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  1. Article ; Online: Respiratory pathogens among ill pilgrims and the potential benefit of using point-of-care rapid molecular diagnostic tools during the Hajj.

    Hoang, Van-Thuan / Dao, Thi-Loi / Ly, Tran Duc Anh / Drali, Tassadit / Yezli, Saber / Parola, Philippe / Pommier de Santi, Vincent / Gautret, Philippe

    Acta microbiologica et immunologica Hungarica

    2022  Volume 69, Issue 4, Page(s) 283–289

    Abstract: We investigated respiratory pathogens among ill Hajj pilgrims from Marseille. We also discuss the potential role of point-of-care (POC) rapid molecular diagnostic tools for this purpose. Clinical data were collected using a standardised questionnaire. ... ...

    Abstract We investigated respiratory pathogens among ill Hajj pilgrims from Marseille. We also discuss the potential role of point-of-care (POC) rapid molecular diagnostic tools for this purpose. Clinical data were collected using a standardised questionnaire. Influenza A and B viruses, human rhinovirus and human coronaviruses, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae were investigated using real-time PCR in respiratory samples obtained during travel, at the onset of symptoms. 207 participants were included. A cough, expectoration, rhinitis and a sore throat were the most frequent respiratory symptoms, followed by loss of voice and dyspnoea. 38.7% and 25.1% of pilgrims reported a fever and influenza-like symptoms, respectively. 59.4% pilgrims received antibiotics. Rhinovirus (40.6%) was the most frequent pathogen, followed by S. aureus (35.8%) and H. influenzae (30.4%). Virus and bacteria co-infections were identified in 28.5% of participants. 25.1% pilgrims who were positive for respiratory bacteria did not receive antibiotic treatment. In the context of the Hajj pilgrimage, it is important to detect infections that can be easily managed with appropriate treatment, and those that can affect prognosis, requiring hospitalisation. POC rapid molecular diagnostic tools could be used for patient management at small Hajj medical missions and to rationalise antibiotic consumption among Hajj pilgrims.
    MeSH term(s) Humans ; Pathology, Molecular ; Point-of-Care Systems ; Staphylococcus aureus/genetics ; Influenza, Human
    Language English
    Publishing date 2022-11-11
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/030.2022.01895
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  2. Article ; Online: Corrigendum to "Risk factors for symptoms of infection and microbial carriage among French medical students abroad" [International Journal of Infectious Diseases, Vol 100 (2020) Pages 104-111].

    Dao, Thi Loi / Canard, Naomie / Hoang, Van Thuan / Ly, Tran Duc Anh / Drali, Tassadit / Ninove, Laetitia / Fenollar, Florence / Raoult, Didier / Parola, Philippe / Marty, Pierre / Gautret, Philippe

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 134, Page(s) 153

    Language English
    Publishing date 2023-06-24
    Publishing country Canada
    Document type Published Erratum
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.06.012
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  3. Article ; Online: Corrigendum to "Infectious disease symptoms and microbial carriage among French medical students travelling abroad: A prospective study" [Travel Med Infect Dis 34 (2020 Mar-Apr) 101548].

    Dao, Thi Loi / Hoang, Van Thuan / Ly, Tran Duc Anh / Magmoun, Amal / Canard, Naomie / Drali, Tassadit / Fenollar, Florence / Ninove, Laetitia / Raoult, Didier / Parola, Philippe / Courjon, Johan / Gautret, Philippe

    Travel medicine and infectious disease

    2023  Volume 54, Page(s) 102609

    Language English
    Publishing date 2023-08-08
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum to "Acquisition of multidrug-resistant bacteria and colistin resistance genes in French medical students on internships abroad" [Travel Med Infect Dis. 39 (2021 Jan-Feb) 101940].

    Dao, Thi Loi / Hoang, Van Thuan / Magmoun, Amal / Ly, Tran Duc Anh / Baron, Sophie Alexandra / Hadjadj, Linda / Canard, Naomie / Drali, Tassadit / Gouriet, Frédérique / Raoult, Didier / Parola, Philippe / Marty, Pierre / Rolain, Jean-Marc / Gautret, Philippe

    Travel medicine and infectious disease

    2023  Volume 54, Page(s) 102610

    Language English
    Publishing date 2023-08-08
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102610
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  5. Article ; Online: Risk factors for symptoms of infection and microbial carriage among French medical students abroad.

