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Article ; Online: Ivabradine-sensitive incessant atrial tachycardia during pregnancy: a case report.

Tonko, Johanna B / Douglas, Hannah / Wright, Matthew J

European heart journal. Case reports

2021 Volume 5, Issue 10, Page(s) ytab367

Abstract: Background: Automaticity is the dominant mechanism in maternal focal atrial tachycardia (FAT) during pregnancy and if incessant, can cause tachycardia-induced cardiomyopathy. Medication failure for FATs is common, however, for the subgroup due to ... ...

Abstract	Background: Automaticity is the dominant mechanism in maternal focal atrial tachycardia (FAT) during pregnancy and if incessant, can cause tachycardia-induced cardiomyopathy. Medication failure for FATs is common, however, for the subgroup due to increased automaticity ivabradine sensitivity has been described and may represent a valuable treatment option. Little data are available regarding the safety profile of ivabradine during pregnancy. Case summary: We report the case of a 38-year-old woman with background of peripartum cardiomyopathy and incessant atrial tachycardia with deteriorating ventricular function during her second pregnancy unresponsive to betablockade and demonstrating the immediate successful rate-controlling effect of ivabradine. Discussion: Early recognition of persistent maternal FAT is essential due to its frequent association with tachycardia-mediated cardiomyopathy. Our case report highlights the challenges of providing an equally safe and effective treatment of these notoriously difficult to treat arrhythmias during pregnancy. Ivabradine in combination with a betablocker can be effective for abnormal automaticity but its safety profile during pregnancy remains uncertain.
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytab367
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Article ; Online: Population burst propagation across interacting areas of the brain.

Chen, Yu / Douglas, Hannah / Medina, Bryan J / Olarinre, Motolani / Siegle, Joshua H / Kass, Robert E

Journal of neurophysiology

2022 Volume 128, Issue 6, Page(s) 1578–1592

Abstract: For many perceptual and behavioral tasks, a prominent feature of neural spike trains involves high firing rates across relatively short intervals of time. We call these events "population bursts." Because during a population burst information is, ... ...

Abstract	For many perceptual and behavioral tasks, a prominent feature of neural spike trains involves high firing rates across relatively short intervals of time. We call these events "population bursts." Because during a population burst information is, presumably, transmitted from one part of the brain to another, burst timing should reveal activity related to the flow of information across neural circuits. We developed a statistical method (based on a point process model) of determining, accurately, the time of the maximum (peak) population firing rate on a trial-by-trial basis and used it to characterize burst propagation across areas. We then examined the tendency of peak firing rates in distinct brain areas to shift earlier or later in time, together, across repeated trials, and found this trial-to-trial coupling of peak times to be a sensitive indicator of interaction across populations. In the data we examined, from the Allen Brain Observatory, we found many very strong correlations (95% confidence intervals above 0.75) in cases where standard methods were unable to demonstrate cross-area correlation. The statistical model introduced cross-area covariation only through population-level trial-dependent time shifts and gain constants (values of which were learned from the data), yet it provided very good fits to data histograms, including histograms of spike count correlations within and across visual areas. Our results demonstrate the utility of carefully assessing timing and propagation, across brain regions, of transient bursts in neural population activity, based on multiple spike train recordings.
MeSH term(s)	Brain
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00066.2022
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Article ; Online: Management of pulmonary arterial hypertension during pregnancy.

Krishnathasan, Kaushiga / Constantine, Andrew / Rafiq, Isma / Barradas Pires, Ana / Douglas, Hannah / Price, Laura C / Dimopoulos, Konstantinos

Expert review of respiratory medicine

2023 Volume 17, Issue 5, Page(s) 413–423

Abstract: Introduction: Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure >20 mmHg and pulmonary vascular resistance >2 Wood Units (WU) on right-heart catheterization. Pregnancy is generally contraindicated in PAH, it is ... ...

