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  1. AU="Drajac, Carole"
  2. AU="Jovanovski, Sara D"
  3. AU="Navarro, M"
  4. AU="Raetz, Jaqueline"
  5. AU="Staudenmayer, Kristan"
  6. AU="Ferreyra-Reyes, Leticia Dolores"
  7. AU="Das, Papita"
  8. AU="Napoletano, Brian M"
  9. AU="Georgia Paxton"
  10. AU="Hepworth, L R"
  11. AU="Loghmani, Mary Terry"
  12. AU="Sykes, Craig"
  13. AU="Mes, S D"
  14. AU="Dragojevic, Irena"
  15. AU="Berti, Aldo F"
  16. AU="Kähne, Thilo"
  17. AU="Díaz Díaz, Domingo"
  18. AU=Aziz Monowar
  19. AU=Zaki Ahmed A
  20. AU="Pandey, Shalini"
  21. AU="Goversen, Birgit"
  22. AU="Caicedo, Carlos"
  23. AU=Fribley Andrew AU=Fribley Andrew
  24. AU="Boffelli, Stefano"
  25. AU="Draper, Evan W"
  26. AU="Rosenblum, Shira T"
  27. AU=Kavousi Javid
  28. AU="Mukram, Mohd Azeemuddin"
  29. AU="Farzana Yasmin"
  30. AU=Epel Elissa S
  31. AU="Voet, W"
  32. AU="Jay Patel"
  33. AU="Iacob, Nicusor"
  34. AU="Guo, Dengyang"
  35. AU="Galacho-Harriero, Ana María"
  36. AU="Awoyelu, E H"
  37. AU="Tinajero, Jose"
  38. AU=Vashishtha Vipin M AU=Vashishtha Vipin M
  39. AU="D'Agostino, Nicole"
  40. AU="Lunetta, Kathryn L"
  41. AU="Tirschmann, Felix"
  42. AU="Adetuyi, B.O."

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  1. Artikel ; Online: Pulmonary Susceptibility of Neonates to Respiratory Syncytial Virus Infection: A Problem of Innate Immunity?

    Drajac, Carole / Laubreton, Daphné / Riffault, Sabine / Descamps, Delphyne

    Journal of immunology research

    2017  Band 2017, Seite(n) 8734504

    Abstract: Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the ... ...

    Abstract Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. Although different risk factors are associated with acute RSV bronchiolitis, the immunological factors contributing to the susceptibility of RSV infection in infants are not clearly elucidated. Epidemiological studies have established that the age at initial infection plays a central role in the severity of the disease. Thus, neonatal susceptibility is intrinsically linked to the immunological characteristics of the young pulmonary mucosa. Early life is a critical period for the lung development with the first expositions to external environmental stimuli and microbiota colonization. Furthermore, neonates display a lung immune system that profoundly differs to those from adults, with the predominance of type 2 immune cells. In this review, we discuss the latest information about the lung immune environment in the early period of life at a steady state and upon RSV infection and how we can modulate neonatal susceptibility to RSV infection.
    Mesh-Begriff(e) Cellular Microenvironment ; Disease Susceptibility ; Humans ; Immune Tolerance ; Immunity, Innate ; Immunomodulation ; Infant, Newborn ; Lung/immunology ; Lung/virology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus, Human/physiology
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland Egypt
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2017/8734504
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner

    Laubreton, Daphné / Drajac, Carole / Eléouët, Jean-François / Rameix-Welti, Marie-Anne / Lo-Man, Richard / Riffault, Sabine / Descamps, Delphyne

    Viruses. 2020 July 29, v. 12, no. 8

    2020  

    Abstract: Respiratory syncytial virus (RSV) is the prevalent pathogen of lower respiratory tract infections in children. The presence of neonatal regulatory B lymphocytes (nBreg) has been associated with a poor control of RSV infection in human newborns and with ... ...

