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  1. Book ; Online: Reading the Bible Ethically

    Douglass, Eric J

    Recovering the Voice in the Text

    (Biblical Interpretation Series)

    2014  

    Abstract: ... In ... Reading the Bible Ethically ... , Eric Douglass takes account of the author's subjective contributions, so that the text functions as the author's voice. Dealing with a voice suggests ethical principles, where interpretation doesn't silence or ... ...

    Series title Biblical Interpretation Series
    Abstract In Reading the Bible Ethically, Eric Douglass takes account of the author's subjective contributions, so that the text functions as the author's voice. Dealing with a voice suggests ethical principles, where interpretation doesn't silence or manipulated that voice
    Language English
    Size Online-Ressource (309 p)
    Publisher BRILL
    Publishing place Leiden
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9789004282865 ; 9004282866
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: ROBOT: A Tool for Automating Ontology Workflows.

    Jackson, Rebecca C / Balhoff, James P / Douglass, Eric / Harris, Nomi L / Mungall, Christopher J / Overton, James A

    BMC bioinformatics

    2019  Volume 20, Issue 1, Page(s) 407

    Abstract: Background: Ontologies are invaluable in the life sciences, but building and maintaining ontologies often requires a challenging number of distinct tasks such as running automated reasoners and quality control checks, extracting dependencies and ... ...

    Abstract Background: Ontologies are invaluable in the life sciences, but building and maintaining ontologies often requires a challenging number of distinct tasks such as running automated reasoners and quality control checks, extracting dependencies and application-specific subsets, generating standard reports, and generating release files in multiple formats. Similar to more general software development, automation is the key to executing and managing these tasks effectively and to releasing more robust products in standard forms. For ontologies using the Web Ontology Language (OWL), the OWL API Java library is the foundation for a range of software tools, including the Protégé ontology editor. In the Open Biological and Biomedical Ontologies (OBO) community, we recognized the need to package a wide range of low-level OWL API functionality into a library of common higher-level operations and to make those operations available as a command-line tool.
    Results: ROBOT (a recursive acronym for "ROBOT is an OBO Tool") is an open source library and command-line tool for automating ontology development tasks. The library can be called from any programming language that runs on the Java Virtual Machine (JVM). Most usage is through the command-line tool, which runs on macOS, Linux, and Windows. ROBOT provides ontology processing commands for a variety of tasks, including commands for converting formats, running a reasoner, creating import modules, running reports, and various other tasks. These commands can be combined into larger workflows using a separate task execution system such as GNU Make, and workflows can be automatically executed within continuous integration systems.
    Conclusions: ROBOT supports automation of a wide range of ontology development tasks, focusing on OBO conventions. It packages common high-level ontology development functionality into a convenient library, and makes it easy to configure, combine, and execute individual tasks in comprehensive, automated workflows. This helps ontology developers to efficiently create, maintain, and release high-quality ontologies, so that they can spend more time focusing on development tasks. It also helps guarantee that released ontologies are free of certain types of logical errors and conform to standard quality control checks, increasing the overall robustness and efficiency of the ontology development lifecycle.
    MeSH term(s) Biological Ontologies ; Disease ; Humans ; Programming Languages ; Software ; Workflow
    Language English
    Publishing date 2019-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-019-3002-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.

    Engel, Stacia R / Wong, Edith D / Nash, Robert S / Aleksander, Suzi / Alexander, Micheal / Douglass, Eric / Karra, Kalpana / Miyasato, Stuart R / Simison, Matt / Skrzypek, Marek S / Weng, Shuai / Cherry, J Michael

    Genetics

    2021  Volume 220, Issue 4

    Abstract: Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic genetics, gene product function, and cellular biological processes. Saccharomyces Genome Database (SGD) has been supporting the yeast research community since 1993, ... ...

    Abstract Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic genetics, gene product function, and cellular biological processes. Saccharomyces Genome Database (SGD) has been supporting the yeast research community since 1993, serving as its de facto hub. Over the years, SGD has maintained the genetic nomenclature, chromosome maps, and functional annotation, and developed various tools and methods for analysis and curation of a variety of emerging data types. More recently, SGD and six other model organism focused knowledgebases have come together to create the Alliance of Genome Resources to develop sustainable genome information resources that promote and support the use of various model organisms to understand the genetic and genomic bases of human biology and disease. Here we describe recent activities at SGD, including the latest reference genome annotation update, the development of a curation system for mutant alleles, and new pages addressing homology across model organisms as well as the use of yeast to study human disease.
    MeSH term(s) Alleles ; Databases, Genetic ; Genome, Fungal ; Humans ; Saccharomyces/genetics ; Saccharomyces cerevisiae/genetics
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyab224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of the temporal requirement for eda in hair and sweat gland development.