Abstract	Introduction: Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure >20 mmHg and pulmonary vascular resistance >2 Wood Units (WU) on right-heart catheterization. Pregnancy is generally contraindicated in PAH, it is associated with high maternal mortality. Despite current recommendations, the number of women with PAH wishing to become pregnant is increasing. Specialist care is essential for preconception counseling, and the management of pregnancy and delivery in such patients. Areas covered: We cover the physiology of pregnancy, and its effects on the cardiovascular system in PAH. We also discuss optimal management based on available evidence and guidance. Expert opinion: Pregnancy should be avoided in most patients with PAH. Counseling on appropriate contraception should be offered routinely. Education of women with childbearing potential is essential and should start at the time of diagnosis of PAH, or the time of transition from pediatric to adult services in patients developing PAH in childhood. Women wishing to become pregnant should receive individualized risk assessment and optimization of PAH therapies via a dedicated specialist pre-pregnancy counseling service, to minimize risk and improve outcomes. Pregnant PAH patients should receive expert multidisciplinary management in a PH center, including close monitoring and early initiation of therapies.
MeSH term(s)	Pregnancy ; Adult ; Humans ; Female ; Child ; Pulmonary Arterial Hypertension ; Hypertension, Pulmonary ; Familial Primary Pulmonary Hypertension/complications ; Risk Assessment ; Counseling
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2479146-5
ISSN	1747-6356 ; 1747-6348
ISSN (online)	1747-6356
ISSN	1747-6348
DOI	10.1080/17476348.2023.2210838
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Zs.A 6963: Show issues

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Article ; Online: The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis.

Seely, Kevin D / Kotelko, Cody A / Douglas, Hannah / Bealer, Brandon / Brooks, Amanda E

International journal of molecular sciences

2021 Volume 22, Issue 17

Abstract: An expanding body of research asserts that the gut microbiota has a role in bone metabolism and the pathogenesis of osteoporosis. This review considers the human gut microbiota composition and its role in osteoclastogenesis and the bone healing process, ... ...

Abstract	An expanding body of research asserts that the gut microbiota has a role in bone metabolism and the pathogenesis of osteoporosis. This review considers the human gut microbiota composition and its role in osteoclastogenesis and the bone healing process, specifically in the case of osteoporosis. Although the natural physiologic processes of bone healing and the pathogenesis of osteoporosis and bone disease are now relatively well known, recent literature suggests that a healthy microbiome is tied to bone homeostasis. Nevertheless, the mechanism underlying this connection is still somewhat enigmatic. Based on the literature, a relationship between the microbiome, osteoblasts, osteoclasts, and receptor activator of nuclear factor-kappa-Β ligand (RANKL) is contemplated and explored in this review. Studies have proposed various mechanisms of gut microbiome interaction with osteoclastogenesis and bone health, including micro-RNA, insulin-like growth factor 1, and immune system mediation. However, alterations to the gut microbiome secondary to pharmaceutical and surgical interventions cannot be discounted and are discussed in the context of clinical therapeutic consideration. The literature on probiotics and their mechanisms of action is examined in the context of bone healing. The known and hypothesized interactions of common osteoporosis drugs and the human gut microbiome are examined. Since dysbiosis in the gut microbiota can function as a biomarker of bone metabolic activity, it may also be a pharmacological and nutraceutical (i.e., pre- and probiotics) therapeutic target to promote bone homeostasis.
MeSH term(s)	Bone Density Conservation Agents ; Bone and Bones/metabolism ; Bone and Bones/microbiology ; Dysbiosis/microbiology ; Dysbiosis/physiopathology ; Gastrointestinal Microbiome/physiology ; Homeostasis ; Humans ; MicroRNAs ; Microbiota ; Osteoblasts ; Osteoclasts ; Osteogenesis/physiology ; Osteoporosis/metabolism ; Osteoporosis/microbiology ; Osteoporosis/physiopathology ; Probiotics/metabolism ; Probiotics/pharmacology
Chemical Substances	Bone Density Conservation Agents ; MicroRNAs
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22179452
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Article ; Online: Authorship climate: A new tool for studying ethical issues in authorship.

Douglas, Hannah M / Elliott, Kevin C / Settles, Isis H / Montgomery, Georgina M / Davis, Tangier / Nadolsky, Lexi / Cheruvelil, Kendra Spence

Accountability in research

2022 , Page(s) 1–25

Abstract: Authorship of academic publications is central to scientists' careers, but decisions about how to include and order authors on publications are often fraught with difficult ethical issues. To better understand scholars' experiences with authorship, we ... ...

