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  1. Article ; Online: Reply to the Editor - Are we close to a major impact on prevention of sudden cardiac death among coronary artery disease patients?

    Downey, Michael C / Hooks, Matthew / Adabag, Selçuk

    Heart rhythm O2

    2022  Volume 3, Issue 2, Page(s) 219

    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Critically Ill Without COVID-19 Infection During the COVID-19 Pandemic: an Analysis of Race and Ethnicity at an Urban Safety-Net Hospital.

    Downey, Michael C / Hoover, Madison R / Prekker, Matthew E / Kempainen, Robert R

    Journal of racial and ethnic health disparities

    2022  Volume 10, Issue 4, Page(s) 1776–1782

    Abstract: Purpose: This investigation sought to compare admissions, length of stay, and mortality among medical intensive care unit (MICU) patients without coronavirus disease 2019 (COVID-19) infection admitted to an urban safety-net hospital during the pandemic ... ...

    Abstract Purpose: This investigation sought to compare admissions, length of stay, and mortality among medical intensive care unit (MICU) patients without coronavirus disease 2019 (COVID-19) infection admitted to an urban safety-net hospital during the pandemic by patients' self-identified race and ethnicity.
    Materials and methods: We conducted a retrospective observational study comparing MICU admissions before and during the first surge of COVID-19 illness at an urban, safety-net hospital in Minneapolis, Minnesota.
    Results: MICU admissions declined from a pre-pandemic average of 968 to 761 during the first COVID surge, including 627 patients (82%) without COVID-19 infection. MICU mortality among patients without COVID-19 infection during the pandemic was 12.8% compared to 9.6% in the pre-pandemic period (p = 0.045). However, rates of non-COVID-19 MICU admissions, mortality, volume, and length of stay did not differ by race and ethnicity between time periods. Of the 131 MICU admissions with COVID-19 infection, patients were more frequently Hispanic ethnicity (24%) or Black (40%), and less frequently White (22%) compared to the pre-pandemic cohort (7%, 30%, and 48%, respectively [p < 0.001]).
    Conclusions: During the first COVID-19 surge, MICU admissions for non-COVID-19 disease decreased from pre-pandemic levels, but these patients experienced greater mortality. Unlike critically ill patients admitted with COVID-19 infection, admissions and hospital mortality did not differ by race and ethnicity compared to the pre-pandemic period.
    MeSH term(s) Humans ; Ethnicity ; COVID-19 ; Pandemics ; Critical Illness ; Safety-net Providers ; Retrospective Studies
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-022-01361-z
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  3. Article ; Online: Perioperative changes in left ventricular systolic function following surgical revascularization.

    Downey, Michael C / Hooks, Matthew / Gravely, Amy / Naksuk, Niyada / Buelt-Gebhardt, Melissa / Carlson, Selma / Tholakanahalli, Venkat / Adabag, Selçuk

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0277454

    Abstract: Background: Nearly 1/3rd of patients undergoing coronary artery bypass graft surgery (CABG) have left ventricular systolic dysfunction. However, the extent, direction and implications of perioperative changes in left ventricular ejection fraction (LVEF) ...

    Abstract Background: Nearly 1/3rd of patients undergoing coronary artery bypass graft surgery (CABG) have left ventricular systolic dysfunction. However, the extent, direction and implications of perioperative changes in left ventricular ejection fraction (LVEF) have not been well characterized in these patients.
    Methods: We studied the changes in LVEF among 549 patients with left ventricular systolic dysfunction (LVEF <50%) who underwent CABG as part of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. Patients had pre- and post-CABG (4 month) LVEF assessments using identical cardiac imaging modality, interpreted at a core laboratory. An absolute change of >10% in LVEF was considered clinically significant.
    Results: Of the 549 patients (mean age 61.4±9.55 years, and 72 [13.1%] women), 145 (26.4%) had a >10% improvement in LVEF, 369 (67.2%) had no change and 35 (6.4%) had >10% worsening of LVEF following CABG. Patients with lower preoperative LVEF were more likely to experience an improvement after CABG (odds ratio 1.36; 95% CI 1.21-1.53; per 5% lower preoperative LVEF; p <0.001). Notably, incidence of postoperative improvement in LVEF was not influenced by presence, nor absence, of myocardial viability (25.5% vs. 28.3% respectively, p = 0.67). After adjusting for age, sex, baseline LVEF, and NYHA Class, a >10% improvement in LVEF after CABG was associated with a 57% lower risk of all-cause mortality (HR: 0.43, 95% CI: 0.26-0.71).
    Conclusions: Among patients with ischemic cardiomyopathy undergoing CABG, 26.4% had >10% improvement in LVEF. An improvement in LVEF was more likely in patients with lower preoperative LVEF and was associated with improved long-term survival.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Myocardial Ischemia/complications ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/etiology ; Ventricular Function, Left ; Clinical Trials as Topic
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Arrhythmic causes of in-hospital cardiac arrest among patients with heart failure with preserved ejection fraction.

    Hooks, Matthew / Downey, Michael C / Joppa, Stephanie / Beard, Albertine / Gravely, Amy / Tholakanahalli, Venkat / Adabag, Selçuk

    Heart rhythm O2

    2021  Volume 2, Issue 6Part A, Page(s) 665–667

    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2021.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: National Trends in Bariatric Surgery 2012-2015: Demographics, Procedure Selection, Readmissions, and Cost.

