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Book: Pediatric Ocular Surface Disease

Douglas, Vivian Paraskevi / Traish, Aisha

2023

Author's details	¿Aisha Traish, MD is an Assistant Professor of Ophthalmology at the Massachusetts Eye and Ear Infirmary/Harvard Medical School and the Associate Residency Director of the Harvard Ophthalmology Residency Program. She began her academic career at the University of Illinois at Chicago in 2010 where she was awarded the Golden Apple teaching award the first two consecutive years as faculty and Best Doctors in America 2015, 2017, 2019. She has been practicing pediatric cornea for the past decade and is currently a pediatric cornea specialist at Boston Children's Hospital. She has published peer-reviewed publications in Pediatrics, Neurology, Cornea and JAMA Ophthalmology and is a reviewer for Cornea, American Journal of Ophthalmology and The Ocular Surface. Vivian Paraskevi Douglas, MD, DVM, MBA, MSc is a postdoctoral research fellow at the Massachusetts Eye and Ear Infirmary/Harvard Medical School. She graduated from the Medical School of Comenius University of Bratislava (Slovakia) and
Keywords	Ocularsurfacedisease ; pediatricophthalmology ; PediatricOcularSurfaceDisease ; dryeyedisease ; Conjunctivitis ; ExposureKeratopathy ; OcularRosacea ; graftversushostdisease ; NeurotrophicKeratitis ; StevensJohnsonSyndrome ; TherapeuticContactLens ; SurgicalRehabilitation ; EyelidMarginDisease ; Ocular Surface Disease ; Pediatric Ophthalmology ; Pediatric Ocular Surface Disease ; Dry Eye Disease ; Exposure Keratopathy ; Ocular Rosacea ; Graft Versus Host Disease ; Neurotrophic Keratitis ; Stevens Johnson Syndrome ; Therapeutic Contact Lens ; Surgical Rehabilitation ; Eyelid Margin Disease
Language	English
Size	184 p.
Edition	1
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_21
Format	160 x 241 x 16
ISBN	9783031305610 ; 3031305612
Database	PDA

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Article ; Online: Optical coherence tomography angiography in neuro-ophthalmology.

Douglas, Vivian Paraskevi / Douglas, Konstantinos A A / Torun, Nurhan

Current opinion in ophthalmology

2023 Volume 34, Issue 4, Page(s) 354–360

Abstract: Purpose of review: Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid. Although OCTA has been widely used for the ... ...

Abstract	Purpose of review: Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid. Although OCTA has been widely used for the evaluation of a number of retinal diseases, its use in the field of neuro-ophthalmology has been less studied. In this review, we provide an update on the utility of OCTA in neuro-ophthalmic conditions. Recent findings: Peripapillary and macular microvasculature analyses have indicated that OCTA can be a promising tool for early detection of a number of neuro-ophthalmic diseases, differential diagnosis, and monitoring of disease progression. Recent studies have demonstrated that structural and functional impairment can develop at early stages in some conditions such as in multiple sclerosis and Alzheimer's disease even in the absence of overt clinical symptoms. Furthermore, this dye-less technique can be a valuable adjunct tool in the detection of complications commonly seen in some congenital entities such optic disc drusen. Summary: Since its introduction, OCTA has emerged as an important imaging approach shedding light on unrevealed pathophysiological mechanisms of several ocular diseases. The use of OCTA as a biomarker in the field of neuro-ophthalmology has recently gained considerable attention with studies supporting its role in clinical setting while larger studies are warranted for correlating these findings with traditional diagnostic procedures and clinical features and outcomes.
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Ophthalmology ; Angiography/methods ; Retina ; Retinal Diseases/diagnostic imaging ; Fluorescein Angiography/methods ; Retinal Vessels
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000955
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Article: Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Douglas, Vivian Paraskevi / Rachapudi, Sruti S / Davila-Siliezar, Pamela / Laylani, Noor A R / Lee, Andrew G

Ophthalmology and therapy

2024

Abstract: Transient monocular visual loss (TMVL), also known as transient monocular blindness or amaurosis fugax ("fleeting blindness"), is a temporary loss of vision often due to ischemia to the retina. While acute TMVL should be considered an emergency that ... ...

