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  1. Article ; Online: Radio frequency measurement and tuning of a 13 MeV Alvarez-type drift tube linac for a compact pulsed hadron source.

    Lei, Y / Xing, Q Z / Wang, B C / Zheng, S X / Tang, R / Ma, P F / Zhang, H Y / Guan, X L / Wang, X W / Du, C T / Guo, Q K / Li, J / Guan, W Q

    The Review of scientific instruments

    2019  Volume 90, Issue 1, Page(s) 13302

    Abstract: This paper describes the radio frequency (RF) measurement and tuning result of a 13 MeV Alvarez-type drift tube linac (DTL) for a compact pulsed hadron source (CPHS) at Tsinghua University. The design, machining, assembly, and alignment of the DTL are ... ...

    Abstract This paper describes the radio frequency (RF) measurement and tuning result of a 13 MeV Alvarez-type drift tube linac (DTL) for a compact pulsed hadron source (CPHS) at Tsinghua University. The design, machining, assembly, and alignment of the DTL are presented for integrity. The CPHS project consists of a high-current proton linac (13 MeV, 16 kW, peak current of 50 mA, 0.5 ms pulse width at 50 Hz), a neutron target station, a small-angle neutron scattering instrument, and a neutron imaging/radiology station. The linac contains an electron cyclotron resonance ion source, a low energy beam transport line, a four-vane radio frequency quadrupole (RFQ) accelerator, an Alvarez-type DTL, a high energy beam transport line, and a RF power supply and distributor. Construction on the CPHS started in June 2009, and the CPHS has provided 2000 h since 2013 to users with the neutrons produced by the 3 MeV proton beam from the radio frequency quadrupole bombarding on the beryllium target as an achievement of its mid-term objective. Presently, the tuning of the assembled DTL cavity has been completed successfully. The 4.3-m-long DTL consists of 40 accelerating cells, among which 39 full-length drift tubes (DTs) are suspended inside the cavity, and two half-length DTs are mounted inside the two end flanges of the cavity. Each DT contains a permanent magnet quadrupole. Thirteen post couplers and nine tuners are available for the tuning of the field. The relative error of the field after tuning is within ±1.6%, with a tilt sensitivity within ±33%/MHz in all cells. The beam energy will reach its designed value of 13 MeV after the DTL is installed in the beam line downstream the 3 MeV RFQ accelerator.
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/1.5064462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.

    Hu, G-Q / Song, P-X / Li, N / Chen, W / Lei, Q-Q / Yu, S-X / Zhang, X-J / Du, C-T / Deng, X-M / Han, W-Y / Yang, Y-J

    Mucosal immunology

    2016  Volume 9, Issue 5, Page(s) 1330–1339

    Abstract: The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. ... ...

    Abstract The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal but not systemic infection by Salmonella typhimurium, indicating a protective role for AIM2 in the gastrointestinal tract. In a Salmonella colitis model, compared with wild-type mice, AIM2(-/-) mice exhibited more severe body weight loss, intestinal damage, intestinal inflammation, and disruption of basal and activated epithelial cell turnover. In vivo and in vitro data showed that AIM2 restricted the early epithelial paracellular invasion of Salmonella and decreased epithelial permeability. The decreased epithelial barrier in AIM2(-/-) mice might be attributed to the altered expression of tight junction proteins that contribute to epithelial integrity. AIM2 promoted the expression of tight junction proteins through Akt activation. Together, these results suggest that AIM2 is required for maintaining the integrity of the epithelial barrier.
    MeSH term(s) Animals ; Caco-2 Cells ; Cecum/immunology ; Cecum/microbiology ; Cecum/pathology ; Claudin-3/genetics ; Claudin-3/immunology ; Colitis/genetics ; Colitis/immunology ; Colitis/microbiology ; Colitis/pathology ; Cytokines/genetics ; Cytokines/immunology ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/immunology ; Epithelial Cells/immunology ; Epithelial Cells/microbiology ; Epithelial Cells/pathology ; Gene Expression Regulation ; Humans ; Immunity, Mucosal ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Permeability ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/immunology ; Salmonella Infections/genetics ; Salmonella Infections/immunology ; Salmonella Infections/microbiology ; Salmonella Infections/pathology ; Salmonella typhimurium/growth & development ; Salmonella typhimurium/immunology ; Severity of Illness Index ; Signal Transduction ; Survival Analysis ; Tight Junctions/immunology ; Tight Junctions/microbiology ; Tight Junctions/pathology
    Chemical Substances Aim2 protein, mouse ; Claudin-3 ; Cldn3 protein, mouse ; Cytokines ; DNA-Binding Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2016-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/mi.2015.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Patient delay in the diagnosis and treatment of tuberculosis in China: findings of case detection projects.

