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  1. Article ; Online: When the microbiome helps the brain-current evidence.

    Drljača, Jovana / Milošević, Nataša / Milanović, Maja / Abenavoli, Ludovico / Milić, Nataša

    CNS neuroscience & therapeutics

    2023  Volume 29 Suppl 1, Page(s) 43–58

    Abstract: The gut microbiota-brain axis has been recognized as a network of connections that provides communication between the gut microflora and both central and autonomic nervous system. The gut microbiota alteration has been targeted for therapy in various ... ...

    Abstract The gut microbiota-brain axis has been recognized as a network of connections that provides communication between the gut microflora and both central and autonomic nervous system. The gut microbiota alteration has been targeted for therapy in various neurodegenerative and psychiatric disbalances. Psychobiotics are probiotics that contribute beneficially to the brain function and the host mental health as a result of an interaction with the commensal gut bacteria, although their mechanism of action has not been completely revealed. In this state-of-art review, the findings about the potential therapeutic effects of the psychobiotics alone or in combination with conventional medicine in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as in some psychiatric diseases like depression, schizophrenia, and bipolar disorder, have been summarized. The evidence of the psychobiotics therapeutic outcomes obtained in preclinical and clinical trials have been given respectively for the observed neurodegenerative and psychiatric disorders.
    MeSH term(s) Humans ; Brain ; Microbiota/physiology ; Gastrointestinal Microbiome/physiology ; Neurodegenerative Diseases/therapy ; Parkinson Disease
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.14076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4537: Show issues Location:
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  2. Article ; Online: Ultrasound-assisted and subcritical water extraction techniques for maximal recovery of phenolic compounds from raw ginger herbal dust toward in vitro biological activity investigation.

    Sulejmanović, Mirjana / Milić, Nataša / Mourtzinos, Ioannis / Nastić, Nataša / Kyriakoudi, Anastasia / Drljača, Jovana / Vidović, Senka

    Food chemistry

    2023  Volume 437, Issue Pt 1, Page(s) 137774

    Abstract: This study examined the impact of two green extraction techniques in order to maximize the usage and recovery of phenolic compounds from the by-product of the filter tea industry, the so-called ginger herbal dust. The main phenolic compounds extraction ... ...

    Abstract This study examined the impact of two green extraction techniques in order to maximize the usage and recovery of phenolic compounds from the by-product of the filter tea industry, the so-called ginger herbal dust. The main phenolic compounds extraction was performed by ultrasound-assisted extraction (UAE) with the sonication amplitude ranging from 20% to 100%, and the subcritical water extraction (SWE), with the temperature ranging from 120 °C to 220 °C. All obtained extracts were characterized in terms of extraction yield, total phenolic content (TPC), and 6-ginerol, 6-shogaol, and 8-ginerol contents using RP-HPLC-DAD. Based on the results, we selected the extract obtained from raw ginger herbal dust using a sonication amplitude of 100% for further biological investigation of the cytotoxic effect on short- and long-term cell viability on liver and pancreatic cancer cells. This extract contained high TPC concentration, and 6-gingerol (44.57 mg/gDE), 8-gingerol (8.62 mg/gDE), and 6-shogaol (6.92 mg/gDE).
    MeSH term(s) Water ; Zingiber officinale ; Plant Extracts/pharmacology ; Phenols/pharmacology
    Chemical Substances shogaol (83DNB5FIRF) ; Water (059QF0KO0R) ; Plant Extracts ; Phenols
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.137774
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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Hallmarks of tumor-associated microglia response to experimental U87 human glioblastoma xenograft.

    Dugandžija, Tihomir / Drljača, Jovana / Bulajić, Dragica / Isaković, Aleksandra / Stilinović, Nebojša / Sekulić, Slobodan / Čapo, Ivan

    Tissue & cell

    2021  Volume 72, Page(s) 101557

    Abstract: Glioblastoma (GBM) is one of the deadliest primary brain neoplasm, heavily infiltrated with tumor-associated microglia/macrophages (TAM), which has received a great deal of interest. Bearing in mind that the number of peripheral macrophages by the ... ...

    Abstract Glioblastoma (GBM) is one of the deadliest primary brain neoplasm, heavily infiltrated with tumor-associated microglia/macrophages (TAM), which has received a great deal of interest. Bearing in mind that the number of peripheral macrophages by the 14
    MeSH term(s) Animals ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Glioblastoma/pathology ; Heterografts ; Humans ; Male ; Microglia/pathology ; Rats ; Rats, Wistar ; Tumor-Associated Macrophages/pathology
    Language English
    Publishing date 2021-05-23
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2021.101557
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1016: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Biocompatibility of mesoporous SBA-16/hydroxyapatite nanocomposite and dentin demineralized particles on human dental pulp stem cells.

    Bulajić, Dragica V / Drljača, Jovana / Čapo, Ivan / Savić, Slavica M / Vojisavljević, Katarina / Hodžić, Aden / Sekulić, Slobodan / Bajkin, Branislav V

    Microscopy research and technique

    2021  Volume 85, Issue 4, Page(s) 1557–1567

    Abstract: In the present work, a biomaterial (SBA-16/HA) based on the growth of hydroxyapatite (HA) particles within an organized silica structure SBA-16 (Santa Barbara Amorphous-16) was developed to evaluate its application to act as a porous microenvironment ... ...

