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  1. Article ; Online: Reporting of health-related quality of life in emergency laparotomy trials: a systematic review and narrative synthesis.

    Downey, Candice L / Lessing, J / Jayne, D G

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2023  Volume 33, Issue 3, Page(s) 599–605

    Abstract: Purpose: Emergency laparotomy is associated with high morbidity for the surgical patient. Understanding patients' health-related quality of life after their surgery is important to enhance the informed consent process, and to enable the evaluation and ... ...

    Abstract Purpose: Emergency laparotomy is associated with high morbidity for the surgical patient. Understanding patients' health-related quality of life after their surgery is important to enhance the informed consent process, and to enable the evaluation and improvement of surgical care. This review aims to summarise the use of health-related quality of life tools in clinical trials involving patients undergoing emergency laparotomy.
    Methods: A systematic review was undertaken of the scientific literature published in the MEDLINE
    Results: Eleven studies were selected for inclusion. Most of the studies had a low risk of bias. Two of the studies used health-related quality of life as the primary outcome measure. A variety of health-related quality of life measurement tools were used; the EQ-5D tool was the most popular questionnaire. Protocol adherence was dependent on the length of time which had elapsed after emergency surgery.
    Conclusion: There are many perceived challenges to collecting health-related quality of life data in the emergency surgery setting. Many of these can be offset with progressive trial designs. There is a need for further research in the systematic development of patient-reported outcomes for use in emergency surgery.
    MeSH term(s) Humans ; Laparotomy ; Quality of Life/psychology
    Language English
    Publishing date 2023-10-26
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-023-03531-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of in-hospital postoperative complications on quality of life up to 12 months after major abdominal surgery.

    Downey, Candice L / Bainbridge, Jamie / Jayne, David G / Meads, David M

    The British journal of surgery

    2023  Volume 110, Issue 9, Page(s) 1206–1212

    Abstract: Background: Postoperative complications are common, but there are limited data regarding their implications on patients' quality of life. This study aimed to address this gap in the literature by analysing the impact of postoperative complications on ... ...

    Abstract Background: Postoperative complications are common, but there are limited data regarding their implications on patients' quality of life. This study aimed to address this gap in the literature by analysing the impact of postoperative complications on patients' health-related quality of life.
    Methods: Data from the Perioperative Quality Improvement Programme were analysed, and included patient-level data for 19 685 adults who underwent elective major abdominal procedures in England since 2016. Postoperative complications were graded using the Clavien-Dindo classification. Quality of life was assessed by responses to the EuroQol five-dimension five-levels-of-response (EQ-5D-5L™) questionnaire before surgery, and at 6 and 12 months after operation. Ordinal logistic regression was used to estimate the association between Clavien-Dindo grades and quality of life. Tobit and ordinary least squares regression analyses were used to estimate the quality-adjusted life-year (QALY) loss resulting from postoperative complications between admission and 12 months after surgery.
    Results: At 6 and 12 months after surgery, increasingly severe postoperative complications were significantly associated with poorer health-related quality of life. The effect of postoperative complications on quality of life was sustained until at least 12 months after operation. Between admission and 12 months after surgery, 0.012, 0.026, 0.033, and 0.086 QALYs were lost for those experiencing a grade I, II, III, or IV postoperative complication respectively.
    Conclusion: Postoperative complications have a significant and sustained effect on patients' quality of life after surgery; this effect worsens as the severity of the complications increases.
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nursing staff perspectives of continuous remote vital signs monitoring on surgical wards: Theory elicitation for a realist evaluation.

    Downey, Candice / Brown, Julia / Jayne, David / Randell, Rebecca

    Journal of evaluation in clinical practice

    2022  Volume 28, Issue 3, Page(s) 394–403

    Abstract: Rationale, aims and objectives: Continuous remote monitoring (CRM) provides a novel solution to the challenges of monitoring patients' vital signs in hospital, but the results of quantitative studies have been mixed. Acceptance by staff is a crucial ... ...

