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  1. AU="Drabo, Emmanuel F"
  2. AU="Raux, M"
  3. AU="Kubba, Haytham"
  4. AU="Hence, Deanna"
  5. AU="Swiger, James"
  6. AU="Loftus Jr, E. V."
  7. AU="Pozzi Mucelli, Roberto"
  8. AU="Subedi, Prajan"
  9. AU=Xiao Xizhu
  10. AU="Franzén, Anna"
  11. AU=Klonoff David C
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  1. Article ; Online: Appealing to Americans' altruism is not enough to nudge them to accept novel vaccines.

    Drabo, Emmanuel F / Kelley, Marcella A / Gong, Cynthia L

    Journal of public health (Oxford, England)

    2024  

    Abstract: Background: The role of altruism in the acceptance of novel preventive healthcare technologies like vaccines has not been thoroughly elucidated.: Methods: We 1:1 randomized n = 2004 Amazon Mechanical Turk (MTurk) participants residing in the USA into ...

    Abstract Background: The role of altruism in the acceptance of novel preventive healthcare technologies like vaccines has not been thoroughly elucidated.
    Methods: We 1:1 randomized n = 2004 Amazon Mechanical Turk (MTurk) participants residing in the USA into a control or treatment arm with vaccination decisions framed altruistically, to elicit their preferences for COVID-19 vaccination using web-based discrete choice experiments. We used conditional and mixed logit models to estimate the impact of framing decisions in terms of altruism on vaccination acceptance.
    Results: Valid responses were provided by 1674 participants (control, n = 848; treatment, n = 826). Framing vaccination decisions altruistically had no significant effect on vaccination acceptance. Further, respondents' degree of altruism had no association with vaccination acceptance.
    Limitations: The MTurk sample may not be representative of the American population. We were unable to ascertain concordance between stated and revealed preferences.
    Conclusions and implications: Framing vaccination decisions in terms of altruism does not appear to significantly influence vaccination acceptance and may not be an effective nudging mechanism to increase the uptake of novel vaccines. Instead, a favorable vaccination profile appears to be the primary driver of uptake.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdae048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study.

    Chyr, Linda C / Wolff, Jennifer L / Zissimopoulos, Julie M / Drabo, Emmanuel F

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 4, Page(s) 2817–2829

    Abstract: Background: Subjective cognitive impairment (SCI) measures in population-based surveys offer potential for dementia surveillance, yet their validation against established dementia measures is lacking.: Methods: We assessed agreement between SCI and a ...

    Abstract Background: Subjective cognitive impairment (SCI) measures in population-based surveys offer potential for dementia surveillance, yet their validation against established dementia measures is lacking.
    Methods: We assessed agreement between SCI and a validated probable dementia algorithm in a random one-third sample (n = 1936) of participants in the 2012 National Health and Aging Trends Study (NHATS).
    Results: SCI was more prevalent than probable dementia (12.2% vs 8.4%). Agreement between measures was 90.0% and of substantial strength. Misclassification rates were higher among older and less-educated subgroups due to higher prevalence of false-positive misclassification but did not vary by sex or race and ethnicity.
    Discussion: SCI sensitivity (63.4%) and specificity (92.5%) against dementia were comparable with similar metrics for the NHATS probable dementia measure against the "gold-standard" Aging, Demographics, and Memory Study-based dementia criteria, implying that population-based surveys may afford cost-effective opportunities for dementia surveillance to assess risk and inform policy.
    Highlights: The prevalence of subjective cognitive impairment (SCI) is generally higher than that of a validated measure of probable dementia, particularly within the youngest age group, females, Whites, and persons with a college or higher degree. Percent agreement between SCI and a validated measure of probable dementia was 90.0% and of substantial strength (prevalence- and bias-adjusted kappa, 0.80). Agreement rates were higher in older and less-educated subgroups, driven by the higher prevalence of false-positive disagreement, but did not vary significantly by sex or race and ethnicity. SCI's overall sensitivity and specificity were 63.4% and 92.5%, respectively, against a validated measure of probable dementia, suggesting utility as a low-cost option for dementia surveillance. Heterogeneity in agreement quality across subpopulations warrants caution in its use for subgroup analyses.
    MeSH term(s) Female ; Humans ; Aged ; Cognition Disorders/epidemiology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Aging ; Sensitivity and Specificity ; Dementia/diagnosis ; Dementia/epidemiology
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An effectiveness-implementation trial protocol to evaluate PrEP initiation among U.S. cisgender women using eHealth tools vs. standard care.

