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Article ; Online: Selective reorienting response of the left hemisphere to invalid visual targets in the right side of space: relevance for the spatial neglect syndrome.

Dragone, Alessio / Lasaponara, Stefano / Silvetti, Massimo / Macaluso, Emiliano / Doricchi, Fabrizio

Cortex; a journal devoted to the study of the nervous system and behavior

2015 Volume 65, Page(s) 31–35

MeSH term(s)	Brain/pathology ; Brain Mapping ; Humans ; Image Processing, Computer-Assisted ; Perceptual Disorders/diagnosis ; Perceptual Disorders/pathology ; Space Perception/physiology ; Visual Perception
Language	English
Publishing date	2015-04
Publishing country	Italy
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2014.12.009
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Article ; Online: Expectancy modulates pupil size both during endogenous orienting and during re-orienting of spatial attention: A study with isoluminant stimuli.

Lasaponara, Stefano / Fortunato, Gianfranco / Dragone, Alessio / Pellegrino, Michele / Marson, Fabio / Silvetti, Massimo / Pinto, Mario / D'Onofrio, Marianna / Doricchi, Fabrizio

The European journal of neuroscience

2019 Volume 50, Issue 5, Page(s) 2893–2904

Abstract: We have recently demonstrated that when endogenous orienting of spatial attention is guided by central directional cues that reliably predict the position of lateral targets. Pupil Dilation (PDil) is higher as compared with directional cues that do not ... ...

Abstract	We have recently demonstrated that when endogenous orienting of spatial attention is guided by central directional cues that reliably predict the position of lateral targets. Pupil Dilation (PDil) is higher as compared with directional cues that do not predict target position. These findings were interpreted as reflecting different levels of Locus Coeruleus-Noradrenergic activity during endogenous orienting. In contrast to this, we were not able to highlight reliable differences between PDil responses to infrequent invalid targets that are associated with predictive cues and frequent invalid targets that are associated with non-predictive ones. These null findings might have been due to the spurious influence of transitory changes in luminance at the moment of target presentation or to the short time window used for the analysis of target-related changes in PDil. Here, we re-explored cue- and target-related changes in PDil using cue and target stimuli that were kept isoluminant to their background and long lasting cue and target periods for data recording and analysis. We fully replicate our previous cue-related results and, in addition, we demonstrate that infrequent invalid targets in the predictive experimental condition evoke larger PDil as compared with frequent ones. Analyses with Linear Mixed Models highlighted that both during the cue and target period, higher levels of PDil were associated with slower reaction times. These findings confirm that PDil is a reliable marker of the expectancy components of endogenous cue-related and exogenous target-related orienting of spatial attention.
MeSH term(s)	Adult ; Anticipation, Psychological/physiology ; Attention/physiology ; Cues ; Female ; Humans ; Male ; Orientation, Spatial/physiology ; Photic Stimulation ; Pupil/physiology ; Reaction Time/physiology
Language	English
Publishing date	2019-04-01
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.14391
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Zs.A 2548: Show issues

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Article: Association between time-related changes in routine blood morphological parameters and renal function after transcatheter aortic valve implantation - a preliminary study.

Stelmark, Konrad / Zaher, Eli Adrian / Olasińska-Wiśniewska, Anna / Adesina, Michael / Dragone, Alicia / Isaac, Martha / Misterski, Marcin / Grygier, Marek / Puślecki, Mateusz / Lesiak, Maciej / Jemielity, Marek / Perek, Bartłomiej

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

2021 Volume 18, Issue 3, Page(s) 152–158

Abstract: Introduction: Transcatheter aortic valve implantation (TAVI) although minimally invasive is still accompanied by changes in blood morphological parameters, some of them linked to unfavorable outcomes.: Aim: To find any association between changes in ... ...

