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  1. Article ; Online: Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI.

    Driehuys, Bastiaan

    Academic radiology

    2016  Volume 24, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2016-11-21
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2016.11.002
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    Zs.A 4594: Show issues Location:
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  2. Article ; Online: MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?

    O'Sullivan-Murphy, Bryan / Driehuys, Bastiaan / Mammarappallil, Joseph

    Radiologic clinics of North America

    2022  Volume 60, Issue 6, Page(s) 1021–1032

    Abstract: Patients with diffuse lung diseases require thorough medical and social history and physical examinations, coupled with a multitude of laboratory tests, pulmonary function tests, and radiologic imaging to discern and manage the specific disease. This ... ...

    Abstract Patients with diffuse lung diseases require thorough medical and social history and physical examinations, coupled with a multitude of laboratory tests, pulmonary function tests, and radiologic imaging to discern and manage the specific disease. This review summarizes the current state of imaging of various diffuse lung diseases by hyperpolarized MR imaging. The potential of hyperpolarized MR imaging as a clinical tool is outlined as a novel imaging approach that enables further understanding of the cause of diffuse lung diseases, permits earlier detection of disease progression before that found with pulmonary function tests, and can delineate physiologic response to lung therapies.
    MeSH term(s) Humans ; Lung/diagnostic imaging ; Lung Diseases/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Xenon Isotopes
    Chemical Substances Xenon Isotopes
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2022.06.007
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  3. Article ; Online: Illuminating Lung Inflammation at the Alveolar Capillary Interface.

    Mummy, David / Driehuys, Bastiaan

    Journal of magnetic resonance imaging : JMRI

    2020  Volume 51, Issue 6, Page(s) 1677–1678

    MeSH term(s) Capillaries/diagnostic imaging ; Capillary Permeability ; Humans ; Inflammation ; Lung/diagnostic imaging ; Pneumonia/diagnostic imaging ; Pulmonary Alveoli/diagnostic imaging
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27086
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  4. Article: Imaging in alpha-1 antitrypsin deficiency: a window into the disease.

    Huang, Yuh-Chin Tony / Wencker, Marion / Driehuys, Bastiaan

    Therapeutic advances in chronic disease

    2021  Volume 12_suppl, Page(s) 20406223211024523

    Abstract: Imaging modalities such as plain chest radiograph and computed tomography (CT) are important tools in the assessment of patients with chronic obstructive pulmonary disease (COPD) of any etiology. These methods facilitate differential diagnoses and the ... ...

    Abstract Imaging modalities such as plain chest radiograph and computed tomography (CT) are important tools in the assessment of patients with chronic obstructive pulmonary disease (COPD) of any etiology. These methods facilitate differential diagnoses and the assessment of individual lung pathologies, such as the presence of emphysema, bullae, or fibrosis. However, as emphysema is the core pathological consequence in the lungs of patients with alpha-1 antitrypsin deficiency (AATD), and because AATD is associated with the development of other lung pathologies such as bronchiectasis, there is a greater need for patients with AATD than those with non-AATD-related COPD to undergo more detailed assessment using CT. In the field of AATD, CT provides essential information regarding the presence, distribution, and morphology of emphysema. In addition, it offers the option to quantify the extent of emphysema. These data have implications for treatment decisions such as initiation of alpha-1 antitrypsin (AAT) therapy, or suitability for surgical or endoscopic interventions for reducing lung volume. Furthermore, CT has provided vital insight regarding the natural history of emphysema progression in AATD, and CT densitometry has underpinned research into the efficacy of AAT therapy. Moving forward, hyperpolarized xenon gas (
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223211024523
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  5. Article ; Online: Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized

    Rankine, Leith J / Lu, Junlan / Wang, Ziyi / Kelsey, Christopher R / Marks, Lawrence B / Das, Shiva K / Driehuys, Bastiaan

    International journal of radiation oncology, biology, physics

    2024  

    Abstract: Purpose: Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.: Methods and materials: Ten patients receiving ... ...