    Izadi, Lillee H / Mmeje, Okeoma / Drabo, Emmanuel F / Perin, Jamie / Martin, Stephen / Coleman, Jenell S

    Frontiers in reproductive health

    2023  Volume 5, Page(s) 1196392

    Abstract: Background: The United States' (U.S.) initiative to End the HIV Epidemic aims to reduce new HIV infections in areas of high HIV prevalence. Despite national efforts to reduce HIV incidence, cisgender women continue to represent approximately one out of ... ...

    Abstract Background: The United States' (U.S.) initiative to End the HIV Epidemic aims to reduce new HIV infections in areas of high HIV prevalence. Despite national efforts to reduce HIV incidence, cisgender women continue to represent approximately one out of every five new HIV diagnoses in the U.S. Taking pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy; however, PrEP initiation among cisgender women is suboptimal, with only 10% of eligible women receiving PrEP prescriptions in 2019.
    Methods: We designed a trial to test the effectiveness of interventions to increase PrEP initiation, while evaluating the implementation strategy (hybrid type II trial) in seven obstetrics and gynecology (OB/GYN) clinics (two federally qualified health centers, three community-based, and two academic) in Baltimore, Maryland. A total of 42 OB/GYN providers will be enrolled and randomized (1:1:1) into one of three clinical trial arms (standard of care, patient-level intervention, or multi-level intervention). Eligible patients of enrolled providers will receive a sexual health questionnaire before their appointment through the electronic health record's (EHR) patient portal. The questionnaire will be scored in three tiers (low, moderate, and high) to assess HIV risk. Patients at low risk will be offered an HIV test only, while those who score medium or high risk will be included in the clinical trial and assigned to the clinical trial arm associated with their provider. Differences in PrEP initiation, our primary outcome, across the three arms will be analyzed using generalized linear mixed-effect models with logistic regression. We will adjust results for demographic differences observed between arms and examine PrEP initiation stratified by patient's and provider's race and ethnicity.Additionally, a comprehensive economic analysis for each intervention will be conducted.
    Discussion: We hypothesize that gathering information on sensitive sexual behaviors electronically, communicating HIV risk in an understandable and relatable format to patients and OB/GYN providers, and deploying EHR alerts will increase PrEP initiation and HIV testing.
    Trial registration: The trial is registered with ClinicalTrials.gov (NCT05412433) on 09 June 2022. https://clinicaltrials.gov/ct2/show/NCT05412433?term=NCT05412433&draw=2&rank=1.
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1196392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on Yang and Moss Commentary.

    Iwashyna, Theodore J / Ferryman, Kadija / Drabo, Emmanuel F / Jackson, John W / Crews, Deidra C

    Chest

    2023  Volume 164, Issue 6, Page(s) e178–e179

    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.07.4224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Patterns and Predictors of Transitions Across Residential Care Settings and Nursing Homes Among Community-Dwelling Older Adults in the United States.

    Chyr, Linda C / Drabo, Emmanuel F / Fabius, Chanee D

    The Gerontologist

    2020  Volume 60, Issue 8, Page(s) 1495–1503

    Abstract: Background and objectives: Older adults prefer to age in place, but sociodemographic, health, and socioeconomic factors may influence their decision to remain in the community. Guided by Andersen's behavioral model, we characterize incident transitions ... ...