Abstract	Transient monocular visual loss (TMVL), also known as transient monocular blindness or amaurosis fugax ("fleeting blindness"), is a temporary loss of vision often due to ischemia to the retina. While acute TMVL should be considered an emergency that further requires exhaustive investigation, there are some cases in which TMVL arises secondary to benign causes. Age has a major impact in the diagnosis of ischemia and although the differential diagnosis of TMVL can be broad, timely and appropriate history, examination, diagnostic testing, and treatment can be vision- or life-saving. We review the causes of TMVL and the impact of age on the differential diagnoses and management.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article ; Review
ISSN	2193-8245
ISSN	2193-8245
DOI	10.1007/s40123-024-00932-z
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Article ; Online: Multimodal Imaging of a Type-1 Retinal Arteriovenous Malformation.

Martinez-Velazquez, Luis A / Douglas, Vivian Paraskevi / Miller, John B

Ophthalmology. Retina

2022 Volume 6, Issue 8, Page(s) 701

MeSH term(s)	Arteriovenous Malformations/diagnosis ; Hemangioma ; Humans ; Multimodal Imaging
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article
ISSN	2468-6530
ISSN (online)	2468-6530
DOI	10.1016/j.oret.2022.05.019
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Article: Subthreshold Exudative Choroidal Neovascularization (CNV): Presentation of This Uncommon Subtype and Other CNVs in Age-Related Macular Degeneration (AMD).

Douglas, Vivian Paraskevi / Garg, Itika / Douglas, Konstantinos A A / Miller, John B

Journal of clinical medicine

2022 Volume 11, Issue 8

Abstract: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in people over the age of 50 worldwide. Exudative or neovascular AMD is a more severe subset of AMD which is characterized by the presence of choroidal ... ...

Abstract	Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in people over the age of 50 worldwide. Exudative or neovascular AMD is a more severe subset of AMD which is characterized by the presence of choroidal neovascularization (CNV). Recent advancements in multimodal ophthalmic imaging, including optical coherence tomography (OCT) and OCT-angiography (OCT-A), have facilitated the detection and characterization of previously undetectable neovascular lesions and have enabled a more refined classification of CNV in exudative as well as nonexudative AMD patients. Subthreshold exudative CNV is a novel subtype of exudative AMD that typically presents asymptomatically with good visual acuity and is characterized by stable persistent or intermittent subretinal fluid (SRF). This review aims to provide an overview of the clinical as well as multimodal imaging characteristics of CNV in AMD, including this new clinical phenotype, and propose effective approaches for management.
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11082083
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Article ; Online: Chronic Relapsing Inflammatory Optic Neuropathy (CRION).

Mukharesh, Loulwah / Douglas, Vivian Paraskevi / Chwalisz, Bart K

Current opinion in ophthalmology

2021 Volume 32, Issue 6, Page(s) 521–526

MeSH term(s)	Humans ; Optic Nerve ; Optic Nerve Diseases/etiology ; Optic Neuritis ; Recurrence
Language	English
Publishing date	2021-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000804
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Article ; Online: Ophthalmic manifestations of dementing disorders.

Douglas, Vivian Paraskevi / Douglas, Konstantinos A A / Cestari, Dean M

Current opinion in ophthalmology

2021 Volume 32, Issue 6, Page(s) 515–520

Abstract: Purpose of review: Dementia is a term for loss of memory, language, problem-solving, and other thinking abilities, which significantly interferes with daily life. Certain dementing conditions may also affect visual function. The eye is an accessible ... ...

