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Article: An Immunological Perspective of Circulating Tumor Cells as Diagnostic Biomarkers and Therapeutic Targets.

Dotse, Eunice / Lim, King H / Wang, Meijun / Wijanarko, Kevin Julio / Chow, Kwan T

2022 Volume 12, Issue 2

Abstract: Immune modulation is a hallmark of cancer. Cancer-immune interaction shapes the course of disease progression at every step of tumorigenesis, including metastasis, of which circulating tumor cells (CTCs) are regarded as an indicator. These CTCs are a ... ...

Abstract	Immune modulation is a hallmark of cancer. Cancer-immune interaction shapes the course of disease progression at every step of tumorigenesis, including metastasis, of which circulating tumor cells (CTCs) are regarded as an indicator. These CTCs are a heterogeneous population of tumor cells that have disseminated from the tumor into circulation. They have been increasingly studied in recent years due to their importance in diagnosis, prognosis, and monitoring of treatment response. Ample evidence demonstrates that CTCs interact with immune cells in circulation, where they must evade immune surveillance or modulate immune response. The interaction between CTCs and the immune system is emerging as a critical point by which CTCs facilitate metastatic progression. Understanding the complex crosstalk between the two may provide a basis for devising new diagnostic and treatment strategies. In this review, we will discuss the current understanding of CTCs and the complex immune-CTC interactions. We also present novel options in clinical interventions, targeting the immune-CTC interfaces, and provide some suggestions on future research directions.
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12020323
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Article ; Online: TLR4 sensitizes plasmacytoid dendritic cells for antiviral response against SARS-CoV-2 coronavirus.

Lim, King Hoo / Wang, Lishi / Dotse, Eunice / Wang, Meijun / Tiu, Cheuk Ying / Wijanarko, Kevin Julio / Wang, Xin / Chow, Kwan T

Journal of leukocyte biology

2023 Volume 115, Issue 1, Page(s) 190–200

Abstract: Plasmacytoid dendritic cells are a rare subset of dendritic cells that exhibit antiviral functions in response to toll-like receptor 7/8 stimulations. Alternative toll-like receptors such as TLR4 have been known to be active in plasmacytoid dendritic ... ...

Abstract	Plasmacytoid dendritic cells are a rare subset of dendritic cells that exhibit antiviral functions in response to toll-like receptor 7/8 stimulations. Alternative toll-like receptors such as TLR4 have been known to be active in plasmacytoid dendritic cells for immune regulatory functions. However, it is unclear whether these toll-like receptors differentially activate plasmacytoid dendritic cells as compared with canonical toll-like receptor 7/8 stimulation. Here, we assessed alternative plasmacytoid dendritic cell activation states mediated by toll-like receptors other than endosomal toll-like receptors via the RNA sequencing approach. We found that toll-like receptor 4 stimulation induced a high degree of similarity in gene expression pattern to toll-like receptor 7/8 stimulation in plasmacytoid dendritic cells. Despite high resemblance to toll-like receptor 7/8, we discovered unique genes that were activated under toll-like receptor 4 activation only, as well as genes that were induced at a higher magnitude in comparison to toll-like receptor 7/8 activation. In comparison between toll-like receptor 4-activated plasmacytoid dendritic cells and conventional dendritic cells, we revealed that plasmacytoid dendritic cells and conventional dendritic cells expressed distinct gene sets, whereby conventional dendritic cells mostly favored antigen presentation functions for adaptive immune response regulation while plasmacytoid dendritic cells leaned toward immune response against infectious diseases. Last, we determined that toll-like receptor 4 activation sensitized plasmacytoid dendritic cells against SARS-CoV-2 (COVID-19) single-stranded RNA by enhancing antiviral-related responses and type I interferon production. These findings provided greater insights into the toll-like receptor 4 activation state in plasmacytoid dendritic cells, which can be beneficial for alternative therapeutic interventions involving plasmacytoid dendritic cells for various diseases.
MeSH term(s)	Humans ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 4/metabolism ; SARS-CoV-2/metabolism ; COVID-19/metabolism ; Toll-Like Receptors/metabolism ; Dendritic Cells ; Antiviral Agents/pharmacology ; Antiviral Agents/metabolism ; Toll-Like Receptor 9/metabolism
Chemical Substances	Toll-Like Receptor 7 ; Toll-Like Receptor 4 ; Toll-Like Receptors ; Antiviral Agents ; Toll-Like Receptor 9 ; TLR4 protein, human
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiad111
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Article ; Online: Antileishmanial anthraquinones from the rhyzomes of Rumex abyssinicus Jacq (Polygonaceae)