    Abstract Rationale, aims and objectives: Continuous remote monitoring (CRM) provides a novel solution to the challenges of monitoring patients' vital signs in hospital, but the results of quantitative studies have been mixed. Acceptance by staff is a crucial determinant of the success of healthcare technologies and may explain these discrepancies. Drawing on the approach of realist evaluation, this paper aims to identify theories about how, why and in what conditions nursing staff perceptions vary regarding the CRM of patients' vital signs.
    Methods: Multiple methods were used to elicit theories about factors likely to facilitate or impede the successful implementation of continuous remote vital signs monitoring. This included a literature review, consultation with patients and observational work conducted during a randomized controlled trial (RCT) of CRM. In addition, a priori theories developed through informal interactions with patients and ward staff during the day-to-day set-up of the trial were included.
    Results: The findings suggest that the perceptions of nursing staff regarding remote monitoring can be influenced by the type of patients under their care and their previous experience of telemetry. Factors which may undermine the engagement of staff are perceived staff burden, which can be dependent on contextual factors such as staffing levels, time of day and senior staff attitudes. Staff attitudes are also likely to be influenced by patient perspectives and the utility of the devices associated with remote monitoring. The successful implementation of CRM may be dependent on staff training, research staff input and hospital culture.
    Conclusions: Theories regarding nursing staff engagement with remote monitoring are numerous, varied and contradictory. The theories elicited in this initial phase will be refined during interviews with the nursing staff involved with the RCT.
    MeSH term(s) Attitude of Health Personnel ; Hospitals ; Humans ; Monitoring, Physiologic/methods ; Nursing Staff ; Vital Signs
    Language English
    Publishing date 2022-04-03
    Publishing country England
    Document type Journal Article ; Observational Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1327355-3
    ISSN 1365-2753 ; 1356-1294
    ISSN (online) 1365-2753
    ISSN 1356-1294
    DOI 10.1111/jep.13678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical applications of contactless photoplethysmography for vital signs monitoring in pediatrics: A systematic review and meta-analysis.

    Bautista, Melissa / Cave, Daniel / Downey, Candice / Bentham, James R / Jayne, David

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e144

    Abstract: Background: Contactless photoplethysmography (PPG) potentially affords the ability to obtain vital signs in pediatric populations without disturbing the child. Most validity studies have been conducted in laboratory settings or with healthy adult ... ...

    Abstract Background: Contactless photoplethysmography (PPG) potentially affords the ability to obtain vital signs in pediatric populations without disturbing the child. Most validity studies have been conducted in laboratory settings or with healthy adult volunteers. This review aims to evaluate the current literature on contactless vital signs monitoring in pediatric populations and within a clinical setting.
    Methods: OVID, Webofscience, Cochrane library, and clinicaltrials.org were systematically searched by two authors for research studies which used contactless PPG to assess vital signs in children and within a clinical setting.
    Results: Fifteen studies were included with a total of 170 individuals. Ten studies were included in a meta-analysis for neonatal heart rate (HR), which demonstrated a pooled mean bias of -0.25 (95% limits of agreement (LOA), -1.83 to 1.32). Four studies assessed respiratory rate (RR) in neonates, and meta-analysis demonstrated a pooled mean bias of 0.65 (95% LOA, -3.08 to 4.37). All studies were small, and there were variations in the methods used and risk of bias.
    Conclusion: Contactless PPG is a promising tool for vital signs monitoring in children and accurately measures neonatal HR and RR. Further research is needed to assess children of different age groups, the effects of skin type variation, and the addition of other vital signs.
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical applications of contactless photoplethysmography for monitoring in adults: A systematic review and meta-analysis.

    Bautista, Melissa Joanne / Kowal, Mikolaj / Cave, Daniel G W / Downey, Candice / Jayne, David G

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e129

    Abstract: Contactless photoplethysmography (cPPG) is a method of physiological monitoring. It differs from conventional monitoring methods (e.g., saturation probe) by ensuring no contact with the subject by use of a camera. The majority of research on cPPG is ... ...

    Abstract Contactless photoplethysmography (cPPG) is a method of physiological monitoring. It differs from conventional monitoring methods (e.g., saturation probe) by ensuring no contact with the subject by use of a camera. The majority of research on cPPG is conducted in a laboratory setting or in healthy populations. This review aims to evaluate the current literature on monitoring using cPPG in adults within a clinical setting. Adhering to the Preferred Items for Systematic Reviews and Meta-analysis (PRISMA, 2020) guidelines, OVID, Webofscience, Cochrane library, and clinicaltrials.org were systematically searched by two researchers. Research articles using cPPG for monitoring purposes in adults within a clinical setting were selected. Twelve studies with a total of 654 individuals were included. Heart rate (HR) was the most investigated vital sign (
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A review of levator ani avulsion after childbirth: Incidence, imaging and management.

    Doxford-Hook, Elizabeth / Downey, Candice / Gibson, Joanna / Marsh, Fiona

    Midwifery

    2022  Volume 115, Page(s) 103494

    Abstract: Key Content • Levator ani muscle (LAM) avulsion injury occurs occultly during childbirth, most commonly during operative vaginal deliveries. • Injuries of levator ani have long term sequelae for pelvic floor health. As life expectancy increases the ... ...