    Kizy, Scott / Jahansouz, Cyrus / Downey, Michael C / Hevelone, Nathanael / Ikramuddin, Sayeed / Leslie, Daniel

    Obesity surgery

    2017  Volume 27, Issue 11, Page(s) 2933–2939

    Abstract: Background: Bariatric surgery is widely accepted as the best treatment for obesity and type 2 diabetes mellitus (T2DM). The Roux-en-Y gastric bypass (RYGB) and the sleeve gastrectomy (SG) have become the predominant bariatric procedures in the USA over ... ...

    Abstract Background: Bariatric surgery is widely accepted as the best treatment for obesity and type 2 diabetes mellitus (T2DM). The Roux-en-Y gastric bypass (RYGB) and the sleeve gastrectomy (SG) have become the predominant bariatric procedures in the USA over the last several years, although the most recent trends in selection are unknown.
    Objective: The objective of this study is to assess selection trends, readmission rates, and cost of bariatric procedures in the USA from 2012 to 2015.
    Methods: We used the Premier database from 2012 to 2015 to examine trends in incidence of RYGB, adjustable gastric banding (LAGB), and SG; readmissions; and cost. Multivariate regression was performed to identify predictors of readmission.
    Results: The proportion of SG went up from 38 to 63% while the RYGB decreased from 44 to 30% over this time period. LAGB has decreased in use from 13 to 2%. In comparison to RYGB, readmission was less likely for SG (OR 0.64), males (OR 0.91), and more likely for black race (OR 1.27). The overall proportion of patients seeking RYGB with type 2 diabetes was higher than with SG (36 versus 25%), but SG has now overtaken RYGB as the most common procedure among diabetics. The SG is less costly than RYGB ($11,183 versus $13,485).
    Conclusions: There is a continued overall trend in the increased popularity of the SG and decreased utilization of the RYGB and LAGB, although growth of the SG appears to be slowing. This is also true among patients with type 2 diabetes mellitus. Regardless of surgery type, underinsured and African-American race were more likely to be readmitted.
    Keywords covid19
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-017-2719-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3381: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ribose 5-phosphate glycation reduces cytochrome c respiratory activity and membrane affinity.

    Hildick-Smith, Gordon J / Downey, Michael C / Gretebeck, Lisa M / Gersten, Rebecca A / Sandwick, Roger K

    Biochemistry

    2011  Volume 50, Issue 51, Page(s) 11047–11057

    Abstract: Spontaneous glycation of bovine heart cytochrome c (cyt c) by the sugar ribose 5-phosphate (R5P) weakens the ability of the heme protein to transfer electrons in the respiratory pathway and to bind to membranes. Trypsin fragmentation studies suggest the ... ...

    Abstract Spontaneous glycation of bovine heart cytochrome c (cyt c) by the sugar ribose 5-phosphate (R5P) weakens the ability of the heme protein to transfer electrons in the respiratory pathway and to bind to membranes. Trypsin fragmentation studies suggest the preferential sites of glycation include Lys72 and Lys87/88 of a cationic patch involved in the association of the protein with its respiratory chain partners and with cardiolipin-containing membranes. Reaction of bovine cyt c with R5P (50 mM) for 8 h modified the protein in a manner that weakened its ability to transfer electrons to cytochrome oxidase by 60%. An 18 h treatment with R5P decreased bovine cyt c's binding affinity with cardiolipin-containing liposomes by an estimated 8-fold. A similar weaker binding of glycated cyt c was observed with mitoplasts. The reversal of the effects of R5P on membrane binding by ATP further supports an A-site modification. A significant decrease in the rate of spin state change for ferro-cyt c, thought to be due to cardiolipin insertion disrupting the coordination of Met to heme, was found for the R5P-treated cyt c. This change occurred to a greater extent than what can be explained by the permanent attachment of the protein to the liposome. Turbidity changes resulting from the multilamellar liposome fusion that is readily promoted by cyt c binding were not seen for the R5P-glycated cyt c samples. Collectively, these results demonstrate the negative impact that R5P glycation can have on critical electron transfer and membrane association functions of cyt c.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cardiolipins/metabolism ; Cattle ; Cytochromes c/antagonists & inhibitors ; Cytochromes c/chemistry ; Cytochromes c/metabolism ; Electron Transport ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/metabolism ; Fungal Proteins/antagonists & inhibitors ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Glycosylation ; Liposomes ; Lysine/chemistry ; Lysine/metabolism ; Membrane Fusion ; Mitochondrial Membranes/enzymology ; Mitochondrial Membranes/metabolism ; Nephelometry and Turbidimetry ; Organelles/enzymology ; Organelles/metabolism ; Oxidation-Reduction ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Ribosemonophosphates/chemistry ; Ribosemonophosphates/metabolism ; Solubility
    Chemical Substances Cardiolipins ; Fungal Proteins ; Liposomes ; Peptide Fragments ; Ribosemonophosphates ; ribose-5-phosphate (4B2428FLTO) ; Adenosine Triphosphate (8L70Q75FXE) ; Cytochromes c (9007-43-6) ; Electron Transport Complex IV (EC 1.9.3.1) ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2011-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/bi2012977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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