    Abstract Background and objectives: Older adults prefer to age in place, but sociodemographic, health, and socioeconomic factors may influence their decision to remain in the community. Guided by Andersen's behavioral model, we characterize incident transitions out of the community into residential care settings or nursing homes and identify predictors of these transitions.
    Research design and methods: Study participants include 2,725 (weighted n = 13,704,390) community-dwelling U.S. older adults of the National Health and Aging Trends Study from 2011 to 2018. We examined the associations between sociodemographic, socioeconomic, and health factors and the probability of transition using a multinomial logit model.
    Results: Over the study period, 86.2% of older adults remained in the community, whereas 9.0% and 4.9% transitioned to residential care settings and nursing homes, respectively. Older age, living alone, having functional and cognitive limitations, and hospitalization were associated with increased risk of transitioning to residential care settings or nursing homes from the community. Blacks and Hispanics were less likely to transition to residential care settings or nursing homes. Adults with lower income had a greater risk of transitioning to nursing homes. Medicaid enrollment did not affect the likelihood of transition.
    Discussion and implications: Majority of older adults remained in the community, and incident transition to residential care settings was more common than to nursing homes. Policy should target sociodemographic, health, and socioeconomic factors that enable older adults to age in place. Future work should examine whether these new residential care settings enhance the quality of life or result in subsequent transitions back into the community.
    MeSH term(s) Aged ; Aging ; Hospitalization ; Humans ; Independent Living ; Nursing Homes ; Quality of Life ; United States
    Language English
    Publishing date 2020-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216760-8
    ISSN 1758-5341 ; 0016-9013
    ISSN (online) 1758-5341
    ISSN 0016-9013
    DOI 10.1093/geront/gnaa070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Guarding Against Seven Common Threats to the Credible Estimation of COVID-19 Policy Effects.

    Drabo, Emmanuel F / Kang, So-Yeon / Gong, Cynthia L

    American journal of public health

    2020  Volume 110, Issue 12, Page(s) 1724–1725

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/economics ; Communicable Disease Control/methods ; Coronavirus Infections/economics ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/economics ; Pandemics/prevention & control ; Pneumonia, Viral/economics ; Pneumonia, Viral/prevention & control ; Public Policy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2020.305991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Caregiving-Related Work Productivity Loss Among Employed Family and Other Unpaid Caregivers of Older Adults.

    Keita Fakeye, Maningbè B / Samuel, Laura J / Drabo, Emmanuel F / Bandeen-Roche, Karen / Wolff, Jennifer L

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2022  Volume 26, Issue 5, Page(s) 712–720

    Abstract: Objectives: Although nearly half of all family and unpaid caregivers to older adults work, little is known about short-term work impacts of caregiving using measures encompassing both missed work time and reduced productivity while physically at work. ... ...

    Abstract Objectives: Although nearly half of all family and unpaid caregivers to older adults work, little is known about short-term work impacts of caregiving using measures encompassing both missed work time and reduced productivity while physically at work. We quantify the prevalence, costs, and correlates of caregiving-related work productivity loss.
    Methods: We used the 2015 National Study of Caregiving and National Health and Aging Trends Study to estimate caregiving-related work absences (absenteeism) and reduced productivity while at work (presenteeism). We calculated costs of lost productivity using hours lost, compensation, and a wage multiplier, accounting for the additional cost of replacing employee time. We examined correlates of caregiving-related absenteeism and presenteeism separately, using multivariable logistic regression models, adjusting for caregiver sociodemographic characteristics, occupation and hours worked, role overload, older adult health, use of respite care, support groups, flexible workplace schedules, help from family or friends, and caregiver training.
    Results: Nearly 1 in 4 (23.3%) of the estimated 8.8 million employed family caregivers reported either absenteeism or presenteeism over a 1-month period owing to caregiving. Among those affected, caregiving reduced work productivity by one-third on average-or an estimated $5600 per employee when annualized across all employed caregivers-primarily because of reduced performance while present at work. Productivity loss was higher among caregivers of older adults with significant care needs and varied according to sociodemographic characteristics and caregiver supports.
    Conclusions: Findings emphasize the potential economic value of targeted policy intervention to support working caregivers.
    MeSH term(s) Humans ; Aged ; Caregivers ; Efficiency ; Absenteeism ; Presenteeism ; Logistic Models
    Language English
    Publishing date 2022-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2022.06.014
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  8. Article ; Online: On All Accounts: Cost-Effectiveness Analysis of Limited Preoperative Optimization Efforts Before Colon Cancer Surgery.

