B alloy samples by low-resolution atomic emission spectrometry: An evaluation of the mathematical approach used to solve spectral interferences.

Papai, Rodrigo / Sousa de Freitas, Millena Aparecida / Torre da Fonseca, Karina / Alves de Almeida, Gilmar / Filipini da Silveira, João Ricardo / Nunis da Silva, André Luiz / Ferreira Neto, João Batista / Lino Dos Santos, Célia Aparecida / Gomes Landgraf, Fernando José / Luz, Maciel Santos

Analytica chimica acta

2019 Volume 1085, Page(s) 21–28

Abstract: In this work, the effectiveness of a mathematical approach to solve the spectral interferences involved in the optical emission of two chemical species (neodymium and praseodymium) when using monochromators with low-resolution in atomic spectrometry is ... ...

Abstract	In this work, the effectiveness of a mathematical approach to solve the spectral interferences involved in the optical emission of two chemical species (neodymium and praseodymium) when using monochromators with low-resolution in atomic spectrometry is evaluated. Although recent technological advances have promoted spectrometers equipped with high-resolution monochromators, which have a great instrumental capability in the separation of nearby lines and consequently avoid spectral interferences, many laboratories still have old spectrometers installed with insufficient resolution to overcome such interferences. In order to evaluate a mathematical approach based on Lambert-Beer's Law, the optical emissions of neodymium and praseodymium were monitored on a low-resolution (200 pm) flame atomic emission spectrometry (F-AES). These two elements were strategically chosen as an application model because they exhibit similar physicochemical properties, joint occurrence in nature and because they are increasingly used in the manufacture of super-magnets, a material increasingly required by the high technology industry. The effectiveness of the mathematical approach was evaluated in three different ways: (i) by recovery of the analytes in synthetic mixtures containing known quantities of the species; (ii) by spike and recovery trials on a representative blend of dissolved samples and (iii) by comparing the results obtained with another analytical method: Inductively coupled plasma optical emission spectrometry (ICP-OES) with a higher spectral resolution. The results indicate the effectiveness of this simple mathematical approach, allow the "survival" of instruments equipped with low-resolution monochromators and demonstrate the applicability of this approach to spectral correction. In addition, this work contributes an analytical method for the quantification of neodymium and praseodymium in metallic alloy samples involved in the production of super-magnets, aiding in the strict quality control of these materials.
Language	English
Publishing date	2019-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2019.07.049
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Article ; Online: Studies of the antitumor mechanism of action of dermaseptin B2, a multifunctional cationic antimicrobial peptide, reveal a partial implication of cell surface glycosaminoglycans.

Dos Santos, Célia / Hamadat, Sabah / Le Saux, Karen / Newton, Clara / Mazouni, Meriem / Zargarian, Loussiné / Miro-Padovani, Mickael / Zadigue, Patricia / Delbé, Jean / Hamma-Kourbali, Yamina / Amiche, Mohamed

PloS one

2017 Volume 12, Issue 8, Page(s) e0182926

Abstract: Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo. In the present study, we ... ...

Abstract	Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo. In the present study, we evaluated the antiproliferative activity of DRS-B2 on numerous tumor cell lines, its cell internalization and studies of its molecular partners as well as their influences on its structure. Confocal microscopy using ([Alexa594]-(Cys0)-DRS-B2) shows that in sensitive human tumor cells (PC3), DRS-B2 seems to accumulate rapidly at the cytoplasmic membranes and enters the cytoplasm and the nucleus, while in less sensitive tumor cells (U87MG), DRS-B2 is found packed in vesicles at the cell membrane. Furthermore FACS analysis shows that PC3 cells viability decreases after DRS-B2 treatment while U87 MG seems to be unaffected. However, "pull down" experiments performed with total protein pools from PC3 or U87MG cells and the comparison between the antiproliferative effect of DRS-B2 and its synthetic analog containing all D-amino acids suggest the absence of a stereo-selective protein receptor. Pretreatment of PC3 cells with sodium chlorate, decreases the antiproliferative activity of DRS-B2. This activity is partially restored after addition of exogenous chondroitin sulfate C (CS-C). Moreover, we demonstrate that at nanomolar concentrations CS-C potentiates the antiproliferative effect of DRS-B2. These results highlight the partial implication of glycosaminoglycans in the mechanism of antiproliferative action of DRS-B2. Structural analysis of DRS-B2 by circular dichroism in the presence of increasing concentration of CS-C shows that DRS-B2 adopts an α-helical structure. Finally, structure-activity-relationship studies suggest a key role of the W residue in position 3 of the DRS-B2 sequence for its antiproliferative activity.
MeSH term(s)	Amino Acid Sequence ; Amphibian Proteins/chemistry ; Amphibian Proteins/pharmacology ; Animals ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Anura ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Glycosaminoglycans/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Structure-Activity Relationship
Chemical Substances	Amphibian Proteins ; Antimicrobial Cationic Peptides ; Antineoplastic Agents ; Glycosaminoglycans ; dermaseptin B2, Phyllomedusa bicolor
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0182926
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Article ; Online: Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.