    Abstract Purpose: Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.
    Methods and materials: Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized
    Results: Compared with pre-RT baseline, 3-month post-RT ventilation decreased by an average of -0.24 ± 0.05%/Gy (ρ = -0.88; P < .001), membrane uptake increased by 0.69 ± 0.14%/Gy (ρ = 0.94; P < .001), and RBC transfer decreased by -0.41 ± 0.06%/Gy (ρ = -0.92; P < .001). Membrane uptake maintained a strong positive correlation with regional dose at 8 months post-RT, demonstrating an increase of 0.73 ± 0.11%/Gy (ρ = 0.92; P = .006). Changes in membrane uptake and RBC transfer appeared greater in magnitude (%/Gy) for individuals with low heterogeneity in their baseline lung function. An increase in whole-lung membrane uptake showed moderate correlation with decreases in forced vital capacity (ρ = -0.50; P = .17) and diffusing capacity for carbon monoxide (ρ = -0.44; P = .23), with neither correlation reaching statistical significance.
    Conclusions: Hyperpolarized
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.02.049
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    Zs.A 1218: Show issues Location:
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  6. Article: Functional gas exchange measures on

    Mummy, David / Zhang, Shuo / Bechtel, Aryil / Lu, Junlan / Mammarappallil, Joseph / Leewiwatwong, Suphachart / Costelle, Anna / Swaminathan, Aparna / Driehuys, Bastiaan

    Frontiers in medicine

    2024  Volume 11, Page(s) 1342499

    Abstract: Introduction: Hyperpolarized : Materials and methods: Healthy subjects (: Results: Age, sex, and BMI were all significant covariates in the RBC:M model. Each additional 10 years of age was associated with a 0.05 decrease in RBC:M (: Discussion: ...

    Abstract Introduction: Hyperpolarized
    Materials and methods: Healthy subjects (
    Results: Age, sex, and BMI were all significant covariates in the RBC:M model. Each additional 10 years of age was associated with a 0.05 decrease in RBC:M (
    Discussion: 129
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1342499
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  7. Article ; Online: Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized

    Leewiwatwong, Suphachart / Lu, Junlan / Dummer, Isabelle / Yarnall, Kevin / Mummy, David / Wang, Ziyi / Driehuys, Bastiaan

    Magnetic resonance imaging

    2023  Volume 103, Page(s) 145–155

    Abstract: Rationale and objectives: Quantification of : Materials and methods: Training and testing data consisted of 22 and 33 3D : Results: Performance of both U-net and 3D segmentation was improved by including synthetic training data. The 3D models ... ...

    Abstract Rationale and objectives: Quantification of
    Materials and methods: Training and testing data consisted of 22 and 33 3D
    Results: Performance of both U-net and 3D segmentation was improved by including synthetic training data. The 3D models performed significantly better than U-net, and the 3D model trained with synthetic
    Conclusion: It is feasible to obtain high-quality segmentations from
    MeSH term(s) Protons ; Neural Networks, Computer ; Magnetic Resonance Imaging ; Lung/diagnostic imaging ; Thoracic Cavity ; Image Processing, Computer-Assisted/methods
    Chemical Substances Protons
    Language English
    Publishing date 2023-07-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2023.07.001
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    Zs.A 1817: Show issues Location:
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  8. Article ; Online: Bias field correction in hyperpolarized

    Lu, Junlan / Wang, Ziyi / Bier, Elianna / Leewiwatwong, Suphachart / Mummy, David / Driehuys, Bastiaan

    Magnetic resonance in medicine

    2022  Volume 88, Issue 2, Page(s) 802–816

    Abstract: Purpose: To correct for RF inhomogeneity for in vivo : Methods: RF-depolarization mapping was evaluated first in digital simulations and then in 51 subjects who had undergone radial : Results: RF-depolarization and template-based mapping methods ... ...

    Abstract Purpose: To correct for RF inhomogeneity for in vivo
    Methods: RF-depolarization mapping was evaluated first in digital simulations and then in 51 subjects who had undergone radial
    Results: RF-depolarization and template-based mapping methods yielded a pattern of RF-inhomogeneity consistent with the expected variation based on coil architecture. The resulting corrected images were visually similar, but meaningfully distinct from those generated using standard N4ITK correction. The N4ITK algorithm eliminated the physiologically expected anterior-posterior gradient (-0.04 ± 1.56%/cm, P < 0.001). These 2 newly introduced methods of RF-depolarization and template correction retained the physiologically expected anterior-posterior ventilation gradient in healthy subjects (2.77 ± 2.09%/cm and 2.01 ± 2.73%/cm, respectively).
    Conclusions: Randomized 3D
    MeSH term(s) Algorithms ; Humans ; Lung ; Magnetic Resonance Imaging/methods ; Respiration ; Xenon Isotopes
    Chemical Substances Xenon Isotopes
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29254
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  9. Article: Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives.