Abstract	Introduction: Transcatheter aortic valve implantation (TAVI) although minimally invasive is still accompanied by changes in blood morphological parameters, some of them linked to unfavorable outcomes. Aim: To find any association between changes in blood morphology reflecting an inflammatory response and acute kidney injury (AKI). Material and methods: This study involved 176 consecutive transfemoral TAVI patients with a mean age of 78.4 ±7.0 years. Serum creatinine concentration (CREA) and blood morphology were analyzed in the blood samples taken before the procedure, then approximately 1, 24, 48 and 72 hours after the procedure, and lastly at the time of discharge. Post-procedural maximal or minimal values (max/min) and max/min-to-bs ratio of the laboratory parameters were also calculated. Results: Leucocyte (WBC) and neutrophil (NEUT) counts increased significantly after the procedure whereas lymphocyte (LYMPH) counts declined markedly, reaching the highest or lowest values 24 hours after the procedure. A significant increase in neutrophil-to-lymphocyte ratio (NLR) was observed. Platelet count (PLT) dropped to a minimum at 72 hours after TAVI but at discharge did not return to the admission level. TAVI was associated with a marked increase in CREA with a peak at 48 hours after the procedure (135.7 ±75.9 μM/l). Patients with AKI ( Conclusions: TAVI is associated with significant changes in blood morphological parameters that reflect an inflammatory response. They are more pronounced among subjects with post-procedural AKI.
Language	English
Publishing date	2021-10-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2237053-5
ISSN	1897-4252 ; 1731-5530
ISSN (online)	1897-4252
ISSN	1731-5530
DOI	10.5114/kitp.2021.109368
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Article ; Online: Expectancy modulates pupil size during endogenous orienting of spatial attention.

Dragone, Alessio / Lasaponara, Stefano / Pinto, Mario / Rotondaro, Francesca / De Luca, Maria / Doricchi, Fabrizio

Cortex; a journal devoted to the study of the nervous system and behavior

2017 Volume 102, Page(s) 57–66

Abstract: fMRI investigations in healthy humans have documented phasic changes in the level of activation of the right temporal-parietal junction (TPJ) during cued voluntary orienting of spatial attention. Cues that correctly predict the position of upcoming ... ...

Abstract	fMRI investigations in healthy humans have documented phasic changes in the level of activation of the right temporal-parietal junction (TPJ) during cued voluntary orienting of spatial attention. Cues that correctly predict the position of upcoming targets in the majority of trials, i.e., predictive cues, produce higher deactivation of the right TPJ as compared with non-predictive cues. Since the right TPJ is the recipient of noradrenergic (NE) innervation, it has been hypothesised that changes in the level of TPJ activity are matched with changes in the level of NE activity. Based on aforementioned fMRI findings, this might imply that orienting with predictive cues is matched with different levels of NE activity as compared with non-predictive cues. To test this hypothesis, we measured changes in pupil dilation, an indirect index of NE activity, during voluntary orienting of attention with highly predictive (80% validity) or non-predictive (50% validity) cues. In agreement with current interpretations of the tonic/phasic activity of the Locus Coeruleus-Norepinephrinic system (LC-NE), we found that the steady level of cue predictiveness that characterised both the predictive and non-predictive conditions caused, across consecutive blocks of trials, a progressive decrement in pupil dilation during the baseline-fixation period that anticipated the cue period. With predictive cues we observed increased pupil dilation as compared with non-predictive cues. In addition, the relative reduction in pupil size observed with non-predictive cues increased as a function of cue-duration. These results show that changes in the predictiveness of cues that guide voluntary orienting of spatial attention are matched with changes in pupil dilation and, putatively, with corresponding changes in LC-NE activity.
MeSH term(s)	Adult ; Attention/physiology ; Cues ; Female ; Functional Laterality/physiology ; Humans ; Locus Coeruleus/physiology ; Male ; Orientation, Spatial/physiology ; Pupil/physiology ; Reaction Time/physiology
Language	English
Publishing date	2017-10-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2017.09.011
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Article ; Online: Changes in predictive cuing modulate the hemispheric distribution of the P1 inhibitory response to attentional targets.

Lasaponara, Stefano / D' Onofrio, Marianna / Dragone, Alessio / Pinto, Mario / Caratelli, Ludovica / Doricchi, Fabrizio

Neuropsychologia

2017 Volume 99, Page(s) 156–164

Abstract: Brain activity related to orienting of attention with spatial cues and brain responses to attentional targets are influenced the probabilistic contingency between cues and targets. Compared to predictive cues, cues predicting at chance the location of ... ...

