Article ; Online: Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver.
2016 Volume 8, Issue 2, Page(s) 38
Abstract: This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN- ... ...
| Abstract | This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression. |
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| MeSH term(s) | Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Arecaceae ; Catalase/metabolism ; Diet ; Food, Fortified ; Glutathione/metabolism ; Hepcidins/genetics ; Hepcidins/metabolism ; Homeostasis ; Intestines/drug effects ; Intestines/metabolism ; Iron/blood ; Iron/metabolism ; Lipid Peroxidation/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Oxidative Stress/drug effects ; Plant Extracts/pharmacology ; Protein Carbonylation/drug effects ; RNA, Messenger/metabolism ; Rats, Wistar ; Spleen/drug effects ; Spleen/metabolism ; Up-Regulation |
| Chemical Substances | Antioxidants ; Hamp protein, rat ; Hepcidins ; Plant Extracts ; RNA, Messenger ; Iron (E1UOL152H7) ; Catalase (EC 1.11.1.6) ; Glutathione (GAN16C9B8O) |
| Language | English |
| Publishing date | 2016-02-17 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2518386-2 |
| ISSN | 2072-6643 ; 2072-6643 |
| ISSN (online) | 2072-6643 |
| ISSN | 2072-6643 |
| DOI | 10.3390/nu8020038 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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