Serova, Maria / de Gramont, Armand / Tijeras-Raballand, Annemilaï / Dos Santos, Célia / Riveiro, Maria Eugenia / Slimane, Khemaies / Faivre, Sandrine / Raymond, Eric

Cancer chemotherapy and pharmacology

2013 Volume 71, Issue 5, Page(s) 1297–1307

Abstract: Purpose: To evaluate first-generation rapamycin analogs (everolimus, temsirolimus, and rapamycin) and second-generation drugs inhibiting mTOR kinase (AZD-8055), PI3K (BKM-120) or both (BEZ-235 and GDC-0980) in hepatocellular carcinoma (HCC) and renal ... ...

Abstract	Purpose: To evaluate first-generation rapamycin analogs (everolimus, temsirolimus, and rapamycin) and second-generation drugs inhibiting mTOR kinase (AZD-8055), PI3K (BKM-120) or both (BEZ-235 and GDC-0980) in hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) cells characterized for acquired resistance to sorafenib or sunitinib. Methods: Anti-proliferative (MTT assay) and cell signaling (Western blot) effects of rapamycin analogs (1-20 μM) and second-generation drugs (0.03-20.0 μM) were assessed in human HCC SK-HEP1, RCC 786-0, and sorafenib- (SK-Sora) or sunitinib-resistant (786-Suni) cells. Results: In SK-HEP1 cells displaying high PTEN and Bcl2 expression, rapamycin analogs had poor anti-proliferative effects. However, SK-Sora cells were more sensitive to rapamycin analogs (≥1 μM) than SK-HEP1 cells. In 786-0 cells, lacking PTEN and Bcl2 expression, ≥1 μM rapamycin analogs blocked mTORC1 signaling, transiently activated Akt, and inhibited cell proliferation. Protracted sunitinib exposure in 786-Suni cells yielded an increase in p27 expression and a decreased sensitivity to rapamycin analogs, although mTORC1 function could be inhibited with rapamycin analogs. Second-generation drugs induced more potent growth inhibition than rapamycin analogs at concentrations >0.03 μM in parental cells, SK-Sora, and 786-Suni cells. Growth inhibitory concentrations of these new drugs also blocked mTORC1 downstream targets. Conclusions: Rapamycin analogs inhibited mTORC1 downstream targets and yielded anti-proliferative effects in HCC and RCC cells. Second-generation drugs also appeared to be potent inhibitors of mTORC1 signaling; however, they appeared to be far more potent in inhibiting cellular proliferation in parental HCC and RCC cells and in cells developing resistance to sorafenib or sunitinib.
MeSH term(s)	Aminopyridines/administration & dosage ; Aminopyridines/pharmacology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm ; Everolimus ; Humans ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Indoles/pharmacology ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Mechanistic Target of Rapamycin Complex 1 ; Morpholines/administration & dosage ; Morpholines/pharmacology ; Multiprotein Complexes/antagonists & inhibitors ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Phenylurea Compounds/pharmacology ; Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Pyrroles/pharmacology ; Quinolines/administration & dosage ; Quinolines/pharmacology ; Signal Transduction/drug effects ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; Sirolimus/pharmacology ; Sorafenib ; Sunitinib ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Chemical Substances	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one ; Aminopyridines ; Antineoplastic Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Imidazoles ; Indoles ; Morpholines ; Multiprotein Complexes ; NVP-BKM120 ; Phenylurea Compounds ; Pyrimidines ; Pyrroles ; Quinolines ; Niacinamide (25X51I8RD4) ; temsirolimus (624KN6GM2T) ; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol (970JJ37FPW) ; Everolimus (9HW64Q8G6G) ; Sorafenib (9ZOQ3TZI87) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; dactolisib (RUJ6Z9Y0DT) ; Sunitinib (V99T50803M) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2013-03-12
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-013-2129-6
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