    Abstract Respiratory syncytial virus (RSV) is the prevalent pathogen of lower respiratory tract infections in children. The presence of neonatal regulatory B lymphocytes (nBreg) has been associated with a poor control of RSV infection in human newborns and with bronchiolitis severity. So far, little is known about how nBreg may contribute to neonatal immunopathology to RSV. We tracked nBreg in neonatal BALB/c mice and we investigated their impact on lung innate immunity, especially their crosstalk with alveolar macrophages (AMs) upon RSV infection. We showed that the colonization by nBreg during the first week of life is a hallmark of neonatal lung whereas this population is almost absent in adult lung. This particular period of age when nBreg are abundant corresponds to the same period when RSV replication in lungs fails to generate a type-I interferons (IFN-I) response and is not contained. When neonatal AMs are exposed to RSV in vitro, they produce IFN-I that in turn enhances IL-10 production by nBreg. IL-10 reciprocally can decrease IFN-I secretion by AMs. Thus, our work identified nBreg as an important component of neonatal lungs and pointed out new immunoregulatory interactions with AMs in the context of RSV infection.
    Schlagwörter B-lymphocytes ; Respiratory syncytial virus ; adults ; bronchiolitis ; children ; humans ; immune response ; immunomodulation ; immunopathology ; innate immunity ; interferons ; interleukin-10 ; lungs ; macrophages ; mice ; neonates ; pathogens ; secretion
    Sprache Englisch
    Erscheinungsverlauf 2020-0729
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12080822
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells.

    Descamps, Delphyne / Evnouchidou, Irini / Caillens, Vivien / Drajac, Carole / Riffault, Sabine / van Endert, Peter / Saveanu, Loredana

    Frontiers in molecular biosciences

    2020  Band 7, Seite(n) 583556

    Abstract: Insulin regulated aminopeptidase (IRAP) is a type II transmembrane protein with broad tissue distribution initially identified as a major component of Glut4 storage vesicles (GSV) in adipocytes. Despite its almost ubiquitous expression, IRAP had been ... ...

    Abstract Insulin regulated aminopeptidase (IRAP) is a type II transmembrane protein with broad tissue distribution initially identified as a major component of Glut4 storage vesicles (GSV) in adipocytes. Despite its almost ubiquitous expression, IRAP had been extensively studied mainly in insulin responsive cells, such as adipocytes and muscle cells. In these cells, the enzyme displays a complex intracellular trafficking pattern regulated by insulin. Early studies using fusion proteins joining the IRAP cytosolic domain to various reporter proteins, such as GFP or the transferrin receptor (TfR), showed that the complex and regulated trafficking of the protein depends on its cytosolic domain. This domain contains several motifs involved in IRAP trafficking, as demonstrated by mutagenesis studies. Also, proteomic studies and yeast two-hybrid experiments showed that the IRAP cytosolic domain engages in multiple protein interactions with cytoskeleton components and vesicular trafficking adaptors. These findings led to the hypothesis that IRAP is not only a cargo of GSV but might be a part of the sorting machinery that controls GSV dynamics. Recent work in adipocytes, immune cells, and neurons confirmed this hypothesis and demonstrated that IRAP has a dual function. Its carboxy-terminal domain located inside endosomes is responsible for the aminopeptidase activity of the enzyme, while its amino-terminal domain located in the cytosol functions as an endosomal trafficking adaptor. In this review, we recapitulate the published protein interactions of IRAP and summarize the increasing body of evidence indicating that IRAP plays a role in intracellular trafficking of several proteins. We describe the impact of IRAP deletion or depletion on endocytic trafficking and the consequences on immune cell functions. These include the ability of dendritic cells to cross-present antigens and prime adaptive immune responses, as well as the control of innate and adaptive immune receptor signaling and modulation of inflammatory responses.
    Sprache Englisch
    Erscheinungsdatum 2020-10-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.583556
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Regulatory B Lymphocytes Colonize the Respiratory Tract of Neonatal Mice and Modulate Immune Responses of Alveolar Macrophages to RSV Infection in IL-10-Dependant Manner.