    Cui, Chang-Yi / Kunisada, Makoto / Esibizione, Diana / Douglass, Eric G / Schlessinger, David

    The Journal of investigative dermatology

    2008  Volume 129, Issue 4, Page(s) 984–993

    Abstract: EDA signaling is important in skin appendage initiation. Its possible involvement in appendage subtype determination and postinduction stage appendage development, however, has not been studied systematically. To address these issues we manipulated Eda- ... ...

    Abstract EDA signaling is important in skin appendage initiation. Its possible involvement in appendage subtype determination and postinduction stage appendage development, however, has not been studied systematically. To address these issues we manipulated Eda-A1 transgene expression in a tetracycline-regulated conditional mouse model, where the transgene is the only source of active ectodysplasin (Eda). We find that Eda-A1 restores sweat glands and all hair subtypes in Tabby, but each requires its action at an idiosyncratic time of development: by E17 for guard, by E19 for awl, and starting at E18 for zigzag/auchen hair. Guard and awl hairs were indistinguishable from their wild-type counterparts; but restored zigzag and auchen hairs, although recognizable, were somewhat smaller and lacked characteristic bends. Notably, secondary hair follicle formation of awl, auchen, and zigzag hairs required higher Eda-A1 expression level than did guard hair or sweat glands. Furthermore, Eda-A1 expression is required until the early dermal papilla stage for guard hair germs to make follicles, but is dispensable for their maturation. Similarly, sweat gland pegs require Eda-A1 at an early stage to form mature glands. Thus we infer that EDA signaling is needed for the determination and development of various skin appendages at spatiotemporally restricted intervals.
    MeSH term(s) Animals ; Doxycycline/pharmacology ; Ectodysplasins/genetics ; Ectodysplasins/physiology ; Female ; Hair Follicle/embryology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Signal Transduction ; Sweat Glands/embryology ; Transgenes
    Chemical Substances Ectodysplasins ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2008-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2008.318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells.

    Ottolenghi, Chris / Pelosi, Emanuele / Tran, Joseph / Colombino, Maria / Douglass, Eric / Nedorezov, Timur / Cao, Antonio / Forabosco, Antonino / Schlessinger, David

    Human molecular genetics

    2007  Volume 16, Issue 23, Page(s) 2795–2804

    Abstract: The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only partial effects have been reported for candidate genes experimentally tested so far. Here we ... ...

    Abstract The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only partial effects have been reported for candidate genes experimentally tested so far. Here we demonstrate that inactivation of two ovarian somatic factors, Wnt4 and Foxl2, produces testis differentiation in XX mice, resulting in the formation of testis tubules and spermatogonia. These genes are thus required to initiate or maintain all major aspects of female sex determination in mammals. The two genes are independently expressed and show complementary roles in ovary morphogenesis. In addition, forced expression of Foxl2 impairs testis tubule differentiation in XY transgenic mice, and germ cell-depleted XX mice lacking Foxl2 and harboring a Kit mutation undergo partial female-to-male sex reversal. The results are all consistent with an anti-testis role for Foxl2. The data suggest that the relative autonomy of the action of Foxl2, Wnt4 and additional ovarian factor(s) in the mouse should facilitate the dissection of their respective contributions to female sex determination.
    MeSH term(s) Animals ; Animals, Newborn ; Disorders of Sex Development ; Female ; Forkhead Box Protein L2 ; Forkhead Transcription Factors/deficiency ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Germ Cells/cytology ; Germ Cells/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Models, Biological ; Ovary/cytology ; Ovary/embryology ; Pregnancy ; Sex Determination Processes ; Sex Differentiation ; Testis/cytology ; Testis/embryology ; Wnt Proteins/deficiency ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt4 Protein
    Chemical Substances Forkhead Box Protein L2 ; Forkhead Transcription Factors ; Foxl2 protein, mouse ; WNT4 protein, human ; Wnt Proteins ; Wnt4 Protein ; Wnt4 protein, mouse
    Language English
    Publishing date 2007-12-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddm235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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