    Dao, Thi Loi / Canard, Naomie / Hoang, Van Thuan / Ly, Tran Duc Anh / Drali, Tassadit / Ninove, Laetitia / Fenollar, Florence / Raoult, Didier / Parola, Philippe / Marty, Pierre / Gautret, Philippe

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 100, Page(s) 104–111

    Abstract: Objectives: To investigate symptoms of infections and their risk factors among French medical students undertaking an internship abroad.: Methods: Clinical follow up, and qPCR-based respiratory, gastrointestinal, and vaginal pathogen carriages were ... ...

    Abstract Objectives: To investigate symptoms of infections and their risk factors among French medical students undertaking an internship abroad.
    Methods: Clinical follow up, and qPCR-based respiratory, gastrointestinal, and vaginal pathogen carriages were prospectively assessed pre-travel and post-travel, in a cohort of medical students departing from Marseille, France.
    Results: 293 students were included. 63.5%, 35.8%, and 3.6% of students reported gastrointestinal, respiratory, and vaginal symptoms, respectively. The acquisition rate of Enteroaggregative Escherichia coli and Enteropathogenic E. coli was 40.9% and 18.6%, respectively. A significant increase was observed for rhinovirus and Streptococcus pneumoniae by comparing the prevalence of pathogens in pre-travel and post-travel samples. Gardnerella vaginalis and Atopobium vaginae acquisition rates were 12.9% and 13.9%, respectively. Being female, primarily traveling to Vietnam, and living in basic accommodation conditions were independent risk factors for reporting respiratory symptoms. Students reporting respiratory symptoms were three times more likely to acquire S. pneumoniae. Traveling primarily to north India and Senegal were independent risk factors for diarrhea.
    Conclusion: This study makes it possible to identify the leading infectious diseases linked to travel in a group of French medical students undertaking an internship abroad and the risk factors on which to base targeting students for reinforced pre-travel advice.
    MeSH term(s) Actinobacteria ; Adult ; Carrier State/epidemiology ; Diarrhea/epidemiology ; Diarrhea/microbiology ; Escherichia coli ; Female ; France/epidemiology ; Humans ; India ; Infections/epidemiology ; Male ; Risk Factors ; Senegal ; Students, Medical ; Travel ; Vietnam ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.08.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acquisition of multidrug-resistant bacteria and colistin resistance genes in French medical students on internships abroad.

    Dao, Thi Loi / Hoang, Van Thuan / Magmoun, Amal / Ly, Tran Duc Anh / Baron, Sophie Alexandra / Hadjadj, Linda / Canard, Naomie / Drali, Tassadit / Gouriet, Frédérique / Raoult, Didier / Parola, Philippe / Marty, Pierre / Rolain, Jean-Marc / Gautret, Philippe

    Travel medicine and infectious disease

    2020  Volume 39, Page(s) 101940

    Abstract: Background: Acquisition of multidrug resistant bacteria (MDR) and colistin resistance genes by international travellers has been demonstrated. Studies conducted in medical students during internships abroad are scant.: Methods: Nasopharyngeal, rectal, ...

    Abstract Background: Acquisition of multidrug resistant bacteria (MDR) and colistin resistance genes by international travellers has been demonstrated. Studies conducted in medical students during internships abroad are scant.
    Methods: Nasopharyngeal, rectal, and vaginal swabs samples were collected from 382 French medical students before and after travel to investigate the acquisition of MDR bacteria. The bacterial diversity in the samples was assessed by culture on selective media. We also genetically characterised the isolates of MDR bacteria including Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA), and Carbapenemase-producing Enterobacteriacae (CPE) using the real-time polymerase chain reaction method. The samples were collected from 293 students and were investigated for mcr colistin-resistance genes using RT-PCR directly on the samples, followed by conventional PCR and sequencing.
    Results: A proportion of 29.3% (112/382) of the participants had acquired ESBL-E and 2.6% (10/382) had acquired CPE. The most common species and ESBL-E encoding gene were Escherichia coli (125/127 isolates, 98.4%) and bla
    Conclusion: Medical students are at a potential risk of acquiring ESBL-E, CPE and colistin resistance genes. A number of risk factors have been identified, which may be used to develop targeted preventive measures.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Child ; Colistin/pharmacology ; Drug Resistance, Bacterial/genetics ; Escherichia coli Proteins ; Female ; France ; Humans ; Internship and Residency ; Methicillin-Resistant Staphylococcus aureus ; Students, Medical ; Travel ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Escherichia coli Proteins ; beta-Lactamases (EC 3.5.2.6) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2020-11-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101940
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  7. Article ; Online: French Hajj pilgrims' experience with pneumococcal infection and vaccination: A knowledge, attitudes and practice (KAP) evaluation.