Guetchueng, Stephanie Tamdem / Djouonzo, Paul Toukam / Lame, Younoussa / Kopa Kowa, Théodora / Dotse, Eunice / Tchokouaha, Lauve R. Y. / Kamdem Wabo, Hippolyte / Appiah-Opong, Regina / Agbor, Gabriel Agbor

Natural Product Research. 2023 Sept. 2, v. 37, no. 17 p.2935-2939

2023

Abstract: Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-β,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and ...

Abstract	Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-β,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and emodin-8-O-β,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC₅₀ 13.82 and 0.26 µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-β,D-glucopyranoside (6) also showed a moderate activity with IC₅₀ 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.
Keywords	Leishmania donovani ; Rumex abyssinicus ; amastigotes ; antileishmanial properties ; emodin ; phytochemicals ; promastigotes ; research ; anthraquinones ; antileishmanial activity
Language	English
Dates of publication	2023-0902
Size	p. 2935-2939.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2137797
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Article: Isolation of colorectal cancer stem-like cells.

Dotse, Eunice / Bian, Yuhong

Cytotechnology

2016 Volume 68, Issue 4, Page(s) 609–619

Abstract: This study is aimed at isolating colorectal cancer stem-like cells in vitro using a neurosphere assay method employed in isolating gliobastoma multiforme tumor cells. This was followed with confirmation of the isolated cells by flow cytometry, ... ...

Abstract	This study is aimed at isolating colorectal cancer stem-like cells in vitro using a neurosphere assay method employed in isolating gliobastoma multiforme tumor cells. This was followed with confirmation of the isolated cells by flow cytometry, pluripotent genes expression and in vivo tumorigenicity assay. Using this culture assay, stem-like and non-stem-like CRC cells were isolated and expanded in vitro from purchased Balb/c mice induced with CT26 colorectal cancer (CRC) cell line. The procedure includes an initial mechanical dissociation and chemical digestion of tumor tissue and subsequently plating the resulting single cell suspension in serum-free medium (SFM) or serum-containing medium (SCM). This selectively permits growth of cancer stem-like cells in SFM and eliminates non-stem-like cancer cells through the process of anoikis or apoptosis. CRC stem cells derived cultures proliferated as non-adherent spheres in vitro in different shapes and sizes. These cells expressed cell surface markers previously reported for tumor stem cells, including CD44, CD133, CD166 and CD26 and formed tumors when implanted in severe combined immunodeficient mice in a concentration dependent manner. Importantly, the stem-like cells had self-renewal properties with significantly higher expression of the pluripotent stem cell genes NANOG, OCT4, and SOX2 compared to the adherent non-stem cells. Collectively, the results of this study indicate that SFM is a defined culture medium that enriches for CRC stem-like cells and represents a suitable in vitro model for the study of CRC stem-like cells. This finding may be useful in developing therapeutic strategies aimed at eradicating the tumorigenic subpopulation within colorectal cancer.
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035772-5
ISSN	0920-9069
ISSN	0920-9069
DOI	10.1007/s10616-014-9806-0
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Article: Antiproliferative Activities of Methanolic Extract and Fractions of

Aikins, Anastasia Rosebud / Birikorang, Peggy Afua / Chama, Mary / Dotse, Eunice / Anning, Abigail / Appiah-Opong, Regina

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 4051555

Abstract: Most of the current cancer chemotherapeutics are associated with harsh and undesirable side effects, including toxicity and chemoresistance, driving the need for safer and more effective alternatives. In this study, the antiproliferative activities of ... ...