    Leeds, Ira L / Drabo, Emmanuel F / Lehmann, Lisa Soleymani / Safar, Bashar / Johnston, Fabian M

    Diseases of the colon and rectum

    2021  Volume 64, Issue 6, Page(s) 744–753

    Abstract: Background: Reports suggest that preoperative optimization of a patient's serious comorbidities is associated with a reduction in postoperative complications.: Objective: The purpose of this study was to assess the cost and benefits of preoperative ... ...

    Abstract Background: Reports suggest that preoperative optimization of a patient's serious comorbidities is associated with a reduction in postoperative complications.
    Objective: The purpose of this study was to assess the cost and benefits of preoperative optimization, accounting for total costs associated with postoperative morbidity.
    Design: This study is a decision tree cost-effectiveness analysis with probabilistic sensitivity analysis (10,000 iterations).
    Setting: This is a hypothetical scenario of stage II colon cancer surgery.
    Patient: The simulated 65-year-old patient has left-sided, stage II colon cancer.
    Intervention: Focused preoperative optimization targets high-risk comorbidities.
    Outcomes: Total discounted (3%) economic costs (US $2018), effectiveness (quality-adjusted life-years), incremental cost-effectiveness ratio (incremental cost-effectiveness ratio, cost/quality-adjusted life-years gained), and net monetary benefit.
    Results: We calculated the per individual expected health care sector total cost of preoperative optimization and sequelae to be $12,395 versus $15,638 in those not optimized (net monetary benefit: $1.04 million versus $1.05 million). A nonoptimized patient attained an average 0.02 quality-adjusted life-years less than one optimized. Thus, preoperative optimization was the dominant strategy (lower total costs; higher quality-adjusted life-years). Probabilistic sensitivity analysis demonstrated 100% of simulations favoring preoperative optimization. The breakeven cost of optimization to remain cost-effective was $6421 per patient.
    Limitations: Generalizability must account for the lack of standardization among existing preoperative optimization efforts, and decision analysis methodology provides guidance for the average patient or general population, and is not patient-specific.
    Conclusions: Although currently not comprehensively reimbursed, focused preoperative optimization may reduce total costs of care while also reducing complications from colon cancer surgery. See Video Abstract at http://links.lww.com/DCR/B494.
    En todo caso anlisis de rentabilidad de los esfuerzos limitados de optimizacin preoperatoria antes de la ciruga de cncer de colon: ANTECEDENTES:Los informes sugieren que la optimización preoperatoria de las comorbilidades graves de un paciente se asocia con una reducción de las complicaciones postoperatorias.OBJETIVO:El propósito de este estudio fue evaluar el costo y los beneficios de la optimización preoperatoria, teniendo en cuenta los costos totales asociados con la morbilidad postoperatoria.DISEÑO:Análisis de costo-efectividad de árbol de decisión con análisis de sensibilidad probabilístico (10,000 iteraciones).AJUSTE ENTORNO CLINICO:Escenario hipotético Cirugía de cáncer de colon en estadio II.PACIENTE:Paciente simulado de 65 años con cáncer de colon en estadio II del lado izquierdo.INTERVENCIÓN:Optimización preoperatoria enfocada dirigida a comorbilidades de alto riesgo.RESULTADOS:Costos económicos totales descontados (3%) (US $ 2018), efectividad (años de vida ajustados por calidad [AVAC]), relación costo-efectividad incremental (ICER, costo / AVAC ganado) y beneficio monetario neto (NMB).RESULTADOS:Calculamos que el costo total esperado por sector de atención médica individual de la optimización preoperatoria y las secuelas es de $ 12,395 versus $ 15,638 en aquellos no optimizados (NMB: $ 1.04 millones versus $ 1.05 millones, respectivamente). Un paciente no optimizado alcanzó un promedio de 0.02 AVAC menos que uno optimizado. Por lo tanto, la optimización preoperatoria fue la estrategia dominante (menores costos totales; mayores AVAC). El análisis de sensibilidad probabilístico demostró que el 100% de las simulaciones favorecían la optimización preoperatoria. El costo de equilibrio de la optimización para seguir siendo rentable fue de $ 6,421 por paciente.LIMITACIONES:La generalización debe tener en cuenta la falta de estandarización entre los esfuerzos de optimización preoperatorios existentes y esa metodología de análisis de decisiones proporciona una guía para el paciente promedio o la población general, no específica del paciente.CONCLUSIONES:Si bien actualmente no se reembolsa de manera integral, la optimización preoperatoria enfocada puede reducir los costos totales de la atención y al mismo tiempo reducir las complicaciones de la cirugía de cáncer de colon. Consulte Video Resumen en http://links.lww.com/DCR/B494.
    MeSH term(s) Aged ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Comorbidity ; Cost-Benefit Analysis/methods ; Cost-Benefit Analysis/statistics & numerical data ; Decision Support Techniques ; Health Care Costs/statistics & numerical data ; Health Care Costs/trends ; Humans ; Neoplasm Staging/methods ; Patient Simulation ; Postoperative Complications/economics ; Postoperative Complications/epidemiology ; Postoperative Period ; Preoperative Care/economics ; Preoperative Care/statistics & numerical data ; Preoperative Exercise/physiology ; Quality-Adjusted Life Years ; Sensitivity and Specificity
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000001926
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  9. Article ; Online: Using Microsimulation Modeling to Inform EHE Implementation Strategies in Los Angeles County.