Abstract	Purpose of review: Dementia is a term for loss of memory, language, problem-solving, and other thinking abilities, which significantly interferes with daily life. Certain dementing conditions may also affect visual function. The eye is an accessible window to the brain that can provide valuable information for the early diagnosis of people who suffer from Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies as well as from more rare causes of dementias, such as Creutzfeldt-Jacob and Huntington's diseases. Herein, we present the ocular manifestations of neurocognitive disorders focusing on the neuro-ophthalmic ones and further discuss potential ocular biomarkers that could help in early detection of these disorders. Recent findings: Ophthalmic examination along with the recent developments in in-vivo testing have provided a strong foundation of useful knowledge about brain disorder in neurodegenerative diseases without the need for invasive studies. Currently, a number of visual measures, such as visual acuity, contrast sensitivity, pupil response, and saccades in addition to various ophthalmic tests, such as electroretinogram, visual evoked potential, optical coherence tomography (OCT), and OCT-angiography have been widely used and evaluated as potential biomarkers for different stages of dementia. Summary: Ophthalmologic and neuro-ophthalmic evaluation is evolving as an important part of the early diagnosis and management of people with dementia. A particular focus on ocular biomarkers in dementing illnesses has arisen over the past few years and there are several promising measures and imaging tools that have been proposed as potential biomarkers for these diseases.
MeSH term(s)	Alzheimer Disease ; Brain ; Evoked Potentials, Visual ; Humans ; Huntington Disease ; Parkinson Disease
Language	English
Publishing date	2021-08-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000807
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Article ; Online: The epidemiology of pediatric dry eye disease in the United States: An IRIS® registry (Intelligent Research in Sight) analysis.

Douglas, Vivian Paraskevi / Hall, Nathan / Ross, Connor / Douglas, Konstantinos A A / Elze, Tobias / Miller, Joan W / Lorch, Alice C / Traish, Aisha S

The ocular surface

2024 Volume 32, Page(s) 106–111

Abstract: Purpose: Dry-eye disease (DED) is a chronic progressive ocular surface disorder with limited studies in the pediatric population. The Academy of Ophthalmology's IRIS® Registry was leveraged to investigate the prevalence of DED in the pediatric ... ...

Abstract	Purpose: Dry-eye disease (DED) is a chronic progressive ocular surface disorder with limited studies in the pediatric population. The Academy of Ophthalmology's IRIS® Registry was leveraged to investigate the prevalence of DED in the pediatric population (PDED, patients <18 years old) and the demographic differences of DED between pediatric and adult patients (ADED). Methods: Retrospective cohort study. Patients with DED between January 1st, 2013 and December 31st, 2019 (N = 4,795,979) were included. Descriptive statistics, Pearson's chi-squared tests and two-sample proportions tests were conducted to compare key demographic distributions between the ADED and PDED cohorts. Results: The average age at onset for ADED patients was 61.06 (±14.75) years and for PDED patients was 12.51 (±3.86). The overall tests for independence and the individual tests of proportions of each category were statistically significant for all demographic characteristics (p < 0.001). Characteristics with the largest discrepancies between patients of PDED and the IRIS Registry pediatric patient pool (PIRIS) included female sex (58.08 % vs. 50.60 %), male sex (41.58 % vs. 48.78 %) and Asian race (6.02 % vs. 3.11 %) respectively. Within the PDED cohort, females were at higher risk of PDED (58 % vs. 42 %). PDED was more prevalent in children with refractive errors (76 %) and eyelid/conjunctival disorders (41 %). Characteristics with the largest discrepancies between PDED and ADED patients included female sex (58.08 % vs. 68.12 %), male sex (41.58 % vs. 31.55 %) and Caucasian race (50.24 % vs. 67.06 %) respectively. Conclusions: Significant differences in the PDED cohort are demonstrated in this study. PDED was more prevalent in the female sex and Caucasian race compared to PIRIS and was more commonly associated with refractive errors and eyelid/conjunctival disorders.
MeSH term(s)	Humans ; Male ; Retrospective Studies ; Female ; Registries ; Dry Eye Syndromes/epidemiology ; United States/epidemiology ; Child ; Adolescent ; Prevalence ; Middle Aged ; Adult ; Child, Preschool ; Aged ; Young Adult ; Age Distribution
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
ZDB-ID	2208578-6
ISSN	1937-5913 ; 1542-0124
ISSN (online)	1937-5913
ISSN	1542-0124
DOI	10.1016/j.jtos.2024.01.012
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Article ; Online: Overlap between ophthalmology and psychiatry - A narrative review focused on congenital and inherited conditions.