    Abstract Key Content • Levator ani muscle (LAM) avulsion injury occurs occultly during childbirth, most commonly during operative vaginal deliveries. • Injuries of levator ani have long term sequelae for pelvic floor health. As life expectancy increases the burden of disease upon urogynaecology services will need to be considered. • Diagnosis of this condition can be difficult as there is no agreed 'gold standard' imaging modality. • There is no consensus regarding surgical management of LAM avulsion. Learning objectives • Review anatomy and function of levator ani muscle • Identify the risk factors for levator ani avulsion injury • Role of imaging to appropriately identify LAM injury and current management options including appropriate follow up • Management of subsequent pregnancy following LAM avulsion Ethical issues • Is there value to the patient in diagnosing levator ani avulsion when there is no recommended treatment for these injuries?
    MeSH term(s) Humans ; Pregnancy ; Female ; Pelvic Floor ; Incidence ; Delivery, Obstetric/adverse effects ; Risk Factors ; Ultrasonography
    Language English
    Publishing date 2022-09-26
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 1036567-9
    ISSN 1532-3099 ; 0266-6138
    ISSN (online) 1532-3099
    ISSN 0266-6138
    DOI 10.1016/j.midw.2022.103494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Management of levator ani avulsion: a systematic review and narrative synthesis.

    Doxford-Hook, Elizabeth A / Slemeck, Elizabeth / Downey, Candice L / Marsh, Fiona A

    Archives of gynecology and obstetrics

    2023  Volume 308, Issue 5, Page(s) 1399–1408

    Abstract: Purpose: Levator ani muscle (LAM) avulsion affects up to 35% of women. Unlike obstetric anal sphincter injury, LAM avulsion is not diagnosed immediately after vaginal delivery, however, has a profound impact on quality of life. The management of pelvic ... ...

    Abstract Purpose: Levator ani muscle (LAM) avulsion affects up to 35% of women. Unlike obstetric anal sphincter injury, LAM avulsion is not diagnosed immediately after vaginal delivery, however, has a profound impact on quality of life. The management of pelvic floor disorders is in growing demand yet the significance of LAM avulsion in the context of pelvic floor dysfunction (PFD) is poorly understood. This study collates information on success of treatment for LAM avulsion to establish the best options for management of women.
    Methods: MEDLINE
    Results: Natural healing of LAM avulsion occurs in 50% of women. Conservative measures, including pelvic floor exercises and pessary use are poorly studied. Pelvic floor muscle training for major LAM avulsions was of no benefit. Post-partum pessary use was only of benefit in the first three months for women. Surgeries for LAM avulsion are poorly researched but studies suggest they may provide benefit for 76-97% of patients.
    Conclusions: Whilst some women with PFD secondary to LAM avulsion improve spontaneously, 50% continue to have pelvic floor symptoms 1 year following delivery. These symptoms result in a significant negative impact on quality of life, however, it is not clear whether conservative or surgical methods are helpful. There is a pressing need for research to find effective treatments and explore appropriate surgical repair techniques for women with LAM avulsion.
    MeSH term(s) Pregnancy ; Humans ; Female ; Quality of Life ; Postpartum Period ; Anal Canal/injuries ; Pelvic Floor Disorders/etiology ; Pelvic Floor Disorders/therapy ; Delivery, Obstetric ; Ultrasonography/methods
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-06955-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Failure to Rescue Deteriorating Patients: A Systematic Review of Root Causes and Improvement Strategies.

    Burke, Joshua R / Downey, Candice / Almoudaris, Alex M

    Journal of patient safety

    2020  Volume 18, Issue 1, Page(s) e140–e155

    Abstract: Objectives: "Failure to rescue" (FTR) is the failure to prevent a death resulting from a complication of medical care or from a complication of underlying illness or surgery. There is a growing body of evidence that identifies causes and interventions ... ...

    Abstract Objectives: "Failure to rescue" (FTR) is the failure to prevent a death resulting from a complication of medical care or from a complication of underlying illness or surgery. There is a growing body of evidence that identifies causes and interventions that may improve institutional FTR rates. Why do patients "fail to rescue" after complications in hospital? What clinically relevant interventions have been shown to improve organizational fail to rescue rates? Can successful rescue methods be classified into a simple strategy?
    Methods: A systematic review was performed and the following electronic databases searched between January 1, 2006, to February 12, 2018: MEDLINE, PsycINFO, Cochrane Library, CINAHL, and BNI databases. All studies that explored an intervention to improve failure to rescue in the adult population were considered.
    Results: The search returned 1486 articles. Eight hundred forty-two abstracts were reviewed leaving 52 articles for full assessment. Articles were classified into 3 strategic arms (recognize, relay, and react) incorporating 6 areas of intervention with specific recommendations.
    Conclusions: Complications occur consistently within healthcare organizations. They represent a huge burden on patients, clinicians, and healthcare systems. Organizations vary in their ability to manage such events. Failure to rescue is a measure of institutional competence in this context. We propose "The 3 Rs of Failure to Rescue" of recognize, relay, and react and hope that this serves as a valuable framework for understanding the phases where failure of patient salvage may occur. Future efforts at mitigating the differences in outcome from complication management between units may benefit from incorporating this proposed framework into institutional quality improvement.
    MeSH term(s) Adult ; Humans ; Quality Improvement
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2394324-5
    ISSN 1549-8425 ; 1549-8417
    ISSN (online) 1549-8425
    ISSN 1549-8417
    DOI 10.1097/PTS.0000000000000720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Participants' Perspectives of Their Involvement in Medical Device Trials: A Focus Groups Study.

