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  1. Book: Current research on naturally transmitted Plasmodium knowlesi

    Drakeley, Chris

    (Advances in parasitology ; volume 113)

    2021  

    Author's details edited by Chris Drakeley
    Series title Advances in parasitology ; volume 113
    Collection
    Language English
    Size xvi, 286 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT021113608
    ISBN 978-0-323-90727-9 ; 0-323-90727-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 158 -113- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Plasmodium knowlesi, an infectious disease challenge for our times.

    Drakeley, Chris

    Advances in parasitology

    2021  Volume 113, Page(s) xiii–xvi

    MeSH term(s) Communicable Diseases ; Humans ; Malaria ; Plasmodium knowlesi
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Editorial
    ZDB-ID 165-x
    ISSN 2163-6079 ; 0065-308X
    ISSN (online) 2163-6079
    ISSN 0065-308X
    DOI 10.1016/S0065-308X(21)00044-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 158: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 453: Show issues

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  3. Article ; Online: Primaquine and

    Greenwood, Brian / Drakeley, Chris

    The New England journal of medicine

    2022  Volume 386, Issue 13, Page(s) 1282–1283

    MeSH term(s) Antimalarials/therapeutic use ; Brazil/epidemiology ; Humans ; Malaria, Vivax/drug therapy ; Malaria, Vivax/epidemiology ; Malaria, Vivax/prevention & control ; Primaquine/therapeutic use ; Reinfection/prevention & control
    Chemical Substances Antimalarials ; Primaquine (MVR3634GX1)
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2201725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023.

    Garcia, Klauss Kleydmann Sabino / Soremekun, Seyi / Abrahão, Amanda Amaral / Marchesini, Paola Barbosa / Drakeley, Chris / Ramalho, Walter Massa / Siqueira, André M

    PLOS global public health

    2024  Volume 4, Issue 1, Page(s) e0002845

    Abstract: In Brazil, 99% of malaria cases occur in the Amazon region, mainly caused by Plasmodium vivax (~83%) and Plasmodium falciparum (Pf) species. Aligned with the Sustainable Development Goals, Brazil aims to eliminate autochthonous malaria by 2035. This ... ...

    Abstract In Brazil, 99% of malaria cases occur in the Amazon region, mainly caused by Plasmodium vivax (~83%) and Plasmodium falciparum (Pf) species. Aligned with the Sustainable Development Goals, Brazil aims to eliminate autochthonous malaria by 2035. This study aims to analyse epidemiological patterns of malaria in Brazil to discuss if Brazil is on track to meet malaria control targets. A time-series study was conducted analysing autochthonous malaria new infections notifications in the Brazilian Amazon region from 2011 until June 2023. Descriptive analyses were conducted, along with joinpoint regression and forecast models to verify trend and future behaviour. A total of 2,067,030 malaria cases were reported in the period. Trend analysis indicated a decreasing trend in all malaria infections since late 2017 (monthly reduction = 0.81%, p-value <0.05), while Pf infections have increased progressively since 2015 (monthly increase = 0.46%, p-value <0.05). Forecast models predict over 124,000 malaria cases in 2023 and over 96,000 cases in 2024. Predictions for Pf infections are around 23,900 cases in 2023 and 22,300 in 2024. Cases in indigenous population villages are predicted to reach 48,000 cases in 2023 and over 51,000 in 2024. In gold mining areas it is expected over 21,000 cases in 2023 and over 20.000 in 2024. Malaria elimination in Brazil has advanced over the last decade, but its speed has slowed. The country exhibits noteworthy advancements in the reduction of overall malaria cases. It is imperative, however, to proactively target specific issues such as the incidence raise among indigenous populations and in gold mining areas. Pf infections remain a persistent challenge to control in the country and may require novel measures for containment. Current government supporting actions towards combating illegal goldmining activities and protecting indigenous populations may help malaria control indicators for the following years.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Zoonotic malaria requires new policy approaches to malaria elimination.

    Fornace, Kimberly M / Drakeley, Chris J / Lindblade, Kim A / Jelip, Jenarun / Ahmed, Kamruddin

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5750

    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41546-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Achieving global malaria eradication in changing landscapes.

    Fornace, Kimberly M / Diaz, Adriana V / Lines, Jo / Drakeley, Chris J

    Malaria journal

    2021  Volume 20, Issue 1, Page(s) 69

    Abstract: Land use and land cover changes, such as deforestation, agricultural expansion and urbanization, are one of the largest anthropogenic environmental changes globally. Recent initiatives to evaluate the feasibility of malaria eradication have highlighted ... ...