Abstract	Brain activity related to orienting of attention with spatial cues and brain responses to attentional targets are influenced the probabilistic contingency between cues and targets. Compared to predictive cues, cues predicting at chance the location of targets reduce the filtering out of uncued locations and the costs in reorienting attention to targets presented at these locations. Slagter et al. (2016) have recently suggested that the larger target related P1 component that is found in the hemisphere ipsilateral to validly cued targets reflects stimulus-driven inhibition in the processing of the unstimulated side of space contralateral to the same hemisphere. Here we verified whether the strength of this inhibition and the amplitude of the corresponding P1 wave are modulated by the probabilistic link between cues and targets. Healthy participants performed a task of endogenous orienting once with predictive and once with non-predictive directional cues. In the non-predictive condition we observed a drop in the amplitude of the P1 ipsilateral to the target and in the costs of reorienting. No change in the inter-hemispheric latencies of the P1 was found between the two predictive conditions. The N1 facilitatory component was unaffected by predictive cuing. These results show that the predictive context modulates the strength of the inhibitory P1 response and that this modulation is not matched with changes in the inter-hemispheric interaction between the P1 generators of the two hemispheres.
MeSH term(s)	Adult ; Analysis of Variance ; Attention/physiology ; Brain/physiology ; Cues ; Dominance, Cerebral ; Electroencephalography ; Electrooculography ; Evoked Potentials ; Female ; Humans ; Male ; Neuropsychological Tests ; Orientation/physiology ; Reaction Time ; Space Perception/physiology ; Visual Perception/physiology
Language	English
Publishing date	2017-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2017.03.010
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Zs.A 524: Show issues

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Article ; Online: The Response of the Left Ventral Attentional System to Invalid Targets and its Implication for the Spatial Neglect Syndrome: a Multivariate fMRI Investigation.

Silvetti, Massimo / Lasaponara, Stefano / Lecce, Francesca / Dragone, Alessio / Macaluso, Emiliano / Doricchi, Fabrizio

Cerebral cortex (New York, N.Y. : 1991)

2016 Volume 26, Issue 12, Page(s) 4551–4562

Abstract: In humans, invalid visual targets that mismatch spatial expectations induced by attentional cues are considered to selectively engage a right hemispheric "reorienting" network that includes the temporal parietal junction (TPJ), the inferior frontal gyrus ...

Abstract	In humans, invalid visual targets that mismatch spatial expectations induced by attentional cues are considered to selectively engage a right hemispheric "reorienting" network that includes the temporal parietal junction (TPJ), the inferior frontal gyrus (IFG), and the medial frontal gyrus (MFG). However, recent findings suggest that this hemispheric dominance is not absolute and that it is rather observed because the TPJ and IFG areas in the left hemisphere are engaged both by invalid and valid cued targets. Because of this, the BOLD response of the left hemisphere to invalid targets is usually cancelled out by the standard "invalid versus valid" contrast used in functional magnetic resonance imaging investigations of spatial attention. Here, we used multivariate pattern recognition analysis (MVPA) to gain finer insight into the role played by the left TPJ and IFG in reorienting to invalid targets. We found that in left TPJ and IFG blood oxygen level-dependent (BOLD) responses to invalid and valid targets were associated to different patterns of neural activity, possibly reflecting the presence of functionally distinct neuronal populations. Pattern segregation was significant at group level, it was present in almost all of the participants to the study and was observed both for targets in the left and right side of space. A control whole-brain MVPA ("Searchlight" analysis) confirmed the results obtained in predefined regions of interest and highlighted that also other areas, that is, superior parietal and frontal-polar cortex, show different patterns of BOLD response to valid and invalid targets. These results confirm and expand previous evidence highlighting the involvement of the left hemisphere in reorienting of visual attention (Doricchi et al. 2010; Dragone et al. 2015). These findings suggest that asymmetrical reorienting deficits suffered by right brain damaged patients with left spatial neglect, who have severe impairments in contralesional reorienting and less severe impairments in ipsilesional reorienting, are due to preserved reorienting abilities in the intact left hemisphere.
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhv208
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Zs.A 3235: Show issues

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Article ; Online: EEG Correlates of Preparatory Orienting, Contextual Updating, and Inhibition of Sensory Processing in Left Spatial Neglect.

