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  1. Article: Selection and Amplification of Fungicide Resistance in

    Doughty, Kevin J / Sierotzki, Helge / Semar, Martin / Goertz, Andreas

    Microorganisms

    2021  Volume 9, Issue 12

    Abstract: Aspergillus ... ...

    Abstract Aspergillus fumigatus
    Language English
    Publishing date 2021-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Selection and Amplification of Fungicide Resistance in Aspergillus fumigatus in Relation to DMI Fungicide Use in Agronomic Settings: Hotspots versus Coldspots

    Doughty, Kevin J. / Sierotzki, Helge / Semar, Martin / Goertz, Andreas

    Microorganisms. 2021 Nov. 26, v. 9, no. 12

    2021  

    Abstract: Aspergillus fumigatus is a ubiquitous saprophytic fungus. Inhalation of A. fumigatus spores can lead to Invasive Aspergillosis (IA) in people with weakened immune systems. The use of triazole antifungals with the demethylation inhibitor (DMI) mode of ... ...

    Abstract Aspergillus fumigatus is a ubiquitous saprophytic fungus. Inhalation of A. fumigatus spores can lead to Invasive Aspergillosis (IA) in people with weakened immune systems. The use of triazole antifungals with the demethylation inhibitor (DMI) mode of action to treat IA is being hampered by the spread of DMI-resistant “ARAf” (azole-resistant Aspergillus fumigatus) genotypes. DMIs are also used in the environment, for example, as fungicides to protect yield and quality in agronomic settings, which may lead to exposure of A. fumigatus to DMI residues. An agronomic setting can be a “hotspot” for ARAf if it provides a suitable substrate and favourable conditions for the growth of A. fumigatus in the presence of DMI fungicides at concentrations capable of selecting ARAf genotypes at the expense of the susceptible wild-type, followed by the release of predominantly resistant spores. Agronomic settings that do not provide these conditions are considered “coldspots". Identifying and mitigating hotspots will be key to securing the agronomic use of DMIs without compromising their use in medicine. We provide a review of studies of the prevalence of ARAf in various agronomic settings and discuss the mitigation options for confirmed hotspots, particularly those relating to the management of crop waste.
    Keywords Aspergillus fumigatus ; antifungal agents ; aspergillosis ; breathing ; crop residues ; demethylation ; fungi ; fungicide resistance ; fungicides ; mechanism of action ; medicine ; people ; saprophytes ; triazoles
    Language English
    Dates of publication 2021-1126
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122439
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Exposure to pesticide residues during manual removal of bolting sugar beets: determination of transfer coefficients for worker risk assessment

    Baumann, Jenny / Anft, Thomas / Doughty, Kevin J / Kuster, Christian J

    Journal für Verbraucherschutz und Lebensmittelsicherheit. 2019 Sept., v. 14, no. 3

    2019  

    Abstract: Plant protection products often leave external residues on crops. Workers can be exposed to these residues when re-entering a recently-treated crop. Therefore, task- and crop-specific transfer coefficients are used to estimate the exposure of workers ... ...

    Abstract Plant protection products often leave external residues on crops. Workers can be exposed to these residues when re-entering a recently-treated crop. Therefore, task- and crop-specific transfer coefficients are used to estimate the exposure of workers during re-entry: these relate to the transfer of foliar residues to clothing or skin. In this study, we considered a re-entry task not currently covered by European risk assessments: “manual removal of bolting beets” from sugar beet crops. This task can overlap with pesticide treatment, and it involves extensive contact with crop foliage. Therefore, we conducted a worker exposure study along with a dislodgeable foliar residue study in a sugar beet crop previously treated with a fungicide. We determined residues on the clothing of workers who had manually removed bolting beets, and we propose transfer coefficients that can be used in risk assessments to estimate worker exposure during the task “manual removal of bolting beets”.
    Keywords beets ; bolting ; clothing ; fungicides ; leaves ; pesticide application ; pesticide residues ; plant protection ; risk assessment ; sugar beet
    Language English
    Dates of publication 2019-09
    Size p. 283-286.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 2232114-7
    ISSN 1661-5867 ; 1661-5751
    ISSN (online) 1661-5867
    ISSN 1661-5751
    DOI 10.1007/s00003-019-01221-9
    Database NAL-Catalogue (AGRICOLA)

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