Article ; Online: Complications of rabbit anti-thymocyte globulin induction immunosuppression in HIV-infected kidney transplant recipients.
Frontiers in nephrology
2022 Volume 2, Page(s) 1047170
Abstract: Background: Kidney transplantation in HIV-infected individuals with end-stage kidney disease is associated with improved survival compared to dialysis. Rabbit anti-thymocyte globulin (rATG) induction in HIV-infected kidney transplant recipients has been ...
| Abstract | Background: Kidney transplantation in HIV-infected individuals with end-stage kidney disease is associated with improved survival compared to dialysis. Rabbit anti-thymocyte globulin (rATG) induction in HIV-infected kidney transplant recipients has been associated with a lower risk of acute rejection, but data on the rates of Methods: We performed a single-center retrospective cohort study of adult HIV-infected individuals who underwent kidney transplantation with rATG induction between January 2006 and December 2016. The primary outcome was the development of Results: Twenty-seven HIV-infected individuals with end-stage kidney disease received deceased (n=23) or living (n=4) donor kidney transplants. The cumulative rate of malignancy at five years was 29%, of whom 29% died because of advanced malignancy. BK viremia was detected in six participants (22%), of whom one had biopsy-proven BK virus-associated nephropathy and all of whom cleared the BK viremia. Five-year acute rejection rates, patient survival and death-censored allograft survival were 17%, 85% and 80% respectively. Conclusion: rATG induction in HIV-infected kidney transplant recipients was associated with a low risk of acute rejection, but a potentially higher risk of |
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| Language | English |
| Publishing date | 2022-12-14 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ISSN | 2813-0626 |
| ISSN (online) | 2813-0626 |
| DOI | 10.3389/fneph.2022.1047170 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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