    Sridhar, Shruti / Belhouchat, Khadidja / Drali, Tassadit / Benkouiten, Samir / Parola, Philippe / Brouqui, Philippe / Gautret, Philippe

    Travel medicine and infectious disease

    2015  Volume 13, Issue 3, Page(s) 251–255

    Abstract: Background: Transmission of respiratory infections poses a major public health challenge during the Hajj and Umrah in the Kingdom of Saudi Arabia. Acquisition of Streptococcus pneumoniae during Hajj has been studied in the past and recommendations for ... ...

    Abstract Background: Transmission of respiratory infections poses a major public health challenge during the Hajj and Umrah in the Kingdom of Saudi Arabia. Acquisition of Streptococcus pneumoniae during Hajj has been studied in the past and recommendations for vaccination against S. pneumoniae have been made for high risk groups.
    Methods: The purpose of this study was to assess the knowledge and attitudes of French Hajj pilgrims towards pneumococcal vaccination. Adult pilgrims departing from Marseille, France to Mecca for the 2014 Hajj season were administered a face-to-face questionnaire to ascertain their knowledge and attitudes towards pneumococcal vaccination before departing for Hajj.
    Results: A total of 300 participants took part. Their overall knowledge about the severity of pneumonia and the existence of the vaccine was very low. Out of 101 participants who had an indication for pneumococcal vaccination, irrespective of their travel status, only 7% were advised to have the vaccine by their general practitioner.
    Conclusions: These results reinforce the need for better dissemination of information either before or during the pre-travel counselling. The visit to the travel clinic for receiving the mandatory meningococcal vaccination for Hajj is a good opportunity to update routine immunizations, including pneumococcal vaccination.
    MeSH term(s) Adult ; Female ; France ; Health Knowledge, Attitudes, Practice/ethnology ; Humans ; Islam ; Male ; Meningococcal Vaccines/administration & dosage ; Middle Aged ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Saudi Arabia/epidemiology ; Surveys and Questionnaires ; Travel ; Vaccination
    Chemical Substances Meningococcal Vaccines ; Pneumococcal Vaccines
    Keywords covid19
    Language English
    Publishing date 2015-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2015.02.002
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  8. Article ; Online: Infectious disease symptoms and microbial carriage among French medical students travelling abroad: A prospective study.

    Dao, Thi Loi / Hoang, Van Thuan / Ly, Tran Duc Anh / Magmoun, Amal / Canard, Naomie / Drali, Tassadit / Fenollar, Florence / Ninove, Laetitia / Raoult, Didier / Parola, Philippe / Courjon, Johan / Gautret, Philippe

    Travel medicine and infectious disease

    2019  Volume 34, Page(s) 101548

    Abstract: Background: In France, no previous studies have focused specifically on health problems among medical students during internships abroad including the clinical symptoms suggestive of infectious diseases and the acquisition of pathogen carriage.: ... ...

