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  1. Article ; Online: Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19.

    Ramalingam, Sandeep / Graham, Catriona / Dove, Jenny / Morrice, Lynn / Sheikh, Aziz

    Journal of global health

    2020  Volume 10, Issue 1, Page(s) 10332

    MeSH term(s) Administration, Intranasal ; Betacoronavirus ; Coronavirus/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Humans ; Nasal Cavity/virology ; Nasal Lavage ; Pandemics ; Pharynx/virology ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Randomized Controlled Trials as Topic ; Saline Solution, Hypertonic/administration & dosage ; Saline Solution, Hypertonic/pharmacology ; Saline Solution, Hypertonic/therapeutic use ; Therapeutic Irrigation/methods
    Chemical Substances Saline Solution, Hypertonic
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Scotland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2978
    ISSN (online) 2047-2986
    ISSN 2047-2978
    DOI 10.7189/jogh.10.010332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold.

    Ramalingam, Sandeep / Graham, Catriona / Dove, Jenny / Morrice, Lynn / Sheikh, Aziz

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 1015

    Abstract: There are no antivirals to treat viral upper respiratory tract infection (URTI). Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate antiviral response in epithelial cells, we ... ...

    Abstract There are no antivirals to treat viral upper respiratory tract infection (URTI). Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate antiviral response in epithelial cells, we conducted a pilot, non-blinded, randomised controlled trial of hypertonic saline nasal irrigation and gargling (HSNIG) vs standard care on healthy adults within 48 hours of URTI onset to assess recruitment (primary outcome). Acceptability, symptom duration and viral shedding were secondary outcomes. Participants maintained a symptom diary until well for two days or a maximum of 14 days and collected 5 sequential mid-turbinate swabs to measure viral shedding. The intervention arm prepared hypertonic saline and performed HSNIG. We recruited 68 participants (2.6 participants/week; November 2014-March 2015). A participant declined after randomisation. Another was on antibiotics and hence removed (Intervention:32, Control:34). Follow up data was available from 61 (Intervention:30, Control:31). 87% found HSNIG acceptable, 93% thought HSNIG made a difference to their symptoms. In the intervention arm, duration of illness was lower by 1.9 days (p = 0.01), over-the-counter medications (OTCM) use by 36% (p = 0.004), transmission within household contacts by 35% (p = 0.006) and viral shedding by ≥0.5 log
    MeSH term(s) Adult ; Common Cold/therapy ; Common Cold/virology ; Feedback ; Female ; Humans ; Male ; Nasal Lavage ; Pilot Projects ; Saline Solution, Hypertonic/pharmacology ; Virus Shedding/drug effects
    Chemical Substances Saline Solution, Hypertonic
    Keywords covid19
    Language English
    Publishing date 2019-01-31
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-37703-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19

    Ramalingam, Sandeep / Graham, Catriona / Dove, Jenny / Morrice, Lynn / Sheikh, Aziz

    J Glob Health

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32395245
    Database COVID19

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