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  1. Article ; Online: Utilizing literature-based rodent toxicology data to derive potency estimates for quantitative risk assessment.

    Boots, Theresa E / Kogel, Alyssa M / Drew, Nathan M / Kuempel, Eileen D

    Nanotoxicology

    2021  Volume 15, Issue 6, Page(s) 740–760

    Abstract: Evaluating the potential occupational health risk of engineered nanomaterials is an ongoing need. The objective of this meta-analysis, which consisted of 36 studies containing 86 materials, was to assess the availability of ... ...

    Abstract Evaluating the potential occupational health risk of engineered nanomaterials is an ongoing need. The objective of this meta-analysis, which consisted of 36 studies containing 86 materials, was to assess the availability of published
    MeSH term(s) Animals ; Lung Diseases ; Nanostructures ; Nanotubes, Carbon ; Risk Assessment ; Rodentia
    Chemical Substances Nanotubes, Carbon
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2237988-5
    ISSN 1743-5404 ; 1743-5390
    ISSN (online) 1743-5404
    ISSN 1743-5390
    DOI 10.1080/17435390.2021.1918278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stability of lipids in plasma and serum: Effects of temperature-related storage conditions on the human lipidome.

    Reis, Gregory B / Rees, Jon C / Ivanova, Anna A / Kuklenyik, Zsuzsanna / Drew, Nathan M / Pirkle, James L / Barr, John R

    Journal of mass spectrometry and advances in the clinical lab

    2021  Volume 22, Page(s) 34–42

    Abstract: Large epidemiological studies often require sample transportation and storage, presenting unique considerations when applying advanced lipidomics techniques. The goal of this study was to acquire lipidomics data on plasma and serum samples stored at ... ...

    Abstract Large epidemiological studies often require sample transportation and storage, presenting unique considerations when applying advanced lipidomics techniques. The goal of this study was to acquire lipidomics data on plasma and serum samples stored at potential preanalytical conditions (e.g., thawing, extracting, evaporating), systematically monitoring lipid species for a period of one month. Split aliquots of 10 plasma samples and 10 serum samples from healthy individuals were kept in three temperature-related environments: refrigerator, laboratory benchtop, or heated incubator. Samples were analyzed at six different time points over 28 days using a Bligh & Dyer lipid extraction protocol followed by direct infusion into a lipidomics platform using differential mobility with tandem mass spectrometry. The observed concentration changes over time were evaluated relative to method and inter-individual biological variability. In addition, to evaluate the effect of lipase enzyme levels on concentration changes during storage, we compared corresponding fasting and post-prandial plasma samples collected from 5 individuals. Based on our data, a series of low abundance free fatty acid (FFA), diacylglycerol (DAG), and cholesteryl ester (CE) species were identified as potential analytical markers for degradation. These FFA and DAG species are typically produced by endogenous lipases from numerous triacylglycerols (TAGs), and certain high abundance phosphatidylcholines (PCs). The low concentration CEs, which appeared to increase several fold, were likely mass-isobars from oxidation of other high concentration CEs. Although the concentration changes of the high abundant TAG, PC, and CE precursors remained within method variability, the concentration trends of FFA, DAG, and oxidized CE products should be systematically monitored over time to inform analysts about possible pre-analytical biases due to degradation in the study sample sets.
    Language English
    Publishing date 2021-10-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-145X
    ISSN (online) 2667-145X
    DOI 10.1016/j.jmsacl.2021.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A quantitative framework to group nanoscale and microscale particles by hazard potency to derive occupational exposure limits: Proof of concept evaluation.

    Drew, Nathan M / Kuempel, Eileen D / Pei, Ying / Yang, Feng

    Regulatory toxicology and pharmacology : RTP

    2017  Volume 89, Page(s) 253–267

    Abstract: The large and rapidly growing number of engineered nanomaterials (ENMs) presents a challenge to assessing the potential occupational health risks. An initial database of 25 rodent studies including 1929 animals across various experimental designs and ... ...

    Abstract The large and rapidly growing number of engineered nanomaterials (ENMs) presents a challenge to assessing the potential occupational health risks. An initial database of 25 rodent studies including 1929 animals across various experimental designs and material types was constructed to identify materials that are similar with respect to their potency in eliciting neutrophilic pulmonary inflammation, a response relevant to workers. Doses were normalized across rodent species, strain, and sex as the estimated deposited particle mass dose per gram of lung. Doses associated with specific measures of pulmonary inflammation were estimated by modeling the continuous dose-response relationships using benchmark dose modeling. Hierarchical clustering was used to identify similar materials. The 18 nanoscale and microscale particles were classified into four potency groups, which varied by factors of approximately two to 100. Benchmark particles microscale TiO
    MeSH term(s) Animals ; Lung/drug effects ; Nanostructures/toxicity ; Occupational Exposure ; Silicon Dioxide ; Titanium/toxicity
    Chemical Substances titanium dioxide (15FIX9V2JP) ; Silicon Dioxide (7631-86-9) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2017-08-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2017.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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