    Drabo, Emmanuel F / Moucheraud, Corrina / Nguyen, Anthony / Garland, Wendy H / Holloway, Ian W / Leibowitz, Arleen / Suen, Sze-Chuan

    Journal of acquired immune deficiency syndromes (1999)

    2022  Volume 90, Issue S1, Page(s) S167–S176

    Abstract: Background: Pre-exposure prophylaxis (PrEP) is essential to ending HIV. Yet, uptake remains uneven across racial and ethnic groups. We aimed to estimate the impacts of alternative PrEP implementation strategies in Los Angeles County.: Setting: Men ... ...

    Abstract Background: Pre-exposure prophylaxis (PrEP) is essential to ending HIV. Yet, uptake remains uneven across racial and ethnic groups. We aimed to estimate the impacts of alternative PrEP implementation strategies in Los Angeles County.
    Setting: Men who have sex with men, residing in Los Angeles County.
    Methods: We developed a microsimulation model of HIV transmission, with inputs from key local stakeholders. With this model, we estimated the 15-year (2021-2035) health and racial and ethnic equity impacts of 3 PrEP implementation strategies involving coverage with 9000 additional PrEP units annually, above the Status-quo coverage level. Strategies included PrEP allocation equally (strategy 1), proportionally to HIV prevalence (strategy 2), and proportionally to HIV diagnosis rates (strategy 3), across racial and ethnic groups. We measured the degree of relative equalities in the distribution of the health impacts using the Gini index (G) which ranges from 0 (perfect equality, with all individuals across all groups receiving equal health benefits) to 1 (total inequality).
    Results: HIV prevalence was 21.3% in 2021 [Black (BMSM), 31.1%; Latino (LMSM), 18.3%, and White (WMSM), 20.7%] with relatively equal to reasonable distribution across groups (G, 0.28; 95% confidence interval [CI], 0.26 to 0.34). During 2021-2035, cumulative incident infections were highest under Status-quo (n = 24,584) and lowest under strategy 3 (n = 22,080). Status-quo infection risk declined over time among all groups but remained higher in 2035 for BMSM (incidence rate ratio, 4.76; 95% CI: 4.58 to 4.95), and LMSM (incidence rate ratio, 1.74; 95% CI: 1.69 to 1.80), with the health benefits equally to reasonably distributed across groups (G, 0.32; 95% CI: 0.28 to 0.35). Relative to Status-quo, all other strategies reduced BMSM-WMSM and BMSM-LMSM disparities, but none reduced LMSM-WMSM disparities by 2035. Compared to Status-quo, strategy 3 reduced the most both incident infections (% infections averted: overall, 10.2%; BMSM, 32.4%; LMSM, 3.8%; WMSM, 3.5%) and HIV racial inequalities (G reduction, 0.08; 95% CI: 0.02 to 0.14).
    Conclusions: Microsimulation models developed with early, continuous stakeholder engagement and inputs yield powerful tools to guide policy implementation.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Homosexuality, Male ; Humans ; Los Angeles/epidemiology ; Male ; Pre-Exposure Prophylaxis ; Sexual and Gender Minorities
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000002977
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