Abstract	Most of the current cancer chemotherapeutics are associated with harsh and undesirable side effects, including toxicity and chemoresistance, driving the need for safer and more effective alternatives. In this study, the antiproliferative activities of the methanolic extract of
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/4051555
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Article ; Online: Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants.

Appiah-Opong, Regina / Agyemang, Kojo / Dotse, Eunice / Atchoglo, Philip / Owusu, Kofi Baffour-Awuah / Aning, Abigail / Sakyiamah, Maxwell / Adegle, Richard / Ayertey, Frederick / Appiah, Alfred Ampomah / Nyarko, Alexander K

Journal of evidence-based integrative medicine

2022 Volume 27, Page(s) 2515690X211073709

Abstract: Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural ... ...

Abstract	Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural product origin. Some secondary metabolites demonstrate adjuvant antioxidant effects and selective activity. The focus of this study was to investigate the anti-plasmodial activity, cytotoxicities and antioxidant properties of eight (8) Ghanaian medicinal plants. The anti-plasmodial activity was determined using the SYBR green assay and the tetrazolium-based colorimetric assay (MTT) was employed to assess cytotoxicity of extracts to human RBCs and HL-60 cells. Antioxidant potential of plant extracts was evaluated using Folin-Ciocalteu and superoxide dismutase assays. Phytochemical contstituents of the plant extracts were also assessed. All the extracts demonstrated anti-plasmodial activities at concentrations <50 μg/ml.
MeSH term(s)	Antioxidants/pharmacology ; Ghana ; Humans ; Plants, Medicinal/chemistry ; Plasmodium berghei ; Plasmodium falciparum
Chemical Substances	Antioxidants
Language	English
Publishing date	2022-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2515-690X
ISSN (online)	2515-690X
DOI	10.1177/2515690X211073709
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Article ; Online: Antileishmanial anthraquinones from the rhyzomes of

Guetchueng, Stephanie Tamdem / Djouonzo, Paul Toukam / Lame, Younoussa / Kopa Kowa, Théodora / Dotse, Eunice / Tchokouaha, Lauve R Y / Kamdem Wabo, Hippolyte / Appiah-Opong, Regina / Agbor, Gabriel Agbor

Natural product research

2022 Volume 37, Issue 17, Page(s) 2935–2939

Abstract: Phytochemical investigation of the rhyzomes ... ...

Abstract	Phytochemical investigation of the rhyzomes of
Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2137797
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Article: Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae)

Kowa, Theodora K / Tchokouaha, Lauve R. Y / Cieckiewicz, Ewa / Philips, Trudy Janice / Dotse, Eunice / Wabo, Hippolyte K / Tchinda, Alembert T / Tane, Pierre / Frédérich, Michel

Natural product research. 2020 Nov. 16, v. 34, no. 22

2020

Abstract: One new limonoid, trigilgianin (1), one new phenyl alkene, epoxy gilgialkene (2), together with five known compounds: scopoletin (3), sitosteryl-6’-O-undecanoate-β-D-glucoside (4), sitosteryl-O-β-D-glucopyranoside (5), cinchonain A (6) and cinchonain B ( ... ...