    Laubreton, Daphné / Drajac, Carole / Eléouët, Jean-François / Rameix-Welti, Marie-Anne / Lo-Man, Richard / Riffault, Sabine / Descamps, Delphyne

    Viruses

    2020  Band 12, Heft 8

    Abstract: Respiratory syncytial virus (RSV) is the prevalent pathogen of lower respiratory tract infections in children. The presence of neonatal regulatory B lymphocytes (nBreg) has been associated with a poor control of RSV infection in human newborns and with ... ...

    Abstract Respiratory syncytial virus (RSV) is the prevalent pathogen of lower respiratory tract infections in children. The presence of neonatal regulatory B lymphocytes (nBreg) has been associated with a poor control of RSV infection in human newborns and with bronchiolitis severity. So far, little is known about how nBreg may contribute to neonatal immunopathology to RSV. We tracked nBreg in neonatal BALB/c mice and we investigated their impact on lung innate immunity, especially their crosstalk with alveolar macrophages (AMs) upon RSV infection. We showed that the colonization by nBreg during the first week of life is a hallmark of neonatal lung whereas this population is almost absent in adult lung. This particular period of age when nBreg are abundant corresponds to the same period when RSV replication in lungs fails to generate a type-I interferons (IFN-I) response and is not contained. When neonatal AMs are exposed to RSV in vitro, they produce IFN-I that in turn enhances IL-10 production by nBreg. IL-10 reciprocally can decrease IFN-I secretion by AMs. Thus, our work identified nBreg as an important component of neonatal lungs and pointed out new immunoregulatory interactions with AMs in the context of RSV infection.
    Mesh-Begriff(e) Animals ; Animals, Newborn ; B-Lymphocyte Subsets/immunology ; B-Lymphocytes, Regulatory/immunology ; Cells, Cultured ; Immunity, Innate ; Interferon Type I/biosynthesis ; Interferon Type I/immunology ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Lung/immunology ; Lung/virology ; Macrophages, Alveolar/immunology ; Mice ; Mice, Inbred BALB C ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses/immunology ; Respiratory Syncytial Viruses/physiology ; Spleen/immunology ; Turbinates/immunology ; Virus Replication
    Chemische Substanzen IL10 protein, mouse ; Interferon Type I ; Interleukin-10 (130068-27-8)
    Sprache Englisch
    Erscheinungsdatum 2020-07-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12080822
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.

    Drajac, Carole / Laubreton, Daphné / Marquant, Quentin / Chottin, Claire / Ferret, Cécile / Bouguyon, Edwige / Schwartz-Cornil, Isabelle / Saveanu, Loredana / Riffault, Sabine / Descamps, Delphyne

    Mucosal immunology

    2021  Band 14, Heft 4, Seite(n) 949–962

    Abstract: Respiratory Syncytial Virus (RSV) is the major cause of lower respiratory tract infection in infants, in whom, the sensing of RSV by innate immune receptors and its regulation are still poorly described. However, the severe bronchiolitis following RSV ... ...

    Abstract Respiratory Syncytial Virus (RSV) is the major cause of lower respiratory tract infection in infants, in whom, the sensing of RSV by innate immune receptors and its regulation are still poorly described. However, the severe bronchiolitis following RSV infection in neonates has been associated with a defect in type I interferons (IFN-I) production, a cytokine produced mainly by alveolar macrophages (AMs) upon RSV infection in adults. In the present study, neonatal C57BL/6 AMs mobilized very weakly the IFN-I pathway upon RSV infection in vitro and failed to restrain virus replication. However, IFN-I productions by neonatal AMs were substantially increased by the deletion of Insulin-Responsive AminoPeptidase (IRAP), a protein previously involved in the regulation of IFN-I production by dendritic cells. Moreover, neonatal IRAP
    Mesh-Begriff(e) Animals ; Animals, Newborn ; Cystinyl Aminopeptidase/metabolism ; Disease Models, Animal ; Host-Pathogen Interactions/immunology ; Interferon Type I/metabolism ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/metabolism ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses ; Signal Transduction ; Toll-Like Receptors/metabolism ; Virus Replication
    Chemische Substanzen Interferon Type I ; Toll-Like Receptors ; Cystinyl Aminopeptidase (EC 3.4.11.3) ; leucyl-cystinyl aminopeptidase (EC 3.4.11.3)
    Sprache Englisch
    Erscheinungsdatum 2021-04-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-021-00402-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The microbiota plays a critical role in the reactivity of lung immune components to innate ligands.