Abstract	Authorship of academic publications is central to scientists' careers, but decisions about how to include and order authors on publications are often fraught with difficult ethical issues. To better understand scholars' experiences with authorship, we developed a novel concept,
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2069334-5
ISSN	1545-5815 ; 0898-9621
ISSN (online)	1545-5815
ISSN	0898-9621
DOI	10.1080/08989621.2022.2140587
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Article: Streptococcus oralis

Mohan, Naina / O'Connor, Lucy / Douglas, Hannah / Banerjee, Anita / Nelson-Piercy, Catherine / Klein, John L

Obstetric medicine

2022 Volume 17, Issue 1, Page(s) 61–62

Abstract: While pregnancy is a time of relative immunosuppression, infective endocarditis and bacterial meningitis remain rare. We present a case of a pregnant woman ... ...

Abstract	While pregnancy is a time of relative immunosuppression, infective endocarditis and bacterial meningitis remain rare. We present a case of a pregnant woman with
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2612229-7
ISSN	1753-4968 ; 1753-495X
ISSN (online)	1753-4968
ISSN	1753-495X
DOI	10.1177/1753495X221118168
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Zs.A 7029: Show issues

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Article ; Online: Amplified cortical neural responses as animals learn to use novel activity patterns.

Akitake, Bradley / Douglas, Hannah M / LaFosse, Paul K / Beiran, Manuel / Deveau, Ciana E / O'Rawe, Jonathan / Li, Anna J / Ryan, Lauren N / Duffy, Samuel P / Zhou, Zhishang / Deng, Yanting / Rajan, Kanaka / Histed, Mark H

Current biology : CB

2023 Volume 33, Issue 11, Page(s) 2163–2174.e4

Abstract: Cerebral cortex supports representations of the world in patterns of neural activity, used by the brain to make decisions and guide behavior. Past work has found diverse, or limited, changes in the primary sensory cortex in response to learning, ... ...

Abstract	Cerebral cortex supports representations of the world in patterns of neural activity, used by the brain to make decisions and guide behavior. Past work has found diverse, or limited, changes in the primary sensory cortex in response to learning, suggesting that the key computations might occur in downstream regions. Alternatively, sensory cortical changes may be central to learning. We studied cortical learning by using controlled inputs we insert: we trained mice to recognize entirely novel, non-sensory patterns of cortical activity in the primary visual cortex (V1) created by optogenetic stimulation. As animals learned to use these novel patterns, we found that their detection abilities improved by an order of magnitude or more. The behavioral change was accompanied by large increases in V1 neural responses to fixed optogenetic input. Neural response amplification to novel optogenetic inputs had little effect on existing visual sensory responses. A recurrent cortical model shows that this amplification can be achieved by a small mean shift in recurrent network synaptic strength. Amplification would seem to be desirable to improve decision-making in a detection task; therefore, these results suggest that adult recurrent cortical plasticity plays a significant role in improving behavioral performance during learning.
MeSH term(s)	Mice ; Animals ; Neurons/physiology ; Learning ; Cerebral Cortex ; Visual Perception/physiology
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.04.032
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Article ; Online: Perceptions of water insecurity from urban and peri-urban Haiti: A quantitative analysis.

Wood, Elizabeth A / Douglas, Hannah / Fiore, Andrew J / Bernier, Robinson / Chapman, Kelly S

PloS one

2019 Volume 14, Issue 4, Page(s) e0214789

Abstract: Safe drinking water access has continued to be a growing issue in Haiti. Water accessibility, availability, and quality can have severe implications on health and safety, with those in urban areas often having more access. Key differences relating to ... ...

Abstract	Safe drinking water access has continued to be a growing issue in Haiti. Water accessibility, availability, and quality can have severe implications on health and safety, with those in urban areas often having more access. Key differences relating to water accessibility can be seen between the urban and peri-urban areas of Haiti. One major objective of this research is to examine the disparities between the two areas and determine limiting and enabling factors that are contributing to the perceived access to clean water. A cross-cultural household water insecurity experiences (HWISE) survey (n = 499) was distributed to determine barriers and accessibility to sufficient water quality and quantity at the household level. This paper explores the relationship between water insecurity between two urban and peri-urban communes in Haiti using this data. Fisher's Exact and Kruskal-Wallis tests were used to identify significant differences between strata, and logistic regression was used to determine significant associations with water security outcomes. Results indicated there were differences in both the costs and the sources of drinking and non-drinking water between urban and peri-urban Haiti. Certain demographic and behavioral characteristics were associated with increased water insecurity, including a household size greater than five and experiencing injury during collection.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Cross-Cultural Comparison ; Drinking Water ; Family Characteristics ; Female ; Haiti ; Humans ; Infant ; Male ; Middle Aged ; Surveys and Questionnaires ; Urban Population ; Water Resources/supply & distribution ; Water Supply/economics ; Water Supply/statistics & numerical data ; Young Adult
Chemical Substances	Drinking Water
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0214789
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Article ; Online: Perceived water insecurity among adults from urban and peri-urban Haiti: A qualitative study.