Lasaponara, Stefano / D'Onofrio, Marianna / Pinto, Mario / Dragone, Alessio / Menicagli, Dario / Bueti, Domenica / De Lucia, Marzia / Tomaiuolo, Francesco / Doricchi, Fabrizio

The Journal of neuroscience : the official journal of the Society for Neuroscience

2018 Volume 38, Issue 15, Page(s) 3792–3808

Abstract: Studies with event-related potentials have highlighted deficits in the early phases of orienting to left visual targets in right-brain-damaged patients with left spatial neglect (N+). However, brain responses associated with preparatory orienting of ... ...

Abstract	Studies with event-related potentials have highlighted deficits in the early phases of orienting to left visual targets in right-brain-damaged patients with left spatial neglect (N+). However, brain responses associated with preparatory orienting of attention, with target novelty and with the detection of a match/mismatch between expected and actual targets (contextual updating), have not been explored in N+. Here in a study in healthy humans and brain-damaged patients of both sexes we demonstrate that frontal activity that reflects supramodal mechanisms of attentional orienting (Anterior Directing Attention Negativity, ADAN) is entirely spared in N+. In contrast, posterior responses that mark the early phases of cued orienting (Early Directing Attention Negativity, EDAN) and the setting up of sensory facilitation over the visual cortex (Late Directing Attention Positivity, LDAP) are suppressed in N+. This uncoupling is associated with damage of parietal-frontal white matter. N+ also exhibit exaggerated novelty reaction to targets in the right side of space and reduced novelty reaction for those in the left side (P3a) together with impaired contextual updating (P3b) in the left space. Finally, we highlight a drop in the amplitude and latency of the P1 that over the left hemisphere signals the early blocking of sensory processing in the right space when targets occur in the left one: this identifies a new electrophysiological marker of the rightward attentional bias in N+. The heterogeneous effects and spatial biases produced by localized brain damage on the different phases of attentional processing indicate relevant functional independence among their underlying neural mechanisms and improve the understanding of the spatial neglect syndrome.
MeSH term(s)	Adult ; Aged ; Cerebral Cortex/physiopathology ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Neural Inhibition ; Orientation, Spatial ; Perceptual Disorders/physiopathology
Language	English
Publishing date	2018-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2817-17.2018
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Article ; Online: The "serendipitous brain": Low expectancy and timing uncertainty of conscious events improve awareness of unconscious ones (evidence from the Attentional Blink).

Lasaponara, Stefano / Dragone, Alessio / Lecce, Francesca / Di Russo, Francesco / Doricchi, Fabrizio

Cortex; a journal devoted to the study of the nervous system and behavior

2015 Volume 71, Page(s) 15–33

Abstract: To anticipate upcoming sensory events, the brain picks-up and exploits statistical regularities in the sensory environment. However, it is untested whether cumulated predictive knowledge about consciously seen stimuli improves the access to awareness of ... ...

Abstract	To anticipate upcoming sensory events, the brain picks-up and exploits statistical regularities in the sensory environment. However, it is untested whether cumulated predictive knowledge about consciously seen stimuli improves the access to awareness of stimuli that usually go unseen. To explore this issue, we exploited the Attentional Blink (AB) effect, where conscious processing of a first visual target (T1) hinders detection of early following targets (T2). We report that timing uncertainty and low expectancy about the occurrence of consciously seen T2s presented outside the AB period, improve detection of early and otherwise often unseen T2s presented inside the AB. Recording of high-resolution Event Related Potentials (ERPs) and the study of their intracranial sources showed that the brain achieves this improvement by initially amplifying and extending the pre-conscious storage of T2s' traces signalled by the N2 wave originating in the extra-striate cortex. This enhancement in the N2 wave is followed by specific changes in the latency and amplitude of later components in the P3 wave (P3a and P3b), signalling access of the sensory trace to the network of parietal and frontal areas modulating conscious processing. These findings show that the interaction between conscious and unconscious processing changes adaptively as a function of the probabilistic properties of the sensory environment and that the combination of an active attentional state with loose probabilistic and temporal expectancies on forthcoming conscious events favors the emergence to awareness of otherwise unnoticed visual events. This likely provides an insight on the attentional conditions that predispose an active observer to unexpected "serendipitous" findings.
MeSH term(s)	Adolescent ; Adult ; Attention/physiology ; Attentional Blink/physiology ; Awareness/physiology ; Brain/physiology ; Consciousness/physiology ; Electroencephalography ; Event-Related Potentials, P300/physiology ; Evoked Potentials/physiology ; Female ; Frontal Lobe/physiology ; Humans ; Learning ; Male ; Nerve Net/physiology ; Parietal Lobe/physiology ; Psychomotor Performance ; Uncertainty ; Unconscious (Psychology) ; Visual Cortex/physiology ; Young Adult
Language	English
Publishing date	2015-10
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2015.05.029
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Article ; Online: The ePix10k 2-megapixel hard X-ray detector at LCLS.