    Abstract Land use and land cover changes, such as deforestation, agricultural expansion and urbanization, are one of the largest anthropogenic environmental changes globally. Recent initiatives to evaluate the feasibility of malaria eradication have highlighted impacts of landscape changes on malaria transmission and the potential of these changes to undermine malaria control and elimination efforts. Multisectoral approaches are needed to detect and minimize negative impacts of land use and land cover changes on malaria transmission while supporting development aiding malaria control, elimination and ultimately eradication. Pathways through which land use and land cover changes disrupt social and ecological systems to increase or decrease malaria risks are outlined, identifying priorities and opportunities for a global malaria eradication campaign. The impacts of land use and land cover changes on malaria transmission are complex and highly context-specific, with effects changing over time and space. Landscape changes are only one element of a complex development process with wider economic and social dimensions affecting human health and wellbeing. While deforestation and other landscape changes threaten to undermine malaria control efforts and have driven the emergence of zoonotic malaria, most of the malaria elimination successes have been underpinned by agricultural development and land management. Malaria eradication is not feasible without addressing these changing risks while, conversely, consideration of malaria impacts in land management decisions has the potential to significantly accelerate progress towards eradication. Multisectoral cooperation and approaches to linking malaria control and environmental science, such as conducting locally relevant ecological monitoring, integrating landscape data into malaria surveillance systems and designing environmental management strategies to reduce malaria burdens, are essential to achieve malaria eradication.
    MeSH term(s) Disease Eradication/standards ; Disease Eradication/statistics & numerical data ; Ecosystem ; Global Health ; Humans ; Malaria/prevention & control
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/s12936-021-03599-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Developing sero-diagnostic tests to facilitate Plasmodium vivax Serological Test-and-Treat approaches: modeling the balance between public health impact and overtreatment.

    Obadia, Thomas / Nekkab, Narimane / Robinson, Leanne J / Drakeley, Chris / Mueller, Ivo / White, Michael T

    BMC medicine

    2022  Volume 20, Issue 1, Page(s) 98

    Abstract: Background: Eliminating Plasmodium vivax will require targeting the hidden liver-stage reservoir of hypnozoites. This necessitates new interventions balancing the benefit of reducing vivax transmission against the risk of over-treating some individuals ... ...

    Abstract Background: Eliminating Plasmodium vivax will require targeting the hidden liver-stage reservoir of hypnozoites. This necessitates new interventions balancing the benefit of reducing vivax transmission against the risk of over-treating some individuals with drugs which may induce haemolysis. By measuring antibodies to a panel of vivax antigens, a strategy of serological-testing-and-treatment (PvSeroTAT) can identify individuals with recent blood-stage infections who are likely to carry hypnozoites and target them for radical cure. This provides a potential solution to selectively treat the vivax reservoir with 8-aminoquinolines.
    Methods: PvSeroTAT can identify likely hypnozoite carriers with ~80% sensitivity and specificity. Diagnostic test sensitivities and specificities ranging 50-100% were incorporated into a mathematical model of vivax transmission to explore how they affect the risks and benefits of different PvSeroTAT strategies involving hypnozoiticidal regimens. Risk was measured as the rate of overtreatment and benefit as reduction of community-level vivax transmission.
    Results: Across a wide range of combinations of diagnostic sensitivity and specificity, PvSeroTAT was substantially more effective than bloodstage mass screen and treat strategies and only marginally less effective than mass drug administration. The key test characteristic determining of the benefit of PvSeroTAT strategies is diagnostic sensitivity, with higher values leading to more hypnozoite carriers effectively treated and greater reductions in vivax transmission. The key determinant of risk is diagnostic specificity: higher specificity ensures that a lower proportion of uninfected individuals are unnecessarily treated with primaquine. These relationships are maintained in both moderate and low transmission settings (qPCR prevalence 10% and 2%). Increased treatment efficacy and adherence can partially compensate for lower test performance. Multiple rounds of PvSeroTAT with a lower performing test may lead to similar or higher reductions in vivax transmission than fewer rounds with a higher performing test, albeit with higher rate of overtreatment.
    Conclusions: At current performance, PvSeroTAT is predicted to be a safe and efficacious option for targeting the hypnozoite reservoir towards vivax elimination. P. vivax sero-diagnostic tests should aim for both high performance and ease of use in the field. The target product profiles informing such development should thus reflect the trade-offs between impact, overtreatment, and ease of programmatic implementation.
    MeSH term(s) Diagnostic Tests, Routine ; Humans ; Overtreatment ; Plasmodium vivax ; Public Health ; Serologic Tests
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-022-02285-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Is there evidence of sustained human-mosquito-human transmission of the zoonotic malaria Plasmodium knowlesi? A systematic literature review.