    Abstract In the present work, a biomaterial (SBA-16/HA) based on the growth of hydroxyapatite (HA) particles within an organized silica structure SBA-16 (Santa Barbara Amorphous-16) was developed to evaluate its application to act as a porous microenvironment promoting attachment and viability of human dental pulp stem cells of healthy deciduous teeth (SHED). First, SHED were isolated and their phenotypes were evaluated by flow cytometry. The samples of SBA-16/HA were characterized by X-ray diffraction (XRD), small and wide angle X-ray scattering (SWAXS), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) equipped with energy dispersive spectra detector (EDS). Afterward, cells were cultured in the eluates of the above-mentioned biomaterial aged for 24 hr, 7. and 14 days. Bio-Oss® and dentin particles are involved for comparison and cells are cultured in the eluates of these two materials also. Thiazolyl Blue Tetrazolium bromide assay-MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay) was used for the determination of cell viability. The results obtained by all aforementioned characterization methods of SBA-16/HA, revealed a uniform spherical mesoporous structure, an intrinsic characteristic of this material. This material displayed excellent biocompatibility on SHEDs, and even proliferative potential, indicating that SBA-16/HA could potentially serve as a suitable substrate for bone regeneration. Contrary to SBA-16/HA, dentin particles showed low cytotoxicity at all time points, compared to control and Bio-Oss®groups. Our results substantiate the idea that SBA-16/HA has a beneficial effect on SHEDs, thus paving the way toward developing new material for bone replacement.
    MeSH term(s) Aged ; Dental Pulp ; Dentin/chemistry ; Durapatite/chemistry ; Humans ; Nanocomposites ; Silicon Dioxide/analysis ; Silicon Dioxide/chemistry ; Silicon Dioxide/pharmacology ; Stem Cells ; X-Ray Diffraction
    Chemical Substances SBA-16 ; Silicon Dioxide (7631-86-9) ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2021-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Diazepam diminishes temozolomide efficacy in the treatment of U87 glioblastoma cell line.

    Drljača, Jovana / Popović, Aleksandra / Bulajić, Dragica / Stilinović, Nebojša / Vidičević Novaković, Sašenka / Sekulić, Slobodan / Milenković, Ivan / Ninković, Srđan / Ljubković, Marko / Čapo, Ivan

    CNS neuroscience & therapeutics

    2022  Volume 28, Issue 9, Page(s) 1447–1457

    Abstract: Aims: Many patients with glioblastoma (GBM) suffer from comorbid neurological/psychiatric disorders and, therefore, are treated with psychopharmacological agents. Diazepam (DIA) is widely adopted to treat status epilepticus, alleviate anxiety, and ... ...

    Abstract Aims: Many patients with glioblastoma (GBM) suffer from comorbid neurological/psychiatric disorders and, therefore, are treated with psychopharmacological agents. Diazepam (DIA) is widely adopted to treat status epilepticus, alleviate anxiety, and inhibit chemotherapy-associated delayed emesis in GBM patients. Even though temozolomide (TMZ) and DIA could be found as possible combination therapy in clinical practice, there are no reports of their combined effects in GBM. Hence, it may be of interest to investigate whether DIA enhances the antitumor efficacy of TMZ in GBM cells.
    Methods: U87 human GBM was used to examine the effects of combined TMZ and DIA on cell viability, and the oxygen consumption within the cells, in order to evaluate mitochondrial bioenergetic response upon the treatment.
    Results: The cooperative index showed the presence of antagonism between TMZ and DIA, which was confirmed on long-term observation. Moreover, the level of apoptosis after the TMZ treatment was significantly decreased when administered with DIA (p < 0.001). Concomitant use of TMZ and DIA increased the basal cell respiration rate, the oxidative phosphorylation rate, and maximal capacity of mitochondrial electron transport chain, as well as the activities of complexes I and II, vs. TMZ alone (p < 0.001).
    Conclusion: Comparing our results with data reported that DIA elicits cell cycle arrest in the G0/G1 phase and favors senescence reveals that DIA diminishes TMZ efficacy in concomitant use in the treatment of GBM. However, due to its great potency to hinder GBM proliferation and metabolism, it could be considered using DIA as maintenance therapy after TMZ cycles.
    MeSH term(s) Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Apoptosis ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Diazepam/pharmacology ; Diazepam/therapeutic use ; Drug Resistance, Neoplasm ; Glioblastoma/metabolism ; Humans ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents, Alkylating ; Diazepam (Q3JTX2Q7TU) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.13889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4537: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Changes in mouse thymus after exposure to tube-restraint stress

    Drljača Jovana N. / Vejnović Ana-Marija T. / Miljković Dejan M. / Popović Milan J. / Rakić Dušica B. / Sekulić Slobodan R. / Čapo Ivan Đ. / Petković Branka B.

    Archives of Biological Sciences, Vol 72, Iss 1, Pp 5-

    2020  Volume 11

    Abstract: The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on ... ...

    Abstract The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175006]
    Keywords immobilization ; physical restraint ; thymus ; proliferation ; apoptosis ; Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher University of Belgrade, University of Novi Sad
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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