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  1. Article ; Online: The superior frontal sulcus in the human brain: Morphology and probability maps.

    Drudik, Kristina / Petrides, Michael

    Human brain mapping

    2024  Volume 45, Issue 5, Page(s) e26635

    Abstract: The superior frontal sulcus (SFS) is the major sulcus on the dorsolateral frontal cortex that defines the lateral limit of the superior frontal gyrus. Caudally, it originates near the superior precentral sulcus (SPRS) and, rostrally, it terminates near ... ...

    Abstract The superior frontal sulcus (SFS) is the major sulcus on the dorsolateral frontal cortex that defines the lateral limit of the superior frontal gyrus. Caudally, it originates near the superior precentral sulcus (SPRS) and, rostrally, it terminates near the frontal pole. The advent of structural neuroimaging has demonstrated significant variability in this sulcus that is not captured by the classic sulcal maps. The present investigation examined the morphological variability of the SFS in 50 individual magnetic resonance imaging (MRI) scans of the human brain that were registered to the Montreal Neurological Institute (MNI) standard stereotaxic space. Two primary morphological patterns were identified: (i) the SFS was classified as a continuous sulcus or (ii) the SFS was a complex of sulcal segments. The SFS showed a high probability of merging with neighbouring sulci on the superior and middle frontal gyri and these patterns were documented. In addition, the morphological variability and spatial extent of the SFS were quantified using volumetric and surface spatial probability maps. The results from the current investigation provide an anatomical framework for understanding the morphology of the SFS, which is critical for the interpretation of structural and functional neuroimaging data in the dorsolateral frontal region, as well as for improving the accuracy of neurosurgical interventions.
    MeSH term(s) Humans ; Brain Mapping/methods ; Brain ; Prefrontal Cortex ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/anatomy & histology ; Magnetic Resonance Imaging ; Probability
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Morphological patterns and spatial probability maps of the superior parietal sulcus in the human brain.

    Drudik, Kristina / Zlatkina, Veronika / Petrides, Michael

    Cerebral cortex (New York, N.Y. : 1991)

    2022  Volume 33, Issue 4, Page(s) 1230–1245

    Abstract: The superior parietal sulcus (SPS) is the defining sulcus within the superior parietal lobule (SPL). The morphological variability of the SPS was examined in individual magnetic resonance imaging (MRI) scans of the human brain that were registered to the ...

    Abstract The superior parietal sulcus (SPS) is the defining sulcus within the superior parietal lobule (SPL). The morphological variability of the SPS was examined in individual magnetic resonance imaging (MRI) scans of the human brain that were registered to the Montreal Neurological Institute (MNI) standard stereotaxic space. Two primary morphological patterns were consistently identified across hemispheres: (i) the SPS was identified as a single sulcus, separating the anterior from the posterior part of the SPL and (ii) the SPS was found as a complex of multiple sulcal segments. These morphological patterns were subdivided based on whether the SPS or SPS complex remained distinct or merged with surrounding parietal sulci. The morphological variability and spatial extent of the SPS were quantified using volumetric and surface spatial probabilistic mapping. The current investigation established consistent morphological patterns in a common anatomical space, the MNI stereotaxic space, to facilitate structural and functional analyses within the SPL.
    MeSH term(s) Humans ; Parietal Lobe/diagnostic imaging ; Parietal Lobe/anatomy & histology ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhac132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evidence of Hyperacusis in Adult Rats Following Non-traumatic Sound Exposure.

    Thomas, Maryse E / Guercio, Gerson D / Drudik, Kristina M / de Villers-Sidani, Étienne

    Frontiers in systems neuroscience

    2019  Volume 13, Page(s) 55

    Abstract: Manipulations that enhance neuroplasticity may inadvertently create opportunities for maladaptation. We have previously used passive exposures to non-traumatic white noise to open windows of plasticity in the adult rat auditory cortex and induce ... ...

    Abstract Manipulations that enhance neuroplasticity may inadvertently create opportunities for maladaptation. We have previously used passive exposures to non-traumatic white noise to open windows of plasticity in the adult rat auditory cortex and induce frequency-specific functional reorganizations of the tonotopic map. However, similar reorganizations in the central auditory pathway are thought to contribute to the generation of hearing disorders such as tinnitus and hyperacusis. Here, we investigate whether noise-induced reorganizations are accompanied by electrophysiological or behavioral evidence of tinnitus or hyperacusis in adult Long-Evans rats. We used a 2-week passive exposure to moderate-intensity (70 dB SPL) broadband white noise to reopen a critical period for spectral tuning such that a second 1-week exposure to 7 kHz tone pips produced an expansion of the 7 kHz frequency region in the primary auditory cortex (A1). We demonstrate for the first time that this expansion also takes place in the ventral auditory field (VAF). Sound exposure also led to spontaneous and sound-evoked hyperactivity in the anterior auditory field (AAF). Rats were assessed for behavioral evidence of tinnitus or hyperacusis using gap and tone prepulse inhibition of the acoustic startle response. We found that sound exposure did not affect gap-prepulse inhibition. However, sound exposure led to an improvement in prepulse inhibition when the prepulse was a 7 kHz tone, showing that exposed rats had enhanced sensorimotor gating for the exposure frequency. Together, our electrophysiological and behavioral results provide evidence of hyperacusis but not tinnitus in sound-exposed animals. Our findings demonstrate that periods of prolonged noise exposure may open windows of plasticity that can also be understood as windows of vulnerability, potentially increasing the likelihood for maladaptive plasticity to take place.
    Language English
    Publishing date 2019-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2019.00055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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