Abstract	One new limonoid, trigilgianin (1), one new phenyl alkene, epoxy gilgialkene (2), together with five known compounds: scopoletin (3), sitosteryl-6’-O-undecanoate-β-D-glucoside (4), sitosteryl-O-β-D-glucopyranoside (5), cinchonain A (6) and cinchonain B (7) were isolated from the stem bark of Trichilia gilgiana Harms. (Meliaceae). All compounds were isolated for the first time from this species. The structures were elucidated on the basis of spectral studies and by comparison of these data with those from the literature. Compounds 1, 2, 3, 6 and 7 were tested for in vitro antileishmanial activity against visceral leishmaniasis parasite Leishmania donovani and cytotoxicity against macrophage RAW 264.7 cell line. Compounds 1 and 3 showed the highest antileishmanial activity (IC₅₀ values of 6.044 and 6.804 µg/mL, respectively) with low cytotoxicity (CC₅₀ values of >200 and 47.47 µg/mL, respectively), while compound 2 was moderately active on L. donovani promastigotes (IC₅₀ 56.81 µg/mL).
Keywords	Leishmania donovani ; Trichilia ; antileishmanial properties ; bark ; cell lines ; cytotoxicity ; epoxides ; literature ; macrophages ; parasites ; promastigotes ; research ; scopoletin ; spectral analysis ; visceral leishmaniasis
Language	English
Dates of publication	2020-1116
Size	p. 3182-3188.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-light
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2018.1553879
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Article ; Online: Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of

Kowa, Theodora K / Tchokouaha, Lauve R Y / Cieckiewicz, Ewa / Philips, Trudy Janice / Dotse, Eunice / Wabo, Hippolyte K / Tchinda, Alembert T / Tane, Pierre / Frédérich, Michel

Natural product research

2019 Volume 34, Issue 22, Page(s) 3182–3188

Abstract: One new limonoid, trigilgianin ( ...

Abstract	One new limonoid, trigilgianin (
MeSH term(s)	Alkenes/chemistry ; Animals ; Leishmania donovani/drug effects ; Limonins/chemistry ; Magnetic Resonance Spectroscopy ; Meliaceae/chemistry ; Mice ; Molecular Structure ; Plant Bark/chemistry ; RAW 264.7 Cells ; Scopoletin/isolation & purification ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/pharmacology
Chemical Substances	Alkenes ; Limonins ; Trypanocidal Agents ; Scopoletin (KLF1HS0SXJ)
Language	English
Publishing date	2019-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2018.1553879
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Article: In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity.

N'guessan, Benoit B / Amponsah, Seth K / Dugbartey, George J / Awuah, Kwabena D / Dotse, Eunice / Aning, Abigail / Kukuia, Kennedy K E / Asiedu-Gyekye, Isaac J / Appiah-Opong, Regina

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 7462839

Abstract: Background: There is considerable evidence that many people take dietary supplements including those of herbal origin as an alternative therapy to improve their health. One such supplement, with an amalgam of constituents, is CellGevity®. However, the ... ...

Abstract	Background: There is considerable evidence that many people take dietary supplements including those of herbal origin as an alternative therapy to improve their health. One such supplement, with an amalgam of constituents, is CellGevity®. However, the effect of this dietary supplement on drug-metabolizing enzymes is poorly understood, as it has not been studied extensively. Therefore, we investigated the effect of CellGevity dietary supplement on selected rat liver microsomal cytochrome P450 (CYP) enzymes, the most common drug-metabolizing enzymes. We also determined the total antioxidant potential of this dietary supplement Methods: To determine the antioxidant potential of CellGevity dietary supplement, 2,2-diphenyl-2-picryl-hydrazyl (DPPH), total phenolic, and flavonoid assays were used after initial preparation of a solution form of the supplement (low dose, LD; 4 mg/kg and high dose, HD; 8 mg/kg). Rats received oral administration of these doses of the supplement for 7 days, after which the effect of the supplement on selected liver CYP enzymes was assessed using probe substrates and spectroscopic and high-performance liquid chromatographic methods. Rats which received daily administration of 80 mg/kg of phenobarbitone and distilled water served as positive and negative controls, respectively. Results: The IC Conclusion: CellGevity dietary supplement possesses moderate antioxidant activity
Language	English
Publishing date	2018-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/7462839
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