Article ; Online: Periodontal Disease Associated With Interstitial Myocardial Fibrosis: The Multiethnic Study of Atherosclerosis.
Journal of the American Heart Association
2023 Volume 12, Issue 3, Page(s) e8146
Abstract: Background Periodontitis is a chronic inflammatory disease common among adults. It has been suggested that periodontal disease (PD) may be a contributing risk factor for cardiovascular disease; however, pathways underlying such a relationship require ... ...
| Abstract | Background Periodontitis is a chronic inflammatory disease common among adults. It has been suggested that periodontal disease (PD) may be a contributing risk factor for cardiovascular disease; however, pathways underlying such a relationship require further investigation. Methods and Results A total of 665 men (mean age 68±9 years) and 611 women (mean age 67±9 years) enrolled in the MESA (Multiethnic Study of Atherosclerosis) underwent PD assessment using a 2-item questionnaire at baseline (2000-2002) and had cardiovascular magnetic resonance 10 years later. PD was defined when participants reported either a history of periodontitis or gum disease or lost teeth caused by periodontitis or gum disease. Multivariable linear regression models were constructed to assess the associations of baseline self-reported PD with cardiovascular magnetic resonance-obtained measures of interstitial myocardial fibrosis (IMF), including extracellular volume and native T1 time. Men with a self-reported history of PD had greater extracellular volume percent (ß=0.6%±0.2, |
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| MeSH term(s) | Male ; Humans ; Middle Aged ; Aged ; Ethnicity ; Cardiomyopathies ; Fibrosis ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Risk Factors ; Myocardial Infarction ; Periodontal Diseases/complications ; Periodontal Diseases/diagnosis ; Periodontal Diseases/epidemiology |
| Language | English |
| Publishing date | 2023-01-31 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2653953-6 |
| ISSN | 2047-9980 ; 2047-9980 |
| ISSN (online) | 2047-9980 |
| ISSN | 2047-9980 |
| DOI | 10.1161/JAHA.122.027974 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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