    El Haddad, Léa / Khan, Mainur / Soufny, Rania / Mummy, David / Driehuys, Bastiaan / Mansour, Wissam / Kishnani, Priya S / ElMallah, Mai K

    Therapeutics and clinical risk management

    2023  Volume 19, Page(s) 713–729

    Abstract: Pompe disease (PD) is a neuromuscular disorder caused by a deficiency of acid alpha-glucosidase (GAA) - a lysosomal enzyme responsible for hydrolyzing glycogen. GAA deficiency leads to accumulation of glycogen in lysosomes, causing cellular disruption. ... ...

    Abstract Pompe disease (PD) is a neuromuscular disorder caused by a deficiency of acid alpha-glucosidase (GAA) - a lysosomal enzyme responsible for hydrolyzing glycogen. GAA deficiency leads to accumulation of glycogen in lysosomes, causing cellular disruption. The severity of PD is directly related to the extent of GAA deficiency - if no or minimal GAA is produced, symptoms are severe and manifest in infancy, known as infantile onset PD (IOPD). If left untreated, infants with IOPD experience muscle hypotonia and cardio-respiratory failure leading to significant morbidity and mortality in the first year of life. In contrast, late-onset PD (LOPD) patients have more GAA activity and present later in life, but also have significant respiratory function decline. Despite FDA-approved enzyme replacement therapy, respiratory insufficiency remains a major cause of morbidity and mortality, emphasizing the importance of early detection and management of respiratory complications. These complications include impaired cough and airway clearance, respiratory muscle weakness, sleep-related breathing issues, and pulmonary infections. This review aims to provide an overview of the respiratory pathology, monitoring, and management of PD patients. In addition, we discuss the impact of novel approaches and therapies on respiratory function in PD.
    Language English
    Publishing date 2023-09-01
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S362871
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  10. Article ; Online: Establishing a hemoglobin adjustment for

    Bechtel, Aryil / Lu, Junlan / Mummy, David / Bier, Elianna / Leewiwatwong, Suphachart / Mugler, John / Kabir, Sakib / Church, Alex / Driehuys, Bastiaan

    Magnetic resonance in medicine

    2023  Volume 90, Issue 4, Page(s) 1555–1568

    Abstract: Purpose: 129: Methods: We combined the 1D model of xenon gas exchange (MOXE) with the principle of TR-flip angle equivalence to establish scaling factors that normalize the dissolved-phase signals with respect to a standard : Results: Adjusting ... ...

    Abstract Purpose: 129
    Methods: We combined the 1D model of xenon gas exchange (MOXE) with the principle of TR-flip angle equivalence to establish scaling factors that normalize the dissolved-phase signals with respect to a standard
    Results: Adjusting for Hb caused RBC/M to change by up to 20% in healthy individuals with normal Hb and had marked impacts on M/gas and RBC/gas distributions in 3D gas-exchange maps. RBC/M was higher in males than females both before and after Hb adjustment (p < 0.001). After Hb adjustment, the healthy reference value for RBC/M for a consortium-recommended acquisition of TR = 15 ms and flip = 20° was 0.589
    Conclusion: MOXE provides a useful framework for evaluating the Hb dependence of the membrane and RBC signals. This work indicates that adjusting for Hb is essential for accurately assessing
    MeSH term(s) Male ; Female ; Humans ; Adult ; Xenon Isotopes ; Magnetic Resonance Imaging/methods ; Hemoglobins ; Xenon ; Erythrocytes ; Pulmonary Gas Exchange ; Gases ; Lung
    Chemical Substances Xenon Isotopes ; Hemoglobins ; Xenon (3H3U766W84) ; Gases
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29712
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