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  1. Article ; Online: Immune and inflammatory mechanisms in hypertension.

    Guzik, Tomasz J / Nosalski, Ryszard / Maffia, Pasquale / Drummond, Grant R

    Nature reviews. Cardiology

    2024  

    Abstract: Hypertension is a global health problem, with >1.3 billion individuals with high blood pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension, emphasizing the crucial roles of immune cells, cytokines and chemokines in ... ...

    Abstract Hypertension is a global health problem, with >1.3 billion individuals with high blood pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension, emphasizing the crucial roles of immune cells, cytokines and chemokines in disease initiation and progression. T cells, monocytes, macrophages, dendritic cells, B cells and natural killer cells are all implicated in hypertension. Neoantigens, the NLRP3 inflammasome and increased sympathetic outflow, as well as cytokines (including IL-6, IL-7, IL-15, IL-18 and IL-21) and a high-salt environment, can contribute to immune activation in hypertension. The activated immune cells migrate to target organs such as arteries (especially the perivascular fat and adventitia), kidneys, the heart and the brain, where they release effector cytokines that elevate blood pressure and cause vascular remodelling, renal damage, cardiac hypertrophy, cognitive impairment and dementia. IL-17 secreted by CD4
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00964-1
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  2. Article ; Online: How good are our models of cardiovascular disease? Introducing our themed issue on preclinical models for cardiovascular disease research.

    Sobey, Christopher G / Drummond, Grant R / George, Christopher H

    British journal of pharmacology

    2022  

    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Editorial
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15798
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  3. Article ; Online: How good are our models of cardiovascular disease?

    Sobey, Christopher G / Drummond, Grant R / George, Christopher H

    British journal of pharmacology

    2022  Volume 179, Issue 5, Page(s) 745–747

    MeSH term(s) Cardiovascular Diseases ; Humans ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Editorial
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15761
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  4. Article ; Online: Prior cancer diagnosis and mortality profile in US adults.

    Wang, Yutang / Fang, Yan / Sobey, Christopher G / Drummond, Grant R

    The American journal of the medical sciences

    2022  Volume 365, Issue 2, Page(s) 176–183

    Abstract: Background: Mortality profiles with multivariate adjustment in patients with a prior cancer diagnosis are scarce. This study aimed to investigate multivariate-adjusted mortality profile in US adults with a prior cancer diagnosis.: Methods: This ... ...

    Abstract Background: Mortality profiles with multivariate adjustment in patients with a prior cancer diagnosis are scarce. This study aimed to investigate multivariate-adjusted mortality profile in US adults with a prior cancer diagnosis.
    Methods: This cohort study included 58,109 US adults (5,016 with a prior cancer diagnosis) who attended the National Health and Nutrition Examination Survey. Mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and confidence intervals (CIs) of prior cancer diagnosis for mortality.
    Results: This cohort was followed up for 646,033 person-years with a mean follow-up of 11.1 years. Compared with those without cancer, participants with a prior cancer diagnosis had increased crude cumulative mortality rates in each leading cause. Prior cancer diagnosis was associated with a higher multivariate-adjusted risk of mortality from all causes (HR, 1.29; 95% CI, 1.22-1.35), cancer (HR, 2.32; 95% CI, 2.10-2.56), and accidents (HR, 1.90; 95% CI, 1.34-2.68). Prior cancer diagnosis-associated increase in accident mortality appeared only in males and was significant only in non-Hispanic black participants. Prior cancer diagnosis-associated increase in cancer mortality appeared high in non-Hispanic black participants.
    Conclusions: This study found that patients with a prior cancer diagnosis had higher multivariate-adjusted accident mortality risks, suggesting that oncologists may need to evaluate accident risks in cancer patients and provide preventive interventions in particular for male and non-Hispanic black patients. Increased cancer mortality risk associated with prior cancer diagnosis in non-Hispanic black participants may also need clinical attention.
    MeSH term(s) Humans ; Adult ; Male ; Cohort Studies ; Nutrition Surveys ; Neoplasms/diagnosis ; Black People ; Proportional Hazards Models ; Cardiovascular Diseases ; Risk Factors ; Mortality
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2022.10.008
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  5. Article ; Online: Estrogen: reducing the pressure by arginine vasopressin.

    Dinh, Quynh Nhu / Drummond, Grant R / Sobey, Christopher G

    Cardiovascular research

    2021  Volume 117, Issue 10, Page(s) 2143–2144

    MeSH term(s) Arginine Vasopressin ; Estrogens
    Chemical Substances Estrogens ; Arginine Vasopressin (113-79-1)
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa341
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  6. Article ; Online: Aortic Cellular Heterogeneity in Health and Disease: Novel Insights Into Aortic Diseases From Single-Cell RNA Transcriptomic Data Sets.

    Gibson Hughes, Tayla A / Dona, Malathi S I / Sobey, Christopher G / Pinto, Alexander R / Drummond, Grant R / Vinh, Antony / Jelinic, Maria

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 4, Page(s) 738–751

    Abstract: Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease. With limited pharmacological therapeutic strategies that target the ... ...

    Abstract Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease. With limited pharmacological therapeutic strategies that target the structural changes in the aorta, surgical intervention remains the only option for some patients with these diseases. Although there have been significant contributions to our understanding of the cellular architecture of the diseased aorta, particularly in the context of atherosclerosis, furthering our insight into the cellular drivers of disease is required. The major cell types of the aorta are well defined; however, the advent of single-cell RNA sequencing provides unrivaled insights into the cellular heterogeneity of each aortic cell type and the inferred biological processes associated with each cell in health and disease. This review discusses previous concepts that have now been enhanced with recent advances made by single-cell RNA sequencing with a focus on aortic cellular heterogeneity.
    MeSH term(s) Humans ; RNA ; Aorta/metabolism ; Aortic Diseases/genetics ; Gene Expression Profiling ; Atherosclerosis/genetics ; Atherosclerosis/metabolism
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.20597
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  7. Article ; Online: Optimization of mouse kidney digestion protocols for single-cell applications.