van Driel, Tim Brandt / Nelson, Silke / Armenta, Rebecca / Blaj, Gabriel / Boo, Stephen / Boutet, Sébastien / Doering, Dionisio / Dragone, Angelo / Hart, Philip / Haller, Gunther / Kenney, Christopher / Kwaitowski, Maciej / Manger, Leo / McKelvey, Mark / Nakahara, Kaz / Oriunno, Marco / Sato, Takahiro / Weaver, Matt

Journal of synchrotron radiation

2020 Volume 27, Issue Pt 3, Page(s) 608–615

Abstract: The ePix10ka2M (ePix10k) is a new large area detector specifically developed for X-ray free-electron laser (XFEL) applications. The hybrid pixel detector was developed at SLAC to provide a hard X-ray area detector with a high dynamic range, running at ... ...

Abstract	The ePix10ka2M (ePix10k) is a new large area detector specifically developed for X-ray free-electron laser (XFEL) applications. The hybrid pixel detector was developed at SLAC to provide a hard X-ray area detector with a high dynamic range, running at the 120 Hz repetition rate of the Linac Coherent Light Source (LCLS). The ePix10k consists of 16 modules, each with 352 × 384 pixels of 100 µm × 100 µm distributed on four ASICs, resulting in a 2.16 megapixel detector, with a 16.5 cm × 16.5 cm active area and ∼80% coverage. The high dynamic range is achieved with three distinct gain settings (low, medium, high) as well as two auto-ranging modes (high-to-low and medium-to-low). Here the three fixed gain modes are evaluated. The resulting dynamic range (from single photon counting to 10000 photons pixel
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577520004257
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Article: Identification of an allotypic IgA in cattle serum.

De Benedictis, G / Capalbo, P / Dragone, A

Comparative immunology, microbiology and infectious diseases

1984 Volume 7, Issue 1, Page(s) 35–42

Abstract: Alloimmunization of cattle revealed a polymorphism carried on a serum antigen displayed beta-electrophoretic mobility. A genetic test indicated that the antigen is inherited in a Mendelian manner, as product of a dominant allele at an autosomal locus. By ...

Abstract	Alloimmunization of cattle revealed a polymorphism carried on a serum antigen displayed beta-electrophoretic mobility. A genetic test indicated that the antigen is inherited in a Mendelian manner, as product of a dominant allele at an autosomal locus. By immunochemical investigation the allotypic determinant was found to be located on IgA: there were in fact no differences between the peptidic map of the molecule carrying the allotypic determinant and that of IgA from positive sera. Moreover the peptidic map of IgA from sera lacking of the allotype resulted lacking of an anodic peptide, thus suggesting that the polymorphism is indeed due to such a peptide.
MeSH term(s)	Animals ; Blood Proteins/genetics ; Blood Proteins/immunology ; Cattle/blood ; Female ; Immunodiffusion ; Immunoelectrophoresis ; Immunoglobulin A/analysis ; Immunoglobulin Allotypes/analysis ; Isoantibodies/immunology ; Polymorphism, Genetic
Chemical Substances	Blood Proteins ; Immunoglobulin A ; Immunoglobulin Allotypes ; Isoantibodies
Language	English
Publishing date	1984
Publishing country	England
Document type	Journal Article
ZDB-ID	436522-7
ISSN	1878-1667 ; 0147-9571
ISSN (online)	1878-1667
ISSN	0147-9571
DOI	10.1016/0147-9571(84)90014-6
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