Article: Temperature-dependent structural plasticity of hippocampal synapses.
Frontiers in cellular neuroscience
2022 Volume 16, Page(s) 1009970
Abstract: The function of the central nervous system (CNS) is strongly affected by temperature. However, the underlying processes remain poorly understood. Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic ... ...
Abstract | The function of the central nervous system (CNS) is strongly affected by temperature. However, the underlying processes remain poorly understood. Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in synaptic strengthening, and weakening, respectively. Furthermore, hypothermia remodels inhibitory postsynaptic scaffold into enlarged, sparse synapses enriched in GABAA receptors. This process does not require protein translation, and instead is regulated by actin dynamics. Induction of hypothermia |
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Language | English |
Publishing date | 2022-10-19 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2452963-1 |
ISSN | 1662-5102 |
ISSN | 1662-5102 |
DOI | 10.3389/fncel.2022.1009970 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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