    Ruiz Cuenca, Pablo / Key, Stephanie / Lindblade, Kim A / Vythilingam, Indra / Drakeley, Chris / Fornace, Kimberly

    Malaria journal

    2022  Volume 21, Issue 1, Page(s) 89

    Abstract: Background: The zoonotic malaria parasite Plasmodium knowlesi has emerged across Southeast Asia and is now the main cause of malaria in humans in Malaysia. A critical priority for P. knowlesi surveillance and control is understanding whether ... ...

    Abstract Background: The zoonotic malaria parasite Plasmodium knowlesi has emerged across Southeast Asia and is now the main cause of malaria in humans in Malaysia. A critical priority for P. knowlesi surveillance and control is understanding whether transmission is entirely zoonotic or is also occurring through human-mosquito-human transmission.
    Methods: A systematic literature review was performed to evaluate existing evidence which refutes or supports the occurrence of sustained human-mosquito-human transmission of P. knowlesi. Possible evidence categories and study types which would support or refute non-zoonotic transmission were identified and ranked. A literature search was conducted on Medline, EMBASE and Web of Science using a broad search strategy to identify any possible published literature. Results were synthesized using the Synthesis Without Meta-analysis (SWiM) framework, using vote counting to combine the evidence within specific categories.
    Results: Of an initial 7,299 studies screened, 131 studies were included within this review: 87 studies of P. knowlesi prevalence in humans, 14 studies in non-human primates, 13 studies in mosquitoes, and 29 studies with direct evidence refuting or supporting non-zoonotic transmission. Overall, the evidence showed that human-mosquito-human transmission is biologically possible, but there is limited evidence of widespread occurrence in endemic areas. Specific areas of research were identified that require further attention, notably quantitative analyses of potential transmission dynamics, epidemiological and entomological surveys, and ecological studies into the sylvatic cycle of the disease.
    Conclusion: There are key questions about P. knowlesi that remain within the areas of research that require more attention. These questions have significant implications for malaria elimination and eradication programs. This paper considers limited but varied research and provides a methodological framework for assessing the likelihood of different transmission patterns for emerging zoonotic diseases.
    MeSH term(s) Animals ; Asia, Southeastern/epidemiology ; Culicidae ; Humans ; Malaria/epidemiology ; Plasmodium knowlesi ; Zoonoses/epidemiology
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04110-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quantifying Reductions in

    Ramjith, Jordache / Alkema, Manon / Bradley, John / Dicko, Alassane / Drakeley, Chris / Stone, Will / Bousema, Teun

    Frontiers in immunology

    2022  Volume 13, Page(s) 899615

    Abstract: Malaria transmission depends on the presence of ... ...

    Abstract Malaria transmission depends on the presence of mature
    MeSH term(s) Animals ; Anopheles ; Humans ; Malaria/prevention & control ; Malaria, Falciparum/prevention & control ; Plasmodium falciparum ; Sample Size
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.899615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Record Linkage for Malaria Deaths Data Recovery and Surveillance in Brazil.

    Garcia, Klauss Kleydmann Sabino / Xavier, Danielly Batista / Soremekun, Seyi / Abrahão, Amanda Amaral / Drakeley, Chris / Ramalho, Walter Massa / Siqueira, André M

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 12

    Abstract: Objective: The objective is to describe the results and the methodological processes of record linkage for matching deaths and malaria cases.: Methods: A descriptive cross-sectional study was conducted with probabilistic record linkage of death and ... ...

    Abstract Objective: The objective is to describe the results and the methodological processes of record linkage for matching deaths and malaria cases.
    Methods: A descriptive cross-sectional study was conducted with probabilistic record linkage of death and malaria cases data in Brazil from 2011 to 2020 using death records from the Mortality Information System (SIM) and epidemiological data from the Notifiable Diseases Information System (Sinan) and Epidemiological Surveillance Information Systems for malaria (Sivep-Malaria). Three matching keys were used: patient's name, date of birth, and mother's name, with an analysis of cosine and Levenshtein dissimilarity measures.
    Results: A total of 490 malaria deaths were recorded in Brazil between 2011 and 2020. The record linkage resulted in the pairing of 216 deaths (44.0%). Pairings where all three matching keys were identical accounted for 30.1% of the total matched deaths, 39.4% of the matched deaths had two identical variables, and 30.5% had only one of the three key variables identical. The distribution of the variables of the matched deaths (216) was similar to the distribution of all recorded deaths (490). Out of the 216 matched deaths, 80 (37.0%) had poorly specified causes of death in the SIM.
    Conclusions: The record linkage allowed for the detailing of the data with additional information from other epidemiological systems. Record linkage enables data linkage between information systems that lack interoperability and is an extremely useful tool for refining health situation analyses and improving malaria death surveillance in Brazil.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8120519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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