    Kitchen, William R / Downey, Candice L / Brown, Julia M / Jayne, David G / Randell, Rebecca

    Surgical innovation

    2022  Volume 29, Issue 6, Page(s) 804–810

    Abstract: Background: Medical technologies have the potential to improve quality and efficiency of healthcare. The design of clinical trials should consider participants' perspectives to optimise enrolment, engagement and satisfaction. This study aims to assess ... ...

    Abstract Background: Medical technologies have the potential to improve quality and efficiency of healthcare. The design of clinical trials should consider participants' perspectives to optimise enrolment, engagement and satisfaction. This study aims to assess patients' perceptions of their involvement in medical device trials, to inform the designs of future medical technology implementation and evaluation.
    Methods: Four focus groups were undertaken with a total of 16 participants who had participated in a study testing hospital inpatient remote monitoring devices. Interviews were audio-recorded, transcribed verbatim and underwent thematic analysis.
    Results: Four main themes emerged: patients' motivations for participating in medical device research; patients' perceptions of technology in medicine; patients' understanding of trial methodology; and patients' perceptions of the benefits of involvement in medical device trials. The appeal of new technology is a contributing factor to the decision to consent, although concerns remain regarding risks associated with technology in healthcare settings. Perceived benefits of participating in device trials include extra care, social benefits and comradery with other participants seen using the devices, although there is a perceived lack of confidence in using technology amongst older patients.
    Conclusion: Future device trials should prioritise information sharing with participants both before and after the trial. Verbal and written information alongside practical demonstrations can help to combat a lack of confidence with technology. Randomised trials and those with placebo- or sham-controlled arms should not be considered as barriers to participation. Study results should be disseminated to participants in lay format as soon as possible, subject to participant permission.
    MeSH term(s) Humans ; Focus Groups ; Biomedical Research
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506221089824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reliability of a wearable wireless patch for continuous remote monitoring of vital signs in patients recovering from major surgery: a clinical validation study from the TRaCINg trial.

    Downey, Candice / Ng, Shu / Jayne, David / Wong, David

    BMJ open

    2019  Volume 9, Issue 8, Page(s) e031150

    Abstract: Objective: To validate whether a wearable remote vital signs monitor could accurately measure heart rate (HR), respiratory rate (RR) and temperature in a postsurgical patient population at high risk of complications.: Design: Manually recorded vital ... ...

    Abstract Objective: To validate whether a wearable remote vital signs monitor could accurately measure heart rate (HR), respiratory rate (RR) and temperature in a postsurgical patient population at high risk of complications.
    Design: Manually recorded vital signs data were paired with vital signs data derived from the remote monitor set in patients participating in the Trial of Remote versus Continuous INtermittent monitoring (TRaCINg) study: a trial of continuous remote vital signs monitoring.
    Setting: St James's University Hospital, UK.
    Participants: 51 patients who had undergone major elective general surgery.
    Interventions: The intervention was the SensiumVitals monitoring system. This is a wireless patch worn on the patient's chest that measures HR, RR and temperature continuously. The reference standard was nurse-measured manually recorded vital signs.
    Primary and secondary outcome measures: The primary outcomes were the 95% limits of agreement between manually recorded and wearable patch vital sign recordings of HR, RR and temperature. The secondary outcomes were the percentage completeness of vital sign patch data for each vital sign.
    Results: 1135 nurse observations were available for analysis. There was no clinically meaningful bias in HR (1.85 bpm), but precision was poor (95% limits of agreement -23.92 to 20.22 bpm). Agreement was poor for RR (bias 2.93 breaths per minute, 95% limits of agreement -8.19 to 14.05 breaths per minute) and temperature (bias 0.82
    Conclusions: The continuous monitoring system did not reliably provide HR consistent with nurse measurements. The accuracy of RR and temperature was outside of acceptable limits. Limitations of the system could potentially be overcome through better signal processing. While acknowledging the time pressures placed on nursing staff, inaccuracies in the manually recorded data present an opportunity to increase awareness about the importance of manual observations, particularly with regard to methods of manual HR and RR measurements.
    MeSH term(s) Elective Surgical Procedures ; Heart Rate ; Humans ; Monitoring, Physiologic/instrumentation ; Postoperative Care/methods ; Reproducibility of Results ; Respiratory Rate ; Temperature ; Vital Signs ; Wearable Electronic Devices ; Wireless Technology/standards
    Language English
    Publishing date 2019-08-15
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-031150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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