    Marquant, Quentin / Laubreton, Daphné / Drajac, Carole / Mathieu, Elliot / Bouguyon, Edwige / Noordine, Marie-Louise / Remot, Aude / Riffault, Sabine / Thomas, Muriel / Descamps, Delphyne

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Band 35, Heft 4, Seite(n) e21348

    Abstract: The gut microbiota contributes to shaping efficient and safe immune defenses in the gut. However, little is known about the role of the gut and/or lung microbiota in the education of pulmonary innate immune responses. Here, we tested whether the ... ...

    Abstract The gut microbiota contributes to shaping efficient and safe immune defenses in the gut. However, little is known about the role of the gut and/or lung microbiota in the education of pulmonary innate immune responses. Here, we tested whether the endogenous microbiota in general can modulate the reactivity of pulmonary tissue to pathogen stimuli by comparing the response of specific-pathogen-free (SPF) and germ-free (GF) mice. Thus, we observed earlier and greater inflammation in the pulmonary compartment of GF mice than that of SPF mice after intranasal instillation to lipopolysaccharide (LPS), a component of Gram-negative bacteria. Toll-like receptor 4 (TLR4) was more abundantly expressed in the lungs of GF mice than those of SPF mice at steady state, which could predispose the innate immunity of GF mice to strongly react to the environmental stimuli. Lung explants were stimulated with different TLR agonists or infected with the human airways pathogen, respiratory syncytial virus (RSV), resulting in greater inflammation under almost all conditions for the GF explants. Finally, alveolar macrophages (AM) from GF mice presented a higher innate immune response upon RSV infection than those of SPF mice. Overall, these data suggest that the presence of microbiota in SPF mice induced a process of innate immune tolerance in the lungs by a mechanism which remains to be elucidated. Our study represents a step forward to establishing the link between the microbiota and the immune reactivity of the lungs.
    Mesh-Begriff(e) Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoalveolar Lavage Fluid/cytology ; Cytokines/genetics ; Cytokines/metabolism ; Gastrointestinal Microbiome/physiology ; Gene Expression Regulation/drug effects ; Germ-Free Life ; Inflammation/chemically induced ; Inflammation/metabolism ; Lipopolysaccharides/toxicity ; Lung/immunology ; Lung/metabolism ; Lung Diseases/chemically induced ; Male ; Mice ; Specific Pathogen-Free Organisms ; Tissue Culture Techniques ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
    Chemische Substanzen Cytokines ; Lipopolysaccharides ; TLR4 protein, human ; Toll-Like Receptor 4
    Sprache Englisch
    Erscheinungsdatum 2021-03-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202002338R
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis.

    Jacque, Emilie / Chottin, Claire / Laubreton, Daphné / Nogre, Michel / Ferret, Cécile / de Marcos, Sandrine / Baptista, Linda / Drajac, Carole / Mondon, Philippe / De Romeuf, Christophe / Rameix-Welti, Marie-Anne / Eléouët, Jean-François / Chtourou, Sami / Riffault, Sabine / Perret, Gérald / Descamps, Delphyne

    Frontiers in immunology

    2021  Band 12, Seite(n) 683902

    Abstract: Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk ... ...