Kiely, Chelsea / Douglas, Konstantinos A A / Douglas, Vivian Paraskevi / Miller, John B / Lizano, Paulo

Psychiatry research

2023 Volume 331, Page(s) 115629

Abstract: A number of congenital and inherited diseases present with both ocular and psychiatric features. The genetic inheritance and phenotypic variants play a key role in disease severity. Early recognition of the signs and symptoms of those disorders is ... ...

Abstract	A number of congenital and inherited diseases present with both ocular and psychiatric features. The genetic inheritance and phenotypic variants play a key role in disease severity. Early recognition of the signs and symptoms of those disorders is critical to earlier intervention and improved prognosis. Typically, the associations between these two medical subspecialties of ophthalmology and psychiatry are poorly understood by most practitioners so we hope to provide a narrative review to improve the identification and management of these disorders. We conducted a comprehensive review of the literature detailing the diseases with ophthalmic and psychiatric overlap that were more widely represented in the literature. Herein, we describe the clinical features, pathophysiology, molecular biology, diagnostic tests, and the most recent approaches for the treatment of these diseases. Recent studies have combined technologies for ocular and brain imaging such as optical coherence tomography (OCT) and functional imaging with genetic testing to identify the genetic basis for eye-brain connections. Additional work is needed to further explore these potential biomarkers. Overall, accurate, efficient, widely distributed and non-invasive tests that can help with early recognition of these diseases will improve the management of these patients using a multidisciplinary approach.
MeSH term(s)	Humans ; Ophthalmology ; Genetic Testing ; Psychiatry
Language	English
Publishing date	2023-11-25
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115629
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Article ; Online: Optic nerve sheath meningioma.

Douglas, Vivian Paraskevi / Douglas, Konstantinos A A / Cestari, Dean M

Current opinion in ophthalmology

2020 Volume 31, Issue 6, Page(s) 455–461

Abstract: Purpose of review: Optic nerve sheath meningiomas (ONSMs) are rare benign tumors of the anterior visual pathway which present with slowly progressive and painless vision loss and account for approximately 2% of all orbital tumors. This article provides ... ...

Abstract	Purpose of review: Optic nerve sheath meningiomas (ONSMs) are rare benign tumors of the anterior visual pathway which present with slowly progressive and painless vision loss and account for approximately 2% of all orbital tumors. This article provides an overview as well as an update on the ONSMs with regards to cause, epidemiology, clinical presentation, diagnosis, and management in adults and pediatric population. Recent findings: The clinical presentation and prognosis of ONSMs can vary and largely depend on the location of tumor as well as the histologic type. Overall, the diagnosis is based on clinical presentation, examination, and neuroimaging findings. Nevertheless, delays in diagnosis or misdiagnosis are not uncommon and can result in higher morbidity rates. Recent advances in diagnostic as well as more effective and less-invasive treatment options are discussed in this review. Summary: ONSMs are a rare cause of slowly progressive and inexorable visual loss. Although ONSM diagnosis depends on the characteristic clinical and radiologic findings, prompt diagnosis, and appropriate management is critical for favorable visual outcomes. Thus, current focus is optimizing diagnostic as well-treatment methods for patients with ONSMs.
MeSH term(s)	Humans ; Meningioma/diagnosis ; Meningioma/therapy ; Neuroimaging ; Optic Nerve Neoplasms/diagnosis ; Optic Nerve Neoplasms/therapy ; Prognosis ; Vision Disorders/etiology
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000700
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