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  1. Article ; Online: Symptom study app provides real-world data on COVID-19 vaccines.

    Drury, Ruth E / O'Connor, Daniel

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 7, Page(s) 890–891

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Mobile Applications ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00264-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease.

    Drury, Ruth E / Camara, Susana / Chelysheva, Irina / Bibi, Sagida / Sanders, Katherine / Felle, Salle / Emary, Katherine / Phillips, Daniel / Voysey, Merryn / Ferreira, Daniela M / Klenerman, Paul / Gilbert, Sarah C / Lambe, Teresa / Pollard, Andrew J / O'Connor, Daniel

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3402

    Abstract: The immune mechanisms mediating COVID-19 vaccine attenuation of COVID-19 remain undescribed. We conducted comprehensive analyses detailing immune responses to SARS-CoV-2 virus in blood post-vaccination with ChAdOx1 nCoV-19 or a placebo. Samples from ... ...

    Abstract The immune mechanisms mediating COVID-19 vaccine attenuation of COVID-19 remain undescribed. We conducted comprehensive analyses detailing immune responses to SARS-CoV-2 virus in blood post-vaccination with ChAdOx1 nCoV-19 or a placebo. Samples from randomised placebo-controlled trials (NCT04324606 and NCT04400838) were taken at baseline, onset of COVID-19-like symptoms, and 7 days later, confirming COVID-19 using nucleic amplification test (NAAT test) via real-time PCR (RT-PCR). Serum cytokines were measured with multiplexed immunoassays. The transcriptome was analysed with long, short and small RNA sequencing. We found attenuation of RNA inflammatory signatures in ChAdOx1 nCoV-19 compared with placebo vaccinees and reduced levels of serum proteins associated with COVID-19 severity. KREMEN1, a putative alternative SARS-CoV-2 receptor, was downregulated in placebo compared with ChAdOx1 nCoV-19 vaccinees. Vaccination ameliorates reductions in cell counts across leukocyte populations and platelets noted at COVID-19 onset, without inducing potentially deleterious Th2-skewed immune responses. Multi-omics integration links a global reduction in miRNA expression at COVID-19 onset to increased pro-inflammatory responses at the mRNA level. This study reveals insights into the role of COVID-19 vaccines in mitigating disease severity by abrogating pro-inflammatory responses associated with severe COVID-19, affirming vaccine-mediated benefit in breakthrough infection, and highlighting the importance of clinically relevant endpoints in vaccine evaluation.
    MeSH term(s) Humans ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/administration & dosage ; SARS-CoV-2/immunology ; ChAdOx1 nCoV-19 ; Cytokines/blood ; Male ; Inflammation/immunology ; Female ; Middle Aged ; Adult ; Transcriptome ; Vaccination ; Multiomics ; Breakthrough Infections
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Cytokines
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47463-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Clinical Application of MicroRNAs in Infectious Disease.

    Drury, Ruth E / O'Connor, Daniel / Pollard, Andrew J

    Frontiers in immunology

    2017  Volume 8, Page(s) 1182

    Abstract: MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by ... ...

    Abstract MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by regulating proteins involved in innate and adaptive immune pathways. miRNAs can govern the cellular tropism of some viruses, are implicated in the resistance of some individuals to infections like HIV, and are associated with impaired vaccine response in older people. Not surprisingly, pathogens have evolved ways to undermine the effects of miRNAs on immunity. Recognition of this has led to new experimental treatments, RG-101 and Miravirsen-hepatitis C treatments which target host miRNA. miRNAs are being investigated as novel infection biomarkers, and they are being used to design attenuated vaccines, e.g., against Dengue virus. This comprehensive review synthesizes current knowledge of miRNA in host response to infection with emphasis on potential clinical applications, along with an evaluation of the challenges still to be overcome.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.

    O'Connor, Daniel / Pinto, Marta Valente / Sheerin, Dylan / Tomic, Adriana / Drury, Ruth E / Channon-Wells, Samuel / Galal, Ushma / Dold, Christina / Robinson, Hannah / Kerridge, Simon / Plested, Emma / Hughes, Harri / Stockdale, Lisa / Sadarangani, Manish / Snape, Matthew D / Rollier, Christine S / Levin, Michael / Pollard, Andrew J

    Molecular systems biology

    2020  Volume 16, Issue 11, Page(s) e9888

    Abstract: Neisseria meningitidis is a major cause of meningitis and septicaemia. A MenB vaccine (4CMenB) was licensed by the European Medicines Agency in January 2013. Here we describe the blood transcriptome and proteome following infant immunisations with or ... ...

    Abstract Neisseria meningitidis is a major cause of meningitis and septicaemia. A MenB vaccine (4CMenB) was licensed by the European Medicines Agency in January 2013. Here we describe the blood transcriptome and proteome following infant immunisations with or without concomitant 4CMenB, to gain insight into the molecular mechanisms underlying post-vaccination reactogenicity and immunogenicity. Infants were randomised to receive control immunisations (PCV13 and DTaP-IPV-Hib) with or without 4CMenB at 2 and 4 months of age. Blood gene expression and plasma proteins were measured prior to, then 4 h, 24 h, 3 days or 7 days post-vaccination. 4CMenB vaccination was associated with increased expression of ENTPD7 and increased concentrations of 4 plasma proteins: CRP, G-CSF, IL-1RA and IL-6. Post-vaccination fever was associated with increased expression of SELL, involved in neutrophil recruitment. A murine model dissecting the vaccine components found the concomitant regimen to be associated with increased gene perturbation compared with 4CMenB vaccine alone with enhancement of pathways such as interleukin-3, -5 and GM-CSF signalling. Finally, we present transcriptomic profiles predictive of immunological and febrile responses following 4CMenB vaccine.
    MeSH term(s) Animals ; Blood Chemical Analysis ; Diphtheria-Tetanus-Pertussis Vaccine/adverse effects ; Diphtheria-Tetanus-Pertussis Vaccine/immunology ; Female ; Fever/blood ; Fever/epidemiology ; Fever/etiology ; Fever/genetics ; Gene Expression Profiling ; Haemophilus Vaccines/adverse effects ; Haemophilus Vaccines/immunology ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity/genetics ; Incidence ; Infant ; Male ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines/adverse effects ; Meningococcal Vaccines/immunology ; Mice ; Mice, Inbred C57BL ; Microarray Analysis ; Pneumococcal Vaccines/adverse effects ; Pneumococcal Vaccines/immunology ; Poliovirus Vaccine, Inactivated/adverse effects ; Poliovirus Vaccine, Inactivated/immunology ; Proteome/analysis ; Transcriptome ; Vaccination/adverse effects ; Vaccines, Conjugate/adverse effects ; Vaccines, Conjugate/immunology
    Chemical Substances 13-valent pneumococcal vaccine ; Diphtheria-Tetanus-Pertussis Vaccine ; Haemophilus Vaccines ; Meningococcal Vaccines ; Pneumococcal Vaccines ; Poliovirus Vaccine, Inactivated ; Proteome ; Vaccines, Conjugate ; diphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis -Haemophilus influenzae type b conjugate vaccine
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.20209888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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