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  1. Article ; Online: An animal model of limitation of gut colonization by carbapenemase-producing Klebsiella pneumoniae using rifaximin.

    Xenofontos, Eleni / Renieris, Georgios / Kalogridi, Maria / Droggiti, Dionyssia-Eirini / Synodinou, Kalliopi / Damoraki, Georgia / Koufargyris, Panagiotis / Sabracos, Labros / Giamarellos-Bourboulis, Evangelos J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3789

    Abstract: Current knowledge suggests that infection by carbapenem-resistant enterobacteria is preceded by gut colonization. It is hypothesized that colonization is eradicated by non-absorbable antibiotics like rifaximin. We investigated the effect of rifaximin ... ...

    Abstract Current knowledge suggests that infection by carbapenem-resistant enterobacteria is preceded by gut colonization. It is hypothesized that colonization is eradicated by non-absorbable antibiotics like rifaximin. We investigated the effect of rifaximin against carbapenem-resistant Klebsiella pneumoniae (CRKP) in vitro and in a mouse model. We studied the in vitro efficacy of rifaximin against 257 CRKP clinical isolates, 188 KPC producers and 69 OXA-48 producers, by minimum inhibitory concentration and time-kill assays. We then developed a model of gut colonization by feeding 30 C57Bl6 mice with 10
    MeSH term(s) Ampicillin/pharmacology ; Ampicillin/therapeutic use ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/pharmacology ; Carbapenem-Resistant Enterobacteriaceae ; Carbapenems/pharmacology ; Disease Models, Animal ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae ; Mice ; Mice, Inbred C57BL ; Microbial Sensitivity Tests ; Rifaximin/pharmacology ; Rifaximin/therapeutic use ; beta-Lactamases/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Carbapenems ; Ampicillin (7C782967RD) ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; Rifaximin (L36O5T016N)
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07827-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of Vitamin D with Severity and Outcome of COVID-19: Clinical and Experimental Evidence.

    Renieris, Georgios / Foutadakis, Spyros / Andriopoulou, Theano / Spanou, Victoria-Marina / Droggiti, Dionyssia-Eirini / Kafousopoulos, Dionysios / Gkavogianni, Theologia / Damoraki, Georgia / Vatsellas, Giannis / Giamarellos-Bourboulis, Evangelos J

    Journal of innate immunity

    2023  Volume 16, Issue 1, Page(s) 1–11

    Abstract: Introduction: The role of vitamin in COVID-19 remains controversial. We investigated the association between endogenous vitamin D and the severity of COVID-19 as well as the mechanisms of action of vitamin D supplementation.: Methods: 25(OH)D3 in ... ...

    Abstract Introduction: The role of vitamin in COVID-19 remains controversial. We investigated the association between endogenous vitamin D and the severity of COVID-19 as well as the mechanisms of action of vitamin D supplementation.
    Methods: 25(OH)D3 in serum was associated with disease severity and outcome in 190 COVID-19 patients. In a COVID-19 animal model using intravenous injection of plasma from patients with COVID-19 acute respiratory distress syndrome into C57/BL6 mice, mice were treated with 0.25 μg human 1,25(OH)D3 or vehicle. Mice were sacrificed on day 4. Cytokines and myeloperoxidase (MPO) in tissues were measured. Changes in gene expression after vitamin D supplementation were measured.
    Results: Vitamin D deficiency and insufficiency were associated with increased severity and unfavorable outcome after 28 days. Vitamin D levels were negatively associated with biomarkers of COVID-19 severity. Vitamin D supplementation after challenge of mice with COVID-19 plasma led to reduced levels of TNFα, IL-6, IFNγ, and MPO in the lung, as well as down-regulation of pro-inflammatory pathways.
    Conclusion: Normal levels of endogenous vitamin D are associated with reduced severity and risk of unfavorable outcome in COVID-19, possibly through attenuation of tissue-specific hyperinflammation.
    MeSH term(s) Humans ; Animals ; Mice ; Vitamin D/pharmacology ; COVID-19 ; Vitamins/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/metabolism ; Biomarkers
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins ; Biomarkers
    Language English
    Publishing date 2023-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000535302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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