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  1. Book ; Online: IL-1 Family Members in Health and Disease

    Brint, Elizabeth / Doyle, Sarah L. / Kamradt, Thomas

    2019  

    Keywords Medicine ; Immunology ; inflammation ; disease ; interleukin ; IL-1 ; IL-18 ; IL-33
    Size 1 electronic resource (159 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229888
    ISBN 9782889632411 ; 2889632415
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Persistence of Privilege for a Healthy Retina.

    Doyle, Sarah L

    Immunity

    2020  Volume 53, Issue 2, Page(s) 240–242

    Abstract: A minor haplotype of chromosome 10q26 accounts for much of the genetic risk of age-related macular degeneration (AMD). In this issue of Immunity, Beguier et al. demonstrate that carriers of the 10q26 AMD-risk haplotype overexpress the peptidase HTRA1, ... ...

    Abstract A minor haplotype of chromosome 10q26 accounts for much of the genetic risk of age-related macular degeneration (AMD). In this issue of Immunity, Beguier et al. demonstrate that carriers of the 10q26 AMD-risk haplotype overexpress the peptidase HTRA1, which in turns results in mononuclear phagocyte persistence in an immune privileged site and pathogenic inflammation.
    MeSH term(s) Haplotypes ; High-Temperature Requirement A Serine Peptidase 1 ; Humans ; Inflammation ; Macular Degeneration/genetics ; Monocytes ; Proteins ; Retina ; Serine Endopeptidases/genetics
    Chemical Substances Proteins ; High-Temperature Requirement A Serine Peptidase 1 (EC 3.4.21.-) ; HTRA1 protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  3. Article ; Online: In vitro

    Mulfaul, Kelly / Doyle, Sarah L

    Bio-protocol

    2021  Volume 11, Issue 4, Page(s) e3916

    Abstract: Initiation of the complement system results in the formation of a multiprotein pore termed the membrane attack complex (MAC, C5b-C9). MAC pores accumulate on a cell surface and can result in cell lysis. The retinal pigment epithelium (RPE) is a single ... ...

    Abstract Initiation of the complement system results in the formation of a multiprotein pore termed the membrane attack complex (MAC, C5b-C9). MAC pores accumulate on a cell surface and can result in cell lysis. The retinal pigment epithelium (RPE) is a single monolayer of pigmented epithelial cells located at the posterior poll of the eye that forms the outer blood retinal barrier. RPE cells are highly polarized with apical microvilli and basolateral contact with Bruch's membrane. In order to obtain biologically relevant polarized RPE cultures
    Language English
    Publishing date 2021-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.

    Ozaki, Ema / Delaney, Conor / Campbell, Matthew / Doyle, Sarah L

    Experimental eye research

    2022  Volume 217, Page(s) 108953

    Abstract: As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal diseases. The semi-synthetic ... ...

    Abstract As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal diseases. The semi-synthetic tetracycline antibiotic, minocycline, appears to inhibit pro-inflammatory microglia which coincides with protection against photoreceptor cell degeneration. A sub-type of microglia termed disease associated microglia (DAM) have recently been associated with a wide range of central nervous system (CNS) diseases. In this study we examine the kinetics of microglia infiltration towards the outer retina of rhodopsin knockout mice (Rho
    MeSH term(s) Animals ; Disease Models, Animal ; Mice ; Microglia/metabolism ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Photoreceptor Cells, Vertebrate/metabolism ; Retina ; Retinal Degeneration/drug therapy ; Retinal Degeneration/metabolism ; Retinal Degeneration/prevention & control
    Chemical Substances Minocycline (FYY3R43WGO)
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2022.108953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis.

    Fahey, Erin / Doyle, Sarah L

    Frontiers in immunology

    2019  Volume 10, Page(s) 1426

    Abstract: The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously regulating inflammation and ... ...

    Abstract The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously regulating inflammation and angiogenesis, indeed one of IL-1's earliest names was haemopoeitn-1 due to its pro-angiogenic effects. Other IL-1 family cytokines are also known to have roles in mediating angiogenesis, either directly or indirectly via induction of proangiogenic factors such as VEGF. Of note, some of these family members appear to have directly opposing effects in different tissues and pathologies. Here we will review what is known about how the various IL-1 family members regulate vascular permeability and angiogenic function in a range of different tissues, and describe some of the mechanisms employed to achieve these effects.
    MeSH term(s) Capillary Permeability/immunology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Interleukin-1/immunology ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/pathology ; Vascular Endothelial Growth Factor A/immunology
    Chemical Substances Interleukin-1 ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2019-06-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Current perspectives on established and novel therapies for pathological neovascularization in retinal disease.

    Campbell, Matthew / Doyle, Sarah L

    Biochemical pharmacology

    2019  Volume 164, Page(s) 321–325

    Abstract: Neovascularization is a hallmark pathology of numerous retinal diseases from diabetic retinopathy (DR) to age-related related macular degeneration (AMD). Over the past 2 decades, the rise of anti-VEGF based medications for neovascular eye conditions has ... ...