Wood, Elizabeth A / Douglas, Hannah / Fiore, Andrew J / Nappy, Meredith K / Bernier, Robinson / Chapman, Kelly S

PloS one

2019 Volume 14, Issue 4, Page(s) e0214790

Abstract: Water and sanitation services are fundamental in preventing the spread of waterborne and hygiene-related diseases. However, in developing countries, such as Haiti, access to clean water continues to pose major challenges despite efforts to improve ... ...

Abstract	Water and sanitation services are fundamental in preventing the spread of waterborne and hygiene-related diseases. However, in developing countries, such as Haiti, access to clean water continues to pose major challenges despite efforts to improve quality and reduce distance. With Léogâne being the epicenter of the earthquake in Haiti in 2010, there were dozens of interventions aimed to improve access to clean water, specifically well construction and use of water treatment strategies. Using the socioecological framework, this study collected qualitative data to supplement a household water insecurity experiences (HWISE) survey in order to fully understand the narratives around water in Léogâne (urban) and its neighboring commune Gressier (peri-urban). The inclusion criteria for this study was that the participant must be a resident of either site, at least 18 years or older, and a female. Only females were included in this study so that researchers could better understand how perceived water insecurity impacts reproductive health, specifically gynecological infections. This cross-sectional study yielded 61 total in-depth interviews using a semi-structured open ended questionnaire to allow participants the ability to elaborate. Results suggest that there are common misconceptions about water and reproductive health specifically that engaging in sexual intercourse in saltwater will not result in pregnancy. Relevant narratives among the two communes included water acquisition, use of water, and bathing practices, among several others. Through understanding the local Haitian perspective and practices that surround water insecurity, we can better tailor public health interventions to improve access to water, female hygiene practices, and ultimately lower and prevent disease transmission.
MeSH term(s)	Adult ; Aged ; Developing Countries ; Drinking Water ; Earthquakes ; Female ; Haiti ; Humans ; Hygiene ; Middle Aged ; Pregnancy ; Public Health ; Qualitative Research ; Sanitation ; Urban Population ; Water Purification ; Water Resources/supply & distribution ; Water Supply ; Young Adult
Chemical Substances	Drinking Water
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0214790
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Article: Transthoracic Echocardiographic Assessment of the Heart in Pregnancy-a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society.

Curtis, Stephanie L / Belham, Mark / Bennett, Sadie / James, Rachael / Harkness, Allan / Gamlin, Wendy / Thilaganathan, Baskaran / Giorgione, Veronica / Douglas, Hannah / Carroll, Aisling / Kitt, Jamie / Colebourn, Claire / Ribeiro, Isabel / Fairbairn, Sarah / Augustine, Daniel X / Robinson, Shaun / Thorne, Sara A

Echo research and practice

2023 Volume 10, Issue 1, Page(s) 7

Abstract: Pregnancy is a dynamic process associated with profound hormonally mediated haemodynamic changes which result in structural and functional adaptations in the cardiovascular system. An understanding of the myocardial adaptations is important for ... ...

Abstract	Pregnancy is a dynamic process associated with profound hormonally mediated haemodynamic changes which result in structural and functional adaptations in the cardiovascular system. An understanding of the myocardial adaptations is important for echocardiographers and clinicians undertaking or interpreting echocardiograms on pregnant and post-partum women. This guideline, on behalf of the British Society of Echocardiography and United Kingdom Maternal Cardiology Society, reviews the expected echocardiographic findings in normal pregnancy and in different cardiac disease states, as well as echocardiographic signs of decompensation. It aims to lay out a structure for echocardiographic scanning and surveillance during and after pregnancy as well as suggesting practical advice on scanning pregnant women.
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2777997-X
ISSN	2055-0464
ISSN	2055-0464
DOI	10.1186/s44156-023-00019-8
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