    Robertson, Jake N / Diep, Henry / Pinto, Alexander / Sobey, Christopher G / Drummond, Grant R / Vinh, Antony / Jelinic, Maria

    Physiological genomics

    2024  

    Abstract: Single-cell technologies such as flow cytometry and single-cell RNA sequencing (scRNAseq) have allowed for comprehensive characterisation of the kidney cellulome. However, there is disparity in the various protocols for preparing kidney single-cell ... ...

    Abstract Single-cell technologies such as flow cytometry and single-cell RNA sequencing (scRNAseq) have allowed for comprehensive characterisation of the kidney cellulome. However, there is disparity in the various protocols for preparing kidney single-cell suspensions. We aimed to address this limitation by characterising kidney cellular heterogeneity using three previously published single-cell preparation protocols. Single-cell suspensions were prepared from male and female C57BL/6 kidneys using the following kidney tissue dissociation protocols: (P1) a scRNAseq protocol; (P2) a multi-tissue digestion kit from
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00002.2024
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  8. Article ; Online: Using machine learning to ace cardiovascular risk tests.

    Bell, James R / Figtree, Gemma A / Drummond, Grant R

    Cardiovascular research

    2020  Volume 116, Issue 14, Page(s) 2173–2174

    MeSH term(s) Calcium ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Death ; Heart Disease Risk Factors ; Humans ; Machine Learning ; Myocardial Infarction ; Prospective Studies ; Risk Factors
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa305
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  9. Article: Adipose Tissue Compartments, Inflammation, and Cardiovascular Risk in the Context of Depression.

    Stapel, Britta / Jelinic, Maria / Drummond, Grant R / Hartung, Dagmar / Kahl, Kai G

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 831358

    Abstract: The neurobiological and behavioral underpinnings linking mental disorders, in particular, major depressive disorder (MDD), with cardiovascular disorders are a matter of debate. Recent research focuses on visceral (intra-abdominal and epicardial) adipose ... ...

    Abstract The neurobiological and behavioral underpinnings linking mental disorders, in particular, major depressive disorder (MDD), with cardiovascular disorders are a matter of debate. Recent research focuses on visceral (intra-abdominal and epicardial) adipose tissue and inflammation and their impact on the development of cardiometabolic disorders. Intra-abdominal adipose tissue is defined as an endocrine active fat compartment surrounding inner organs and is associated with type 2 diabetes mellitus, a risk factor for the later development of cardiovascular disorders. Epicardial (pericardial) adipose tissue is a fat compartment surrounding the heart with close proximity to the arteries supporting the heart. Visceral adipose tissue (VAT) is an important source of inflammatory mediators that, in concert with other risk factors, plays a leading role in cardiovascular diseases. In conjunction with the behavioral (physical inactivity, sedentary lifestyle), psychological (adherence problems), and hormonal (dysfunction of the hypothalamus-pituitary-adrenal axis with subsequent hypercortisolism) alterations frequently accompanying MDD, an enhanced risk for cardiovascular disorders results.
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.831358
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  10. Article ; Online: The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease.

    Thomas, Jordyn M / Huuskes, Brooke M / Sobey, Christopher G / Drummond, Grant R / Vinh, Antony

    Pharmacology & therapeutics

    2022  Volume 239, Page(s) 108191

    Abstract: Chronic kidney disease (CKD) is inherently an inflammatory condition, which ultimately results in the development of end stage renal disease or cardiovascular events. Low-grade inflammatory diseases such as hypertension and diabetes are leading causes of ...

    Abstract Chronic kidney disease (CKD) is inherently an inflammatory condition, which ultimately results in the development of end stage renal disease or cardiovascular events. Low-grade inflammatory diseases such as hypertension and diabetes are leading causes of CKD. Declines in renal function correlate with elevated circulating pro-inflammatory cytokines in patients with these conditions. The inflammasome is an important inflammatory signalling platform that has been associated with low-grade chronic inflammatory diseases. Notably, activation and assembly of the inflammasome causes the auto cleavage of pro-caspase-1 into its active form, which then processes the pro-inflammatory cytokines pro-interleukin (IL)-1β and pro-IL-18 into their active forms. Currently, the nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in the development of CKD in pre-clinical and clinical settings, and the ablation or inhibition of inflammasome components have been shown to be reno-protective in models of CKD. While clinical trials have demonstrated that neutralisation of IL-1β signalling by the drug anakinra lowers inflammation markers in haemodialysis patients, ongoing preclinical studies are showing that this ability to attenuate disease is limited in progressive models of kidney disease. These results suggest a potential predominant role for IL-18 in the development of CKD. This review will discuss the role of the inflammasome and its pro-inflammatory product IL-18 in the development of renal fibrosis and inflammation that contribute to the pathophysiology of CKD. Furthermore, we will examine the potential of the IL-18 signalling axis as an anti-inflammatory target in CKD and its usefulness as diagnostic biomarker to predict acute kidney injury.
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Interleukin-18/metabolism ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Hypertension ; Cytokines/metabolism ; Inflammation
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Interleukin-18 ; Cytokines
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108191
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