    Abstract Neovascularization is a hallmark pathology of numerous retinal diseases from diabetic retinopathy (DR) to age-related related macular degeneration (AMD). Over the past 2 decades, the rise of anti-VEGF based medications for neovascular eye conditions has revolutionized the treatment paradigm for patients and preserved the vision of millions. With any form of therapy however, there remain pitfalls and areas for improved interventions. Here, we succinctly present some current views on treatment options for patients with retinal and choroidal neovascularization. We also highlight some of the most promising therapeutic strategies currently being developed and where these therapies may fit with the current clinical standard of care.
    MeSH term(s) Animals ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/metabolism ; Choroidal Neovascularization/pathology ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/pathology ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Protein Kinase Inhibitors/administration & dosage ; Retina/drug effects ; Retina/pathology ; Retinal Diseases/drug therapy ; Retinal Diseases/metabolism ; Retinal Diseases/pathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Protein Kinase Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2019-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2019.04.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation.

    Kelly, Alanna M / Leech, John M / Doyle, Sarah L / McLoughlin, Rachel M

    PLoS pathogens

    2022  Volume 18, Issue 7, Page(s) e1010647

    Abstract: Staphylococcus aureus persistently colonises the anterior nares of a significant proportion of the healthy population, however the local immune response elicited during S. aureus nasal colonisation remains ill-defined. Local activation of IL-17/IL-22 ... ...

    Abstract Staphylococcus aureus persistently colonises the anterior nares of a significant proportion of the healthy population, however the local immune response elicited during S. aureus nasal colonisation remains ill-defined. Local activation of IL-17/IL-22 producing T cells are critical for controlling bacterial clearance from the nasal cavity. However, recurrent and long-term colonisation is commonplace indicating efficient clearance does not invariably occur. Here we identify a central role for the regulatory cytokine IL-10 in facilitating bacterial persistence during S. aureus nasal colonisation in a murine model. IL-10 is produced rapidly within the nasal cavity following S. aureus colonisation, primarily by myeloid cells. Colonised IL-10-/- mice demonstrate enhanced IL-17+ and IL-22+ T cell responses and more rapidly clear bacteria from the nasal tissues as compared with wild-type mice. S. aureus also induces the regulatory cytokine IL-27 within the nasal tissue, which acts upstream of IL-10 promoting its production. IL-27 blockade reduces IL-10 production within the nasal cavity and improves bacterial clearance. TLR2 signalling was confirmed to be central to controlling the IL-10 response. Our findings conclude that during nasal colonisation S. aureus creates an immunosuppressive microenvironment through the local induction of IL-27 and IL-10, to dampen protective T cell responses and facilitate its persistence.
    MeSH term(s) Animals ; Cytokines ; Immunosuppression Therapy ; Interleukin-10 ; Interleukin-17 ; Interleukin-27 ; Mice ; Staphylococcal Infections/microbiology ; Staphylococcus aureus
    Chemical Substances Cytokines ; Interleukin-17 ; Interleukin-27 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial: IL-1 Family Members in Health and Disease.

    Brint, Elizabeth / Kamradt, Thomas / Doyle, Sarah L

    Frontiers in immunology

    2019  Volume 10, Page(s) 2596

    MeSH term(s) Animals ; Disease Susceptibility ; Homeostasis ; Humans ; Interleukin-1/genetics ; Interleukin-1/metabolism ; Multigene Family
    Chemical Substances Interleukin-1
    Language English
    Publishing date 2019-11-13
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Refractory Kawasaki disease: diagnostic and management challenges.

    Duignan, Sophie / Doyle, Sarah L / McMahon, Colin J

    Pediatric health, medicine and therapeutics

    2019  Volume 10, Page(s) 131–139

    Abstract: Kawasaki disease (KD), an acute, self-limiting, medium-sized arterial vasculitis, is now the most common cause of acquired heart disease in childhood in the developed world. In this review, we discuss the diagnosis of KD, predicting resistance to ... ...

    Abstract Kawasaki disease (KD), an acute, self-limiting, medium-sized arterial vasculitis, is now the most common cause of acquired heart disease in childhood in the developed world. In this review, we discuss the diagnosis of KD, predicting resistance to traditional therapy and treatment options in refractory or high-risk disease. We also highlight ongoing clinical trials and other potential avenues of research which may prove beneficial in managing children, especially those with resistant KD.
    Language English
    Publishing date 2019-10-30
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2616891-1
    ISSN 1179-9927 ; 1179-9927
    ISSN (online) 1179-9927
    ISSN 1179-9927
    DOI 10.2147/PHMT.S165935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors.

    Husebye, Harald / Doyle, Sarah L

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1390, Page(s) 65–77

    Abstract: Toll-like receptors (TLR) survey the extracellular space, cytoplasm, and endosomal compartments for signs of infection or tissue injury. Over the past decade, it has become evident that TLR activation and signal transduction can be regulated by ... ...

    Abstract Toll-like receptors (TLR) survey the extracellular space, cytoplasm, and endosomal compartments for signs of infection or tissue injury. Over the past decade, it has become evident that TLR activation and signal transduction can be regulated by subcellular compartmentalization of both the receptors and their downstream signaling components. Immunofluorescence and/or overexpression of fluorescently "tagged"' proteins teamed with confocal microscopy presents a powerful technique for studying the spatial organization of TLRs, their signaling mediators, and the dynamic processes they activate. This chapter details the common methods for determining the subcellular location of TLRs in both live and fixed cells.
    MeSH term(s) Animals ; Cell Line ; Gene Expression ; Genes, Reporter ; HEK293 Cells ; Humans ; Intracellular Space/metabolism ; Leukocytes, Mononuclear ; Ligands ; Microscopy, Confocal/methods ; Protein Transport ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism
    Chemical Substances Ligands ; Recombinant Fusion Proteins ; Toll-Like Receptors
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3335-8_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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