    Abstract Background: In France, no previous studies have focused specifically on health problems among medical students during internships abroad including the clinical symptoms suggestive of infectious diseases and the acquisition of pathogen carriage.
    Methods: Clinical follow up and qPCR based respiratory, gastrointestinal and vaginal pathogen carriage before and after travel were prospectively assessed in a cohort of medical students departing from Marseille, France.
    Results: 134 students were included. 73.9%, 38.8% and 5.0% of students reported gastrointestinal, respiratory and vaginal symptoms, respectively. The acquisition rate of Enteroaggregative Escherichia coli (EAEC) and Enteropathogenic E. coli (EPEC) was 53% and 41%, respectively. The acquisition of respiratory viruses was low but associated with persisting symptoms, while bacterial acquisition ranged from 3.3% for Streptococcus pyogenes to 15.0% for Haemophilus influenzae. Gardnerella vaginalis and Atopobium vaginae acquisition rates were 7.7% and 14.3% respectively. Five students (5.1%) had molecular quantification criteria for bacterial vaginosis on return.
    Conclusion: This preliminary study demonstrates that besides the known risk of gastrointestinal and respiratory infections and associated changes in intestinal and respiratory microbiota, medical students abroad may also experience changes in vaginal microbiota leading, in some cases, to clinical symptoms or the acquisition of bacterial vaginosis, which may be asymptomatic.
    MeSH term(s) Asia ; Carrier State/microbiology ; Female ; France/epidemiology ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/microbiology ; Humans ; Male ; Prospective Studies ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; South America ; Students, Medical ; Travel ; Vaginal Diseases/epidemiology ; Vaginal Diseases/microbiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2019-12-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.101548
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  9. Article ; Online: Lack of Vibrio cholerae among French pilgrims during the 2017 and 2018 Hajj.

    Hoang, Van-Thuan / Dao, Thi-Loi / Ly, Tran Duc Anh / Belhouchat, Khadidja / Chaht, Kamel Larbi / Drali, Tassadit / Yezli, Saber / Alotaibi, Badriah / Raoult, Didier / Parola, Philippe / Fournier, Pierre-Edouard / Pommier de Santi, Vincent / Gautret, Philippe

    Travel medicine and infectious disease

    2019  Volume 36, Page(s) 101506

    MeSH term(s) Humans ; Islam ; Saudi Arabia ; Travel ; Vibrio cholerae
    Language English
    Publishing date 2019-10-29
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.101506
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  10. Article ; Online: Acquisition of respiratory viruses and presence of respiratory symptoms in French pilgrims during the 2016 Hajj: A prospective cohort study.

    Hoang, Van-Thuan / Sow, Doudou / Dogue, Fabiola / Edouard, Sophie / Drali, Tassadit / Yezli, Saber / Alotaibi, Badriah / Raoult, Didier / Parola, Philippe / Pommier de Santi, Vincent / Gautret, Philippe

    Travel medicine and infectious disease

    2019  Volume 30, Page(s) 32–38

    Abstract: Background: Viral respiratory tract infections are frequent among Hajj pilgrims. However, it is still not known whether viruses are responsible for the symptoms observed in sick pilgrims or whether they only colonize sick and asymptomatic pilgrims.: ... ...

    Abstract Background: Viral respiratory tract infections are frequent among Hajj pilgrims. However, it is still not known whether viruses are responsible for the symptoms observed in sick pilgrims or whether they only colonize sick and asymptomatic pilgrims.
    Patients and methods: A prospective cohort study was conducted among French Hajj pilgrims in 2016. Medical follow-up and systematic nasal swabbing were performed pre- and post-Hajj. Additional samples were obtained per-Hajj, at symptom onset in ill pilgrims. Viruses were identified using the BioFire FilmArray
    Results: 109 pilgrims were included. 83.5% presented respiratory symptoms during Hajj and 39.5% were still symptomatic on return. 5.5% of pre-Hajj, 95.2% of per-Hajj (at symptom onset) and 46.5% of post-Hajj samples tested positive (p < 0.0001). Acquisition rates of rhinovirus/enterovirus, coronavirus 229E and influenza A virus were respectively 38.6%, 19.8% and 2.0%. Although rhinovirus/enterovirus, coronavirus 229E and influenza A clearance were respectively 70.6%, 71.4% and 100% on return, overall virus carriage proportion on return was 75.0% in pilgrims with influenza-like illness and 44.0% in those who have never experienced this symptoms or resolved it (OR = 4.05, 95% CI [1.02-16.02]).
    Conclusions: Viruses likely play some role in the pathogenesis of the respiratory tract infections at the Hajj. Point of care-rapid multiplex PCR assays are valuable diagnosis tools in this context when used at respiratory symptom onset or soon after.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; France ; Humans ; Islam ; Male ; Middle Aged ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/pathology ; Respiratory Tract Infections/virology ; Saudi Arabia/epidemiology ; Travel/statistics & numerical data ; Virus Diseases/epidemiology ; Virus Diseases/pathology ; Viruses
    Keywords covid19
    Language English
    Publishing date 2019-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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