Article ; Online: Cystatin F (
2023 Volume 12
Abstract: Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's ... ...
| Abstract | Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's disease (AD) models and human AD brain, and that the emergence of this state is emphasised in females. |
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| MeSH term(s) | Animals ; Female ; Humans ; Male ; Mice ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Cystatins/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Microglia/metabolism ; Neurodegenerative Diseases/pathology |
| Chemical Substances | Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Cystatins ; cystatin F, mouse |
| Language | English |
| Publishing date | 2023-12-12 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2687154-3 |
| ISSN | 2050-084X ; 2050-084X |
| ISSN (online) | 2050-084X |
| ISSN | 2050-084X |
| DOI | 10.7554/eLife.85279 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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