    Lin, Y / Enarson, D A / Chiang, C-Y / Rusen, I D / Qiu, L-X / Kan, X-H / Yuan, Y-L / Du, J / Zhang, T-H / Li, Y / Li, X-F / Du, C-T / Zhang, L-X

    Public health action

    2015  Volume 5, Issue 1, Page(s) 65–69

    Abstract: Objective: 1) To assess patient delay among new smear-positive pulmonary tuberculosis (PTB) patients in accessing health services in seven FIDELIS (Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB) projects from 2003 to 2008 in ... ...

    Abstract Objective: 1) To assess patient delay among new smear-positive pulmonary tuberculosis (PTB) patients in accessing health services in seven FIDELIS (Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB) projects from 2003 to 2008 in China; 2) to compare treatment delay by province; and 3) to assess factors associated with delay.
    Method: Records of new smear-positive PTB patients were reviewed. Data sources were the consultation book, laboratory register, patient record, treatment card and the PWLAHS (people with limited access to health services) evaluation form. Data were collected using a standard questionnaire, cross-checked by staff from the sites and by the International Union Against Tuberculosis and Lung Disease (The Union) and analysed by The Union.
    Results: Of the 75 401 new smear-positive PTB patients included in the study, 63-89% were PWLAHS. The average gross domestic product of the project sites and at national level were respectively US$557 and US$998. The median patient delay was 93 days (range 68-128). Delays were longer among females, older patients, rural residents and PWLAHS. Delayed access to health services was significantly associated with a greater number of symptoms.
    Conclusion: Patient delay in accessing health care in China was lengthy; TB care and control needs to be improved.
    Language English
    Publishing date 2015-05-08
    Publishing country France
    Document type Journal Article
    ISSN 2220-8372
    ISSN 2220-8372
    DOI 10.5588/pha.14.0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Anthocyanins of mangosteen, Garcinia mangostana

    Du, C.T / Francis, F.J

    Journal of food science. Nov/Dec 1977, 46 (2)

    1977  

    Keywords plant physiology ; plant biochemistry ; horticultural crops
    Language English
    Size p. 1667-1668.
    Document type Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Anthocyanins of garlic

    Du, C.T / Francis, F.J

    Journal of food science. Sept/Oct 1975, 40 (5)

    1975  

    Title variant Anthocyanins of garlic [Allium sativum L.]
    Keywords Allium sativum
    Language English
    Dates of publication 1975-09
    Size p. 1101-1102.
    Document type Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Anthocyanins of Cotoneaster and barberry

    Du, C.T / Francis, F.J

    Hortsci Feb 1974, 9 (1)

    1974  

    Title variant Anthocyanins of Cotoneaster[divaricata] and barberry. [Berberis thunbergii]
    Keywords Berberis thunbergii
    Language English
    Dates of publication 1974-02
    Size p. 40.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Anthocyanins of Roselle (Hibiscus sabdariffa, L.)

    Du, C.T / Francis, F.J

    Journal of food science. July/Aug 1973, 38 (5)

    1973  

    Keywords plant products ; horticultural crops
    Language English
    Dates of publication 1973-07
    Size p. 810-812.
    Document type Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    Database NAL-Catalogue (AGRICOLA)

    Kategorien

  8. Article: Light-induced oxidation in milkfat

    Du, C.T / Armstrong, J.G

    Canadian Institute of Food Technology journal. Oct 1970, 3 (4)

    1970  

    Keywords organic production ; alternative farming
    Language English
    Dates of publication 1970-10
    Size p. 167-171.
    Document type Article
    ISSN 0008-3860
    Database NAL-Catalogue (AGRICOLA)

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