    Abstract Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk infants and young children is a monoclonal antibody (Synagis
    Importance: Respiratory Syncytial Virus (RSV) is the major cause of acute lower respiratory infections in children, and is also recognized as a cause of morbidity in the elderly. There are still no vaccines and no efficient antiviral therapy against this virus. Here, we described an approach of passive immunization with a new class of hyper-enriched anti-RSV immunoglobulins (Ig) manufactured from human normal plasma. This new class of immunoglobulin plasma derived product is generated by an innovative bioprocess, called Ig cracking, which requires a combination of expertise in both plasma derived products and affinity chromatography. The strong efficacy in a small volume of these hyper-enriched anti-RSV IgG to inhibit the viral infection was demonstrated using a mouse model. This new class of immunoglobulin plasma-derived products could be applied to other pathogens to address specific therapeutic needs in the field of infectious diseases or even pandemics, such as COVID-19.
    Mesh-Begriff(e) Administration, Intranasal ; Animals ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/immunology ; Antibodies, Viral/isolation & purification ; Disease Models, Animal ; Humans ; Immunization, Passive ; Immunoglobulin G/administration & dosage ; Immunoglobulin G/immunology ; Immunoglobulin G/isolation & purification ; Lung/drug effects ; Lung/virology ; Neutralization Tests ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus, Human/immunology ; Turbinates/drug effects ; Turbinates/virology ; Viral Fusion Proteins/immunology ; Virus Replication/drug effects
    Chemische Substanzen Antibodies, Viral ; F protein, human respiratory syncytial virus ; Immunoglobulin G ; Viral Fusion Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-06-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.683902
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection.

    Descamps, Delphyne / Peres de Oliveira, Andressa / Gonnin, Lorène / Madrières, Sarah / Fix, Jenna / Drajac, Carole / Marquant, Quentin / Bouguyon, Edwige / Pietralunga, Vincent / Iha, Hidekatsu / Morais Ventura, Armando / Tangy, Frédéric / Vidalain, Pierre-Olivier / Eléouët, Jean-François / Galloux, Marie

    Journal of virology

    2021  Band 95, Heft 22, Seite(n) e0091221

    Abstract: Respiratory syncytial virus (RSV) is the main cause of acute respiratory infections in young children and also has a major impact on the elderly and immunocompromised people. In the absence of a vaccine or efficient treatment, a better understanding of ... ...

    Abstract Respiratory syncytial virus (RSV) is the main cause of acute respiratory infections in young children and also has a major impact on the elderly and immunocompromised people. In the absence of a vaccine or efficient treatment, a better understanding of RSV interactions with the host antiviral response during infection is needed. Previous studies revealed that cytoplasmic inclusion bodies (IBs), where viral replication and transcription occur, could play a major role in the control of innate immunity during infection by recruiting cellular proteins involved in the host antiviral response. We recently showed that the morphogenesis of IBs relies on a liquid-liquid-phase separation mechanism depending on the interaction between viral nucleoprotein (N) and phosphoprotein (P). These scaffold proteins are expected to play a central role in the recruitment of cellular proteins to IBs. Here, we performed a yeast two-hybrid screen using RSV N protein as bait and identified the cellular protein TAX1BP1 as a potential partner of this viral protein. This interaction was validated by pulldown and immunoprecipitation assays. We showed that TAX1BP1 suppression has only a limited impact on RSV infection in cell cultures. However, RSV replication is decreased in TAX1BP1-deficient (TAX1BP1 knockout [TAX1BP1
    Mesh-Begriff(e) Animals ; Cell Line ; Cricetinae ; Humans ; Immunity, Innate ; Intracellular Signaling Peptides and Proteins/immunology ; Mice ; Mice, Knockout ; Neoplasm Proteins/immunology ; Nucleocapsid Proteins/immunology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus, Human/immunology ; Virus Replication
    Chemische Substanzen Intracellular Signaling Peptides and Proteins ; Neoplasm Proteins ; Nucleocapsid Proteins ; TAX1BP1 protein, human ; TAX1BP1 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2021-08-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00912-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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